The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Activation of the classical complement pathway in brain tissue of Alzheimer patients
Abstract
Positive immunohistochemical staining of Alzheimer brain tissue was obtained with antibodies to proteins associated with classical, but not the alternative, complement pathway. Clq, C3d, C4d are fractions of complement proteins that bind to tissue when the classical complement pathway is activated. Antibodies to these fractions stained senile plaques, dystrophic neurites and some neurofibrillary tangles. C5b-9 is the membrane attack complex which promotes cell lysis when assembled on the plasma membrane. An antibody to a neoantigenic site on this complex stained dystrophic neurites and many neurofibrillary tangles, but not extracellular amyloid. Properdin and fraction Bb of factor B, two proteins that bind to tissue when the alternative complement pathway is activated, were not detected immunohistochemically.
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“in normal aging [300] and in tauopathy patients [75], C1q is dramatically upregulated and is shown to co-localize with hyperphosphorylated tau, plaques and neurofibrillary tangles in AD brain sections [1, 219, 282]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [219]
In the citing paper
“The classical complement cascade is triggered by C1q-complex, and C1q is strongly expressed by microglia and enriched in the plaque cellular niche, as shown in Figure 4I and S4B (Eikelenboom et al. , 1988; McGeer et al. , 1989).”
From Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease (2020) · cites this paper as McGeer et al., 1989
Citations
Cites
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940
Self-citationMcGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836
Self-citationRogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study
Eikelenboom, P., & Stam, F. C. (1982) · Acta Neuropathologica · doi:10.1007/bf00685397 · Cited by 454
Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease
Selkoe, D. J., Abraham, C. R., Podlisny, M. B., & Duffy, L. K. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb08501.x · Cited by 452
Complement activation in amyloid plaques in Alzheimer’s dementia
Eikelenboom, P., Hack, C. E., Rozemüller, A. J. M., & Stam, F. C. (1988) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890024 · Cited by 288
YAMAGUCHI, H., Hirai, S., Morimatsu, M., Shoji, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00689591 · Cited by 283
Itagaki, S., McGeer, P. L., & Akiyama, H. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90690-8 · Cited by 271
Self-citationGatenby, P. A., & Axiak, S. M. (1988) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1988.tb02238.x · Cited by 269
An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia
Eikelenboom, P., & Stam, F. C. (1984) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890185 · Cited by 83
Loss of glutaminase-positive cortical neurons in Alzheimer's disease
Akiyama, H., McGeer, P. L., Itagaki, S., McGeer, E. G., & Kaneko, T. (1989) · Neurochemical Research · doi:10.1007/bf01000038 · Cited by 42
Self-citationImmunology and Alzheimer’s Disease
(1988) · Springer eBooks · doi:10.1007/978-3-642-46634-2 · Cited by 39
Ishii, T., Haga, S., & Kametani, F. (1988) · Springer eBooks · doi:10.1007/978-3-642-46634-2_3 · Cited by 32
Xia, P.-F., Jordon, R. E., & Geoghegan, W. D. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113813 · Cited by 24
Immunological Markers and Neuropathological Lesions in Alzheimer’s Disease
Pouplard-Barthelaix, A. (1988) · Springer eBooks · doi:10.1007/978-3-642-46634-2_2 · Cited by 22
Research works printed but not linked: 1
- Kolb, 1988, Development of a highly sensitive capture EIA for the quantitation of the SC5b-9 complex in human plasma using a monoclonal antibody reactive with a poly-C9 neoantigenic determinant, Complement, 5, 213
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Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Self-citationAlzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
Karch, C. M., & Goate, A. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.006 · Cited by 1,357
Risk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.038 · Cited by 949
Metadata
- Authors
- McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, P.L.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1989-12
- Volume
- 107
- Issue
- 1-3
- Pages
- 341-346
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1980565738
- Cited by
- 383
- References
- 15
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 10
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- classical complement pathway, Alzheimer's disease, complement activation, C1q, C3d, C4d, C5b-9 membrane attack complex, amyloid plaques, dystrophic neurites, neurofibrillary tangles, amyloid, alternative complement pathway, properdin, factor B
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Complement Activation, Complement Pathway, Classical, Complement C4, Humans, Immunohistochemistry, Neurofibrils, Peptide Fragments, Complement C1q, Complement C3d, Complement C4b, Complement Membrane Attack Complex
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