Oxytocin cell number in the human paraventricular nucleus remains constant with aging and in Alzheimer’s disease
Open accessAbstract
Total cell numbers in the paraventricular nucleus (PVN) were previously shown to remain unaltered with aging and in AD. The aim of the present study was to determine the aging pattern of the oxytocin (OXT) cell population in the PVN. For this purpose, the number of immunocytochemically identified oxytocin cells was determined in the PVN of the human hypothalamus in 20 control subjects ranging in age from 15 to 90 years and in 10 Alzheimer's disease (AD) patients aged 46 to 97 years. The results show that the number of OXT cells in the PVN is similar in males and females and remains unaltered in senescence and AD. It is concluded that the remarkable stability of the PVN in these conditions also applies for the subpopulation of OXT cells in this nucleus and that reports in the literature on diminished OXT secretion in AD do not seem to be based on a decrease in the number of OXT expressing neurons from the PVN.
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There is a lack of sex differences in OT neuron size and number in humans.
“There is also a lack of sex differences in OT neuron size and number in humans”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Wierda et al., 1991
In Homo, males and females do not differ in the number or size of OT-ir neurons in the neurohypophyseal tract.
“In Homo, males and females do no differ in the number or size of OT-ir neurons in the neurohypophyseal tract (Fliers et al., 1985; Ishunina and Swaab, 1999; Wierda et al., 1991).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Wierda et al., 1991
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- Authors
- Wierda, M., Goudsmit, E., Van Der Woude, P. F., Purba, J. S., Hofman, M. A., Bogte, H., & Swaab, D. F.
- Corresponding author
- Goudsmit, E.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1991-09
- Volume
- 12
- Issue
- 5
- Pages
- 511-516
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2055374671
- Cited by
- 92
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 9 · 2013: 2 · 2012: 2
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- oxytocin, paraventricular nucleus, hypothalamus, Alzheimer's disease, aging, neuron number, human brain, sex differences, oxytocin neurons
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Female, Humans, Immunohistochemistry, Male, Middle Aged, Oxytocin, Paraventricular Hypothalamic Nucleus
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