The DOI matches its Crossref record; 321 of the 325 references it cites were found in a registry or an index.
Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
Abstract
This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules. Special consideration is given to the function of neurotrophic factors in the adult and aging brain. Strategies are discussed for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.
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“It is known that BDNF exerts positive effects such as anti-apoptosis, anti-inflammation, anti-neurotoxicity and neural regeneration.”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [99]
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Cites
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Physiology of nerve growth factor.
Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,573
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,445
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Strickland, S., & Mahdavi, V. (1978) · Cell · doi:10.1016/0092-8674(78)90008-9 · Cited by 1,420
Actions of Insulin-Like Growth Factors
Froesch, E. R., Schmid, C., Schwander, J., & Zapf, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002303 · Cited by 1,154
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120
Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093
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Silver, R., & LeSauter, J. (1995) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0003750x · Cited by 1
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Walicke, P. A. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90119-x · Cited by 1
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Asthana, S., Baker, L. D., & Tate, P. S. (1997) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.6.9.1203 · Cited by 1
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Tolédano, A. (1997) · Cited by 1
Cuello, A. C. (1995) · Advances in behavioral biology · doi:10.1007/978-1-4757-9145-7_90 · Cited by 1
Ontogenic Profile of Epidermal Growth Factor Receptors in Rat Brain
Chabot, J., Kar, S., & Quirion, R. (1993) · Springer eBooks · doi:10.1007/978-94-011-1540-7_5 · Cited by 1
Functions of NGF on Central Cholinergic Neurons
Gage, F. H., Chen, K. S., Tuszynski, M. H., & Fagan, A. M. (1990) · doi:10.1007/978-1-349-11358-3_9 · Cited by 1
Cholinergic Systems in Alzheimer’s Disease, Parkinson’s Disease and Progressive Supranuclear Palsy
Agid, Y., Graybiel, A. M., Ruberg, M., Hirsch, É. C., Brandel, J., Cervera, P., Juncos, J. J., Lehéricy, S., Malessa, S., Ransmayr, G. N., et al. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2_88 · Cited by 1
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Astroglial neurotrophic and neurite-promoting factors
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Sofroniew, M. V., & Svendsen, C. N. (1991) · Springer eBooks · doi:10.1007/978-3-642-76208-6_13 · Cited by 1
Cotman, C. W., & Cummings, B. J. (1999) · Elsevier eBooks · doi:10.1016/b978-012705070-6/50022-6
Ferrero, M. E., Fulgenzi, A., & Tiengo, M. (1999) · Springer eBooks · doi:10.1007/978-88-470-2240-9_6
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Li, S., Fa-qing, L., Tan, W., Yang, N. Q., Jin, H., & Chen, H. (1998) · Biotechnology and Applied Biochemistry · doi:10.1111/j.1470-8744.1998.tb00532.x
Burke, M. A., Mufson, E. J., & Kordower, J. H. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1929-4_22
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The spinal cord as an alternative model for nerve tissue graft
Privat, A., & y Ribotta, M. G. (1995) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00037456
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Elegant studies of transplant-derived repair of cognitive performance
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Sinden, J. D., Hodges, H., & Gray, J. A. (1995) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00037584
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Knüsel, B., & Hefti, F. F. (1994) · Key topics in brain research · doi:10.1007/978-3-7091-9376-1_9
Modifizierende Faktoren in der Pathogenese der Alzheimer-Krankheit
Eppendorf, U., & Naber, D. (1999)
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Winblad, B. G., Cowburn, R. F., O’Neill, C., & Fowler, C. J. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6805-2_20
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Knežević, S., Bogdanović, N., Spilich, G. J., & Chudy, D. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6805-2_23
Walicke, P. A. (1989) · Advances in behavioral biology · doi:10.1007/978-1-4684-5727-8_13
Cardoso, A. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/sc5e-2g25
Trophic Control of Central Cholinergic Neuron Development In Vitro
Hefti, F. F., & Knüsel, B. (1990) · doi:10.1007/978-1-349-11358-3_2
Dixon, D. A. (2014) · CORE Scholar (Wright State University)
Tajrine, D. (1996) · Library and Archives Canada (Government of Canada) · doi:10.82308/54483
Neurobiología molecular de la enfermedad de Alzheimer: prospecciones terapéuticas
Cacabelos, R. (1992) · Dialnet (Universidad de la Rioja)
Dooley, A. (1997) · UCL Discovery (University College London)
Effects of Brain-Derived Neurotrophic Factor on Injured Dopaminergic Neurons
Hefti, F. F., Beck, K. D., & Knüsel, B. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-042276-3.50013-6
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Mecocci, P., Polidori, M. C., Cherubini, A., & Senin, U. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1483-5_21
Maintenance and Regulation in Brain of Neurotransmission, Trophic Factors, and Immune Responses
Cotman, C. W., Kahle, J. S., & Korotzer, A. R. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01685.x
Effect of Nerve Growth Factor on Lesioned and Intact CNS
Vantini, G., Fusco, M., Toso, R. D., CAVICCHIOLI, L., Leon, A., & Toffano, G. (1991) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6738-1_45
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Hefti, F. F. (1994) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-9203-3_3
The aging hippocampus: Neural mechanisms underlying learning and memory deficits in old rats
Shen, J. (1996) · UA Campus Repository (The University of Arizona)
Sofroniew, M. V., Svendsen, C. N., & Ole Isacson, A. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2_132
Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1
Metadata
- Authors
- Hefti, F., Hartikka, J., & Knusel, B.
- Affiliations
- University of Southern California (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1989-09
- Volume
- 10
- Issue
- 5
- Pages
- 515-533
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2020771907
- Cited by
- 466
- References
- 325
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-22933)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neurotrophic factors, nerve growth factor, brain aging, adult brain, neurodegenerative diseases, neurotrophic therapy, neuroprotection
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Nerve Growth Factors, Nervous System, Nervous System Physiological Phenomena, Parkinson Disease
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