The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Cerebrospinal fluid and plasma concentrations of oxytocin and vasopressin during parturition and vaginocervical stimulation in the sheep
Abstract
Simultaneous blood and cerebrospinal fluid (CSF) samples were taken from conscious sheep before, during and after parturition. Concentrations of plasma and CSF oxytocin were significantly elevated during contractions and particularly at birth. Mean prepartum CSF concentrations of oxytocin were around 55% of those found in plasma but postpartum they were up to 2-fold higher than those in plasma. Plasma concentrations of oxytocin were only significantly elevated, compared to prepartum levels, for 15 min postpartum whereas those in CSF were increased for the whole of the 120 min postpartum sampling period. Plasma, but not CSF, concentrations of arginine-vasopressin (AVP) were significantly raised during contractions and birth, and for 15 min postpartum. During the prepartum period CSF AVP concentrations were 67% of those found in plasma whereas at birth plasma levels were 10-fold higher than in CSF. In a separate experiment it was shown that 5 min of mechanical vaginocervical stimulation also stimulated significant increases in CSF and plasma oxytocin concentrations and in plasma vasopressin. Results support previous work suggesting an important role for central oxytocin release in the postpartum induction of maternal behavior and demonstrate that elevated concentrations of oxytocin in the CSF are present for a greater period than in blood. Elevated plasma AVP concentrations during contractions, birth or vaginocervical stimulation may be stimulated by stress associated with these stimuli.
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“Central oxytocin seems fundamental for this mother-infant bonding, as cerebral injections of oxytocin induce acceptance of an unfamiliar lamb by ewes even after initial bonding”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Kendrick et al. 1991
In the citing paper
“Oxytocin is released into blood and brain during parturition, but in sheep (81), plasma concentrations were only elevated for 15min postpartum whereas those in CSF were increased for >120min.”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [81]
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Cites
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep
Kendrick, K. M., Keverne, E. B., & Baldwin, B. A. (2008) · Neuroendocrinology · doi:10.1159/000124796 · Cited by 373
Self-citationMens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322
Vasopressin : principles and properties
Gash, D. M., & Boer, G. J. (1987) · Plenum Press eBooks · Cited by 250
Vaginal stimulation: an important determinant of maternal bonding in sheep
Keverne, E. B., Levy, F., Poindron, P., & Lindsay, D. R. (1983) · Science · doi:10.1126/science.6849123 · Cited by 230
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187
Self-citationKendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91455-2 · Cited by 175
Self-citationKendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91447-3 · Cited by 168
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Research works printed but not linked: 1
- Kendrick, 1989, Release of monoamines, amino acids and oxytocin from the sheep brain during parturition, Curr. Sep., 9, 114
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Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771
Self-citationIntranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 480
“Central oxytocin seems fundamental for this mother-infant bonding, as cerebral injections of oxytocin induce acceptance of an unfamiliar lamb by ewes even after initial bonding (Kendrick et al. 1991, 1992).”
BackgroundStriepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013) · Scientific Reports · doi:10.1038/srep03440 · Cited by 452
Self-citation
Metadata
- Authors
- Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Kendrick, K.M.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 26
- Issue
- 5
- Pages
- 803-807
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2059265899
- Cited by
- 128
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, cerebrospinal fluid, plasma concentration, childbirth, vaginocervical stimulation, labor contractions, stress response, sheep
- MeSH terms
- Animals, Cervix Uteri, Female, Labor, Obstetric, Oxytocin, Pregnancy, Radioimmunoassay, Sheep, Vagina, Vasopressins
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