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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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Coderre, Terence J., Katz, Joel, Vaccarino, Anthony L., Melzack, Ronald·1993·Pain

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Abstract

Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.

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Moharari, R. S., Motalebi, M., Najafi, A., Zamani, M. M., Imani, F., Etezadi, F., Pourfakhr, P., & Khajavi, M. R. (2013) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.12750 · Cited by 40
“Pain severity was reported as none (0), mild (14), moderate (5-7), and severe (8-10).”
Background
Independent time courses of supraspinal nociceptive activity and spinally mediated behavior during tonic pain
Porro, C. A., Cavazzuti, M., Lui, F., Giuliani, D., Pellegrini, M., & Baraldi, P. (2003) · Pain · doi:10.1016/s0304-3959(03)00015-0 · Cited by 41
“Central sensitization mechanisms (Coderre et al., 1993) may also contribute to maintaining high activity in the deep laminae of the ipsilateral dorsal horn and anterior horn of the spinal cord, 60–80 min after s.”
Background
Factors contributing to physical activity in a chronic low back pain clinical sample: A comprehensive analysis using continuous ambulatory monitoring
Alschuler, K. N., Hoodin, F., Murphy, S. L., Rice, J., & Geisser, M. E. (2011) · Pain · doi:10.1016/j.pain.2011.07.017 · Cited by 39
The role of the dorsal columns in neuropathic behavior: evidence for plasticity and non-specificity
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Functional and immunocytochemical characterization of D‐serine transporters in cortical neuron and astrocyte cultures
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“…and pathological events, including synaptic plasticity (Collingridge and Singer, 1990), learning and memory (Danysz et al., 1995), cerebral blood flow regulation (Hara et al., 1996; Busija et al., 2007), chronic pain (Coderre et al., 1993), and glutamate excitotoxicity (Choi et al., 1988).”
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Descending modulation of central neural plasticity in the formalin pain test
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“These observations have led us and others to hypothesize that the sensitization of dorsal horn neurons, a phenomenon thought important to the generation of secondary hyperalgesia (Woolf 1983; Wall 1984; Willis 1990), is due to the combined action of the EAAs and tachykinin peptides (Sakurada et al. 1990; Dougherty and…”
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Pediatric nurses' thinking in response to vignettes on administering analgesics
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Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer
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Tourniquet inflation during arthroscopic knee ligament surgery does not increase postoperative pain
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Guidelines for the Diagnosis and Management of Neuropathic Pain: Consensus of a Group of Latin American Experts
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Patients with rheumatoid arthritis adapt differently to repetitive painful stimuli compared to healthy controls
Wendler, J., Hummel, T. R., Reissinger, M., Manger, B., Pauli, E., Kalden, J. R., & Kobal, G. (2001) · Journal of Clinical Neuroscience · doi:10.1054/jocn.1999.0775 · Cited by 39
Comparison of postoperative pain management techniques on endocrine response to surgery: A randomised controlled trial
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Electrophysiological Changes in Adult Rat Dorsal Horn Neurons After Neonatal Peripheral Inflammation
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“Conditions of tissue or nerve injury often induce persistent pain, a phenomenon of central sensitization, which can last for several days or months (Coderre et al. 1993; Dubner and Ruda 1992; Woolf 1989).”
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Injectable neuromodulatory agents: botulinum toxin therapy
Frenkl, T. L., & Rackley, R. R. (2005) · Urologic Clinics of North America · doi:10.1016/j.ucl.2004.09.005 · Cited by 39
Cervical spine curvature and craniofacial morphology in an adult Caucasian group: a multiple regression analysis
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“…a constant nociceptive input on secondorder neurons increases the sensitivity of these neurons then non-nociceptive neural impulses from other areas within the same segment, which converge into these neurons, may give rise to nociceptive sensations ( Sessle et al. , 1986 ; Coderre et al. , 1993 ).”
BackgroundInfluential
Orofacial pain: basic mechanisms and implication for successful management
Conti, P. C. R., Pertes, R. A., Heir, G. M., Nasri‐Heir, C., Cohen, H. V., & de Araújo, C. D. R. P. (2003) · Journal of Applied Oral Science · doi:10.1590/s1678-77572003000100002 · Cited by 39
Severe Post-herpetic Neuralgia Successfully Treated with Botulinum Toxin A: Three Case Reports
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Serotonin 5-HT2Receptors Induce a Long-Lasting Facilitation of Spinal Reflexes Independent of Ionotropic Receptor Activity
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“Central sensitization, for example, is a long-lasting facilitation in spinal cord nocisponsive activity mediated by A and C fiber nociceptive input (Coderre et al. 1993) and facilitated nociceptive afferent responses may be responsible for our previously observed amplification in longer-latency…”
Ketamine does not decrease postoperative pain after remifentanil‐based anaesthesia for tonsillectomy in adults
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Neurosensitization: A model for persistent disability in chronic pain, depression, and posttraumatic stress disorder following injury
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“[10], could potentially occur following intense noxious stimulation or injury.”
Influential
Severity of skin lesions of herpes zoster at the worst phase rather than age and involved region most influences the duration of acute herpetic pain
Higa, K., Mori, M., Hirata, K., Hori, K., Manabe, H., & Dan, K. (1997) · Pain · doi:10.1016/s0304-3959(96)03229-0 · Cited by 39
“If acute pain is not relieved effectively in the acute phase, it can persist and widening of the painful area will ensue (Coderre et al., 1993).”
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Strategies Aimed at Preventing Chronic Post-surgical Pain: Comprehensive Perioperative Pain Management after Total Joint Replacement Surgery
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The effectiveness of gabapentin on post-tonsillectomy pain control
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“Thereafter, aVerent nociceptive stimulus arrives in the pain center of the brain and induces central neuronal sensitization [7–9].”
Background

Authors: Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R.
Affiliations: University of Toronto (CA)
LSU New Orleans (US)
McGill University (CA)
Corresponding author: Vaccarino, Anthony L.
ORCID: Coderre, Terence J.
Katz, Joel
Vaccarino, Anthony L.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1993-03
Volume: 52
Issue: 3
Pages: 259-285
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/0304-3959(93)90161-h
OpenAlex: W2062625412
Cited by: 1,966
References: 304
Citations by year: 2026: 2 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 24 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 30 · 2015: 30 · 2014: 37 · 2013: 42 · 2012: 53
FWCI: 12.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
YorkSpace (York University) (submittedVersion)
Funders: Medical Research Council Canada
Natural Sciences and Engineering Research Council of Canada (A7891)
Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: pathological pain, hyperalgesia, allodynia, spontaneous pain, central sensitization, nerve injury, nociceptor sensitization, neuroma formation, central nervous system plasticity, noxious stimulation, pain mechanisms
MeSH terms: Acute Disease, Animals, Central Nervous System, Chronic Disease, Humans, Models, Neurological, Neuronal Plasticity, Pain, Palliative Care, Pain Management

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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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