The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Activation of the classical complement pathway in brain tissue of Alzheimer patients
Abstract
Positive immunohistochemical staining of Alzheimer brain tissue was obtained with antibodies to proteins associated with classical, but not the alternative, complement pathway. Clq, C3d, C4d are fractions of complement proteins that bind to tissue when the classical complement pathway is activated. Antibodies to these fractions stained senile plaques, dystrophic neurites and some neurofibrillary tangles. C5b-9 is the membrane attack complex which promotes cell lysis when assembled on the plasma membrane. An antibody to a neoantigenic site on this complex stained dystrophic neurites and many neurofibrillary tangles, but not extracellular amyloid. Properdin and fraction Bb of factor B, two proteins that bind to tissue when the alternative complement pathway is activated, were not detected immunohistochemically.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“in normal aging [300] and in tauopathy patients [75], C1q is dramatically upregulated and is shown to co-localize with hyperphosphorylated tau, plaques and neurofibrillary tangles in AD brain sections [1, 219, 282]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [219]
In the citing paper
“The classical complement cascade is triggered by C1q-complex, and C1q is strongly expressed by microglia and enriched in the plaque cellular niche, as shown in Figure 4I and S4B (Eikelenboom et al. , 1988; McGeer et al. , 1989).”
From Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease (2020) · cites this paper as McGeer et al., 1989
Citations
Cites
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940
Self-citationMcGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836
Self-citationRogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study
Eikelenboom, P., & Stam, F. C. (1982) · Acta Neuropathologica · doi:10.1007/bf00685397 · Cited by 454
Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease
Selkoe, D. J., Abraham, C. R., Podlisny, M. B., & Duffy, L. K. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb08501.x · Cited by 452
Complement activation in amyloid plaques in Alzheimer’s dementia
Eikelenboom, P., Hack, C. E., Rozemüller, A. J. M., & Stam, F. C. (1988) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890024 · Cited by 288
YAMAGUCHI, H., Hirai, S., Morimatsu, M., Shoji, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00689591 · Cited by 283
Itagaki, S., McGeer, P. L., & Akiyama, H. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90690-8 · Cited by 271
Self-citationGatenby, P. A., & Axiak, S. M. (1988) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1988.tb02238.x · Cited by 269
An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia
Eikelenboom, P., & Stam, F. C. (1984) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890185 · Cited by 83
Research works printed but not linked: 1
- Kolb, 1988, Development of a highly sensitive capture EIA for the quantitation of the SC5b-9 complex in human plasma using a monoclonal antibody reactive with a poly-C9 neoantigenic determinant, Complement, 5, 213
Cited by
Sorted by citations
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Self-citationAlzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
Karch, C. M., & Goate, A. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.006 · Cited by 1,357
Risk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.038 · Cited by 949
Review: Activation patterns of microglia and their identification in the human brain
Boche, D., Perry, V. H., & Nicoll, J. A. R. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 955
Biran, R., Martin, D. C., & Tresco, P. A. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.04.020 · Cited by 893
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817
Self-citationChen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 698
Neuroinflammation in Alzheimer disease
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638
Microglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 596
Self-citationHensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08126.1998 · Cited by 508
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
McGeer, P. L., & McGeer, E. G. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1177-7 · Cited by 467
Self-citationInflammation and Alzheimer's disease pathogenesis
Rogers, J., Webster, S. D., Lue, L., Brachova, L., CIVIN, W. H., Emmerling, M. R., Shivers, B. D., Walker, D. G., & McGeer, P. L. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00115-7 · Cited by 438
Self-citationAnti-inflammatory drugs and Alzheimer disease
McGeer, P. L., McGeer, E. G., Rogers, J., & Sibley, J. T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91101-f · Cited by 437
Self-citationBrain microglia constitutively express β-2 integrins
Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430
Self-citationThe toxicity in vitro of β-amyloid protein
Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 428
Inflammatory process in Alzheimer's Disease
Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427
Veerhuis, R., Nielsen, H. M., & Tenner, A. J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.003 · Cited by 436
Glial cytokines in Alzheimer's disease: Review and pathogenic implications
Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90001-2 · Cited by 415
Microglia and inflammatory mechanisms in the clearance of amyloid β peptide
Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381
Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies
Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M., & Buckley, N. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00164 · Cited by 381
Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β
Atwood, C., Perry, G. L., Zeng, H., Kato, Y., Jones, W. D., Ling, K.-Q., Huang, X., Moir, R. D., Wang, D., Sayre, L. M., et al. (2003) · Biochemistry · doi:10.1021/bi0358824 · Cited by 371
Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.068 · Cited by 363
Complement components of the innate immune system in health and disease in the CNS
Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J., & Morgan, B. P. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)80302-1 · Cited by 343
Biran, R., Martin, D. C., & Tresco, P. A. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31138 · Cited by 340
Microglial Dynamics and Role in the Healthy and Diseased Brain: A Paradigm of Functional Plasticity
Gomez-Nicola, D., & Perry, V. H. (2015) · The Neuroscientist · doi:10.1177/1073858414530512 · Cited by 340
Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients
Fiala, M., Lin, J., Ringman, J. M., Kermani-Arab, V., Tsao, G., Patel, A. J., Lossinsky, A. S., Graves, M. C., Gustavson, A. R., Sayre, J. W., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7304 · Cited by 331
Maier, M., Peng, Y., Jiang, L., Seabrook, T. J., Carroll, M. C., & Lemere, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0829-08.2008 · Cited by 323
Butyrylcholinesterase in the life cycle of amyloid plaques
Guillozet-Bongaarts, A. L., Mesulam, M. M., Smiley, J. F., & Mash, D. C. (1997) · Annals of Neurology · doi:10.1002/ana.410420613 · Cited by 313
Fiala, M., Liu, Q. N., Sayre, J., Pop, V., Brahmandam, V., Graves, M. C., & Vinters, H. V. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00994.x · Cited by 307
Atwood, C., Obrenovich, M. E., Liu, T., Chan, H., Perry, G. L., Smith, M. A., & Martins, R. N. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00174-7 · Cited by 297
Microglia actions in Alzheimer's disease
Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
Guerreiro, R. J., Gustafson, D. R., & Hardy, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.025 · Cited by 285
Parallel findings in age-related macular degeneration and Alzheimer’s disease
Ohno-Matsui, K. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.02.004 · Cited by 280
Genetic Analysis of Pathways to Parkinson Disease
Hardy, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.014 · Cited by 276
Webster, S. D., Lue, L., Brachova, L., Tenner, A. J., McGeer, P. L., Terai, K., Walker, D. G., Bradt, B. M., Cooper, N. R., & Rogers, J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00042-0 · Cited by 258
Self-citationComplement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide
Bradt, B. M., Kolb, W. P., & Cooper, N. R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.3.431 · Cited by 255
The cause of neuronal degeneration in Alzheimer’s disease
Vickers, J. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00023-4 · Cited by 254
Biological markers for therapeutic trials in Alzheimer’s disease
Frank, R., Galasko, D., Hampel, H. J., Hardy, J., de Leon, M. J., Mehta, P. D., Rogers, J., Siemers, E., & Trojanowski, J. Q. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00002-2 · Cited by 254
Complement and cytokine gene expression in cultured microglia derived from postmortem human brains
Walker, D. G., Kim, S. U., & McGeer, P. L. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490400407 · Cited by 248
Self-citationThe Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234
MHC class II‐positive microglia in human brain: Association with alzheimer lesions
Perlmutter, L. S., Scott, S. A., Barrón, E., & Chui, H. C. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330407 · Cited by 228
Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins
Yamada, T., McGeer, P. L., & McGeer, E. G. (1992) · Acta Neuropathologica · doi:10.1007/bf00427222 · Cited by 231
Self-citationComplement Component C3 Mediates Inflammatory Injury Following Focal Cerebral Ischemia
Mocco, J., Mack, W. J., Ducruet, A. F., Sosunov, S. A., Sughrue, M. E., Hassid, B. G., Nair, M. N., Laufer, I., Komotar, R. J., Claire, M. B. F. S., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000232544.90675.42 · Cited by 226
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220
Microglial immunophenotype in dementia with Alzheimer’s pathology
CFAS, M., Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A. R., & Boche, D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0601-z · Cited by 219
Activation of Complement in the Central Nervous System
van Beek, J., Elward, K., & Gasque, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03138.x · Cited by 220
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216
“While more investigation in the human is required to confirm microglial association with C1q-mediated tagging of synapses, in normal aging [300] and in tauopathy patients [75], C1q is dramatically upregulated and is shown to co-localize with hyperphosphorylated tau, plaques and neurofibrillary tangles in AD brain sect…”
BackgroundThe role of the immune system in Alzheimer disease: Etiology and treatment
Jevtic, S. D., Sengar, A. S., Salter, M. W., & McLaurin, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.005 · Cited by 224
Huell, M., Strauss, S., Volk, B., Berger, M., & Bauer, J. (1995) · Acta Neuropathologica · doi:10.1007/bf00571510 · Cited by 214
Innate Immunity and Neuroinflammation
Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 207
Intersection of pathological tau and microglia at the synapse
Vogels, T., Murgoci, A.-N., & Hromádka, T. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0754-y · Cited by 197
Stoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., & Lemere, C. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64753-0 · Cited by 187
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184
Role of microglia in senile plaque formation
Mackenzie, I. R. A., Hao, C., & Munoz, D. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00092-s · Cited by 183
Can oral infection be a risk factor for Alzheimer's disease?
Olsen, I., & Singhrao, S. K. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.29143 · Cited by 192
Johnson, S. A., Lampert-Etchells, M., Pasinetti, G. M., Rozovsky, I., & Finch, C. E. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90086-d · Cited by 176
Landel, V., Baranger, K., Virard, I., Loriod, B., Khrestchatisky, M., Rivera, S., Benech, P., & Féron, F. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-33 · Cited by 176
Complement activation in the brain after experimental intracerebral hemorrhage
Ya, H., Xi, G., Keep, R. F., & Hoff, J. T. (2000) · Journal of neurosurgery · doi:10.3171/jns.2000.92.6.1016 · Cited by 175
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
(2024) · aging and disease · doi:10.14336/ad.2023.0608 · Cited by 183
Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration
May, P. C., & Finch, C. E. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90190-j · Cited by 170
Lorent, K., Overbergh, L., Moechars, D., Strooper, B. D., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00555-j · Cited by 170
Complement gene expression in human brain: comparison between normal and Alzheimer disease cases
Walker, D. G., & McGeer, P. L. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90017-6 · Cited by 167
Self-citationKalman, J. L., Juhász, A., Laird, G., Dickens, P., Járdánházy, T., Rimanóczy, Á., Boncz, I., Parry-Jones, W. L., & Janka, Z. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1997.tb00275.x · Cited by 168
Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair
Siebert, J. R., Conta, A. C., & Osterhout, D. J. (2014) · BioMed Research International · doi:10.1155/2014/845323 · Cited by 159
The Role of the Complement Cascade in Ischemia/Reperfusion Injury: Implications for Neuroprotection
D’Ambrosio, A. L., Pinsky, D. J., & Connolly, E. S. (2001) · Molecular Medicine · doi:10.1007/bf03402183 · Cited by 153
Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
Harris, S. A., & Harris, E. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00048 · Cited by 154
Mhatre, M., Floyd, R. A., & Hensley, K. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6206 · Cited by 148
Hecker, L. A., Edwards, A. O., Ryu, E., Tosakulwong, N., Baratz, K. H., Brown, W. L., Issa, P. C., Scholl, H. P. N., Pollok‐Kopp, B., Schmid‐Kubista, K. E., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp472 · Cited by 149
Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease
Gomez-Nicola, D., & Boche, D. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0126-1 · Cited by 147
Xiong, Z., Eika Weihua, Q. I. A. N., Suzuki, K., & McNamara, J. O. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00955.2003 · Cited by 145
Hauwel, M., Furon, E., Canova, C., Griffiths, M., Neal, J. W., & Gasque, P. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.012 · Cited by 144
The effects of a novel NSAID on chronic neuroinflammation are age dependent☆
Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00028-7 · Cited by 141
Mirzaei, M., Gupta, V. B., Chick, J. M., Greco, T. M., Wu, Y., Chitranshi, N., Wall, R. V., Hone, E., Deng, L., Dheer, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12858-7 · Cited by 141
The Complement System in Schizophrenia
Mayilyan, K. R., Weinberger, D. R., & Sim, R. B. (2008) · Drug News & Perspectives · doi:10.1358/dnp.2008.21.4.1213349 · Cited by 139
Complement C1qB and C4 mRNAs responses to lesioning in rat brain
Pasinetti, G. M., Johnson, S. A., Rozovsky, I., Lampert-Etchells, M., Morgan, D., Gordon, M. N., Morgan, T. E., Willoughby, D., & Finch, C. E. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90028-o · Cited by 138
Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica · doi:10.1007/bf00334673 · Cited by 137
Self-citationAtwood, C., Martins, R. N., Smith, M. A., & Perry, G. L. (2002) · Peptides · doi:10.1016/s0196-9781(02)00070-0 · Cited by 142
Griffiths, M., Neal, J., & Gasque, P. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82002-2 · Cited by 138
Xiao, H., Hasegawa, T., & Isobe, K. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990601)73:3 · Cited by 131
Yang, L., Li, R., Meri, S., Rogers, J., & Shen, Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07505.2000 · Cited by 136
Haga, S., Ikeda, K., Sato, M., & Ishii, T. (1993) · Brain Research · doi:10.1016/0006-8993(93)91698-r · Cited by 136
Singhrao, S. K., Neal, J., Rushmere, N. K., Morgan, B. P., & Gasque, P. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64604-4 · Cited by 134
Leveugle, B., Spik, G., Perl, D. P., Bouras, C., Fillit, H. M., & Hof, P. R. (1994) · Brain Research · doi:10.1016/0006-8993(94)90202-x · Cited by 131
Complement receptor 1 (CR1) and Alzheimer's disease
Crehan, H., Holton, P., Wray, S., Pocock, J., Guerreiro, R., & Hardy, J. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.07.017 · Cited by 129
Goldknopf, I. L., Sheta, E. A., Bryson, J., Folsom, B., Wilson, C., Duty, J., Yen, A. A., & Appel, S. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.051 · Cited by 126
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
Schwab, C., Hosokawa, M., & McGeer, P. L. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.03.016 · Cited by 126
Self-citationWilhelmus, M. M. M., de Waal, R. M. W., & Verbeek, M. M. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0029-7 · Cited by 125
Reichwald, J., Danner, S., Wiederhold, K., & Staufenbiel, M. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-35 · Cited by 122
Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging
Zimmer, E. R., Leuzy, A., Benedet, A. L., Breitner, J., Gauthier, S., & Rosa-Neto, P. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-120 · Cited by 121
Padmanabhan, J., Levy, M. M., Dickson, D. W., & Potter, H. (2006) · Brain · doi:10.1093/brain/awl255 · Cited by 124
Neuroinflammation‐induced acceleration of amyloid deposition in the APPV717F transgenic mouse
Qiao, X., Cummins, D. J., & Paul, S. M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01666.x · Cited by 119
Akiyama, H., Kawamata, T., Dedhar, S., & McGeer, P. L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90067-h · Cited by 120
Self-citationSoane, L., Cho, H.-J., Niculescu, F. I., Rus, H., & Shin, M. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2305 · Cited by 115
Detection of complement alternative pathway mRNA and proteins in the Alzheimer’s disease brain
Strohmeyer, R., Shen, Y., & Rogers, J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00149-2 · Cited by 114
Pasinetti, G. M. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00113-3 · Cited by 115
Ma, J., Jiang, T., Tan, L., & Yu, J.-T. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8811-9 · Cited by 113
Araujo, D. M., & Lapchak, P. A. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90398-0 · Cited by 113
Itagaki, S., Akiyama, H., Saito, H., & McGeer, P. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)91640-3 · Cited by 112
Self-citation
Metadata
- Authors
- McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, P.L.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1989-12
- Volume
- 107
- Issue
- 1-3
- Pages
- 341-346
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1980565738
- Cited by
- 383
- References
- 15
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 10
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- classical complement pathway, Alzheimer's disease, complement activation, C1q, C3d, C4d, C5b-9 membrane attack complex, amyloid plaques, dystrophic neurites, neurofibrillary tangles, amyloid, alternative complement pathway, properdin, factor B
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Complement Activation, Complement Pathway, Classical, Complement C4, Humans, Immunohistochemistry, Neurofibrils, Peptide Fragments, Complement C1q, Complement C3d, Complement C4b, Complement Membrane Attack Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review