Cited by 1,966Pain Mechanisms and TreatmentsPain Management and TreatmentNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 303 of the 304 references it cites were found in a registry or an index.

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

Open access

Coderre, Terence J., Katz, Joel, Vaccarino, Anthony L., Melzack, Ronald·1993·Pain

Open this paper in CoChat — free account Open PDF

Abstract

Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/0304-3959(93)90161-h

Cites

303 of 303 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Studies and Perspectives of Protein Kinase C
Nishizuka, Y. (1986) · Science · doi:10.1126/science.3014651 · Cited by 5,068
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986

Show all 304 references

Research works printed but not linked: 16

Albe-Fessard, 1983, Use of an animal model to evaluate the origin of and protection against deafferentation pain, Vol. 5, 691
Bigot, 1989, Rapid induction of c-fos protein in glial and neuronal cells studied in vitro, Neurosci. Lett., S75
Chi, 1990, Time course of peripheral neuroma-induced expression of Fos protein immunoreactivity in the spinal cord of rats and effects of local anesthetics, Soc. Neurosci. Abst., 16, 566
David, 1980, Spontaneous activity generated in sciatic neuromas, a [14C]2-deoxyglucose uptake study in the rat, Neurosci. Abst., 6, 439
Dubner, 1991, Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury, Vol. 4, 263
Heapy, 1987, Afferent C-fibre and A-delta activity in models of inflammation, Br. J. Pharmacol., 90, 164P
Herdegen, 1991, Noxious stimulation induces molecular genetic events in neurons of the central nervous system: expression of immediate-early gene encoded proteins, Vol. 4, 325
Kajander, 1990, Labeling of fos protein increases in an experimental model of peripheral neuropathy in the rat, Soc. Neurosci. Abst., 16, 1281
Kehl, 1991, The NMDA antagonist MK-801 reduces noxious stimulus-evoked Fos expression in the spinal dorsal horn, Vol. 4, 307
Lombard, 1979, Thalamic recordings in rats with hyperalgesia, Vol. 3, 767
Van Bogaert, 1934, Sur la pathologie de l'image de soi (átudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 519
Van Bogaert, 1934, Sur la pathologie de l'image de soi (âtudes anatomo-cliniques), Annales Médico Psychologiques (Paris), 14, 714
Wallgren, 1954, Phantom experience at spinal anaesthesia, Ann. Chir. et Gynaec. Fenniae, 43, 486
Wilcox, 1991, Excitatory neurotransmitters and pain, Vol. 4, 97
Womack, 1989, Substance P increases [Ca2+]i in dorsal horn neurons via two distinct mechanisms, Soc. Neurosci. Abst., 15, 184
Yashpal, 1992, Comparison of the efficacy of a non-peptide substance P receptor (NK-1) antagonist, CP-96,345, in blocking responses to noxious thermal vs chemical stimulation in the rat, Can. Pain Soc. Abst.

Sorted by citations

The prevalence and characteristics of fibromyalgia in the general population
Wolfe, F., Ross, K., Anderson, J., Russell, I. J., & Hebert, L. E. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380104 · Cited by 2,425
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
“Recent studies have begun to unravel the mutually-interactive pattern of cellular events which underlies the sensitization of DH neurones by C ®bre input from the skin and other organs (Baranauskas and Nistri, 1998; Coderre et al., 1993; Coutinho et al., 1996; Dickenson, 1997; Ide et al., 1997; Kolhekar and Gebhart, 1…”
BackgroundInfluential
Low Back Pain
Deyo, R. A., & Weinstein, J. N. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440508 · Cited by 1,675
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
Herdegen, T., & Leah, J. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00018-6 · Cited by 1,369
Effect of neonatal circumcision on pain response during subsequent routine vaccination
Taddio, A., Katz, J. D., Ilersich, A. L., & Koren, G. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10316-0 · Cited by 1,202
Self-citation
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
“Another often used definition implies that “central sensitization” would be an enhanced responsiveness of neurons in the central nervous system leading to hyperalgesia (76).”
Background
Acute Pain after Thoracic Surgery Predicts Long-Term Post-Thoracotomy Pain
Katz, J., Jackson, M., Kavanagh, B. P., & Sandler, A. N. (1996) · The Clinical Journal of Pain · doi:10.1097/00002508-199603000-00009 · Cited by 915
Self-citation
Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00073-2 · Cited by 817
“…neurochemical consequences in the development and maintenance of injury-induced central hyperactive states, a form of CNS neuronal plasticity that may well underlie behavioral manifestations of hyperalgesia, allodynia, and spontaneous pain (Dubner 1991a; Coderre et al. 1993; Mao et al. 1993a).”
Background
A Qualitative and Quantitative Systematic Review of Preemptive Analgesia for Postoperative Pain Relief
Møiniche, S., Kehlet, H., & Dahl, J. B. (2002) · Anesthesiology · doi:10.1097/00000542-200203000-00032 · Cited by 814
Transition from acute to chronic postsurgical pain: risk factors and protective factors
Katz, J., & Seltzer, Z. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.20 · Cited by 782
Self-citation
Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome
Staud, R., Vierck, C. J., Cannon, R. L., Mauderli, A. P., & Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(00)00432-2 · Cited by 774
“E-mail address: staudrm@medicine.u¯.edu (R. Staud). nociceptive stimuli, and enlarged receptive ®elds of dorsal horn neurons (Coderre et al., 1993; Dougherty et al., 1992; Price et al., 1997).”
Extensive reorganization of primary somatosensory cortex in chronic back pain patients
Flor, H., Braun, C., Elbert, T. R., & Birbaumer, N. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13441-3 · Cited by 715
Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates
Sessle, B. J. (2000) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411000110010401 · Cited by 702
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690
Nerve growth factor: from neurotrophin to neurokine
Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 686
Chronic pain after surgery
Macrae, W. A. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.88 · Cited by 677
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain
Cui, M., Khanijou, S., Rubino, J., & Aoki, K. R. (2003) · Pain · doi:10.1016/j.pain.2003.10.008 · Cited by 675
“The second phase is either the result of sensitization of dorsal horn neurons (central sensitization), inflammation-induced hyperactivity of primary afferent nociceptors, or a combination of both (Coderre et al., 1993; Dickenson and Sullivan, 1987; Tjolsen et al., 1992).”
Background
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Upregulation of Dorsal Root Ganglion α 2 δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats
Luo, Z. D., Chaplan, S. R., Higuera, E. S., Sorkin, L. S., Stauderman, K. A., Williams, M. E., & Yaksh, T. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01868.2001 · Cited by 616
“It has been hypothesized that disordered sensory processing arises from long-term changes in the function of sensory afferents and the organization of sensory input into the dorsal horn (Coderre et al., 1993; Woolf and Doubell, 1994).”
Background
Mechanisms of inflammatory pain
Kidd, B. L., & Urbán, L. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.3 · Cited by 595
Central Sensitization in Tension-Type Headache—Possible Pathophysiological Mechanisms
Bendtsen, L. (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00070.x · Cited by 593
Neurophysiologic evidence for a central sensitization in patients with fibromyalgia
Desmeules, J. A., Cedraschi, C., Rapiti, E., Baumgartner, E., Finckh, A., Cohen, P., Dayer, P., & VISCHER, T. L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10893 · Cited by 561
Experimental and Clinical Applications of Quantitative Sensory Testing Applied to Skin, Muscles and Viscera
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548
“shown that a certain amount of hyperalgesia remains even quite some time after cessation of the spontaneous pain.(34) More than 100 years ago, Sturge(155) noted that attacks of angina are associated with a persistent cutaneous tenderness that remains after the attack.”
Background
Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome
Meeus, M., & Nijs, J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0433-9 · Cited by 541
“These changes cause exaggerated perception of painful stimuli (hyperalgesia), a perception of innocuous stimuli as painful (allodynia) and may be involved in the generation of referred pain and hyperalgesia across multiple spinal segments [25, 30–33].”
Background
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes
Schmid, R., Sandler, A. N., & Katz, J. D. (1999) · Pain · doi:10.1016/s0304-3959(99)00044-5 · Cited by 540
“The rationale for preemptive analgesia in the management of postoperative pain has been reviewed in detail (Katz et al., 1992; Coderre et al., 1993; Dahl and Kehlet, 1993; Woolf and Chong, 7993;Katz,1995 ).”
BackgroundSelf-citation
Ligands for Glutamate Receptors: Design and Therapeutic Prospects
Bräuner‐Osborne, H., Egebjerg, J., Nielsen, E. Ø., Madsen, U., & Krogsgaard‐Larsen, P. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000007r · Cited by 528
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery
Stubhaug, A., Breivik, H., Eide, P. K., KREUNEN, M., & Foss, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb04854.x · Cited by 514
Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo
Eide, P. K., Jørum, E., Stubhaug, A., Bremnes, J., & Breivik, H. (1994) · Pain · doi:10.1016/0304-3959(94)90129-5 · Cited by 488
“Long-lasting hyperexcitability in nociceptive neurons initiated by increased activity in primary afferents seems to play an important role in the pathogenesis of nerve injury pain (for review see Coderre et al. 1993).”
Background
Pathophysiologic and electrophysiologic mechanisms of myofascial trigger points.
Hong, C., & Simons, D. (1998) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(98)90371-9 · Cited by 478
Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia
Banič, B., Petersen‐Felix, S., Andersen, O. K., Radanov, B. P., Villiger, M. P., Arendt‐Nielsen, L., & Curatolo, M. (2003) · Pain · doi:10.1016/j.pain.2003.05.001 · Cited by 462
“This central hypersensitivity causes exaggerated perception of painful stimuli (hyperalgesia) and a perception of innocuous stimuli as painful (allodynia) (Coderre et al., 1993; Dickenson, 1995).”
BackgroundMethod
Pathophysiology of tinnitus
Møller, A. R. (2003) · Otolaryngologic Clinics of North America · doi:10.1016/s0030-6665(02)00170-6 · Cited by 452
Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury
Liu, C., Wall, P. D., Ben‐Dor, E., Michaelis, M., Amir, R., & Devor, M. G. (2000) · Pain · doi:10.1016/s0304-3959(00)00251-7 · Cited by 443
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
Stratton, P., & Berkley, K. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq050 · Cited by 442
“…D ow nloaded from contributing, along with peripheral sensitization, to the association between endometriosis and pain (Woolf, 1983; McMahon, 1991; Coderre et al., 1993; Giamberardino et al., 1997; Ren and Dubner, 1999; Melzack et al., 2001; Ji et al., 2003b; DeLeo, 2006; Woolf and Ma, 2007; Ren…”
Background
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
Sluka, K. A., Price, M. P., Breese, N. M., Stucky, C. L., Wemmie, J. A., & Welsh, M. J. (2003) · Pain · doi:10.1016/s0304-3959(03)00269-0 · Cited by 433
“However, persistent hyperalgesia after tissue healing and spread of hyperalgesia to areas remote from the site of injury are likely a result of changes in the central nervous system (for review, see Coderre et al., 1993).”
Background
Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons
Sangameswaran, L., Delgado, S. G., Fish, L. M., Koch, B., Jakeman, L. B., Stewart, G. R., Sze, P., Hunter, J. C., Eglen, R. M., & Herman, R. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.5953 · Cited by 432
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients
Gwilym, S. E., Keltner, J. R., Warnaby, C. E., Carr, A. J., Chizh, B. A., Chessell, I. P., & Tracey, I. (2009) · Arthritis Care & Research · doi:10.1002/art.24837 · Cited by 431
Mechanisms of neuropathic pain
Bridges, D., Thompson, S., & Rice, A. S. C. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.12 · Cited by 403
The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord
Gorman, A., Elliott, K. J., & Inturrisi, C. E. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13391-2 · Cited by 398
Psychoneuroimmunology: The interface between behavior, brain, and immunity.
Maier, S. F., Watkins, L. R., & Fleshner, M. (1994) · American Psychologist · doi:10.1037//0003-066x.49.12.1004 · Cited by 398
The influence of preamputation pain on postamputation stump and phantom pain
Nikolajsen, L., Ilkjær, S., Krøner, K., Christensen, J. H., & Jensen, T. S. (1997) · Pain · doi:10.1016/s0304-3959(97)00061-4 · Cited by 395
Fibromyalgia in women
Mountz, J. M., Bradley, L. A., Modell, J. G., ALEXANDER, R. W., Triana‐Alexander, M., Aaron, L. A., Stewart, K. E., Alarcón, G. S., & Mountz, J. D. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380708 · Cited by 394
Central Neuroplasticity and Pathological Pain
Melzack, R., Coderre, T. J., Katz, J. D., & Vaccarino, A. L. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05822.x · Cited by 373
Self-citation
Forebrain mechanisms of nociception and pain: Analysis through imaging
Casey, K. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7668 · Cited by 369
Efficacy of Spinal NMDA Receptor Antagonism in Formalin Hyperalgesia and Nerve Injury Evoked Allodynia in the Rat
Chaplan, S. R., Malmberg, A. B., & Yaksh, T. L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36427-4 · Cited by 372
Cell Signaling and the Genesis of Neuropathic Pain
Ji, R., & Strichartz, G. R. (2004) · Science s STKE · doi:10.1126/stke.2522004re14 · Cited by 372
PELVIC FLOOR MYOFASCIAL TRIGGER POINTS: MANUAL THERAPY FOR INTERSTITIAL CYSTITIS AND THE URGENCY-FREQUENCY SYNDROME
Weiss, J. M. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65539-5 · Cited by 370
Pain following spinal cord injury
Siddall, P., & Loeser, J. D. (2001) · Spinal Cord · doi:10.1038/sj.sc.3101116 · Cited by 370
Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors
Bannon, A. W., Decker, M. W., Holladay, M. W., Curzon, P., Donnelly‐Roberts, D. L., Puttfarcken, P. S., Bitner, R. S., Díaz, Á., Dickenson, A. H., Porsolt, R. D., et al. (1998) · Science · doi:10.1126/science.279.5347.77 · Cited by 368
Adenosine in the spinal cord and periphery: release and regulation of pain
Sawynok, J., & Liu, X. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00050-9 · Cited by 355
The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input
Nikolajsen, L., Hansen, C. L., Nielsen, J., Keller, J. O., Arendt‐Nielsen, L., & Jensen, T. S. (1996) · Pain · doi:10.1016/0304-3959(96)03080-1 · Cited by 352
Topical and Peripherally Acting Analgesics
Sawynok, J. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.1 · Cited by 347
“…-amino-3-hydroxy-5-methylis- oxazole-4-propionic acid (AMPA), kainic acid (KA)] and metabotropic glutamate receptors are involved in nociceptive signaling and central sensitization in conditions of chronic pain (Coderre et al., 1993; Dickenson, 1994; Price et al., 1994; Dickenson et al., 1997).”
Background
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
Laulin, J.-P., Maurette, P., Corcuff, J.-B., Rivat, C., Chauvin, M., & Simonnet, G. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200205000-00040 · Cited by 344
“Although multiple mechanisms may account for pain hypersensitivity (8, 13 ), a growing body of evidence indicates that pronociceptive systems associated with central pain sensitization are mainly underlain by excitatory amino acid activity at the NMDA-receptor level (8,14,25).”
Background
Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
Sweitzer, S. M., Martin, D., & DeLeo, J. A. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00574-1 · Cited by 345
Preservation of Upper Limb Function Following Spinal Cord Injury: A Clinical Practice Guideline for Health-Care Professionals
(2005) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2005.11753844 · Cited by 342
“Although there are no data for individuals with SCI, empirical evidence suggests that untreated or undertreated acute pain may produce long-lasting changes in the peripheral and central neural mechanisms that are associated with increased pain perception (Coderre et al., 1993; Arnstein, 1997; Tinazzi et al., 2000).”
Background
Physiologic Effects of Dry Needling
Cagnie, B. J., Dewitte, V., Barbe, T., Timmermans, F., Delrue, N., & Meeus, M. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0348-5 · Cited by 340
“Central sensitization entails altered sensory processing in the brain, increased spontaneous activity of dorsal horn neurons, dysfunctional endogenous analgesia, expansion of receptive field sizes, reduction in threshold, prolonged after-discharges, and increased activity of brain-orchestrated facilitatory pathways, w…”
Preemptive analgesia I: physiological pathways and pharmacological modalities
Kelly, D. J., Ahmad, M., & Brull, S. J. (2001) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03016591 · Cited by 339
The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
Meller, S. T., Dykstra, C. L., Grzybycki, D., Murphy, S. P., & Gebhart, G. F. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90051-5 · Cited by 339
Disability Prevention: New Paradigm for the Management of Occupational Back Pain
Loisel, P., Durand, M.-J., Berthelette, D., V??zina, N., Baril, R., Gagnon, D., Larivi??re, C., & Tremblay, C. (2001) · Disease Management and Health Outcomes · doi:10.2165/00115677-200109070-00001 · Cited by 339
First onset of common pain symptoms: a prospective study of depression as a risk factor
Von Korff, M., Resche, L. L., & Dworkin, S. F. (1993) · Pain · doi:10.1016/0304-3959(93)90154-h · Cited by 334
“The evidence that noxious stimulation is capable of producing long-lasting changes in central pain pathways (cf., review by Coderre et al. 1993) provides a framework for understanding how the presence of pain at baseline could predict increased onset rates of pain at other anatomical sites.”
Background
Wind‐up and the NMDA receptor complex from a clinical perspective
Eide, P. K. (2000) · European Journal of Pain · doi:10.1053/eujp.1999.0154 · Cited by 337
Genetic enhancement of inflammatory pain by forebrain NR2B overexpression
Feng, W., Wang, G., Kerchner, G. A., Kim, S. J., Xu, H., Chen, Z., & Zhuo, M. (2001) · Nature Neuroscience · doi:10.1038/83993 · Cited by 330
Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00022-k · Cited by 329
Efficacy of Antidepressants as Analgesics: A Review
Dharmshaktu, P., Tayal, V., & Kalra, B. S. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010394852 · Cited by 326
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317
“It is proposed that long term nociceptive input from the OA joints in the lower limb may result in central sensitization in the spinal cord (Schaible et al., 1987; Woolf et al., 1988; Neugebauer and Schaible, 1990; Coderre et al., 1993).”
Magnesium Sulfate Reduces Intra- and Postoperative Analgesic Requirements
Koinig, H., Wallner, T., Marhofer, P., Andel, H. L., Hörauf, K., & Mayer, N. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199807000-00042 · Cited by 316
Antidepressant-Induced Sexual Dysfunction
Gregorian, R. S., Golden, K. A., Bahce, A., Goodman, C., Kwong, W. J., & Khan, Z. M. (2002) · Annals of Pharmacotherapy · doi:10.1345/aph.1a195 · Cited by 320
Chronic Pain and Neuropsychological Functioning
Hart, R. P., Martelli, M. F., & Zasler, N. D. (2000) · Neuropsychology Review · doi:10.1023/a:1009020914358 · Cited by 304
Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons
Noguchi, K., Kawai, Y., Fukuoka, T., Senba, E., & Miki, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07633.1995 · Cited by 299
Pathophysiological Mechanisms of Tension-Type Headache: A Review of Epidemiological and Experimental Studies
Jensen, R. (1999) · Cephalalgia · doi:10.1046/j.1468-2982.1999.019006602.x · Cited by 297
SENSITIZATION OF PAIN PATHWAYS IN THE SPINAL CORD: CELLULAR MECHANISMS
Baranauskas, G., & Nistri, A. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00067-1 · Cited by 295
Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
Langevin, H. M., & Sherman, K. J. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.06.033 · Cited by 302
“Ongoing pain is associated with widespread neuroplastic changes at multiple levels within the nervous system [27–29] including primary afferent neurons, spinal cord, brainstem, thalamus, limbic system and cortex [30–33].”
Background
Mechanisms of migraine as a chronic evolutive condition
Andreou, A. P., & Edvinsson, L. I. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1066-0 · Cited by 294
Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts
Ibuki, T., Hama, A. T., Wang, X.-T., Pappas, G. D., & Sagen, J. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00341-7 · Cited by 290
Somatic and Psychologic Predictors of Long-term Unfavorable Outcome After Surgical Intervention
Peters, M. L., Sommer, M., de Rijke, J. M., Kessels, F., Heineman, E., Patijn, J., Marcus, M. A. E., Vlaeyen, J. W. S., & van Kleef, M. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000245495.79781.65 · Cited by 356
“Another potential cause of sustained pain is neuroplastic change in the central nervous system induced by high-intensity pain in the first days following surgery.(13) Several studies found severe acute postoperative pain to be a risk factor for chronic pain.”
Background
Changes in Urinary Bladder Neurotrophic Factor mRNA and NGF Protein Following Urinary Bladder Dysfunction
Vizzard, M. A. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7254 · Cited by 289
Central hyperexcitability triggered by noxious inputs
McMahon, S. B., Lewin, G. R., & Wall, P. D. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90062-4 · Cited by 288
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride
Felsby, S., Nielsen, J., Arendt‐Nielsen, L., & Jensen, T. S. (1996) · Pain · doi:10.1016/0304-3959(95)00113-1 · Cited by 288
“The mechanisms responsible for spinal hyperexcitability in neuropathic pain are not clarified in detail, but a large body of evidence indicates that excitatory amino acids acting at N-methyl-o-aspartate (NMDA) receptor sites play a role (Dickenson and Sullivan 1987; Davies and Lodge 1987; Dickenson 1990; Haley et al.…”
Background
Neurocircuitry of illness-induced hyperalgesia
Watkins, L. R., Wiertelak, E. P., Goehler, L. E., Mooney-Heiberger, K., Martinez, J., Furness, L. E., Smith, K. P., & Maier, S. F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91742-6 · Cited by 284
Myofascial Trigger Points and Sensitization: An Updated Pain Model for Tension-Type Headache
Fernández‐de‐las‐Peñas, C., Cuadrado, M. L., Arendt‐Nielsen, L., Simons, D. G., & Pareja, J. A. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01295.x · Cited by 282
The irritable larynx syndrome
Morrison, M. D., Rammage, L., & Emami, A. J. (1999) · Journal of Voice · doi:10.1016/s0892-1997(99)80049-6 · Cited by 279
Mechanisms of touch-evoked pain (allodynia): a new model
Cerveró, F., & Laird, J. M. A. (1996) · Pain · doi:10.1016/s0304-3959(96)03165-x · Cited by 278
Characterization of Long-Term Potentiation of C-Fiber–Evoked Potentials in Spinal Dorsal Horn of Adult Rat: Essential Role of NK1 and NK2 Receptors
Liu, X., & Sandkühler, J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.4.1973 · Cited by 281
“In response to 1-Hz stimulation of afferent C fibers, amplitudes of C-fiber–evoked field to noxious stimuli (Coderre et al. 1993; Dubner 1991; Sandpotentials remained constant, whereas number of action potentials kühler 1996; Woolf 1983). of some dorsal horn neurons increased progressively…”
Background
Opioid-induced hyperalgesia: abnormal or normal pain?
Simonnet, G., & Rivat, C. (2003) · NeuroReport · doi:10.1097/00001756-200301200-00001 · Cited by 273
Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord
Ebert, B., Mikkelsen, S. S., Thorkildsen, C., & Borgbjerg, F. M. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01116-3 · Cited by 270
Cell-Specific Alterations of T-Type Calcium Current in Painful Diabetic Neuropathy Enhance Excitability of Sensory Neurons
Jagodic, M. M., Pathirathna, S., Nelson, M. T., Mancuso, S., Joksovic, P. M., Rosenberg, E. R., Bayliss, D. A., Jevtović‐Todorović, V., & Todorovic, S. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4866-06.2007 · Cited by 268
“…cellular mechanisms of hyperalgesia and allodynia in neuropathic pain remain poorly understood, but the remodeling of voltage- and ligand-gated ion channels that can increase excitability of the sensory neurons may play a critical role (Coderre et al., 1993; Woolf, 2004; Campbell and Meyer, 2006).”
Background
Fos, Nociception and the Dorsal Horn
Coggeshall, R. E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.11.002 · Cited by 268
Analgesic Effect of Intravenous Ketamine in Cancer Patients on Morphine Therapy
Mercadante, S., Arcuri, E., Tirelli, W., & Casuccio, A. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00194-9 · Cited by 264
Neuropathic pain symptoms in a community knee OA cohort
Hochman, J. R., Gagliese, L., Davis, A. M., & HAWKER, G. A. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.03.007 · Cited by 264
Preemptive Analgesia
Kissin, I. (1996) · Anesthesiology · doi:10.1097/00000542-199605000-00001 · Cited by 258
Evidence for central sensitization in chronic whiplash: A systematic literature review
Oosterwijck, J. V., Nijs, J., Meeus, M., & Paul, L. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00193.x · Cited by 255
“Persistent pain complaints, local and widespread hyperalgesia, referred pain and (thoracic) allodynia were established in chronic WAD patients and are clinical manifestations of the hyperexcitability of the central nervous system (Coderre et al., 1993; GravenNielsen and Arendt-Nielsen, 2002; Staud and Smitherman, 2002…”
Background
Characteristics of Temporal Summation of Second Pain Sensations Elicited by Brief Contact of Glabrous Skin by a Preheated Thermode
Vierck, C. J., Cannon, R. L., Fry, G., Maixner, W. D., & Whitsel, B. L. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.992 · Cited by 257
“…in the creation and/or maintenanceeminence, at interstimulus intervals (ISIs) of 3 s, progressively increased the perceived intensity of a thermal sensation that fol- of chronic pain (Coderre et al. 1993; Price 1991; Wilcox lowed each contact at an onset latency ú2 s. Temporal summation 1993).”
Background
Continuous subcutaneous administration of the N -methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia
Eide, P. K., Stubhaug, A., Øye, I., & Breivik, H. (1995) · Pain · doi:10.1016/0304-3959(94)00182-e · Cited by 257
Emerging Concepts in the Neurobiology of Chronic Pain: Evidence of Abnormal Sensory Processing in Fibromyalgia
Bennett, R. M. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.4.385 · Cited by 252
Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord
Ebert, B., Andersen, S., & Krogsgaard‐Larsen, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11364-3 · Cited by 255
Visceral pain
Sikandar, S., & Dickenson, A. H. (2012) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e32834f6ec9 · Cited by 254
“Axons can send peripheral terminals to anatomically distinct segments to produce pain sensations distant to the primary site [36].”
Background
Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment
Kosek, E., & Ordeberg, G. (2000) · European Journal of Pain · doi:10.1053/eujp.2000.0175 · Cited by 253
“Longlasting intense nociceptive barrage from the periphery, however, has been reported to give rise to persistent and self-sustaining central hyperexcitability (Dubner, 1991; Price, 1991; Coderre et al., 1993), providing the basis for ‘pathological pain’ (Coderre et al., 1993).”
Background
Redox Modulation of T-Type Calcium Channels in Rat Peripheral Nociceptors
Todorovic, S. M., Jevtović‐Todorović, V., Meyenburg, A., Mennerick, S. J., Perez‐Reyes, E., Romano, C., Olney, J. W., & Zorumski, C. F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00338-5 · Cited by 256
The Effects of Postoperative Pain Management on Immune Response to Surgery
Beilin, B., Shavit, Y., Trabekin, E., Mordashev, B., Mayburd, E., Zeidel, A., & Bessler, H. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000078586.82810.3b · Cited by 250
“Local anesthetics can reduce the postoperative inflammatory response in two ways: they block neural transmission at the site of tissue injury and thus may attenuate the neurogenic inflammation ( 18 ), or they have systemic antiinflammatory properties of their own (13).”
Background
Evaluation of Gabapentin and S-(+)-3-Isobutylgaba in a Rat Model of Postoperative Pain
Field, M. J., Holloman, E. F., McCleary, S., Hughes, J. M., & Singh, L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36908-3 · Cited by 248
Endometriosis is associated with central sensitization: a psychophysical controlled study
Bajaj, P. (2003) · The Journal of Pain · doi:10.1016/s1526-5900(03)00720-x · Cited by 247

Authors: Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R.
Affiliations: University of Toronto (CA)
LSU New Orleans (US)
McGill University (CA)
Corresponding author: Vaccarino, Anthony L.
ORCID: Coderre, Terence J.
Katz, Joel
Vaccarino, Anthony L.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1993-03
Volume: 52
Issue: 3
Pages: 259-285
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/0304-3959(93)90161-h
OpenAlex: W2062625412
Cited by: 1,966
References: 304
Citations by year: 2026: 2 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 24 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 30 · 2015: 30 · 2014: 37 · 2013: 42 · 2012: 53
FWCI: 12.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
YorkSpace (York University) (submittedVersion)
Funders: Medical Research Council Canada
Natural Sciences and Engineering Research Council of Canada (A7891)
Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: pathological pain, hyperalgesia, allodynia, spontaneous pain, central sensitization, nerve injury, nociceptor sensitization, neuroma formation, central nervous system plasticity, noxious stimulation, pain mechanisms
MeSH terms: Acute Disease, Animals, Central Nervous System, Chronic Disease, Humans, Models, Neurological, Neuronal Plasticity, Pain, Palliative Care, Pain Management

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks