Cited by 737Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

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Effects of DNA methylation on DNA-binding proteins and gene expression

Tate, Peri H., Bird, Adrian P.·1993·Current Opinion in Genetics & Development

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Abstract

DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.

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Authors: Tate, P. H., & Bird, A. P.
Affiliations: University of Edinburgh (GB)
ORCID: Bird, Adrian P.
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 1993
Volume: 3
Issue: 2
Pages: 226-231
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/0959-437x(93)90027-m
OpenAlex: W1984004239
Cited by: 737
References: 57
Citations by year: 2026: 7 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 29 · 2021: 21 · 2020: 34 · 2019: 22 · 2018: 21 · 2017: 20 · 2016: 31 · 2015: 25 · 2014: 33 · 2013: 26 · 2012: 35
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Genetics & Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: DNA methylation, DNA methyltransferases, DNA-binding proteins, gene expression regulation, transcriptional repression, promoter methylation, transcription factors, repressor protein, epigenetics, development (biology)
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cytosine, DNA, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Gene Expression Regulation, Humans, Methylation, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Transcription Factors, Transcription, Genetic, Consensus Sequence, 5-Methylcytosine

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Effects of DNA methylation on DNA-binding proteins and gene expression

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