Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP
Abstract
Both human and animal studies support the idea that memory consolidation of waking experiences occurs during sleep. In experimental models, rapid-eye-movement (REM) sleep has been shown to be necessary for cortical synaptic plasticity and for the acquisition of spatial and nonspatial memory. Because the hippocampus and medial prefrontal cortex (mPFC) play distinct and important roles in memory processing, we sought to determine the role of sleep in the maintenance of long-term potentiation (LTP) in the dentate gyrus (DG) and mPFC of freely behaving rats. Animals were implanted with stimulating and recording electrodes, either in the medial perforant path and DG or CA1 and mPFC, for the recording of field potentials. Following baseline recordings, LTP was induced and the animals were assigned to three different groups: REM sleep-deprived (REMD), total sleep-deprived (TSD) and control which were allowed to sleep (SLEEP). The deprivation protocol lasted for 4 h and the recordings were made during the first hour and at 5, 24 and 48 h following LTP induction. Our results show that REMD impaired the maintenance of late-phase (48-h) LTP in the DG, whereas it enhanced it in the mPFC. Sleep, therefore, could have distinct effects on the consolidation of different forms of memory.
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Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction.
“Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction (269,270,596,636,743,970,1010).”
From About Sleep's Role in Memory (2013) · cites this paper as [1010]
A 4-hour period of sleep deprivation by gentle stimulation enhances late-phase LTP in the prefrontal cortex.
“but had the opposite effect to enhance late-phase LTP in the prefrontal cortex.70”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [70]
A 4-hour period of sleep deprivation by gentle stimulation impairs late-phase LTP in the dentate gyrus 48 hours later.
“A 4-hour period of sleep deprivation by gentle stimulation impaired the late phase long term potentiation (LTP) in the dentate gyrus 48 hours later”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [70]
A 4-hour period of sleep deprivation by gentle stimulation impairs late-phase long-term potentiation in the dentate gyrus 48 hours later, but enhances late-phase LTP in the prefrontal cortex.
“Furthermore, a 4-hour period of sleep deprivation by gentle stimulation impaired the latephase long-term potentiation (LTP) in the dentate gyrus 48 hours later, but had the opposite effect of enhancing latephase LTP in the prefrontal cortex.36”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [36]
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- Authors
- Romcy‐Pereira, R., & Pavlides, C.
- Affiliations
- Rockefeller University (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 20
- Issue
- 12
- Pages
- 3453-3462
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2169812222
- Cited by
- 95
- References
- 92
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 8
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL069699, HL69699)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep, long-term potentiation, REM sleep deprivation, total sleep deprivation, hippocampus, medial prefrontal cortex, dentate gyrus, CA1, memory consolidation, synaptic plasticity, medial perforant path
- MeSH terms
- Animals, Hippocampus, Male, Sleep, Sleep Deprivation, Rats, Sprague-Dawley, Prefrontal Cortex, Long-Term Potentiation, Rats
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