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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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Coderre, Terence J., Katz, Joel, Vaccarino, Anthony L., Melzack, Ronald·1993·Pain

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Abstract

Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Studies and Perspectives of Protein Kinase C
Nishizuka, Y. (1986) · Science · doi:10.1126/science.3014651 · Cited by 5,068
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986

Show all 304 references

Research works printed but not linked: 16

Albe-Fessard, 1983, Use of an animal model to evaluate the origin of and protection against deafferentation pain, Vol. 5, 691
Bigot, 1989, Rapid induction of c-fos protein in glial and neuronal cells studied in vitro, Neurosci. Lett., S75
Chi, 1990, Time course of peripheral neuroma-induced expression of Fos protein immunoreactivity in the spinal cord of rats and effects of local anesthetics, Soc. Neurosci. Abst., 16, 566
David, 1980, Spontaneous activity generated in sciatic neuromas, a [14C]2-deoxyglucose uptake study in the rat, Neurosci. Abst., 6, 439
Dubner, 1991, Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury, Vol. 4, 263
Heapy, 1987, Afferent C-fibre and A-delta activity in models of inflammation, Br. J. Pharmacol., 90, 164P
Herdegen, 1991, Noxious stimulation induces molecular genetic events in neurons of the central nervous system: expression of immediate-early gene encoded proteins, Vol. 4, 325
Kajander, 1990, Labeling of fos protein increases in an experimental model of peripheral neuropathy in the rat, Soc. Neurosci. Abst., 16, 1281
Kehl, 1991, The NMDA antagonist MK-801 reduces noxious stimulus-evoked Fos expression in the spinal dorsal horn, Vol. 4, 307
Lombard, 1979, Thalamic recordings in rats with hyperalgesia, Vol. 3, 767
Van Bogaert, 1934, Sur la pathologie de l'image de soi (átudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 519
Van Bogaert, 1934, Sur la pathologie de l'image de soi (âtudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 714
Wallgren, 1954, Phantom experience at spinal anaesthesia, Ann. Chir. et Gynaec. Fenniae, 43, 486
Wilcox, 1991, Excitatory neurotransmitters and pain, Vol. 4, 97
Womack, 1989, Substance P increases [Ca2+]i in dorsal horn neurons via two distinct mechanisms, Soc. Neurosci. Abst., 15, 184
Yashpal, 1992, Comparison of the efficacy of a non-peptide substance P receptor (NK-1) antagonist, CP-96,345, in blocking responses to noxious thermal vs chemical stimulation in the rat, Can. Pain Soc. Abst.

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Campbell, W., Kendrick, R. W., Ramsay-Baggs, P., & McCaughey, W. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.219-az0353.x · Cited by 28
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Reuben, S. S., & Yalavarthy, L. (2008) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2008.02.016 · Cited by 27
Temporal summation of trigeminal pain in human anterior cingulate cortex
Obermann, M., Pleger, B., de Greiff, A., Stude, P., Kaube, H., Diener, H., & Katsarava, Z. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.038 · Cited by 28
“This parallels enhanced responsiveness to nociceptive and non-nociceptive stimuli and enlargement of associated receptive fields (Coderre et al., 1993; Dougherty et al., 1992; Rainville et al., 1997).”
Vagal damage enhances polyneuropathy pain: Additive effect of two algogenic mechanisms
Weissman‐Fogel, I., Dashkovsky, A., Rogowski, Z., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.11.017 · Cited by 27
“The latter rats, that had no peripheral pathology, did demonstrate static allodynia and increased response to repetitive noxious stimuli, pain behaviors characterizing central sensitization induced by repetitive peripheral noxious stimuli [5,15].”
Background
Effect of self-setting α-tricalcium phosphate between segments for bone healing and hypoaesthesia in lower lip after sagittal split ramus osteotomy
Ueki, K., Okabe, K., Marukawa, K., Mukozawa, A., Moroi, A., Miyazaki, M., Nakagawa, K., & Yamamoto, E. (2011) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2011.07.002 · Cited by 27
“Functional disturbance in the central nervous system after peripheral nerve injury is known as central sensitization (Coderre et al., 1993; McQuay et al., 1994).”
Background
Docosahexaenoic acid inhibits mechanical allodynia and thermal hyperalgesia in diabetic rats by decreasing the excitability of DRG neurons
Heng, L., Qi, R., Yang, R., & Xu, G. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.022 · Cited by 27
Synthesis of tension-type headache mechanisms
Bendtsen, L., & Schoenen, J. E. (1999) · ORBi (University of Liège) · Cited by 27
The relationship between chronic facial pain and a history of trauma and surgery
Plesh, O., Gansky, S. A., Curtis, D. A., & Pogrel, M. A. (1999) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/s1079-2104(99)70187-3 · Cited by 27
Neurobiological Mechanisms Underlying Chronic Whiplash Associated Pain: The Peripheral Maintenance of Central Sensitization
Munglani, R. (2000) · Journal of Musculoskeletal Pain · doi:10.1300/j094v08n01_14 · Cited by 27
“tacts formed between the A-beta-[laminae 3-4] and C-fibers [superficial laminae] (10).”
Background
What is pain management, and what is its relevance to the rheumatologist?
Cooper, R. G. (2003) · British journal of rheumatology · doi:10.1093/rheumatology/keg313 · Cited by 27
Meeting Proceedings: Recommendations for Improved Acute Pain Services: Canadian Collaborative Acute Pain Initiative
Goldstein, D. H., Ellis, J., Brown, R., Wilson, R. A., Penning, J. P., Chisom, K., VanDenKerkhof, E. G., & Initiative, M. O. T. C. C. A. P. (2004) · Pain Research and Management · doi:10.1155/2004/397452 · Cited by 27
Speaking Out of Turn: A Role for Silent Synapses in Pain
Kerchner, G. A., Li, P., & Zhuo, M. (1999) · IUBMB Life · doi:10.1080/713803505 · Cited by 27
“That dorsal horn neurons become hyperexcitable after tissue or nerve injury is well-established ( 1 , 2 ).”
Background
Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats
Aloisi, A. M., Ceccarelli, I., & Herdegen, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00819-3 · Cited by 27
On the enigma of pain and hyperalgesia: A molecular perspective
Haddad, J. J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.032 · Cited by 27
“These include, as illustration: (i) activation of silent or dormant nociceptors [21]; (ii) peripheral and central sensitization, leading to hyperalgesia (increased reactivity to nociceptive stimuli) and allodynia (nociceptive signaling and/or reaction induced by innocuous stimuli under normal conditions) [22]; (iii) c…”
Background
Late-Onset Preemptive Analgesia Associated with Preincisional Large-Dose Alfentanil
Griffin, M. J., Hughes, D., Knaggs, A. L., Donnelly, M. B., & Boylan, J. F. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199712000-00025 · Cited by 27
Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase Cγ isoform
Ohsawa, M., Narita, M., Mizoguchi, H., Cheng, E. Y., & Tseng, L. F. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01317-6 · Cited by 27
Sex differences in formalin‐induced pain in prenatally stressed infant rats
Буткевич, И. П., Barr, G. A., & Vershinina, E. A. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.02.001 · Cited by 26
The efficacy of pre-emptive analgesia on pain management in total knee arthroplasty: a mini-review
Xu, J., Li, H., Zheng, C. R., Wang, B., Shen, P., Xie, Z., & Qu, Y. (2019) · Arthroplasty · doi:10.1186/s42836-019-0011-7 · Cited by 26
Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
Mahgoub, M. Y., Elnady, B., Abdelkader, H. S., Abdelhalem, R. A., & Hassan, W. A. (2020) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s252748 · Cited by 27
Chronic pain after hip and knee replacement
Vilardo, L., & Shah, M. (2011) · Techniques in Regional Anesthesia and Pain Management · doi:10.1053/j.trap.2011.09.002 · Cited by 26
The novel compound (±)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined μ-opioid receptor agonist and monoamine reuptake inhibitor tramadol
Munro, G., Bæk, C. Æ., Erichsen, H. K., Nielsen, A. N., Nielsen, E. Ø., Scheel‐Krüger, J., Weikop, P., & Peters, D. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.10.005 · Cited by 26
Relationship between recovery period of lower lip hypoesthesia and sagittal split area or plate screw position after sagittal split ramus osteotomy
Hashiba, Y., Ueki, K., Marukawa, K., Nakagawa, K., Yamamoto, E., & Matsubara, K. (2007) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2007.04.006 · Cited by 26
Visceral pain originating from the upper urinary tract
Pedersen, K. V., Drewes, A. M., Frimodt‐Møller, P. C., & Osther, P. J. S. (2010) · Urological Research · doi:10.1007/s00240-010-0278-1 · Cited by 26
“independent of the original peripheral input [18].”
Pain relief after ambulatory surgery: Progress over the last decade
Jafra, A., & Mitra, S. (2018) · Saudi Journal of Anaesthesia · doi:10.4103/sja.sja_232_18 · Cited by 27
“Preoperative administration of NSAIDs decreases tissue prostaglandins and hence reduces primary and secondary hyperalgesia, suggesting their role in preemptive analgesia.[29] The reports suggest that parenteral NSAIDs possess analgesic properties comparable to traditional opioid analgesics without opioid‐related side…”
Background
Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1/MT2 receptor knockout mice
Posa, L., López-Canul, M., Rullo, L., Gregorio, D. D., Domínguez-López, S., Aboud, M. K., Caputi, F. F., Candeletti, S., Romualdi, P., & Gobbi, G. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12671 · Cited by 26
The Effect of Spinal versus General Anesthesia on Postoperative Pain and Analgesic Requirements in Patients Undergoing Lower Abdominal Surgery
Wang, J.-J., Ho, S., Liu, H.-S., Tzeng, J. I., Tze, T.-S., & Liaw, W. (1996) · Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control · doi:10.1136/rapm-00115550-199621040-00002 · Cited by 26
Post-sympathectomy neuralgia: hypotheses on peripheral and central neuronal mechanisms
Kramis, R. C., Roberts, W. J., & Gillette, R. G. (1996) · Pain · doi:10.1016/0304-3959(95)00060-7 · Cited by 26
“(q~e evidence for nociceptiveafferent-induced sensitization of spinal nociceptive neurons occurs is now extensive (Coderre et al. 1993)).”
Background
The Effect of Pre-operative Lornoxicam and Ketoprofen Application on the Morphine Consumption of Post-operative Patient-controlled Analgesia
Karaman, S., Gunusen, I., Uyar, M., & Fırat, V. (2006) · Journal of International Medical Research · doi:10.1177/147323000603400206 · Cited by 26
An investigation of the gate control theory of pain using the experimental pain stimulus of potassium iontophoresis
Humphries, S. A., Johnson, M. H., & Long, N. R. (1996) · Perception & Psychophysics · doi:10.3758/bf03213101 · Cited by 26
Evidence of a role for N-methyl-D-aspartate (NMDA) receptors in the facilitation of tail withdrawal after spinal transection
Ghorpade, A., & Advokat, C. D. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90514-2 · Cited by 26
The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis
Neidhart (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200012)43:12 · Cited by 1
Broca's region revisited: Cytoarchitecture and intersubject variability
Amunts, K., Schleicher, A., B�rgel, U., Mohlberg, H., Uylings, H. B. M., & Zilles, K. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990920)412:2
Untitled work
Rodier (1996) · doi:10.1002/(sici)1096-9861(19960624)370:2
Untitled work
Bayraktar (2000) · doi:10.1002/(sici)1096-9861(20000508)420:3
Untitled work
Wang (1996) · doi:10.1002/(sici)1096-9861(19960318)366:4

Authors: Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R.
Affiliations: University of Toronto (CA)
LSU New Orleans (US)
McGill University (CA)
Corresponding author: Vaccarino, Anthony L.
ORCID: Coderre, Terence J.
Katz, Joel
Vaccarino, Anthony L.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1993-03
Volume: 52
Issue: 3
Pages: 259-285
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/0304-3959(93)90161-h
OpenAlex: W2062625412
Cited by: 1,966
References: 304
Citations by year: 2026: 2 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 24 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 30 · 2015: 30 · 2014: 37 · 2013: 42 · 2012: 53
FWCI: 12.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
YorkSpace (York University) (submittedVersion)
Funders: Medical Research Council Canada
Natural Sciences and Engineering Research Council of Canada (A7891)
Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: pathological pain, hyperalgesia, allodynia, spontaneous pain, central sensitization, nerve injury, nociceptor sensitization, neuroma formation, central nervous system plasticity, noxious stimulation, pain mechanisms
MeSH terms: Acute Disease, Animals, Central Nervous System, Chronic Disease, Humans, Models, Neurological, Neuronal Plasticity, Pain, Palliative Care, Pain Management

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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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