Cited by 120Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Cocaine Uptake Is Decreased in the Brain of Detoxified Cocaine Abusers

Volkow, N·1996·Neuropsychopharmacology

DOI 10.1016/0893-133x(95)00073-m

Open this paper in CoChat — free account

Abstract

Binding of [11C]cocaine in brain was measured with positron emission tomography in 12 detoxified cocaine abusers and in 20 controls to evaluate if there were changes in cocaine binding and in dopamine (DA) transporter availability associated with chronic cocaine use. Nine controls and 10 cocaine abusers had an additional scan with [18F]N-methylspiroperidol to measure dopamine D2 receptors. Cocaine abusers had significantly lower uptake of [11C]cocaine in brain (6.2 +/- 1% dose/cc tissues) than controls (7.7 +/- 2%). The distribution volumes (DV) for [11C]cocaine were reduced in basal ganglia (BG), cortex, thalamus, and cerebellum (CB) of cocaine abusers. However there were no differences in the ratio of the DV in BG to that in CB, which is an estimate of DA transporter availability. Values for DA D2 receptor availability were decreased in cocaine abusers and did not correlate with estimates of dopamine transporter availability. In summary, detoxified cocaine abusers showed decreased uptake of cocaine in brain but did not show changes in DA transporter availability.

Integrity signals

Registry

Crossref · 10.1016/0893-133x(95)00073-m

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
Logan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,481
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
The pharmacology of cocaine related to its abuse.
Johanson, C. E., & Fischman, M. W. (1989) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00022-5 · Cited by 694
New concepts in cocaine addiction: The dopamine depletion hypothesis
Dackis, C. A., & Gold, M. S. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90022-3 · Cited by 607
Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.
de Wit, H., & Wise, R. A. (1977) · Canadian Journal of Psychology / Revue canadienne de psychologie · doi:10.1037/h0081662 · Cited by 491
Changes in brain glucose metabolism in cocaine dependence and withdrawal
Volkow, N. D., Fowler, J. S., Wolf, A. P., Hitzemann, R., Dewey, S. L., Bendriem, B., Alpert, R., & Hoff, A. L. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.5.621 · Cited by 451
The human brain in figures and tables : a quantitative handbook
Blinkov, S. M., Glezer, I. I., Haigh, B., & Lindsley, D. B. (1968) · Medical Entomology and Zoology · Cited by 439
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421

Show all 57 references

Sorted by citations

Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
Franklin, T. R., Acton, P. D., Maldjian, J. A., Gray, J. D., Croft, J. R., Dackis, C. A., O’Brien, C. P., & Childress, A. R. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01269-0 · Cited by 599
Addiction: Decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
Volkow, N. D., Wang, G., Fowler, J. S., Tomasi, D., Telang, F., & Baler, R. (2010) · BioEssays · doi:10.1002/bies.201000042 · Cited by 532
Self-citation
Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis
Ashok, A. H., Mizuno, Y., Volkow, N. D., & Howes, O. D. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0135 · Cited by 330
Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300406 · Cited by 315
Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease
Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 293
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239
Enhanced Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Social Drinkers
Fox, H. C., Hong, K., Siedlarz, K. M., & Sinha, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301470 · Cited by 185
Neuropsychological Consequences of Opiate Use
Gruber, S. A., Silveri, M. M., & Yurgelun-Todd, D. A. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9041-y · Cited by 194
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171
Elevated Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by [123I]β-CIT SPECT
Malison, R. T., Best, S. E., van Dyck, C. H., McCance, E. F., Wallace, E. A., Laruelle, M. A., Baldwin, R. M., Seibyl, J. P., Price, L. H., Kosten, T. R., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.832 · Cited by 156
Molecular mechanisms of opiate and cocaine addiction
Nestler, E. J. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80094-3 · Cited by 149
Efficacy of Psychostimulant Drugs for Cocaine Dependence
Cervelló, X. C., Casas, M., Pérez‐Mañá, C., Roncero, C., Vidal, X., & Capellà, D. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub3 · Cited by 131
Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
Newton, T. F., Garza, R. D. L., Kalechstein, A. D., & Nestor, L. J. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.07.012 · Cited by 125
Gender Effects on Persistent Cerebral Metabolite Changes in the Frontal Lobes of Abstinent Cocaine Users
Chang, L., Ernst, T., Strickland, T. L., & Mehringer, C. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.716 · Cited by 117
Striatal Dopaminergic Abnormalities in Human Cocaine Users
Little, K. Y., Zhang, L., Desmond, T., Frey, K. A., Dalack, G. W., & Cassin, B. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.238 · Cited by 116
Decreased brain dopamine cell numbers in human cocaine users
Little, K. Y., Ramssen, E., Welchko, R. M., Volberg, V., Roland, C. J., & Cassin, B. J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.10.034 · Cited by 113
Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients
Jacobsen, L. K., Staley, J. K., Malison, R. T., Zoghbi, S. S., Seibyl, J. P., Kosten, T. R., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1134 · Cited by 110
Fast uptake and long-lasting binding of methamphetamine in the human brain: Comparison with cocaine
Fowler, J. S., Volkow, N. D., Logan, J., Alexoff, D. L., Telang, F., Wang, G., Wong, C., Ma, Y., Kriplani, A., Pradhan, K., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.020 · Cited by 98
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
Madras, B. K., Miller, G. M., & Fischman, A. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00439-9 · Cited by 97
The habenula in psychiatric disorders: More than three decades of translational investigation
Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 92
Cocaine abuse and sensitization of striatal dopamine transmission: A critical review of the preclinical and clinical imaging literature
Narendran, R., & Martínez, D. (2008) · Synapse · doi:10.1002/syn.20566 · Cited by 84
DARK Classics in Chemical Neuroscience: Cocaine
Drake, L. R., & Scott, P. J. H. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00117 · Cited by 80
[11]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
Fowler, J. S., Volkow, N. D., Wang, G., Gatley, S. J., & Logan, J. (2001) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(01)00211-6 · Cited by 77
Extended access of cocaine self‐administration results in tolerance to the dopamine‐elevating and locomotor‐stimulating effects of cocaine
Calipari, E. S., Ferris, M. J., & Jones, S. R. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12452 · Cited by 81
Brain Dopamine Transporter Messenger RNA and Binding Sites in Cocaine Users
Little, K. Y., McLaughlin, D. P., Zhang, L., McFinton, P. R., Dalack, G. W., Cook, E. H., Cassin, B. J., & Watson, S. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.793 · Cited by 76
Cocaine Abuse in Humans Is Not Associated with Increased Microglial Activation: An 18-kDa Translocator Protein Positron Emission Tomography Imaging Study with [11C]PBR28
Narendran, R., Lopresti, B. J., Mason, N. S., Deuitch, L., Paris, J., Himes, M. L., Kodavali, C. V., & Nimgaonkar, V. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0928-14.2014 · Cited by 66
Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
Ernst, T., Chang, L., Oropilla, G., Gustavson, A. R., & Speck, O. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00056-1 · Cited by 62
Carrier-Mediated Cocaine Transport at the Blood-Brain Barrier as a Putative Mechanism in Addiction Liability
Chapy, H., Smirnova, M., André, P., Schlatter, J., Chiadmi, F., Couraud, P., Scherrmann, J., Declèves, X., & Cisternino, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu001 · Cited by 67
Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation
Siciliano, C. A., Saha, K., Calipari, E. S., Fordahl, S. C., Chen, R., Khoshbouei, H., & Jones, S. R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2604-17.2017 · Cited by 56
8.3 Imaging Dopamine’s Role in Drug Abuse and Addiction
Volkow, N. D., Fowler, J. S., Wang, G., Telang, F., & Baler, R. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0028 · Cited by 58
No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers
van de Giessen, E., Hesse, S., Caan, M. W. A., Zientek, F., Dickson, J. C., Tossici-Bolt, L., Séra, T., Asenbaum, S., Guignard, R., Akdemir, Ü. Ö., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.011 · Cited by 55
Carbon-11: Radiochemistry and Target-Based PET Molecular Imaging Applications in Oncology, Cardiology, and Neurology
Nerella, S. G., Bhattacharya, A., Joshi, R. K., Nagaraj, C., Bharath, R. D., & Kumar, P. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01053 · Cited by 59
Adaptations of Presynaptic Dopamine Terminals Induced by Psychostimulant Self-Administration
Siciliano, C. A., Calipari, E. S., Ferris, M. J., & Jones, S. R. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5002705 · Cited by 57
Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats
Saddoris, M. P., Wang, X., Sugam, J. A., & Carelli, R. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3468-15.2016 · Cited by 57
In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
Narendran, R., Lopresti, B. J., Martinez, D., Mason, N. S., Himes, M., May, M. A., Daley, D. C., Price, J. C., Mathis, C. A., & Frankle, W. G. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11010126 · Cited by 53
Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: Focus on dopamine, norepinephrine and glutamate
Haile, C. N., Mahoney, J. J., Newton, T. F., & Garza, R. D. L. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.01.010 · Cited by 56
Imaging Studies of Cocaine in the Human Brain and Studies of the Cocaine Addicta
Volkow, N. D., Wang, G., & Fowler, J. S. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46188.x · Cited by 56
Neuropsychological effects associated with recreational cocaine use
Soar, K., Mason, C., Potton, A., & Dawkins, L. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2666-4 · Cited by 55
Dopamine transporter levels in cocaine dependent subjects
Crits-Christoph, P. F., Newberg, A. B., Wintering, N., Plöessl, K., Gibbons, M. B. C., Ring‐Kurtz, S., Gallop, R., & Present, J. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.04.014 · Cited by 54
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martínez, D., Kim, J., Krystal, J. H., & Abi‐Dargham, A. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.004 · Cited by 50
Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration
Miguéns, M., Crespo, J. A., Olmo, N. D., Higuera‐Matas, A., Montoya, G. L., Garcı́a-Lecumberri, C., & Ambrosio, E. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.042 · Cited by 49
Demonstration of Dose-Dependent Global and Regional Cocaine-Induced Reductions in Brain Blood Flow Using a Novel Approach to Quantitative Single Photon Emission Computerized Tomography
Johnson, B., Lamki, L., Fang, B., Barron, B., Wagner, L. K., Wells, L., Kenny, P., Overton, D., Dhother, S., Abramson, D., et al. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00168-1 · Cited by 45
Dopamine and Corticotropin-Releasing Factor Synergistically Alter Basolateral Amygdala-to-Medial Prefrontal Cortex Synaptic Transmission: Functional Switch after Chronic Cocaine Administration
Orozco-Cabal, L. F., Liu, J., Pollandt, S., Schmidt, K., Shinnick‐Gallagher, P., & Gallagher, J. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2666-07.2008 · Cited by 46
Too Difficult to Stop: Mechanisms Facilitating Relapse in Alcohol Dependence
Garbusow, M., Sebold, M., Beck, A., & Heinz, A. (2014) · Neuropsychobiology · doi:10.1159/000362838 · Cited by 47
Cocaine self‐administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine
Siciliano, C. A., Ferris, M. J., & Jones, S. R. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12970 · Cited by 50
Cocaine abusers do not show loss of dopamine transporters with age
Wang, G., Volkow, N. D., Fowler, J. S., Fischman, M. W., Foltin, R. W., Abumrad, N. N., Logan, J., & Pappas, N. R. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00614-0 · Cited by 45
Changes in dopamine efflux associated with extinction, CS-induced and d-amphetamine-induced reinstatement of drug-seeking behavior by rats
Ciano, P. D., Blaha, C. D., & Phillips, A. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00373-9 · Cited by 45
Regional and source-based patterns of [ 11 C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D 2 and D 3 receptor availability in cocaine-use disorder
Worhunsky, P. D., Matuskey, D., Gallezot, J., Gaiser, E., Nabulsi, N., Angarita, G. A., Calhoun, V. D., Malison, R. T., Potenza, M. N., & Carson, R. E. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.045 · Cited by 44
One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter
Ben‐Shahar, O., Moscarello, J. M., & Ettenberg, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.002 · Cited by 45
HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System
Nickoloff-Bybel, E. A., Calderon, T. M., Gaskill, P. J., & Berman, J. W. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09927-6 · Cited by 42
Augmentation of locomotor activity by chronic phencyclidine is associated with an increase in striatal NMDA receptor function and an upregulation of the NR1 receptor subunit
Hanania, T., Hillman, G. R., & Johnson, K. M. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990301)31:3 · Cited by 46
Addiction and imaging of the living human brain
Gatley, S. J., & Volkow, N. D. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00069-6 · Cited by 39
Dose–response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis
Tsukada, H., Harada, N., Nishiyama, S., Ohba, H., & Kakiuchi, T. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02057-6 · Cited by 40
Efficacy of indirect dopamine agonists for psychostimulant dependence: a systematic review and meta-analysis of randomized controlled trials
Pérez-Mañá, C., Castells, X., Vidal, X., Casas, M., & Capellà, D. (2011) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2010.08.012 · Cited by 33
Psychostimulant drugs for cocaine dependence
Castells, X., Cunill, R., Pérez-Mañá, C., Vidal, X., & Capellà, D. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub4 · Cited by 110
Differential sensitivity to learning from positive and negative outcomes in cocaine users
Strickland, J. C., Bolin, B. L., Lile, J. A., Rush, C. R., & Stoops, W. W. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.06.022 · Cited by 30
Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings
Hou, H., Wang, C., Jia, S., Hu, S., & Tian, M. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1469-5 · Cited by 33
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Shegani, A., Kealey, S., Luzi, F., Basagni, F., Machado, J. D. M., Ekici, S. D., Ferocino, A., Gee, A. D., & Bongarzone, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00398 · Cited by 28
Predictors of sustained abstinence during psychosocial treatments for cocaine dependence
Crits-Christoph, P. F., Gibbons, M. B. C., Barber, J. P., Hu, B., Hearon, B. A., Worley, M., & Gallop, R. (2007) · Psychotherapy Research · doi:10.1080/10503300600818210 · Cited by 26
Biological markers of cocaine addiction: implications for medications development
Elkashef, A. M., & Vocci, F. J. (2003) · Addiction Biology · doi:10.1080/1355621031000117356 · Cited by 25
Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
Crunelle, C. L., van den Brink, W., Veltman, D. J., Oortmerssen, K. V. E., Dom, G., Schoevers, R. A., & Booij, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.002 · Cited by 25
A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration
Ferris, M. J., Calipari, E. S., Rose, J. H., Siciliano, C. A., Sun, H., Chen, R., & Jones, S. R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.45 · Cited by 21
Therapeutic Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Hepatic Metastasis of Colon Carcinoma along with Apoptosis in Vivo
Ichihara, H., Zako, K., Komizu, Y., Goto, K., & Ueoka, R. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.901 · Cited by 21
Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats
Weikop, P., Jensen, K. L., & Thomsen, M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0684-1 · Cited by 19
Efficacy of Psychostimulant Drugs for Cocaine Dependence
Cervelló, X. C., Casas, M., Pérez‐Mañá, C., Roncero, C., Vidal, X., & Capellà, D. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub2 · Cited by 20
Positron Emission Tomography Molecular Imaging of Dopaminergic System in Drug Addiction
Hou, H., Tian, M., & Zhang, H. (2012) · The Anatomical Record · doi:10.1002/ar.22457 · Cited by 20
STRUCTURAL AND FUNCTIONAL NEUROIMAGING FINDINGS IN SUBSTANCE-RELATED DISORDERS
Netrakom, P., Krasuski, J., Miller, N. S., & O’Tuama, L. A. (1999) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70079-4 · Cited by 19
Neuroreceptor Imaging in Psychiatry: Theory and Applications
Frankle, W. G., Slifstein, M., Talbot, P. S., & Laruelle, M. A. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67011-0 · Cited by 19
Acute Intravenous Low- and High-Dose Cocaine Reduces Quantitative Global and Regional Cerebral Blood Flow in Recently Abstinent Subjects with Cocaine use Disorder
Johnson, B. A., Dawes, M. A., Roache, J. D., Wells, L. T., Ait‐Daoud, N., Mauldin, J. B., Wang, Y., Lancaster, J. L., & Fox, P. T. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600093 · Cited by 15
Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development
Sevarino, K. A., Oliveto, A. H., & Kosten, T. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06676.x · Cited by 15
Imaging addiction with PET: is insight in sight?
Schiffer, W. K., Lee, D. E., Brodie, J. D., & Dewey, S. L. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03412-4 · Cited by 13
RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease
Montañez‐Miranda, C., Bramlett, S. N., & Hepler, J. R. (2022) · Hippocampus · doi:10.1002/hipo.23492 · Cited by 12
Human Brain Imaging of Dopamine Transporters
Varrone, A., & Halldin, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00009-9 · Cited by 13
Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans
Nye, J. A., Votaw, J. R., Bremner, J. D., Davis, M. R., Voll, R. J., Camp, V. M., & Goodman, M. M. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2013.12.013 · Cited by 12
Brain Imaging Studies of Drug Abuse: Therapeutic Implications
Monique Ernst, D., & London, E. D. (1997) · Seminars in Neuroscience · doi:10.1006/smns.1997.0112 · Cited by 12
The Association between Reward Sensitivity and Activity Engagement: the Influence of Delay Discounting and Anhedonia
Tressová, D., Roozen, H. G., & Vingerhoets, A. J. J. M. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz105 · Cited by 13
Pharmacology of Cocaine
Gatley, S. J., Gifford, A. N., Volkow, N. D., & Fowler, J. S. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2913-9_11 · Cited by 11
Small Molecule Receptor Ligands for PET Studies of the Central Nervous System—Focus on G Protein Coupled Receptors
Mach, R. H. (2017) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2017.05.002 · Cited by 10
The Pathology of Methamphetamine Use in the Human Brain
Kish, S. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418679-8.00008-3 · Cited by 10
Cocaine Addiction: Neurobiology and Related Current Research in Pharmacotherapy
Panikkar, G. P. (1999) · Substance Abuse · doi:10.1080/08897079909511403 · Cited by 10
Targeting the treatment of drug abuse with molecular imaging
Schiffer, W. K., Liebling, C. N. B., Patel, V. D., & Dewey, S. L. (2007) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.05.004 · Cited by 9
Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective
van Ruitenbeek, P., Franzen, L., Mason, N. L., Stiers, P. L. J., & Ramaekers, J. G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1208120 · Cited by 8
The Neuroscientific Basis for Aesthetic Preference as an Intervention for Drug Craving Associated with Addiction
Mathis, W. S. (2015) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000213 · Cited by 8
Ecologic Correlations of Selected Food Groups With Disease Incidence and Mortality in Switzerland
Besson, H., Paccaud, F. M., & Marques-Vidal, P. M. (2013) · Journal of Epidemiology · doi:10.2188/jea.je20130029 · Cited by 8
Enhanced Emotional and Physiological Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Socially Drinking Controls
Fox, H. C., Hong, K., Siedlarz, K. M., & Sinha, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301426 · Cited by 8
Neuro-imagerie et cocaïne : une cartographie de la dépendance ?
Lambert, G., Karila, L., & Lowenstein, W. (2008) · La Presse Médicale · doi:10.1016/j.lpm.2007.08.014 · Cited by 7
Comparing olanzapine and ziprasidone in the treatment of schizophrenia: a case study in modeling
Alexeyeva, I., Mauskopf, J., Earnshaw, S., Stauffer, V. L., Gibson, P. J., Ascher‐Svanum, H., & Ramsey, J. (2001) · Journal of Medical Economics · doi:10.3111/200104179192 · Cited by 6
The Linares Addictive Potential Model
Linares, Ó. (2012) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2012.02.02.3 · Cited by 4
Positron Emission Tomography and Single-Photon Emission Computed Tomography
Malison, R. T. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-021-6_2 · Cited by 4
Neurochemical Imaging of Addictive Disorders
Broft, A. I., & Martínez, D. (2012) · Neuromethods · doi:10.1007/7657_2012_48 · Cited by 4
Imaging Substance Use and Misuse: Psychostimulants
White, T. L. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_11 · Cited by 3
Obesity: An Addiction? Imaging of Neurotransmitter Systems in Obesity
van de Giessen, E., McIlwrick, S., Veltman, D. J., van den Brink, W., & Booij, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_26 · Cited by 3
The Role of Positron Emission Imaging (PET) in Understanding Addiction
Wong, D. F., Brašić, J. R., Gean, E. G., & Nandi, A. (2013) · Wiley eBooks · doi:10.1002/9781118384404.ch24 · Cited by 3
Emission Tomographic Studies in Substance Abuse
Levin, J. M. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-021-6_5 · Cited by 3
Pharmacological therapies for substance dependence
Borg, L. (1997) · Current Opinion in Psychiatry · doi:10.1097/00001504-199705000-00009 · Cited by 3
Biphasic Model of Addiction: Neurobehavioral Adaptations
Aggarwal, D., Naik, J., & Lindquist, D. H. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-025-00314-0 · Cited by 3
Imaging Studies in Substance Abuse
Volkow, N. D., Fowler, J. S., Wang, G., & Shreeve, W. W. (2003) · Springer eBooks · doi:10.1007/978-3-642-55539-8_18 · Cited by 2
From in vitro permeability to in vivo brain exposure: continued validation of a human iPSC-derived blood-brain barrier model with pesticides and stimulants
Kurtenbach, P., Hahn, M., Thevis, M., & Lamshöft, M. (2026) · NAM journal. · doi:10.1016/j.namjnl.2026.100092 · Cited by 1

Authors: Volkow, N.
Affiliations: Brookhaven National Laboratory (US)
Corresponding author: Volkow, N
ORCID: Volkow, N
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1996-03
Volume: 14
Issue: 3
Pages: 159-168
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/0893-133x(95)00073-m
OpenAlex: W2042148521
Cited by: 120
References: 57
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 6
FWCI: 2.29
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Energy (DE‐ACO2‐76CH00016, 76CH00016)
National Institutes of Health (5p01ns015638-15)
National Institute on Drug Abuse (5RO1-DA06891, R01DA006891)
National Institute of Neurological Disorders and Stroke (NS15638)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: cocaine, cocaine abusers, detoxification, cocaine binding, dopamine transporter, dopamine D2 receptor, basal ganglia, volume of distribution, chronic cocaine use, brain uptake
MeSH terms: Adult, Basal Ganglia, Binding, Competitive, Brain, Cocaine, Humans, Kinetics, Male, Opioid-Related Disorders, Radioligand Assay, Time Factors, Tomography, Emission-Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cocaine Uptake Is Decreased in the Brain of Detoxified Cocaine Abusers

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks