The DOI matches its Crossref record; 53 of the 57 references it cites were found in a registry or an index.
Effects of DNA methylation on DNA-binding proteins and gene expression
Abstract
DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.
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“It is well known that DNA methylation can affect the binding of some TFs87.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [87]
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Metadata
- Authors
- Tate, P. H., & Bird, A. P.
- Affiliations
- University of Edinburgh (GB)
- ORCID
- Bird, Adrian P.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 1993
- Volume
- 3
- Issue
- 2
- Pages
- 226-231
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W1984004239
- Cited by
- 737
- References
- 57
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 29 · 2021: 21 · 2020: 34 · 2019: 22 · 2018: 21 · 2017: 20 · 2016: 31 · 2015: 25 · 2014: 33 · 2013: 26 · 2012: 35
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- DNA methylation, DNA methyltransferases, DNA-binding proteins, gene expression regulation, transcriptional repression, promoter methylation, transcription factors, repressor protein, epigenetics, development (biology)
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cytosine, DNA, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Gene Expression Regulation, Humans, Methylation, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Transcription Factors, Transcription, Genetic, Consensus Sequence, 5-Methylcytosine
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