Cited by 383Complement system in diseasesAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P.L., Akiyama, H., Itagaki, S., McGeer, E.G.·1989·Neuroscience Letters

Abstract

Positive immunohistochemical staining of Alzheimer brain tissue was obtained with antibodies to proteins associated with classical, but not the alternative, complement pathway. Clq, C3d, C4d are fractions of complement proteins that bind to tissue when the classical complement pathway is activated. Antibodies to these fractions stained senile plaques, dystrophic neurites and some neurofibrillary tangles. C5b-9 is the membrane attack complex which promotes cell lysis when assembled on the plasma membrane. An antibody to a neoantigenic site on this complex stained dystrophic neurites and many neurofibrillary tangles, but not extracellular amyloid. Properdin and fraction Bb of factor B, two proteins that bind to tissue when the alternative complement pathway is activated, were not detected immunohistochemically.

Overview

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Crossref · 10.1016/0304-3940(89)90843-4

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15 of 15 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Kolb, 1988, Development of a highly sensitive capture EIA for the quantitation of the SC5b-9 complex in human plasma using a monoclonal antibody reactive with a poly-C9 neoantigenic determinant, Complement, 5, 213

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Metadata

Authors
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G.
Affiliations
University of British Columbia (CA)
Corresponding author
McGeer, P.L.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1989-12
Volume
107
Issue
1-3
Pages
341-346
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1980565738
Cited by
383
References
15
Citations by year
2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 10
FWCI
3.94
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
classical complement pathway, Alzheimer's disease, complement activation, C1q, C3d, C4d, C5b-9 membrane attack complex, amyloid plaques, dystrophic neurites, neurofibrillary tangles, amyloid, alternative complement pathway, properdin, factor B
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Complement Activation, Complement Pathway, Classical, Complement C4, Humans, Immunohistochemistry, Neurofibrils, Peptide Fragments, Complement C1q, Complement C3d, Complement C4b, Complement Membrane Attack Complex

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