The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

Fliers, E.; Swaab, D.F.; W. Pool, Chr.; Verwer, R.W.H.

doi:10.1016/0006-8993(85)91351-4

Cited by 190Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyElectrolyte and hormonal disorders

The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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Fliers, E., Swaab, D.F., W. Pool, Chr., Verwer, R.W.H.·1985·Brain Research

DOI 10.1016/0006-8993(85)91351-4

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Abstract

The neuropeptides vasopressin (AVP) and oxytocin (OXT) are supposed to be involved not only in peripheral functions (e.g. diuresis, labour and lactation) but also in central processes that are frequently disturbed during aging and senile dementia (e.g. fluid and electrolyte homeostasis and cognitive functions). A concomitant decrease in activity of the hypothalamo-neurohypophyseal system (HNS) with aging has been postulated in the literature, but has not yet been established. In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the Alzheimer type (SDAT). Cell size was used as a parameter for peptide production. Mean profile area of OXT cells did not show any significant changes with increasing age. Mean profile area of AVP cells, however, showed an initial decrease up to the sixth decade of life, after which a gradual increase was observed. Size of AVP and OXT cell nuclei did not change significantly with aging. Observations in brains from patients with SDAT were within the range for their age group. The present results do not support degeneration or diminished function of the HNS in senescence or SDAT, as generally presumed in the literature, but suggest an activation of AVP cells after 80 years of age. The activation of AVP cells in senescence is in accordance with previous findings in the aged Wistar rat.

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There is a lack of sex differences in OT neuron size and number in humans.
“There is also a lack of sex differences in OT neuron size and number in humans”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Fliers et al., 1985
In Homo, males and females do not differ in the number or size of OT-ir neurons in the neurohypophyseal tract.
“In Homo, males and females do no differ in the number or size of OT-ir neurons in the neurohypophyseal tract (Fliers et al., 1985; Ishunina and Swaab, 1999; Wierda et al., 1991).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Fliers et al., 1985
Oscillations in the suprachiasmatic nuclei are disrupted in α-synuclein transgenic mice quite early in the development of the disease.
“As indicated by Willison et al. (Fliers et al., 1985), oscillations in the suprachiasmatic nuclei are disrupted in α-synuclein transgenic mice quite early in the development of the disease.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Fliers et al., 1985

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Authors: Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H.
Corresponding author: Fliers, E.
ORCID: Fliers, E.
Swaab, D.F.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1985-09
Volume: 342
Issue: 1
Pages: 45-53
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(85)91351-4
OpenAlex: W2029372047
Cited by: 190
References: 43
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 17.96
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords: vasopressin, oxytocin, supraoptic nucleus, paraventricular nucleus, hypothalamo-neurohypophysial system, aging, senile dementia, Alzheimer's disease, neuropeptide neurons, cell size, fluid and electrolyte balance
MeSH terms: Adolescent, Adult, Aged, Aging, Alzheimer Disease, Arginine Vasopressin, Child, Female, Histocytochemistry, Humans, Immunochemistry, Male, Middle Aged, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus

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The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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