Cited by 95Sleep and Wakefulness ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP

Romcy‐Pereira, Rodrigo, Pavlides, Constantine·2004·European Journal of Neuroscience

Abstract

Both human and animal studies support the idea that memory consolidation of waking experiences occurs during sleep. In experimental models, rapid-eye-movement (REM) sleep has been shown to be necessary for cortical synaptic plasticity and for the acquisition of spatial and nonspatial memory. Because the hippocampus and medial prefrontal cortex (mPFC) play distinct and important roles in memory processing, we sought to determine the role of sleep in the maintenance of long-term potentiation (LTP) in the dentate gyrus (DG) and mPFC of freely behaving rats. Animals were implanted with stimulating and recording electrodes, either in the medial perforant path and DG or CA1 and mPFC, for the recording of field potentials. Following baseline recordings, LTP was induced and the animals were assigned to three different groups: REM sleep-deprived (REMD), total sleep-deprived (TSD) and control which were allowed to sleep (SLEEP). The deprivation protocol lasted for 4 h and the recordings were made during the first hour and at 5, 24 and 48 h following LTP induction. Our results show that REMD impaired the maintenance of late-phase (48-h) LTP in the DG, whereas it enhanced it in the mPFC. Sleep, therefore, could have distinct effects on the consolidation of different forms of memory.

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Registry

Crossref · 10.1111/j.1460-9568.2004.03808.x

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91 of 91 references verified0 citation errors · 0 not checkable

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  • Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction.

    “Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction (269,270,596,636,743,970,1010).”

    From About Sleep's Role in Memory (2013) · cites this paper as [1010]

  • A 4-hour period of sleep deprivation by gentle stimulation enhances late-phase LTP in the prefrontal cortex.

    “but had the opposite effect to enhance late-phase LTP in the prefrontal cortex.70”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [70]

  • A 4-hour period of sleep deprivation by gentle stimulation impairs late-phase LTP in the dentate gyrus 48 hours later.

    “A 4-hour period of sleep deprivation by gentle stimulation impaired the late phase long term potentiation (LTP) in the dentate gyrus 48 hours later”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [70]

  • A 4-hour period of sleep deprivation by gentle stimulation impairs late-phase long-term potentiation in the dentate gyrus 48 hours later, but enhances late-phase LTP in the prefrontal cortex.

    “Furthermore, a 4-hour period of sleep deprivation by gentle stimulation impaired the latephase long-term potentiation (LTP) in the dentate gyrus 48 hours later, but had the opposite effect of enhancing latephase LTP in the prefrontal cortex.36”

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Authors
Romcy‐Pereira, R., & Pavlides, C.
Affiliations
Rockefeller University (US)
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2004-12
Volume
20
Issue
12
Pages
3453-3462
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2169812222
Cited by
95
References
92
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 8
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL069699, HL69699)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
sleep, long-term potentiation, REM sleep deprivation, total sleep deprivation, hippocampus, medial prefrontal cortex, dentate gyrus, CA1, memory consolidation, synaptic plasticity, medial perforant path
MeSH terms
Animals, Hippocampus, Male, Sleep, Sleep Deprivation, Rats, Sprague-Dawley, Prefrontal Cortex, Long-Term Potentiation, Rats

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