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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence
Open accessAbstract
Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.
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“These rat model findings suggest that central sensitization, a process thought to underlie pain hypersensitivity, is an important mechanism”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Coderre et al., 1993
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Citations
Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Studies and Perspectives of Protein Kinase C
Nishizuka, Y. (1986) · Science · doi:10.1126/science.3014651 · Cited by 5,068
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986
Research works printed but not linked: 16
- Albe-Fessard, 1983, Use of an animal model to evaluate the origin of and protection against deafferentation pain, Vol. 5, 691
- Bigot, 1989, Rapid induction of c-fos protein in glial and neuronal cells studied in vitro, Neurosci. Lett., S75
- Chi, 1990, Time course of peripheral neuroma-induced expression of Fos protein immunoreactivity in the spinal cord of rats and effects of local anesthetics, Soc. Neurosci. Abst., 16, 566
- David, 1980, Spontaneous activity generated in sciatic neuromas, a [14C]2-deoxyglucose uptake study in the rat, Neurosci. Abst., 6, 439
- Dubner, 1991, Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury, Vol. 4, 263
- Heapy, 1987, Afferent C-fibre and A-delta activity in models of inflammation, Br. J. Pharmacol., 90, 164P
- Herdegen, 1991, Noxious stimulation induces molecular genetic events in neurons of the central nervous system: expression of immediate-early gene encoded proteins, Vol. 4, 325
- Kajander, 1990, Labeling of fos protein increases in an experimental model of peripheral neuropathy in the rat, Soc. Neurosci. Abst., 16, 1281
- Kehl, 1991, The NMDA antagonist MK-801 reduces noxious stimulus-evoked Fos expression in the spinal dorsal horn, Vol. 4, 307
- Lombard, 1979, Thalamic recordings in rats with hyperalgesia, Vol. 3, 767
- Van Bogaert, 1934, Sur la pathologie de l'image de soi (átudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 519
- Van Bogaert, 1934, Sur la pathologie de l'image de soi (âtudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 714
- Wallgren, 1954, Phantom experience at spinal anaesthesia, Ann. Chir. et Gynaec. Fenniae, 43, 486
- Wilcox, 1991, Excitatory neurotransmitters and pain, Vol. 4, 97
- Womack, 1989, Substance P increases [Ca2+]i in dorsal horn neurons via two distinct mechanisms, Soc. Neurosci. Abst., 15, 184
- Yashpal, 1992, Comparison of the efficacy of a non-peptide substance P receptor (NK-1) antagonist, CP-96,345, in blocking responses to noxious thermal vs chemical stimulation in the rat, Can. Pain Soc. Abst.
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Bendtsen, L., & Fernández‐de‐las‐Peñas, C. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0216-0 · Cited by 149
“In addition, the effect of Aδ- and Cfiber stimulation of the nociceptive dorsal horn neurons will be potentiated and the receptive fields of the dorsal horn neurons will be expanded [ 61 ].”
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Rabben, T., Skjelbred, P., & Øye, I. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38236-9 · Cited by 149
Psychophysical measures of sensitization to tonic heat discriminate chronic pain patients
Kleinböhl, D., Hölzl, R., Möltner, A., Rommel, C., Weber, C., & Osswald, P. M. (1999) · Pain · doi:10.1016/s0304-3959(98)00266-8 · Cited by 149
“Sensitization may be induced at peripheral sites, in stimulus transduction and transmission, or in the CNS itself, this ‘central sensitization’ being initiated or conditioned by peripheral changes after acute injury (Coderre et al., 1993; Dickenson, 1995).”
BackgroundKonttinen, Y. T., Kemppinen, P., Segerberg, M., Hukkanen, M., Rees, R. G., Santavirta, S. S., Sorsa, T. A., Pertovaara, A., & Polak, J. M. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370701 · Cited by 149
Williams, V., Lascelles, B. D. X., & Robson, M. (2005) · New Zealand Veterinary Journal · doi:10.1080/00480169.2005.36504 · Cited by 148
“These include the suggestion that certain analgesic agents might be most effective if administered prior to the onset of pain (pre-emptive analgesia; Coderre et al 1993; Dahl and Kehlet 1993; Woolf and Chong 1993; Lascelles et al 1995, 1997; Kissin 2000; Moiniche et al 2002), and the suggestion…”
BackgroundMiki, K., Fukuoka, T., Tokunaga, A., & Noguchi, K. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00258-3 · Cited by 147
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Reuben, S. S., & Buvanendran, A. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00906 · Cited by 147
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Urban, M. O., & Gebhart, G. F. (1999) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70125-5 · Cited by 145
Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects
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Liu, X., Morton, C. R., Azkue, J. J., Zimmermann, M., & Sandkühler, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00310.x · Cited by 143
Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?
Trujillo, K. A. (2000) · Psychopharmacology · doi:10.1007/s002130000416 · Cited by 143
“…potentiation , long-term depression, kindling, and neural development, among others (Collingridge and Lester 1989; McDonald and Johnston 1990; Coderre et al. 1993; Davis et al. 1993; Malenka and Nicoll 1993; Bear and Malenka 1994; Collingridge and Watkins 1994; Dickenson 1995; Abraham and…”
BackgroundEvidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin
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Staud, R. M., Price, D. D., Robinson, M. E., Mauderli, A. P., & Vierck, C. J. (2004) · Pain · doi:10.1016/j.pain.2004.05.009 · Cited by 139
“WU-M is likely to be integrally related to central sensitization and persistent pain conditions, because it is accompanied by expanded receptive fields, enhanced responsiveness to nociceptive and non-nociceptive stimulation, and increased spontaneous activity of dorsal horn nociceptive neurons (Coderre et al., 1993; D…”
BackgroundInfluentialSchley, M. T., Töpfner, S., Wiech, K., Schaller, H.-E., Konrad, C., Schmelz, M., & Birbaumer, N. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2006.03.003 · Cited by 138
“After nerve transection, neuronal spontaneous activity develops at the site of injury and in dorsal root ganglion cells, followed by central sensitization (Coderre et al., 1993; Devor and Seltzer, 1999).”
BackgroundDjavid, G. E., Mehrdad, R., Ghasemi, M., Hasan-Zadeh, H., Sotoodeh-Manesh, A., & Pouryaghoub, G. (2007) · Australian Journal of Physiotherapy · doi:10.1016/s0004-9514(07)70022-3 · Cited by 138
“The repeated application of laser may reduce tonic peripheral nociceptive afferent input to the dorsal horn and facilitate reorganisation of synaptic connections in the central nervous system producing pain modulation (Coderre et al 1993, Mense 1993).”
BackgroundCyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons
Lewin, M. R., & Walters, E. T. (1999) · Nature Neuroscience · doi:10.1038/4520 · Cited by 138
“gif" NDATA ITEM> ]> In various species, peripheral injury produces long–lasting sensitization of central and peripheral neurons representing the affected are”
Sensory Assessment of Regional Analgesia in Humans
Curatolo, M., Petersen‐Felix, S., Arendt‐Nielsen, L., & Fisher, D. M. (2000) · Anesthesiology · doi:10.1097/00000542-200012000-00025 · Cited by 137
Urban, M. O., Jiang, M. C., & Gebhart, G. F. (1996) · Brain Research · doi:10.1016/0006-8993(96)00631-2 · Cited by 137
Sarlani, E., Grace, E. G., Reynolds, M. A., & Greenspan, J. D. (2004) · PubMed · Cited by 136
Mense, S. (1994) · APS Journal · doi:10.1016/s1058-9139(05)80227-x · Cited by 135
Dextromethorphan attenuates and reverses analgesic tolerance to morphine
Elliott, K. J., Hynansky, A., & Inturrisi, C. E. (1994) · Pain · doi:10.1016/0304-3959(94)90022-1 · Cited by 136
“This experimental model of inflammatory pain results in spinal glutamate release and is believed to produce central sensitization of spinal cord neurons (Skilling 1988; Coderre et al. 1993).”
BackgroundCuratolo, M., Arendt‐Nielsen, L., & Petersen‐Felix, S. (2004) · Clinical Journal of Pain · doi:10.1097/00002508-200411000-00013 · Cited by 135
“A -fiber-transmitted mechanical stimuli, which do not produce pain under normal conditions, may activate the hyperexcitable dorsal horn neurons, ultimately resulting in pain sensation (allodynia).(1,18)”
BackgroundSomatosensory abnormalities in knee OA
Wylde, V., Palmer, S., Learmonth, I. D., & Dieppe, P. A. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker343 · Cited by 135
Bennett, A. D., Everhart, A. W., & Hulsebosch, C. E. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02483-x · Cited by 135
The integration of pain sciences into clinical practice
Gifford, L., & Butler, D. S. (1997) · Journal of Hand Therapy · doi:10.1016/s0894-1130(97)80063-4 · Cited by 135
Giesbrecht, R. J. S., & Battié, M. C. (2005) · Physical Therapy · doi:10.1093/ptj/85.10.1085 · Cited by 135
Andersen, O. K., Felsby, S., Nicolaisen, L., Bjerring, P., Jensen, T. S., & Arendt‐Nielsen, L. (1996) · Pain · doi:10.1016/0304-3959(96)02995-8 · Cited by 135
“…e-mad: oka@rttiba.auc.dk. tent noxious stimulation, slow-synaptic~potentials in C-fibres are activating the NMDA receptor partly by releaseof neuropeptidesfrom the pre-synapticterminals (reviewedin McMahon et al. 1993;Coderre et al. 1993) and are in this way increasingthe central excitability.”
BackgroundWei, F., Vadakkan, K. I., Toyoda, H., Wu, L., Zhao, M., Xu, H., Shum, F. W. F., Jia, Y. H., & Zhuo, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3292-05.2006 · Cited by 134
“Cumulative evidence suggests that longterm plasticity of glutamatergic synapses in the spinal dorsal horn may contribute to persistent pain caused by tissue or nerve injury (Woolf and Thompson, 1991; Coderre et al., 1993) (for review, see Dubner and Basbaum, 1994; Zhuo, 2004).”
BackgroundBrosseau, L., Milne, S., Robinson, V. A., Marchand, S., Shea, B., Wells, G. A., & Tugwell, P. (2002) · Spine · doi:10.1097/00007632-200203150-00007 · Cited by 134
Sarlani, E., Grace, E. G., Reynolds, M. A., & Greenspan, J. D. (2004) · Pain · doi:10.1016/j.pain.2004.01.019 · Cited by 132
“Hyperexcitability of the central nociceptive pathways constitutes a pathophysiological mechanism that may underlie the development and maintenance of clinical chronic pain (Coderre et al., 1993; Dubner, 1991; Sarlani and Greenspan, 2003).”
BackgroundKawamata, M., Takahashi, T., Kozuka, Y., Nawa, Y., Nishikawa, K., Narimatsu, E., Watanabe, H., & Namiki, A. (2002) · Pain · doi:10.1016/s0304-3959(02)00233-6 · Cited by 133
“Intra-thecal administration of NMDA receptor antagonists has been shown to reduce hyperalgesia in conventional animal models exposed to exogenous algesics (Coderre et al., 1993), whereas these antagonists do not affect hyperalgesia seen in the plantar incision model (Zahn and Brennan, 1999).”
Martinez, V., Fletcher, D., Bouhassira, D., Sessler, D. I., & CHAUVIN, M. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000278091.29062.63 · Cited by 133
“stimulus that is normally painful) (7).”
Shared pain: From empathy to synaesthesia
Fitzgibbon, B. M., Giummarra, M. J., Georgiou‐Karistianis, N., Enticott, P. G., & Bradshaw, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.007 · Cited by 133
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Butrick, C. W. (2003) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-200312000-00011 · Cited by 132
Møller, A. R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)66004-x · Cited by 132
Kawamata, M., & Omote, K. (1996) · Pain · doi:10.1016/s0304-3959(96)03222-8 · Cited by 131
“…in the transduction sensitivity of primary afferents (peripheral sensitization) (Wall and Devor 1981, 1983; CampbelI et al. 1988; Kajander and Bennett 1992) and an increase in the excitability of spinal cord neurons (central sensitization) (Wall 1991; Coderre et al. 1993; Price et al. 1994).”
BackgroundBabenko, V., Graven‐Nielsen, T., Svensson, P. J., Drewes, A. M., Jensen, T. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00026-3 · Cited by 130
“Muscular hyperalgesia is expected to play an important role in painful muscle disorders (Vecchiet et al., 1993), because this phenomenon may build up within minutes and could last for years (Coderre et al., 1993; Reeh and Sauer, 1997).”
BackgroundAida, S., Baba, H., Yamakura, T., Taga, K., Fukuda, S., & Shimoji, K. (1999) · Anesthesia & Analgesia · doi:10.1097/00000539-199909000-00034 · Cited by 130
NEUROUROLOGICAL INSIGHTS INTO THE ETIOLOGY OF GENITOURINARY PAIN IN MEN
Zermann, D., Ishigooka, M., Doggweiler, R., & Schmidt, R. A. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)61802-0 · Cited by 130
Hu, V. Y., Malley, S. E., Dattilio, A., Folsom, J. B., Zvara, P., & Vizzard, M. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00465.2002 · Cited by 130
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BackgroundGalanin knockout mice reveal nociceptive deficits following peripheral nerve injury
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Sawynok, J., Reid, A. R., & Esser, M. J. (1999) · Pain · doi:10.1016/s0304-3959(98)00195-x · Cited by 128
Williamson, E. M., Williams, M. A., Gates, S., & Lamb, S. E. (2007) · Pain · doi:10.1016/j.pain.2007.04.035 · Cited by 127
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BackgroundThe effect of dorsal cochlear nucleus ablation on tinnitus in rats
Brozoski, T. J., & Bauer, C. A. (2005) · Hearing Research · doi:10.1016/j.heares.2004.12.013 · Cited by 126
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Hudspith, M. J. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/78.6.731 · Cited by 126
Staud, R. M., Vierck, C. J., Robinson, M. E., & Price, D. D. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.01.357 · Cited by 125
Peripheral and preemptive opioid antinociception in a mouse visceral pain model
Reichert, J. A., Daughters, R. S., Rivard, R., & Simone, D. A. (2001) · Pain · doi:10.1016/s0304-3959(00)00365-1 · Cited by 124
“…®ndings that intense activation of nociceptive primary afferent ®bers by tissue injury and in¯ammation produces central sensitization or hyperexcitability of nociceptive neurons in the spinal cord dorsal horn that contributes to post-injury pain and hyperalgesia (Woolf, 1983; Coderre et al., 1993).”
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Bılır, A., Gulec, S., Erkan, A., & Özçelik, A. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem029 · Cited by 123
Yashpal, K., Pitcher, G., Parent, A., Quirion, R., & Coderre, T. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03263.1995 · Cited by 123
“…protein kinase C inhibitors, neuronal plasticity] Recent evidence suggests that following peripheral tissue injury or intense noxious stimulation there are specific changes in central neuronal excitability that contribute to persistent pain and hyperalgesia (Woolf, 199 I ; Coderre et al., 1993).”
BackgroundInfluentialSelf-citationPain measurement in TMD patients: evaluation of precision and sensitivity of different scales
Conti, P. C. R., de Azevedo, L. R., Souza, N. V. W. D., & Ferreira, F. V. (2001) · Journal of Oral Rehabilitation · doi:10.1046/j.1365-2842.2001.00727.x · Cited by 122
Mikkelsson, M., El‐Metwally, A., Kautiainen, H., Auvinen, A. P., Macfarlane, G. J., & Salminen, J. J. (2008) · Pain · doi:10.1016/j.pain.2008.06.005 · Cited by 122
“Such changes lead to the generation of referred pain and hyperalgesia across multiple spinal segments [2].”
BackgroundTraub, R. J. (1996) · Pain · doi:10.1016/0304-3959(96)03076-x · Cited by 122
Contemporary Management of Neuropathic Pain for the Primary Care Physician
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Kallakuri, S., Singh, A. K., Chen, C., & Cavanaugh, J. M. (2004) · Spine · doi:10.1097/00007632-200406010-00005 · Cited by 121
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BackgroundInfluentialWeinbroum, A. A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.01.002 · Cited by 120
Instrumental learning within the spinal cord: I. Behavioral properties.
Grau, J. W., Barstow, D. G., & Joynes, R. L. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1366 · Cited by 120
Central Neuronal Plasticity, Low Back Pain and Spinal Manipulative Therapy
Boal, R., & Gillette, R. G. (2004) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2004.04.005 · Cited by 121
Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats
Simmons, R. M. A., Webster, A. A., Kalra, A., & Iyengar, S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00849-3 · Cited by 120
Melzack, R., & Katz, J. D. (2012) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1201 · Cited by 150
Self-citationMogil, J. S., & Grisel, J. E. (1998) · Pain · doi:10.1016/s0304-3959(98)00093-1 · Cited by 115
“…changes in the sensitivity of nociceptive afferents (i.e. peripheral sensitization) and the spinal neurons to which they project (i.e. central sensitization), leading behaviorally to primary and secondary hyperalgesia and/or allodynia (see Coderre et al., 1993; Dickenson, 1995; Woolf, 1995).”
BackgroundCoutinho, V., Urban, O. M., & Gebhart, F. (1998) · Pain · doi:10.1016/s0304-3959(98)00137-7 · Cited by 119
“While some of these studies have investigated the possible involvement of peripheral EAAs (Carlton et al., 1995; Jackson et al., 1995; Zhuo et al., 1996), the majority have focused on the spinal cord (see Wilcox, 1991; Coderre et al., 1993 for reviews).”
BackgroundPsychological aspects of fibromyalgia syndrome: a component of the dysfunctional spectrum syndrome
Yunus, M. B. (1994) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80050-0 · Cited by 119
Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat
Ma, Q., & Woolf, C. J. (1996) · Pain · doi:10.1016/0304-3959(96)03132-6 · Cited by 119
“This, together with a similarity between the time-course of c-fos expression and the development of behavioural hyperalgesia (Draisci and Iadarola 1989; Coderre et al. 1993), has led to a suggestion that the expression of c-fos may be involved in the development of central sensitization (Coderre et al.”
BackgroundThe effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization
Jett, M., McGuirk, J., Waligora, D., & Hunter, J. C. (1997) · Pain · doi:10.1016/s0304-3959(96)03231-9 · Cited by 119
“…interfere in some manner with injury-induced sensitization of dorsal horn neurons (central sensitization), since this process is fundamental to the development of hyperalgesia and allodynia associated with neuropathic pain (Dubner and Ruda, 1992; Coderre et al., 1993b; Woolf and Doubell, 1994a).”
BackgroundThe pharmacology of pain signalling
Zieglgänsberger, W., & Toile, T. R. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90063-5 · Cited by 119
White matter abnormalities in irritable bowel syndrome and relation to individual factors
Chen, J. Y.-W., Blankstein, U., Diamant, N. E., & Davis, K. D. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.069 · Cited by 120
Neurotrophic factors and neuropathic pain
Boucher, T. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00010-8 · Cited by 118
Vaneker, M., Wilder-smith, O., Schrombges, P., de Man-Hermsen, I., & Oerlemans, M. (2005) · Pain · doi:10.1016/j.pain.2005.02.031 · Cited by 79
“central nociceptive sensitisation) (Coderre et al., 1993).”
BackgroundResultInfluentialDo we need preemptive analgesia for the treatment of postoperative pain?
Grape, S., & Tramèr, M. R. (2007) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2006.11.004 · Cited by 117
Ottawa Panel Evidence-Based Clinical Practice Guidelines for Post-Stroke Rehabilitation
Panel, O. (2006) · Topics in Stroke Rehabilitation · doi:10.1310/3tkx-7xec-2dtg-xqkh · Cited by 116
Pertovaara, A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6688 · Cited by 116
Jaggar, S., Scott, H. C., & Rice, A. S. C. (1999) · British Journal of Anaesthesia · doi:10.1093/bja/83.3.442 · Cited by 113
Neurotrypsin, a Novel Multidomain Serine Protease Expressed in the Nervous System
Gschwend, T. P., Krueger, S., Kozlov, S., Wolfer, D. P., & Sonderegger, P. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0616 · Cited by 116
The Missing P in Psychiatric Training
Elman, I., Zubieta, J.-K., & Borsook, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.174 · Cited by 115
Acupuncture Treatment for Irritable Bowel Syndrome
Fireman, Z., Segal, A., Kopelman, Y., Sternberg, A., & Carasso, R. L. (2001) · Digestion · doi:10.1159/000048847 · Cited by 115
“By increasing membrane excitability and activating postsynaptic receptors leading to increased influx of intercellular calcium and to increased neuronal excitability, abnormalities of gut responsiveness in IBS patients to enteric peptides, such as gastrin, cholecystokinin, neuropeptide, etc., may cause ‘visceral hyper…”
BackgroundTreatment effectiveness for patients with a history of repetitive hand use and focal hand dystonia
Byl, N. N., & McKenzie, A. L. (2000) · Journal of Hand Therapy · doi:10.1016/s0894-1130(00)80021-6 · Cited by 115
Alix, M. E., & Bates, D. K. (1999) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/s0161-4754(99)70006-0 · Cited by 115
Khadilkar, A., Milne, S., Brosseau, L., Wells, G. A., Tugwell, P., Robinson, V. A., Shea, B., & Saginur, M. (2005) · Spine · doi:10.1097/01.brs.0000188189.21202.0f · Cited by 114
Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain
Pogatzki-Zahn, E. M., Shimizu, I., Caterina, M. J., & Raja, S. N. (2005) · Pain · doi:10.1016/j.pain.2005.03.010 · Cited by 115
“Thus, although NMDA receptors are necessary for mediating heat hyperalgesia in a variety of animal models of chronic pain (Coderre and Melzack, 1992; Coderre et al., 1993; Kim et al., 1997; Meller et al., 1996; Ren et al., 1992), they appear not to be important for mediating enhanced responses to…”
BackgroundShim, B., Kim, D.-W., Kim, B. H., Nam, T. S., Leem, J. W., & Chung, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.036 · Cited by 115
Graven‐Nielsen, T., Arendt‐Nielsen, L., Svensson, P. J., & Jensen, T. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01077-3 · Cited by 115
Dietrich, P. S., McGivern, J. G., Delgado, S. G., Koch, B., Eglen, R. M., Hunter, J. C., & Sangameswaran, L. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70062262.x · Cited by 115
Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis
Malley, S. E., & Vizzard, M. A. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00117.2001 · Cited by 114
“Increased pain sensitivity can result from changes in peripheral nociceptor afferents (17, 34, 48, 50, 83) or from changes in the central nervous system mechanisms that process nociceptive inputs (9, 11, 41, 46).”
BackgroundChronic neuropathic pain: mechanisms, drug targets and measurement
Finnerup, N. B., Sindrup, S. H., & Jensen, T. S. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00474.x · Cited by 115
Mechanisms of spontaneous tension-type headaches: an analysis of tenderness, pain thresholds and EMG
Jensen, R. (1996) · Pain · doi:10.1016/0304-3959(95)00114-x · Cited by 114
“(1992) and the spontaneous activity in cutaneous afferents was increased in correspondence with previous studies (Heppelman et al. 1987; Coderre et al. 1993).”
BackgroundResultTouche, R. L., Paris‐Alemany, A., von Piekartz, H., Mannheimer, J. S., Fernández‐Carnero, J., & Rocabado, M. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181edc157 · Cited by 118
Long-term ketamine subcutaneous continuous infusion in neuropathic cancer pain
Mercadante, S., Lodi, F., Sapio, M., Caligara, M., & Serretta, R. (1995) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(95)00102-5 · Cited by 113
Chizh, B. A. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881105062484 · Cited by 117
“Although this form of NMDA receptor-dependent plasticity in nociceptive pathways is very short lived, it can lead to pain chronification (Coderre et al., 1993; Urban et al., 1994; Cumberbatch et al., 2002).”
BackgroundPerisphincteric Injection of Botulinum Toxin Type A
Zermann, D.-H., Ishigooka, M., Schubert, J., & Schmidt, R. A. (2000) · European Urology · doi:10.1159/000020314 · Cited by 113
Lateral epicondylalgia I: epidemiology, pathophysiology, aetiology and natural history
Vicenzino, B., & Wright, A. (1996) · Physical Therapy Reviews · doi:10.1179/108331996787247627 · Cited by 111
Correlation between autotomy-behavior and current theories of neuropathic pain
Kauppila, T. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00038-4 · Cited by 111
Atrophy of suboccipital muscles in patients with chronic pain: A pilot study
Greenman, P. E., Hallgren, R. C., & Rechtien, J. J. (1994) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.1994.94.12.1032 · Cited by 111
Lascelles, B. D. X., Waterman, A. E., Cripps, P., Livingston, A., & Henderson, G. (1995) · Pain · doi:10.1016/0304-3959(94)00266-h · Cited by 108
Multi‐modal induction and assessment of allodynia and hyperalgesia in the human oesophagus
Drewes, A. M., Schipper, K., Dimcevski, G. G., Petersen, P., Andersen, O. K., Gregersen, H. N., & Arendt‐Nielsen, L. (2003) · European Journal of Pain · doi:10.1016/s1090-3801(03)00053-3 · Cited by 109
Spinal gabapentin is antinociceptive in the rat formalin test
Shimoyama, N., Shimoyama, M., Davis, A. M., Inturrisi, C. E., & Elliott, K. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13331-6 · Cited by 109
Tsuda, M., Ueno, S., & Inoue, K. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702960 · Cited by 109
“…considered to be dependent on (1) the sensitization of dorsal horn neurons due to the initial barrage of primary a erent input during the ®rst phase and (2) the in¯ammation-induced hyperactivity of primary a erent neurons input to dorsal horn neurons (Tjùlsen et al., 1992; Coderre et al., 1993).”
Background
Metadata
- Authors
- Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R.
- Affiliations
- University of Toronto (CA)
- LSU New Orleans (US)
- McGill University (CA)
- Corresponding author
- Vaccarino, Anthony L.
- Venue
- Pain
- Published
- 1993-03
- Volume
- 52
- Issue
- 3
- Pages
- 259-285
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2062625412
- Cited by
- 1,966
- References
- 304
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 24 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 30 · 2015: 30 · 2014: 37 · 2013: 42 · 2012: 53
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- YorkSpace (York University) (submittedVersion)
- Funders
- Medical Research Council Canada
- Natural Sciences and Engineering Research Council of Canada (A7891)
- Fonds de Recherche du Québec - Santé
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- pathological pain, hyperalgesia, allodynia, spontaneous pain, central sensitization, nerve injury, nociceptor sensitization, neuroma formation, central nervous system plasticity, noxious stimulation, pain mechanisms
- MeSH terms
- Acute Disease, Animals, Central Nervous System, Chronic Disease, Humans, Models, Neurological, Neuronal Plasticity, Pain, Palliative Care, Pain Management
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