Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188 · see citing works

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.Preprint

Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B., & Livingston, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.8.869 · Cited by 1,045 · see citing works

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

Treier, M., Staszewski, L. M., & Bohmann, D. (1994) · Cell · doi:10.1016/s0092-8674(94)90502-9 · Cited by 928 · see citing works

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789 · see citing works

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Binétruy, B., Smeal, T., & Karin, M. (1991) · Nature · doi:10.1038/351122a0 · Cited by 598 · see citing works

The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation

Yang, H.-S., Jansen, A. P., Komar, A. A., Zheng, X., Merrick, W. C., Costes, S., Lockett, S. J., Sonenberg, N., & Colburn, N. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.26-37.2003 · Cited by 494 · see citing works

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

Kallunki, T., Deng, T., Hibi, M., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81999-6 · Cited by 492 · see citing works

The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

Ness, S. A., Marknell, Å., & Graf, T. (1989) · Cell · doi:10.1016/0092-8674(89)90767-8 · Cited by 453 · see citing works

Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail

Moscovici, C., Moscovici, M. G., Jimenez, H., Lai, M. M. C., Hayman, M. J., & Vogt, P. K. (1977) · Cell · doi:10.1016/0092-8674(77)90320-8 · Cited by 402 · see citing works

Interaction and functional collaboration of p300 and C/EBPβ

Mink, S., Haenig, B., & Klempnauer, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6609 · Cited by 344 · see citing works

Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis

Chen, Y., Knösel, T., Kristiansen, G., Pietas, A., Garber, M. E., Matsuhashi, S., Ozaki, I., & Petersen, I. (2003) · The Journal of Pathology · doi:10.1002/path.1378 · Cited by 265 · see citing works

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation

Cmarik, J. L., Min, H., Hegamyer, G., Zhan, S., Kulesz-Martin, M., Yoshinaga, H., Matsuhashi, S., & Colburn, N. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14037 · Cited by 254 · see citing works

Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

Shibahara, K., Asano, M., Ishida, Y., Aoki, T., Koike, T., & Honjo, T. (1995) · Gene · doi:10.1016/0378-1119(95)00607-9 · Cited by 223 · see citing works

A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A

Yang, H.-S., Cho, M.-H., Zakowicz, H., Hegamyer, G., Sonenberg, N., & Colburn, N. H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.9.3894-3906.2004 · Cited by 199 · see citing works

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation

Yang, H.-S., Jansen, A. P., Nair, R., Shibahara, K., Verma, A. K., Cmarik, J. L., & Colburn, N. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204137 · Cited by 185 · see citing works

Promising molecular targets for cancer prevention: AP-1, NF-κB and Pdcd4

Young, M. R., Yang, H., & Colburn, N. H. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)00009-6 · Cited by 167 · see citing works

Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation

Yang, H.-S., Knies, J. L., Stark, C., & Colburn, N. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206433 · Cited by 160 · see citing works

Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300

Lee, J.-S., See, R. H., Deng, T., & Shi, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4312 · Cited by 153 · see citing works

JNK phosphorylation relieves HDAC3‐dependent suppression of the transcriptional activity of c‐Jun

Weiss, C., Schneider, S., Wagner, E. F., Zhang, X. M., Seto, E., & Bohmann, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg364 · Cited by 150 · see citing works

c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors

Fuchs, S. Y., Xie, B., Adler, V., Fried, V. A., Davis, R. J., & Ronai, Z. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32163 · Cited by 141 · see citing works

Intramolecular signal transduction in c‐Jun.

Papavassiliou, A. G., Treier, M., & Bohmann, D. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07193.x · Cited by 125 · see citing works

Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity

Schwartz, C., Schachtrup, K., Mink, S., Schmolke, M., Budde, B., Wenning, D., & Klempnauer, K.-H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg076 · Cited by 122 · see citing works

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA

Böhm, M., Sawicka, K., Siebrasse, J. P., Brehmer-Fastnacht, A., Peters, R., & Klempnauer, K.-H. (2003) · Oncogene · doi:10.1038/sj.onc.1206710 · Cited by 101 · see citing works

Programmed cell death protein 4 (pdcd4): A novel target for antineoplastic therapy?

Lankat–Buttgereit, B., & Göke, R. (2003) · Biology of the Cell · doi:10.1016/j.biolcel.2003.09.003 · Cited by 94 · see citing works

Interaction of C/EBPβ and v-Myb Is Required for Synergistic Activation of the mim -1 Gene

Mink, S., Kerber, U., & Klempnauer, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1316 · Cited by 94 · see citing works

DUG is a novel homologue of translation initiation factor 4G that binds eIF4A

Göke, A., Göke, R., Knolle, A., Trusheim, H., Schmidt, H., Wilmen, A., Carmody, R. J., Göke, B., & Chen, Y. H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02129-0 · Cited by 92 · see citing works

Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II

Lankat–Buttgereit, B., Gregel, C. M., Knolle, A., Hasilík, A., Arnold, R., & Göke, R. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.058 · Cited by 75 · see citing works

Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti‐H731 antibody

Yoshinaga, H., Matsuhashi, S., Fujiyama, C., & Masaki, Z. (1999) · Pathology International · doi:10.1046/j.1440-1827.1999.00995.x · Cited by 62 · see citing works

Up-regulation of PDCD4 in senescent human diploid fibroblasts

Kang, M.-J., Ahn, H.-S., Lee, J.-Y., Matsuhashi, S., & Park, W.-Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00264-4 · Cited by 57 · see citing works

The chicken Pdcd4 gene is regulated by v-Myb

Schlichter, U. H. A., Burk, O., Worpenberg, S., & Klempnauer, K.-H. (2001) · Oncogene · doi:10.1038/sj.onc.1204071 · Cited by 53 · see citing works

Carbonic anhydrase II is an AP‐1 target gene in osteoclasts

David, J. ‐., Rincón, M., Neff, L., Horne, W. C., & Baron, R. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1099 · Cited by 50 · see citing works

Targeted disruption of c-myb in the chicken pre B-cell line DT40

Appl, H., & Klempnauer, K.-H. (2002) · Oncogene · doi:10.1038/sj.onc.1205427 · Cited by 21 · see citing works

Identification of the myb-inducible promoter of the chicken Pdcd4 gene

Schlichter, U., Kattmann, D., Appl, H., Miethe, J., Brehmer-Fastnacht, A., & Klempnauer, K.-H. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00252-4 · Cited by 20 · see citing works

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882 · see citing works

miR‐21: a small multi‐faceted RNA

Krichevsky, A. M., & Gabriely, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00556.x · Cited by 987 · see citing works

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer

Mudduluru, G., George-William, J. N., Muppala, S., Asangani, I. A., Kumarswamy, R., Nelson, L. D., & Allgayer, H. (2011) · Bioscience Reports · doi:10.1042/bsr20100065 · Cited by 332 · see citing works

The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

Lankat–Buttgereit, B., & Göke, R. (2009) · Biology of the Cell · doi:10.1042/bc20080191 · Cited by 307 · see citing works

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression

Stagakis, E., Bertsias, G. K., Verginis, P., Νάκου, Μ., Hatziapostolou, M., Kritikos, H. D., Iliopoulos, D., & Boumpas, D. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.139857 · Cited by 301 · see citing works

Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer

Shibuya, H., Iinuma, H., Shimada, R., Horiuchi, A., & Watanabe, T. (2010) · Oncology · doi:10.1159/000323283 · Cited by 244 · see citing works

An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation

Talotta, F., Cimmino, A., Matarazzo, M. R., Casalino, L., De Vita, G., D'Esposito, M., Di Lauro, R., & Verde, P. (2009) · Oncogene · doi:10.1038/onc.2008.370 · Cited by 242 · see citing works

Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway

Sheth, S., Jajoo, S., Kaur, T., Mukherjea, D., Sheehan, K., Rybak, L. P., & Ramkumar, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051655 · Cited by 225 · see citing works

Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion

Yang, H.-S., Matthews, C. P., Clair, T., Wang, Q., Baker, A. R., Li, C.-C. H., Tan, T.-H., & Colburn, N. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1297-1306.2006 · Cited by 202 · see citing works

Loss of programmed cell death 4 expression marks adenoma‐carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer

Mudduluru, G., Medved, F., Grobholz, R., Jost, C., Gruber, A., Leupold, J. H., Post, S., Jansen, A., Colburn, N. H., & Allgayer, H. (2007) · Cancer · doi:10.1002/cncr.22983 · Cited by 196 · see citing works

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

Williams, M. A., Ravkov, E. V., & Bevan, M. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.014 · Cited by 168 · see citing works

MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma

Liu, C., Yu, J., Yu, S., Lavker, R. M., Cai, L., Liu, W., Yang, K.-G., He, X., & Chen, S. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.021 · Cited by 164 · see citing works

Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

Leupold, J. H., Yang, H.-S., Colburn, N. H., Asangani, I., Post, S., & Allgayer, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210234 · Cited by 163 · see citing works

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R. I., Croce, C. M., & Pekarsky, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3469 · Cited by 151 · see citing works

Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both β-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells

Wang, Q., Sun, Z., & Yang, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210793 · Cited by 147 · see citing works

miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma

Wang, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1682 · Cited by 146 · see citing works

Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions

Matsuhashi, S., Manirujjaman, M., Hamajima, H., & Ozaki, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092304 · Cited by 143 · see citing works

Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma

Reis, P. P., Tomenson, M., Cervigne, N. K., Machado, J., Jurišica, I., Pintilie, M., Sukhai, M. A., Perez‐Ordoñez, B., Grenman, R. A., Gilbert, R. W., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-238 · Cited by 142 · see citing works

Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium

Fish, J. E., & Marsden, P. A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5421-8 · Cited by 138 · see citing works

Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth

Shiota, M., Izumi, H., Tanimoto, A., Takahashi, M., Miyamoto, N., Kashiwagi, E., Kidani, A., Hirano, G., Masubuchi, D., Fukunaka, Y., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2334 · Cited by 134 · see citing works

Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma

Zhen, Y., Liu, Z., Yang, H., Yu, X., Wu, Q., Hua, S., Long, X., Jiang, Q., Song, Y., Cheng, C., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.376 · Cited by 131 · see citing works

Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4

Nakata, K., Sugi, Y., Narabayashi, H., Kobayakawa, T., Nakanishi, Y., Tsuda, M., Hosono, A., Kaminogawa, S., Hanazawa, S., & Takahashi, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.788596 · Cited by 132 · see citing works

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

Chu, J., Cargnello, M., Topisirović, I., & Pelletier, J. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.06.005 · Cited by 127 · see citing works

The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion

Papavassiliou, A. G., & Musti, A. M. (2020) · Cells · doi:10.3390/cells9112470 · Cited by 122 · see citing works

Heterogeneous Nuclear Ribonucleoprotein C1/C2 Controls the Metastatic Potential of Glioblastoma by Regulating PDCD4

Park, Y. M., Hwang, S. J., Masuda, K., Choi, K.-M., Jeong, M., Nam, D., Gorospe, M., & Kim, H. H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00443-12 · Cited by 125 · see citing works

Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer

Mori (2010) · International Journal of Oncology · doi:10.3892/ijo_00000590 · Cited by 124 · see citing works

Pdcd4, a colon cancer prognostic that is regulated by a microRNA

Allgayer, H. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.09.001 · Cited by 123 · see citing works

The role of Pdcd4 in tumour suppression and protein translation

Wang, Q., & Yang, H. (2018) · Biology of the Cell · doi:10.1111/boc.201800014 · Cited by 113 · see citing works

C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

Wu, H., Kong, L., Tan, Y., Epstein, P. N., Zeng, J., Gu, J., Liang, G., Kong, M., Chen, X., Miao, L., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3958-8 · Cited by 101 · see citing works

Frequent loss of PDCD4 expression in human glioma: Possible role in the tumorigenesis of glioma

Gao, F., Zhang, P., Zhou, C., Li, J., Wang, Q., Zhu, F., Ma, C., Sun, W., & Zhang, L. (2007) · Oncology Reports · doi:10.3892/or.17.1.123 · Cited by 100 · see citing works

Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model

Miyanaga, A., Gemma, A., Noro, R., Kataoka, K., Matsuda, K., 奈良, 道., Okano, T., Seike, M., Yoshimura, A., Kawakami, A., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2140 · Cited by 99 · see citing works

Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases

Zhai, Y., Wang, T., Fu, Y., Yu, T., Ding, Y. P., & Nie, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098011 · Cited by 96 · see citing works

Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4

Yang, Y., Meng, H., Peng, Q., Yang, X., Gan, R., Zhao, L., Chen, Z., Lu, J., & Meng, Q. H. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.66 · Cited by 94 · see citing works

The Links between Transcription, β-catenin/JNK Signaling, and Carcinogenesis

Saadeddin, A., Babaei‐Jadidi, R., Spencer‐Dene, B., & Nateri, A. S. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0027 · Cited by 85 · see citing works

Sensing the scent of death: Modulation of microRNAs by curcumin in gastrointestinal cancers.

Ashrafizadeh, M., Zarrabi, A., Hashemipour, M., Massoud Vosough, M. P., Najafi, M., Shahinozzaman, M., Hushmandi, K., Khan, H., & Mirzaei, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105199 · Cited by 77 · see citing works

Targeting the eIF4A RNA helicase as an anti-neoplastic approach

Chu, J., & Pelletier, J. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.09.006 · Cited by 80 · see citing works

Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention

Izzo, S., Naponelli, V., & Bettuzzi, S. (2020) · Nutrients · doi:10.3390/nu12041010 · Cited by 79 · see citing works

FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

Dikshit, B., Irshad, K., Madan, E., Aggarwal, N., Sarkar, C., Chandra, P. S., Gupta, D. K., Chattopadhyay, P., Sinha, S., & Chosdol, K. (2012) · Oncogene · doi:10.1038/onc.2012.393 · Cited by 79 · see citing works

Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer

Wei, N., Liu, S. S., Leung, T. H., Tam, K., Liao, X. Y., Cheung, A., Chan, K. K. L., & Ngan, H. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-70 · Cited by 79 · see citing works

The Role of microRNA-21 in the Onset and Progression of Cancer

Singh, A. K., Singh, A. K., Giri, R., Kumar, D., Sharma, R., Vališ, M., Kuča, K., & Garg, N. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0096 · Cited by 77 · see citing works

MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases

Li, S., Liang, Z., Liu, X., & Zou, F. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1052-6 · Cited by 76 · see citing works

PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis

Fassan, M., Pizzi, M., Giacomelli, L., Mescoli, C., Ludwig, K., Pucciarelli, S., & Rugge, M. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1046-5 · Cited by 76 · see citing works

Tumor Suppressor Protein Pdcd4 Inhibits Translation of p53 mRNA

Wedeken, L., Singh, P., & Klempnauer, K.-H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.269456 · Cited by 75 · see citing works

siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression

Bitomsky, N., Wethkamp, N., Marikkannu, R., & Klempnauer, K.-H. (2008) · Oncogene · doi:10.1038/onc.2008.115 · Cited by 75 · see citing works

Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21

Yang, F., Liu, M., Li, W., Che, J., WANG, G.-C., & Zheng, J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2813 · Cited by 74 · see citing works

PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis

Ludwig, K., Fassan, M., Mescoli, C., Pizzi, M., Balistreri, M., Albertoni, L., Pucciarelli, S., Scarpa, M., Sturniolo, G. C., Angriman, I., et al. (2012) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-012-1345-5 · Cited by 67 · see citing works

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

Santhanam, A. N., Baker, A. R., Hegamyer, G., Kirschmann, D. A., & Colburn, N. H. (2010) · Oncogene · doi:10.1038/onc.2010.158 · Cited by 67 · see citing works

<i>PDCD4</i> gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis

Gao, F., Wang, X., Zhu, F., Wang, Q., Zhang, X., Guo, C., Zhou, C., Ma, C., Sun, W., Zhang, Y., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00497.x · Cited by 66 · see citing works

MicroRNA-21 suppression impedes medulloblastoma cell migration

Grunder, E., D’Ambrosio, R., Fiaschetti, G., Abela, L., Arcaro, A., Zuzak, T. J., Ohgaki, H., Lv, S., Shalaby, T., & Grotzer, M. A. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.06.041 · Cited by 65 · see citing works

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Wang, G., Wang, J. J., Tang, H., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.001 · Cited by 63 · see citing works

Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine

Luo, X., Gu, J., Zhu, R., Feng, M., Zhu, X., Li, Y., & Fei, J. (2014) · BMC Systems Biology · doi:10.1186/1752-0509-8-82 · Cited by 62 · see citing works

miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cells

Xia, H., & Zhao, Y. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1699826 · Cited by 61 · see citing works

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

Wei, N., Liu, S. S., Chan, K. K. L., & Ngan, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030311 · Cited by 58 · see citing works

Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation

Singh, P., Wedeken, L., Waters, L. C., Carr, M. D., & Klempnauer, K.-H. (2011) · Oncogene · doi:10.1038/onc.2011.202 · Cited by 50 · see citing works

Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

Hwang, S.-K., Baker, A. R., Young, M. R., & Colburn, N. H. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu008 · Cited by 49 · see citing works

MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake

Liu, R., Liu, C., He, X., Sun, P., Zhang, B., Yang, H., Shi, W., & Ruan, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31317-0 · Cited by 48 · see citing works

Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A

Waters, L. C., Veverka, V., Böhm, M., Schmedt, T., Choong, P. T., Muskett, F. W., Klempnauer, K.-H., & Carr, M. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210305 · Cited by 48 · see citing works

Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4

Nedaeinia, R., Sharifi, M., Avan, A., Kazemi, M., Nabinejad, A., Ferns, G. A., Ghayour-Mobarhan, M., & Salehi, R. (2017) · Tumor Biology · doi:10.1177/1010428317692261 · Cited by 47 · see citing works

Programmed cell death 4 protein in esophageal cancer

Rugge (2010) · Oncology Reports · doi:10.3892/or_00000838 · Cited by 45 · see citing works

Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer

Zhen, Y., Li, D., Li, W., Yao, W., Wu, A., Huang, J., Gu, H., Huang, Y., Wang, Y., Wu, J., et al. (2016) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504015x14478843952861 · Cited by 42 · see citing works

Effects of quercetin on microRNAs: A mechanistic review

Kordkheyli, V. A., Khonakdar-Tarsi, A., Mishan, M. A., Tafazoli, A., Bardania, H., Zarpou, S., & Bagheri, A. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28663 · Cited by 41 · see citing works

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

Wang, Q., Zhang, Y., & Yang, H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.07.004 · Cited by 41 · see citing works

Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo

Zhang, X., Wang, X., Song, X., Liu, C., Shi, Y., Wang, Y., Afonja, O., Ma, C., Chen, Y. H., & Zhang, L. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01664.x · Cited by 39 · see citing works

Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G

Waters, L. C., Strong, S. L., Ferlemann, E., Oka, O., Muskett, F. W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A. J., Klempnauer, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.166157 · Cited by 37 · see citing works

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: Inhibition of translation elongation

Biyanee, A., Ohnheiser, J., Singh, P., & Klempnauer, K.-H. (2015) · Oncogene · doi:10.1038/onc.2014.83 · Cited by 37 · see citing works

Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis

Rodrigues, P. M., Afonso, M. B., Simão, A. L., Borralho, P. M., Rodrigues, C. M. P., & Castro, R. E. (2015) · Scientific Reports · doi:10.1038/srep17528 · Cited by 37 · see citing works

The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury

Wang, X., Zhang, L., Wei, Z., Zhang, X., Gao, Q., Ma, Y., Liu, X., Jiang, Y. Z., Liu, X., Guo, C., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.174 · Cited by 36 · see citing works

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

Fehler, O., Singh, P., Haas, A., Ulrich, D., Müller, J. P., Ohnheiser, J., & Klempnauer, K.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku800 · Cited by 35 · see citing works

Programmed cell death 4 (PDCD4) expression during multistep Barrett's carcinogenesis

Fassan, M., Pizzi, M., Battaglia, G., Giacomelli, L., Parente, P., Bocus, P., Ancona, E., & Rugge, M. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.078253 · Cited by 35 · see citing works

Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation

Shen, L., Ling, M., Li, Y., Xu, Y., Zhou, Y., Ye, J., Pang, Y., Zhao, Y., Jiang, R., Zhang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057652 · Cited by 33 · see citing works

Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors

Калиниченко, С. В., Kopantzev, E. P., Korobko, E. V., Palgova, I. V., Эдуардовна, З. Л., Mv, B., Petrov, A. N., Frank, G. A., Sverdlov, E. D., & Korobko, I. V. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.03.022 · Cited by 33 · see citing works

Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications

Mladenov, M. I., Bogdanov, J. B., Bogdanov, B., Hadzi‐Petrushev, N., Kamkin, A. G., Stojchevski, R., & Avtanski, D. B. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00559-5 · Cited by 32 · see citing works

Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions

Wedeken, L., Ohnheiser, J., Hirschi, B., Wethkamp, N., & Klempnauer, K. (2010) · Genes & Cancer · doi:10.1177/1947601910364227 · Cited by 32 · see citing works

Current Status and Perspectives Regarding LNA‐Anti‐miR Oligonucleotides and microRNA miR‐21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer

Nedaeinia, R., Avan, A., Ahmadian, M., Nia, S. N., Ranjbar, M., Sharifi, M., Goli, M., Piroozmand, A., Nourmohammadi, E., Manian, M., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26047 · Cited by 32 · see citing works

Epigenetic Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus

Araki, Y., & Mimura, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021019 · Cited by 31 · see citing works

Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46

Kumar, N., Wethkamp, N., Waters, L. C., Carr, M. D., & Klempnauer, K.-H. (2013) · Oncogenesis · doi:10.1038/oncsis.2012.37 · Cited by 30 · see citing works

Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4

Chen, B., Huang, S. G., Ju, L., Li, M., Nie, F. F., Zhang, Y., Zhang, Y. H., Chen, X., & Gao, F. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20155020 · Cited by 30 · see citing works

Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients

Iinuma, H. (2012) · Oncology Reports · doi:10.3892/or.2012.1648 · Cited by 30 · see citing works

Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability

Fay, M. M., Clegg, J. M., Uchida, K. A., Powers, M. A., & Ullman, K. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.541300 · Cited by 30 · see citing works

PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression

Guo, J., Ozaki, I., Xia, J., Kuwashiro, T., Kojima, M., Takahashi, H., Ashida, K., Anzai, K., & Matsuhashi, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00661 · Cited by 29 · see citing works

Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB

Jin, R., Xu, H., Yuan, W.-X., Zhuang, L., Liu, L., Jiang, L., Zhu, L.-H., Liu, J., & Zhou, G.-P. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.04.007 · Cited by 29 · see citing works

PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses

Paolo, A. D., Eastman, G., Mesquita-Ribeiro, R., Farías, J., Macklin, A. M., Kislinger, T., Colburn, N. H., Munroe, D. J., Sosa, J. R. S., Dajas‐Bailador, F., et al. (2020) · RNA · doi:10.1261/rna.075424.120 · Cited by 28 · see citing works

Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications

Tang, C., Liu, Y., Liu, S., Yang, C., Chen, L., Tang, F., Wang, F., Zhan, L., Deng, H., Zhou, W., et al. (2021) · Pharmacology · doi:10.1159/000520311 · Cited by 28 · see citing works

Dual regulation of Myc by Abl

Lobo, V. J. S.-A., Doni, M., Verrecchia, A., Sanulli, S., Fagà, G., Piontini, A., Bianchi, M., Conacci‐Sorrell, M., Mazzarol, G., Peg, V., et al. (2013) · Oncogene · doi:10.1038/onc.2012.621 · Cited by 28 · see citing works

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

Ahn, J., Choi, J., Won, M., Kang, C., Gyun, M.-R., Park, H., Kim, C., & Chung, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.121 · Cited by 26 · see citing works

Increase of RhoB in γ-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells

Kim, C., Won, M., Choi, C.-H., Ahn, J., Kim, B., Song, K.-B., Kang, C., & Chung, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.012 · Cited by 25 · see citing works

Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response

Singh, P. A., Marikkannu, R., Bitomsky, N., & Klempnauer, K. H. (2009) · Oncogene · doi:10.1038/onc.2009.239 · Cited by 24 · see citing works

Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells

Chen, Y., Bian, Y., Zhao, S., Kong, F., & Li, X. (2016) · Oncology Letters · doi:10.3892/ol.2016.5323 · Cited by 22 · see citing works

MiR‑1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1

Zhao, J., Cao, J., Zhou, L., Du, Y., Zhang, X., Yang, B., Gao, Y., Wang, Y., Ma, N., & Yang, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.9307 · Cited by 22 · see citing works

Reversine inhibits Colon Carcinoma Cell Migration by Targeting JNK1

Jèmaà, M., Abassi, Y., Kifagi, C., Fezai, M., Daams, R., Lang, F. J. W., & Massoumi, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-30251-w · Cited by 21 · see citing works

Downstream Effectors of ILK in Cisplatin-Resistant Ovarian Cancer

Reyes‐González, J. M., Quiñones‐Díaz, B. I., Santana‐Rivera, Y., Báez, P., Soto, D., Valiyeva, F., Marcos-Martínez, M. J., Thomas, R. J. F.-D., & Vivas‐Mejía, P. E. (2020) · Cancers · doi:10.3390/cancers12040880 · Cited by 19 · see citing works

Proteomics perturbations promoted by the protein kinase CK2 inhibitor quinalizarin

Franchin, C., Salvi, M., Arrigoni, G., & Pinna, L. A. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.04.002 · Cited by 17 · see citing works

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1

Singh, P., Singh, A. P., Tripathi, S. K., Kumar, V., & Sane, A. P. (2019) · Plant Science · doi:10.1016/j.plantsci.2019.110242 · Cited by 15 · see citing works

Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers

Matsuhashi, S. (2011) · Oncology Reports · doi:10.3892/or.2011.1450 · Cited by 15 · see citing works

Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation

Kloos, B., Chakraborty, S., Lindner, S. G., Noack, K., Steffen, U., Schett, G. A., Krämer, O. H., & Kubatzky, K. F. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0117-7 · Cited by 15 · see citing works

Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma

Jiang, Y., Zhang, S. H., Han, G. Q., & Qin, C. Y. (2010) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2010.01.015 · Cited by 14 · see citing works

Pdcd4 tumor suppressor: Properties, functions, and possible applications in oncology

Вихрева, П. Н., Shepelev, M. V., Korobko, E. V., & Korobko, I. V. (2010) · Molecular Genetics Microbiology and Virology · doi:10.3103/s0891416810020011 · Cited by 13 · see citing works

Programmed cell death 4 (Pdcd4) expression in colorectal adenocarcinoma: Association with clinical stage

Lim, S., & Hong, R. (2011) · Oncology Letters · doi:10.3892/ol.2011.365 · Cited by 13 · see citing works

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation

Jo, S.-H., Kim, D. E., Clocchiatti, A., & Dotto, G. P. (2016) · Oncotarget · doi:10.18632/oncotarget.11227 · Cited by 13 · see citing works

The Role and Interactions of Programmed Cell Death 4 and its Regulation by microRNA in Transformed Cells of the Gastrointestinal Tract

Ferris, W. F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.903374 · Cited by 12 · see citing works

Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation

Yang, H.-S., Knies, J. L., Stark, C., & Colburn, N. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206433 · Cited by 160 · see citing works

Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion

Yang, H.-S., Matthews, C. P., Clair, T., Wang, Q., Baker, A. R., Li, C.-C. H., Tan, T.-H., & Colburn, N. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1297-1306.2006 · Cited by 202 · see citing works

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation

Yang, H.-S., Jansen, A. P., Nair, R., Shibahara, K., Verma, A. K., Cmarik, J. L., & Colburn, N. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204137 · Cited by 185 · see citing works

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R. I., Croce, C. M., & Pekarsky, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3469 · Cited by 151 · see citing works

The transformation supressor Protein Pdcd4 binds to RNA and is involved in the regulation of c-Jun activity.

B�hm, M., Bitomsky, N., & Klempnauer, K. (2004) · GBM Annual Fall meeting M�nster 2004 · doi:10.1240/sav_gbm_2004_h_000659