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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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Coderre, Terence J., Katz, Joel, Vaccarino, Anthony L., Melzack, Ronald·1993·Pain

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Abstract

Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Studies and Perspectives of Protein Kinase C
Nishizuka, Y. (1986) · Science · doi:10.1126/science.3014651 · Cited by 5,068
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986

Show all 304 references

Research works printed but not linked: 16

Albe-Fessard, 1983, Use of an animal model to evaluate the origin of and protection against deafferentation pain, Vol. 5, 691
Bigot, 1989, Rapid induction of c-fos protein in glial and neuronal cells studied in vitro, Neurosci. Lett., S75
Chi, 1990, Time course of peripheral neuroma-induced expression of Fos protein immunoreactivity in the spinal cord of rats and effects of local anesthetics, Soc. Neurosci. Abst., 16, 566
David, 1980, Spontaneous activity generated in sciatic neuromas, a [14C]2-deoxyglucose uptake study in the rat, Neurosci. Abst., 6, 439
Dubner, 1991, Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury, Vol. 4, 263
Heapy, 1987, Afferent C-fibre and A-delta activity in models of inflammation, Br. J. Pharmacol., 90, 164P
Herdegen, 1991, Noxious stimulation induces molecular genetic events in neurons of the central nervous system: expression of immediate-early gene encoded proteins, Vol. 4, 325
Kajander, 1990, Labeling of fos protein increases in an experimental model of peripheral neuropathy in the rat, Soc. Neurosci. Abst., 16, 1281
Kehl, 1991, The NMDA antagonist MK-801 reduces noxious stimulus-evoked Fos expression in the spinal dorsal horn, Vol. 4, 307
Lombard, 1979, Thalamic recordings in rats with hyperalgesia, Vol. 3, 767
Van Bogaert, 1934, Sur la pathologie de l'image de soi (átudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 519
Van Bogaert, 1934, Sur la pathologie de l'image de soi (âtudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 714
Wallgren, 1954, Phantom experience at spinal anaesthesia, Ann. Chir. et Gynaec. Fenniae, 43, 486
Wilcox, 1991, Excitatory neurotransmitters and pain, Vol. 4, 97
Womack, 1989, Substance P increases [Ca2+]i in dorsal horn neurons via two distinct mechanisms, Soc. Neurosci. Abst., 15, 184
Yashpal, 1992, Comparison of the efficacy of a non-peptide substance P receptor (NK-1) antagonist, CP-96,345, in blocking responses to noxious thermal vs chemical stimulation in the rat, Can. Pain Soc. Abst.

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Riva, P., Wesselmann, E. D., Wirth, J. H., Carter‐Sowell, A. R., & Williams, K. D. (2014) · Basic and Applied Social Psychology · doi:10.1080/01973533.2014.917975 · Cited by 85
Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans.
Srbely, J., Dickey, J., Bent, L., Lee, D., & Lowerison, M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.10.005 · Cited by 82
5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain
Pathirathna, S., Todorovic, S. M., Covey, D. F., & Jevtović‐Todorović, V. (2005) · Pain · doi:10.1016/j.pain.2005.06.019 · Cited by 73
“Many investigators have shown an important role of a heterogeneous family of voltage-gated Ca channels in pathophysiology of nociception in general (Coderre et al., 1993; Yaksh, 1999) and their possible role in the pathophysiology of NPP in particular (Chaplan et al.”
Background
Activation of brainstem N-methyl-D-aspartate receptors is required for the analgesic actions of morphine given systemically
Heinricher, M. M., Schouten, J. C., & Jobst, E. E. (2001) · Pain · doi:10.1016/s0304-3959(00)00480-2 · Cited by 73
“Moreover, EAA neurotransmission is strongly implicated in some forms of hyperalgesia, particularly those mediated by central sensitization processes (Coderre et al., 1993; Bennett, 2000).”
Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy
Benison, A. M., Chumachenko, S. Y., Harrison, J. A., Maier, S. F., Falci, S. P., Watkins, L. R., & Barth, D. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0076-11.2011 · Cited by 73
Effect of combined laser acupuncture on knee osteoarthritis: a pilot study
Shen, X., Zhao, L., Ding, G., Tan, M. T., Gao, J., Wang, L., & Lao, L. (2008) · Lasers in Medical Science · doi:10.1007/s10103-007-0536-9 · Cited by 72
Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity
Persson, J., Hasselström, J., Maurset, A., Oye, I., Svensson, J. O., Almqvist, O., Scheinin, H., Gustafsson, L. L., & Almqvist, O. (2001) · European Journal of Clinical Pharmacology · doi:10.1007/s002280100353 · Cited by 72
Second phase of formalin‐induced excitation of spinal dorsal horn neurons in spinalized rats is reversed by sciatic nerve block
Pitcher, G. M., & Henry, J. L. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01984.x · Cited by 72
Pain Perception and Response: Central Nervous System Mechanisms
Hudson, A. J. (2000) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100051908 · Cited by 72
kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord
Randić, M., Cheng, G., & Kojic, L. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06809.1995 · Cited by 72
“However, the cellular mechanism(s) and the role of a-opioid receptors and dynorphin peptides in the regulation of sensory information, including pain at the spinal levels, remains controversial (Millan, 1990; Coderre et al., 1993; Duggan and Fleetwood-Walker, 1993).”
Background
Differential action of morphine and various opioid agonists on thermal allodynia and hyperalgesia in mononeuropathic rats
Lee, S., Kayser, V., Desmeules, J. A., & Guilbaud, G. (1994) · Pain · doi:10.1016/0304-3959(94)90228-3 · Cited by 72
Plasticity in descending pain modulatory systems
Pertovaara, A. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29017-1 · Cited by 71
Cancer pain: A critical review of mechanism-based classification and physical therapy management in palliative care
Kumar, S. P. (2011) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.84532 · Cited by 71
“[48] Spiritual pain due to emotional influences and spirituality was also described as a central sensitization phenomenon among cancer patients.”
Primary Afferent NMDA Receptors Increase Dorsal Horn Excitation and Mediate Opiate Tolerance in Neonatal Rats
Zeng, J., Thomson, L. M., Aicher, S. A., & Terman, G. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2530-06.2006 · Cited by 71
“, 1993), including hypersensitivity in pain-processing systems (Coderre et al., 1993) and, in particular, opiate-induced hyperalgesia (Manning et al.”
Background
Suprathreshold Heat Pain Response Is Associated With Clinical Pain Intensity for Patients With Shoulder Pain
Valencia, C., Fillingim, R. B., & George, S. Z. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.06.002 · Cited by 72
“Prior studies show that TS was altered among patients with chronic pain syndromes.(1,6,22,27,30,33-35) In addition, measures derived from a dynamic QST (suprathreshold heat pain stimuli) approach are thought to better capture the pain-modulatory ability of the central nervous system in comparison with static measures…”
Altered central pain processing after pancreatic surgery for chronic pancreatitis
Bouwense, S. A. W., Ali, U. A., ten Broek, R. P. G., Issa, Y., van Eijck, C. H. J., Wilder‐Smith, O. H. G., & van Goor, H. (2013) · British journal of surgery · doi:10.1002/bjs.9322 · Cited by 71
Topical and Peripheral Ketamine as an Analgesic
Sawynok, J. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000246 · Cited by 71
“These include: (1) binding to multiple opioid receptors (ORs)24; (2) binding to monoamine transporters23,25; (3) binding to muscarinic and nicotinic cholinergic receptors and inhibition of function23; (4) binding to D2 and 5-HT2 receptors26; (5) inhibition of ion channels (Na+, Ca2+, K+)20–22,27,28; (6) decreased acti…”
Background
Effect of low level laser therapy in rheumatoid arthritis patients with carpal tunnel syndrome
Ekim, A. A., & Colak, M. (2007) · Swiss Medical Weekly · doi:10.4414/smw.2007.11581 · Cited by 71
The Role of Descending Noradrenergic and Serotoninergic Pathways in the Modulation of Nociception: Focus on Receptor Multiplicity
Millan, M. J. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60777-6_15 · Cited by 71
From Evidence to Community Practice in Work Rehabilitation: The Quebec Experience
Loisel, P., Durand, M., Diallo, B., Vachon, B., Charpentier, N., & Labelle, J. (2003) · Clinical Journal of Pain · doi:10.1097/00002508-200303000-00005 · Cited by 71
“Advances in neuroscience had confirmed that pain could persist even when the original injury had healed, owing to several mechanisms including lowered threshold of interconnecting spinal neural cells, depending not only on peripheral impulses but also on central impulse.(26) Fear-avoidance had been put forth as a cent…”
Background
Functional Gut Disorders
Ponti, F. D., & Malagelada, J. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00021-7 · Cited by 71
Systematic mechanism-orientated approach to chronic pancreatitis pain
Bouwense, S. A. W. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.47 · Cited by 70
Lumbar Nerve Root Injury Induces Central Nervous System Neuroimmune Activation and Neuroinflammation in the Rat
Rutkowski, M. D., Winkelstein, B. A., Hickey, W. F., Pahl, J. L., & DeLeo, J. A. (2002) · Spine · doi:10.1097/00007632-200208010-00003 · Cited by 70
“A variety of pain states, including referred pain, mirror pain and neuropathic pain, are thought to be centrally mediated.(7) LR may also be the result of similar central nervous system (CNS) mechanisms.”
Background
Mechanisms of Musculoskeletal Physiotherapy
Zusman, M. (2004) · Physical Therapy Reviews · doi:10.1179/108331904225003973 · Cited by 73
Relationship between pain symptoms and referred sensory and trophic changes in patients with gallbladder pathology
Giamberardino, M. A., Affaitati, G., Lerza, R., Lapenna, D., Costantini, R., & Vecchiet, L. (2005) · Pain · doi:10.1016/j.pain.2004.12.024 · Cited by 70
“The fact that a certain amount of hyperalgesia remains even quite some time after cessation of the spontaneous pain could theoretically indicate the persistence of central changes/sensitization in spite of suppression of the peripheral drive (Coderre et al., 1992).”
Background
Antidepressant Drugs for Prevention of Acute and Chronic Postsurgical Pain
Wong, K., Phelan, R., Kalso, E. A., Galvin, I. M., Goldstein, D. H., Raja, S. N., & Gilron, I. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000307 · Cited by 70
Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery
Ilkjær, S., Nikolajsen, L., Hansen, T. M., Wernberg, M., Brennum, J., & Dahl, J. B. (1998) · British Journal of Anaesthesia · doi:10.1093/bja/81.5.707 · Cited by 70
The Preemptive Analgesic Effect of Intraarticular Bupivacaine and Morphine After Ambulatory Arthroscopic Knee Surgery
Reuben, S. S., Sklar, J. H., & El-Mansouri, M. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200104000-00024 · Cited by 70
“Although local anesthetics may also have a preemptive analgesic effect ( 21 ), a study group with IA bupivacaine alone was not included, because our previous studies failed to reveal an analgesic duration of more than four hours when administered for the same surgical procedure (22,23).”
BackgroundInfluential
Maturation of the Biphasic Behavioral and Heart Rate Response in the Formalin Test
Barr, G. A. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00602-3 · Cited by 70
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man
Warncke, T., Stubhaug, A., & Jørum, E. (2000) · Pain · doi:10.1016/s0304-3959(00)00260-8 · Cited by 70
“There are several studies supporting the hypothesis that certain treatments administered preinjury, or preoperatively, may be more effective in reducing postinjury allodynia and hyperalgesia than the same treatments administered postinjury (Woolf and Wall, 1986; Dickenson and Sullivan, 1987a; McQuay et al., 1988; Katz…”
Opioid Poorly-Responsive Cancer Pain. Part 2
Mercadante, S., & Portenoy, R. K. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00236-0 · Cited by 70
Hyperacusis in chronic pain: neural interactions between the auditory and nociceptive systems
Suhnan, A. P., Finch, P. M., & Drummond, P. D. (2017) · International Journal of Audiology · doi:10.1080/14992027.2017.1346303 · Cited by 69
“Perhaps most strikingly, painhyperacusis appears to be the auditory equivalent of allodynia – where pain can be evoked by innocuous stimulation – and hyperalgesia – where noxious stimulation can produce a highly exaggerated pain response (Coderre et al, 1993; Latremoliere & Woolf, 2009).”
Background
Amitriptyline preserves morphine’s antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats
Tai, Y.-H., Wang, Y.-H., Tsai, R., Wang, J., Tao, P., Liu, T.-M., Wang, Y. C., & Wong, C. (2007) · Pain · doi:10.1016/j.pain.2007.01.031 · Cited by 68
“…neuronal adaptation, such as opioid tolerance, dependence, and withdrawal (Trujillo and Akil, 1991; Trujillo and Akil, 1995; Nestler, 1996; Wong et al., 1996; Huang et al., 1997), and neuropathic pain-associated hyperalgesia (Coderre et al., 1993; Urban and Gebhart, 1998; Porreca et al., 2002).”
Background
Is Sacral Nerve Stimulation an Effective Treatment for Chronic Idiopathic Anal Pain?
Falletto, E., Masin, A., Lolli, P., Villani, R. D., Ganio, E., Ripetti, V., Infantino, A., & Stazi, A. (2009) · Diseases of the Colon & Rectum · doi:10.1007/dcr.0b013e31819d1319 · Cited by 69
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia
Todorovic, S. M., Meyenburg, A., & Jevtović‐Todorović, V. (2004) · Pain · doi:10.1016/j.pain.2004.01.026 · Cited by 69
“In addition, many studies have documented the important role of a hetereogeneous family of voltage- and ligand-gated Ca2þ channels in nociception (reviewed by Caterina and Julius, 1999; Coderre et al., 1993; Yaksh, 1999).”
Background
Evaluating the Association Between Acute and Chronic Pain After Surgery
Gilron, I., VanDenKerkhof, E. G., Katz, J. D., Kehlet, H., & Carley, M. E. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000443 · Cited by 69
“Inclusion criteria were: (1) patients undergoing a surgical procedure; (2) at least 1 pain intensity measurement within the first 7 days after surgery; (3) at least 1 pain intensity measurement 3 months or later after surgery; and (4) a statistical evaluation of the relationship between acute and chronic pain.”
InfluentialSelf-citation
The Effectiveness of Preemptive Analgesia Varies According to the Type of Surgery: A Randomized, Double-Blind Study
Aida, S., Baba, H., Yamakura, T., Taga, K., Fukuda, S., & Shimoji, K. (1999) · Anesthesia & Analgesia · doi:10.1213/00000539-199909000-00034 · Cited by 69
Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions
Araujo, M. C., Sinnott, C. J., & Strichartz, G. R. (2003) · Pain · doi:10.1016/s0304-3959(02)00350-0 · Cited by 69
“Prolonged noxious peripheral stimulation produces changes in the central nervous system that may contribute to development of chronic pain (Chapman et al., 1998; Coderre and Melzack, 1985; Coderre et al., 1993; Colvin et al., 1996; Kissen, 2000; Ji and Woolf, 2001).”
Background
Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?
Eisenberg, E., & Pud, D. (1998) · Pain · doi:10.1016/s0304-3959(97)00198-x · Cited by 69
“Recent evidence indicates that N-methyl-d-aspartate (NMDA) receptor antagonists can block pain transmission in dorsal horn spinal neurons, and reduce nociception in animals (Davis and Lodge, 1987; Dickenson and Sullivan, 1987; Dubner and Ruda, 1992; Coderre et al., 1993; Eisenberg et al., 1993; Eisenberg et al., 1995).”
Background
A randomised, controlled study of peri‐operative low dose s(+)‐ketamine in combination with postoperative patient‐controlled s(+)‐ketamine and morphine after radical prostatectomy*
Snijdelaar, D. G., Cornelisse, H. B., Schmid, R., & Katz, J. D. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2003.03620.x · Cited by 69
Self-citation
Analgesia of Small Mammals
Flecknell, P. A. (2001) · Veterinary Clinics of North America Exotic Animal Practice · doi:10.1016/s1094-9194(17)30050-6 · Cited by 69
Role of Spinal γ-Aminobutyric AcidAReceptors in Formalin-Induced Nociception in the Rat
Kaneko, M., & Hammond, D. L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36830-2 · Cited by 69

Authors: Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R.
Affiliations: University of Toronto (CA)
LSU New Orleans (US)
McGill University (CA)
Corresponding author: Vaccarino, Anthony L.
ORCID: Coderre, Terence J.
Katz, Joel
Vaccarino, Anthony L.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1993-03
Volume: 52
Issue: 3
Pages: 259-285
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/0304-3959(93)90161-h
OpenAlex: W2062625412
Cited by: 1,966
References: 304
Citations by year: 2026: 2 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 24 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 30 · 2015: 30 · 2014: 37 · 2013: 42 · 2012: 53
FWCI: 12.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
YorkSpace (York University) (submittedVersion)
Funders: Medical Research Council Canada
Natural Sciences and Engineering Research Council of Canada (A7891)
Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: pathological pain, hyperalgesia, allodynia, spontaneous pain, central sensitization, nerve injury, nociceptor sensitization, neuroma formation, central nervous system plasticity, noxious stimulation, pain mechanisms
MeSH terms: Acute Disease, Animals, Central Nervous System, Chronic Disease, Humans, Models, Neurological, Neuronal Plasticity, Pain, Palliative Care, Pain Management

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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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