Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device
Open accessAbstract
Tissue-engineered devices have the potential to significantly improve human health. A major impediment to the success of clinically scaled transplants, however, is insufficient oxygen transport, which leads to extensive cell death and dysfunction. To provide in situ supplementation of oxygen within a cellular implant, we developed a hydrolytically reactive oxygen generating material in the form of polydimethylsiloxane (PDMS) encapsulated solid calcium peroxide, termed OxySite. Herein, we demonstrate, for the first time, the successful implementation of this in situ oxygen-generating biomaterial to support elevated cellular function and efficacy of macroencapsulation devices for the treatment of type 1 diabetes. Under extreme hypoxic conditions, devices supplemented with OxySite exhibited substantially elevated beta cell and islet viability and function. Furthermore, the inclusion of OxySite within implanted macrodevices resulted in the significant improvement of graft efficacy and insulin production in a diabetic rodent model. Translating to human islets at elevated loading densities further validated the advantages of this material. This simple biomaterial-based approach for delivering a localized and controllable oxygen supply provides a broad and impactful platform for improving the therapeutic efficacy of cell-based approaches.
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In both oxygen-generating examples, the oxygen generated by the device significantly enhanced the viability and function of the islets after transplantation.
“In both these examples, the oxygen generated by the device significantly enhanced the viability and function of the islets after transplantation.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [98]
The Results section on the diabetic mouse model reports improved viability and insulin response in OxySite devices after transplantation, but the transplanted devices contained MIN6 beta cells, not pancreatic islets. The paper reports improved rat and human islet viability and function in vitro; it does not establish those outcomes for islets after transplantation. It also describes one oxygen-generating approach, so it cannot substantiate “both” examples on its own. (LLM, conf=0.89)
Experimental — accuracy not yet measuredOxygen generating materials inserted alongside the islet graft improve oxygen levels at the transplantation site, and another strategy directly pumps oxygen into an encapsulation device.
“To specifically improve oxygen levels at the transplantation site, oxygen generating materials have been inserted alongside the islet graft,96,98,99 while another strategy directly pumps oxygen into an encapsulation device92,97.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [98]
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Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025 · see citing works
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575 · see citing works
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.
Ryan, E., Lakey, J., Rajotte, R., Korbutt, G., Kin, T., Imes, S., Rabinovitch, A., Elliott, J., Bigam, D., Kneteman, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.4.710 · Cited by 875 · see citing works
Stem Cells Applications in Regenerative Medicine and Disease Therapeutics
Mahla, R. S. (2016) · International Journal of Cell Biology · doi:10.1155/2016/6940283 · Cited by 620 · see citing works
Moberg, L., Johansson, H., Lukinius, A., Berne, C., Foss, A., Källen, R., Østraat, Ø., Salmela, K., Tibell, A., Tufveson, G., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)12020-4 · Cited by 568 · cited 1× · see citing works
“Yet, as much as 80% of the graft is estimated to be lost in the early post-transplant period due to hypoxia and initial inflammatory events [60, 61].”
BackgroundImplantable biohybrid artificial organs
Colton, C. (1995) · Cell Transplantation · doi:10.1016/0963-6897(95)00025-s · Cited by 514 · see citing works
Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans
Dionne, K., Colton, C., & Lyarmush, M. (1993) · Diabetes · doi:10.2337/diab.42.1.12 · Cited by 438 · see citing works
Carlsson, P., Palm, F., Andersson, A., & Liss, P. (2001) · Diabetes · doi:10.2337/diabetes.50.3.489 · Cited by 416 · see citing works
Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation
Elliott, R. B., Escobar, L., Tan, P., Muzina, M., Zwain, S., & Buchanan, C. M. (2007) · Xenotransplantation · doi:10.1111/j.1399-3089.2007.00384.x · Cited by 409 · see citing works
Pedraza, E., Coronel, M. M., Fraker, C. A., Ricordi, C., & Stabler, C. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113560109 · Cited by 399 · cited 5× · see citing works
“To this end, we have developed a hydrolytically reactive biomaterial, termed OxySite, which provides controllable and predictable oxygen generation via the encapsulation of solid calcium peroxide within polydimethylsiloxane (PDMS) (Figure 1A) [19, 22, 23].”
BackgroundMethodInfluentialSelf-citationIshihara, H., Asano, T., Tsukuda, K., Katagiri, H., Inukai, K., Anai, M., Kikuchi, M., Yazaki, Y., Miyazaki, J.-I., & Oka, Y. (1993) · Diabetologia · doi:10.1007/bf00401058 · Cited by 385 · see citing works
Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., & Sung, H.-W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01784 · Cited by 372 · see citing works
Bochenek, M. A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0275-1 · Cited by 367 · see citing works
Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E. R., Alejandro, R., & Hering, B. J. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03977.x · Cited by 350 · see citing works
Transplantation of human islets without immunosuppression
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A., Block, N., Colton, C., Ludwig, S., Kersting, S., Bonifacio, E., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317561110 · Cited by 265 · see citing works
Pinchuk, L. (1995) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856294x00347 · Cited by 252 · see citing works
Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering?
Gholipourmalekabadi, M., Zhao, S., Harrison, B., Mozafari, M., & Seifalian, A. (2016) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.05.012 · Cited by 234 · see citing works
Jacobs-Tulleneers-Thevissen, D., Chintinne, M., Ling, Z., Gillard, P., Schoonjans, L., Delvaux, G., Strand, B., Gorus, F., Keymeulen, B., Pipeleers, D., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2906-0 · Cited by 213 · see citing works
O'Sullivan, E., Vegas, A., Anderson, D. G., & Weir, G. (2011) · Endocrine reviews · doi:10.1210/er.2010-0026 · Cited by 206 · see citing works
Carlsson, P.-O., Espes, D., Sedigh, A., Rotem, A., Zimerman, B., Grinberg, H., Goldman, T., Barkai, U., Avni, Y., Westermark, G. T., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14642 · Cited by 205 · cited 1× · see citing works
“Given that aggressive foreign body responses to an implant can lead to significant impairment of clinical function [58], the benign response of the host is encouraging.”
BackgroundFEM-based oxygen consumption and cell viability models for avascular pancreatic islets
Buchwald, P. (2009) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-6-5 · Cited by 187 · see citing works
Reversal of Diabetes by Pancreatic Islet Transplantation into a Subcutaneous, Neovascularized Device
Pileggi, A., Molano, R. D., Ricordi, C., Zahr, E., Collins, J., Valdes, R., & Inverardi, L. (2006) · Transplantation · doi:10.1097/01.tp.0000203858.41105.88 · Cited by 181 · see citing works
Ludwig, B., Rotem, A., Schmid, J., Weir, G., Colton, C., Brendel, M., Neufeld, T., Block, N., Yavriyants, K., Steffen, A., et al. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1201868109 · Cited by 176 · see citing works
Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas
Barkai, U., Weir, G., Colton, C., Ludwig, B., Bornstein, S., Brendel, M., Neufeld, T., Bremer, C., Leon, A., Evron, Y., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657341 · Cited by 175 · see citing works
Weaver, J. D., Headen, D. M., Aquart, J., Johnson, C. T., Shea, L. D., Shirwan, H., & García, A. J. (2017) · Science Advances · doi:10.1126/sciadv.1700184 · Cited by 170 · see citing works
Causes of limited survival of microencapsulated pancreatic islet grafts
de Groot, M., Schuurs, T. A., & van Schilfgaarde, R. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2004.02.018 · Cited by 170 · see citing works
Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice
Papas, K., Colton, C., Nelson, R., Rozak, P. R., Avgoustiniatos, E., Scott, W., Wildey, G. M., Pisania, A., Weir, G., & Hering, B. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01655.x · Cited by 157 · see citing works
Effect of External Oxygen Mass Transfer Resistances on Viability of Immunoisolated Tissuea
Avgoustiniatos, E. S., & Colton, C. K. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52192.x · Cited by 155 · see citing works
Oxygen Releasing Biomaterials for Tissue Engineering
Camci-Unal, G., Alemdar, N., Annabi, N., & Khademhosseini, A. (2013) · Polymer international · doi:10.1002/pi.4502 · Cited by 154 · see citing works
Oxygen supply to encapsulated therapeutic cells.
Colton, C. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.007 · Cited by 153 · see citing works
Soejima, A., Inoue, K., Takai, D., Kaneko, M., Ishihara, H., Oka, Y., & Hayashi, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26194 · Cited by 149 · see citing works
Lanza, R., Butler, D. H., BORLAND, K. M., Staruk, J. E., Faustman, D. L., Solomon, B. A., Muller, T. E., Rupp, R. G., Maki, T., & Monaco, A. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11100 · Cited by 148 · see citing works
Sato, Y., Endo, H., Okuyama, H., Takeda, T., Iwahashi, H., Imagawa, A., Yamagata, K., Shimomura, I., & Inoue, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.194738 · Cited by 145 · see citing works
Efficient assembly of rat hepatocyte spheroids for tissue engineering applications
Wu, F. J., Friend, J. R., Hsiao, C. C., Zilliox, M. J., Ko, W., Cerra, F. B., & Hu, W. (1996) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19960520)50:4 · Cited by 139 · see citing works
Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708420114 · Cited by 122 · see citing works
Foster, E. D., Bridges, N. D., Feurer, I. D., Eggerman, T. L., Hunsicker, L. G., Alejandro, R., Begley, B., Cano, J., Carpentier, S., Hutchinson, J., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1779 · Cited by 119 · see citing works
Biostability and biological performance of a PDMS-based polyurethane for controlled drug release
Simmons, A., Padsalgikar, A., Ferris, L. M., & Poole-Warren, L. A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.007 · Cited by 117 · see citing works
Wilson, D. F., Lee, W. M. F., Makonnen, S., Finikova, O. S., Apreleva, S. V., & Vinogradov, S. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00394.2006 · Cited by 116 · see citing works
Weaver, J. D., Headen, D., Hunckler, M. D., Coronel, M. M., Stabler, C., & García, A. J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.047 · Cited by 114 · see citing works
Self-citationA stirred microchamber for oxygen consumption rate measurements with pancreatic islets
Papas, K., Pisania, A., Wu, H.-Y., Weir, G. C., & Colton, C. K. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21486 · Cited by 114 · see citing works
Macroporous Three Dimensional PDMS Scaffolds for Extrahepatic Islet Transplantation
Pedraza, E., Brady, A.-C., Fraker, C. A., Molano, R., Sukert, S., Berman, D., Kenyon, N. S., Pileggi, A., Ricordi, C., & Stabler, C. (2012) · Cell Transplantation · doi:10.3727/096368912x657440 · Cited by 112 · see citing works
Self-citationA Novel Device for Islet Transplantation Providing Immune Protection and Oxygen Supply
Ludwig, B., Zimerman, B., Steffen, A., Yavriyants, K., Azarov, D., Reichel, A., Vardi, P., German, T., Shabtay, N., Rotem, A., et al. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1267916 · Cited by 105 · see citing works
Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial
Coronel, M. M., Geusz, R. J., & Stabler, C. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.018 · Cited by 104 · see citing works
Self-citationAlemdar, N., Leijten, J., Camci-Unal, G., Hjortnaes, J., Ribas, J., Paul, A., Mostafalu, P., Gaharwar, A., Qiu, Y.-L., Sonkusale, S., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00109 · Cited by 103 · see citing works
Kobayashi, T., Aomatsu, Y., Iwata, H., Kin, T., Kanehiro, H., Hisanaga, M., Ko, S., 長尾, 美., & Nakajima, Y. (2003) · Transplantation · doi:10.1097/01.tp.0000053749.36365.7e · Cited by 101 · see citing works
Effect of Oxygen on Isolated Pancreatic Tissue
Dionne, K. E., Colton, C. K., & Yarmush, M. L. (1989) · ASAIO Transactions · doi:10.1097/00002216-198907000-00185 · Cited by 87 · see citing works
Evron, Y., Colton, C. K., Ludwig, B., Weir, G. C., Zimerman, B., Maimon, S., Neufeld, T., Shalev, N., Goldman, T., Leon, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23862-w · Cited by 76 · see citing works
Biostability of medical elastomers: a review
Vondráček, P., & Doležel, B. (1984) · Biomaterials · doi:10.1016/0142-9612(84)90017-6 · Cited by 68 · see citing works
Engineering a Local Microenvironment for Pancreatic Islet Replacement
Coronel, M. M., & Stabler, C. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.05.004 · Cited by 67 · see citing works
Self-citationResponse of Encapsulated Rat Pancreatic Islets to Hypoxia
de Groot, M., Schuurs, T. A., Keizer, P. P. M., Fekken, S., Leuvenink, H. G. D., & Schilfgaarde, R. V. (2003) · Cell Transplantation · doi:10.3727/000000003771000219 · Cited by 67 · see citing works
Applications of particulate oxygen-generating substances (POGS) in the bioartificial pancreas
McQuilling, J. P., Sittadjody, S., Pendergraft, S. S., Farney, A. C., & Opara, E. C. (2017) · Biomaterials Science · doi:10.1039/c7bm00790f · Cited by 62 · see citing works
Controlled drug release from implantable matrices based on hydrophobia polymers
Colo, G. D. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90178-q · Cited by 61 · see citing works
Pullen, L. C. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14954 · Cited by 53 · see citing works
Prediction of Marginal Mass Required for Successful Islet Transplantation
Papas, K., Colton, C., Qipo, A., Wu, H.-Y., Nelson, R., Hering, B., Weir, G., & Koulmanda, M. (2010) · Journal of investigative surgery · doi:10.3109/08941930903410825 · Cited by 50 · see citing works
Transplantation of Macroencapsulated Insulin-Producing Cells
Hwa, A. J., & Weir, G. C. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1028-y · Cited by 46 · see citing works
Measurements of the Effective Diffusion Coefficient of Oxygen in Pancreatic Islets
Avgoustiniatos, E. S., Dionne, K. E., Wilson, D. F., Yarmush, M. L., & Colton, C. K. (2007) · Industrial & Engineering Chemistry Research · doi:10.1021/ie070662y · Cited by 40 · see citing works
Effect of oxygen supply on the size of implantable islet-containing encapsulation devices.
Papas, K. K., Avgoustiniatos, E. S., & Suszynski, T. M. (2016) · PubMed · Cited by 36 · see citing works
Colo, G. D., Carelli, V., Nannipieri, E., Serafini, M. F., & Vitale, D. (1986) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(86)90129-8 · Cited by 32 · see citing works
The Measurement of Insulin Secretion from Isolated Rodent Islets of Langerhans
Nolan, A. L., & O’Dowd, J. F. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-448-3_4 · Cited by 19 · see citing works
Burns, R. A., McRae, G. I., & Sanders, L. M. (1990) · Journal of Controlled Release · doi:10.1016/0168-3659(90)90163-n · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 61 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [28]Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE III, Wildey GM, Pisania A, Weir GC, Hering BJ, Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice, 7(3) (2007) 707– 713. PMC2857994 17229069
- [39]Shoichet MS, Li RH, White ML, Winn SR, Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose, Biotechnol Bioeng 50(4) (1996) 374– 381. 18626986
- [42]Colton CK, Oxygen supply to encapsulated therapeutic cells, Adv Drug Deliv Rev 67 (2014) 93– 110. 24582600
Cited by
Sorted by citations
Lu, Y., Cheng, D., Niu, B., Wang, X., Wu, X., & Wang, A. (2023) · Pharmaceuticals · doi:10.3390/ph16030454 · Cited by 264 · see citing works
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · see citing works
Hydrogels in Emerging Technologies for Type 1 Diabetes
Fuchs, S., Ernst, A. U., Wang, L., Shariati, K., Wang, X., Liu, Q., & Ma, M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01062 · Cited by 160 · see citing works
Strategies for durable β cell replacement in type 1 diabetes
Brusko, T. M., Russ, H. A., & Stabler, C. L. (2021) · Science · doi:10.1126/science.abh1657 · Cited by 119 · see citing works
Self-citationDomingo‐Lopez, D. A., Lattanzi, G., Schreiber, L. H. J., Wallace, E. J., Wylie, R., O’Sullivan, J., Dolan, E. B., & Duffy, G. P. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114280 · Cited by 103 · see citing works
Oxygen releasing materials: Towards addressing the hypoxia-related issues in tissue engineering
Agarwal, T., Kazemi, S., Costantini, M., Perfeito, F. G., Correia, C. R., Gaspar, V. M., Montazeri, L., Maria, C. D., Mano, J. F., Vosough, M., et al. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111896 · Cited by 90 · see citing works
Liang, J.-P., Accolla, R. P., Soundirarajan, M., Emerson, A. E., Coronel, M. M., & Stabler, C. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.028 · Cited by 52 · see citing works
Self-citationGoswami, D., Domingo‐Lopez, D. A., Ward, N. A., Millman, J. R., Duffy, G. P., Dolan, E. B., & Roche, E. T. (2021) · Advanced Science · doi:10.1002/advs.202100820 · Cited by 68 · see citing works
An inverse-breathing encapsulation system for cell delivery
Wang, L.-H., Ernst, A. U., Flanders, J. A., Liu, W., Wang, X., Datta, A. K., Epel, B., Kotecha, M., Papas, K. K., & Ma, M. (2021) · Science Advances · doi:10.1126/sciadv.abd5835 · Cited by 73 · see citing works
Mohanto, N., Mondal, H., Park, Y., & Jee, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03060-9 · Cited by 55 · see citing works
Integrating bioelectronics with cell-based synthetic biology
Rivnay, J., Raman, R., Robinson, J. T., Schreib, C. C., Cohen‐Karni, T., Galloway, K. E., & Omid Veiseh, A. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00262-6 · Cited by 60 · see citing works
Augsornworawat, P., Velazco-Cruz, L., Song, J., & Millman, J. R. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.031 · Cited by 51 · see citing works
Oxygen-releasing biomaterials for regenerative medicine.
Wang, Z., Chen, T., Li, X., Guo, B., Liu, P., Zhu, Z., & Xu, R. X. (2023) · Journal of materials chemistry. B · doi:10.1039/d3tb00670k · Cited by 28 · see citing works
Aleemardani, M., Solouk, A., Akbari, S., Dehghan, M., & Moeini, M. (2020) · Materialia · doi:10.1016/j.mtla.2020.100877 · Cited by 35 · see citing works
Type 1 diabetes and engineering enhanced islet transplantation
Jeyagaran, A., Lu, C., Zbinden, A., Birkenfeld, A. L., Brucker, S. Y., & Layland, S. L. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114481 · Cited by 41 · see citing works
Samojlik, M. M., & Stabler, C. L. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.039 · Cited by 38 · see citing works
Self-citationMacroencapsulation devices for cell therapy
Liu, W., Wang, Y., Wang, J.-Q., Lanier, O. L., Wechsler, M., Peppas, N., & Gu, Z. (2022) · Engineering · doi:10.1016/j.eng.2021.10.021 · Cited by 32 · see citing works
Mimicking nature-made beta cells: recent advances towards stem cell-derived islets
Tremmel, D. M., Mitchell, S. A., Sackett, S. D., & Odorico, J. S. (2019) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000687 · Cited by 37 · see citing works
Aleemardani, M., Solouk, A., Akbari, S., & Moeini, M. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28259 · Cited by 36 · see citing works
Concise Synthesis of Open‐Cage Fullerenes for Oxygen Delivery
Zhou, Z., Han, H., Chen, Z., Gao, R., Liu, Z., Su, J., Xin, N., Yang, X., & Gan, L. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201911631 · Cited by 36 · see citing works
Krentz, N. A. J., Shea, L. D., Huising, M. O., & Shaw, J. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00170-4 · Cited by 37 · see citing works
Wang, L., Marfil‐Garza, B. A., Ernst, A. U., Pawlick, R. L., Pepper, A. R., Okada, K., Epel, B., Viswakarma, N., Kotecha, M., Flanders, J. A., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01145-8 · Cited by 38 · see citing works
Oxygenation therapies for improved wound healing: current trends and technologies
Garima, Agarwal, T., Costantini, M., Pal, S., & Kumar, A. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01498j · Cited by 32 · see citing works
Electrocatalytic on-site oxygenation for transplanted cell-based-therapies
Lee, I., Surendran, A., Fleury, S., Gimino, I., Curtiss, A., Fell, C., Shiwarski, D. J., Refy, O., Rothrock, B., Jo, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42697-2 · Cited by 31 · see citing works
Shi, Y., Zhao, Y., Jiang, Z., Wang, Z., Wang, Q., Kou, L., & Yao, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923241 · Cited by 33 · see citing works
Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies
Salg, G. A., Blaeser, A., Gerhardus, J. S., Hackert, T., & Kenngott, H. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158589 · Cited by 32 · see citing works
Prevascularized Retrievable Hybrid Implant to Enhance Function of Subcutaneous Encapsulated Islets
Mridha, A. R., Dargaville, T. R., Dalton, P. D., Carroll, L. M., Morris, M. B., Vaithilingam, V., & Tuch, B. E. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0179 · Cited by 30 · see citing works
Li, Y., Frei, A. W., Labrada, I., Rong, Y., Liang, J.-P., Samojlik, M. M., Sun, C., Barash, S. D., Keselowsky, B., Bayer, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653088 · Cited by 35 · see citing works
Self-citationSmart biomaterials for enhancing cancer therapy by overcoming tumor hypoxia: a review
Salim, S. A., Salaheldin, T. A., Elmazar, M. M., Abdel-Aziz, A. F., & Kamoun, E. A. (2022) · RSC Advances · doi:10.1039/d2ra06036a · Cited by 29 · see citing works
Zhao, J., Zhou, C., Xiao, Y., Zhang, K., Zhang, Q., Xia, L., Jiang, B., Jiang, C.-Y., Ming, W., Zhang, H.-J., et al. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1292171 · Cited by 24 · see citing works
A predictive computational platform for optimizing the design of bioartificial pancreas devices
Ernst, A. U., Wang, L.-H., Worland, S., Marfil-Garza, B., Wang, X., Liu, W., Chiu, A., Kin, T., O'Gorman, D., Steinschneider, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33760-5 · Cited by 21 · see citing works
Oxygen‐Releasing Hydrogels for Tissue Regeneration
Jiang, S., Zheng, Y., Xia, H., Liu, Z., Rao, S., Wang, Y., Sun, H., Lu, X., & Xie, C. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300133 · Cited by 25 · see citing works
Oxygen-generating materials and their biomedical applications: a review
Sun, X., Yao, F., Zhang, H., & Li, J. (2022) · Journal of Materials Science · doi:10.1007/s10853-022-07229-1 · Cited by 24 · see citing works
Engineered Biomaterials for Enhanced Function of Insulin‐Secreting β‐Cell Organoids
Hunckler, M. D., & García, A. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000134 · Cited by 17 · see citing works
Jeang, W., Bochenek, M. A., Bose, S., Zhao, Y.-C., Wong, B. M., Yang, J.-W., Jiang, A. L., Langer, R., & Anderson, D. G. (2024) · Science Advances · doi:10.1126/sciadv.adk5949 · Cited by 22 · see citing works
Islet cell encapsulation – Application in diabetes treatment
Opara, A., Jost, A., Dagogo-Jack, S. E., & Opara, E. C. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211040503 · Cited by 22 · see citing works
Si, H., Chen, Y., Jiang, K., Ma, K., Ramsey, E. D., Oakey, J. S., Sun, M., & Jiang, Z. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304386 · Cited by 20 · see citing works
Sarkar, N., Zhao, J.-T., Zhang, N. Y., Horenberg, A. L., & Grayson, W. L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.011 · Cited by 18 · see citing works
Quizon, M. J., & Garcı́a, A. J. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-094846 · Cited by 18 · see citing works
Engineering Modular, Oxygen‐Generating Microbeads for the In Situ Mitigation of Cellular Hypoxia
Accolla, R. P., Liang, J., Lansberry, T. R., Labrada, I. M., Loaisiga, M., Sardi, B. L., & Stabler, C. L. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300239 · Cited by 19 · see citing works
Self-citationIn vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
Kotecha, M., Wang, L.-H., Hameed, S., Viswakarma, N., Ma, M.-L., Stabler, C., Hoesli, C., & Epel, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-42099-w · Cited by 15 · see citing works
Self-citationThree-dimensional bioprinting of functional β-islet-like constructs
Parvaneh, S., Kemény, L. V., Ghaffarinia, A., Yarani, R., & Veréb, Z. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.v9i2.665 · Cited by 17 · see citing works
Hadavi, E., de Vries, R. H. W., Smink, A. M., de Haan, B., Leijten, J., Schwab, L. W., Karperien, M., de Vos, P., Dijkstra, P. J., & van Apeldoorn, A. A. (2020) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34686 · Cited by 16 · see citing works
Integration of Islet/Beta-Cell Transplants with Host Tissue Using Biomaterial Platforms
Clough, D., King, J. L., Li, F., & Shea, L. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa156 · Cited by 16 · see citing works
Smart calcium peroxide with self-sufficience for biomedicine
Gao, S.-T., Fan, M., Li, Z.-H., Ge, K., Liang, X.-J., & Zhang, J.-C. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1578-9 · Cited by 16 · see citing works
Engineering Next-Gen Oxygen-Generating Scaffolds to Enhance Bone Regeneration
Zhao, J.-T., Sarkar, N., Ren, Y., Pathak, A. P., & Grayson, W. L. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2024.09.006 · Cited by 14 · see citing works
Lee, M. C., Lee, J. S., Kim, S.-S., Jamaiyar, A., Wu, W. W., Gonzalez, M. L., Durán, T. C. A., Madrigal‐Salazar, A. D., Bassous, N. J., Carvalho, V. M., et al. (2024) · Advanced Materials · doi:10.1002/adma.202408488 · Cited by 15 · see citing works
Shilleh, A. H., & Russ, H. (2023) · Cells · doi:10.3390/cells12050698 · Cited by 13 · see citing works
Pham, T. T., Tran, P. L., Tempelman, L. A., Stone, S. G., Piccirillo, C., Li, A., Flanders, J. A., & Ma, M. (2025) · Nature Communications · doi:10.1038/s41467-025-62271-2 · Cited by 17 · see citing works
Concise Synthesis of Open‐Cage Fullerenes for Oxygen Delivery
Zhou, Z., Han, H., Chen, Z., Gao, R., Liu, Z., Su, J., Xin, N., Yang, X., & Gan, L. (2019) · Angewandte Chemie · doi:10.1002/ange.201911631 · Cited by 13 · see citing works
From cold chain to ambient: Benefits, risks, and evidence across cell therapy logistics
Gostage, J., Domingo-Lopez, D., Tarpey, R., Duffy, G. P., & Levey, R. (2025) · Molecular Therapy: Methods & Clinical Development · doi:10.1016/j.omtm.2025.101613 · Cited by 12 · see citing works
Einstein, S. A., Steyn, L., Weegman, B., Suszynski, T., Sambanis, A., O'Brien, T. D., Avgoustiniatos, E., Firpo, M., Graham, M. L., Janecek, J., et al. (2023) · Frontiers in Transplantation · doi:10.3389/frtra.2023.1257029 · Cited by 10 · see citing works
Tokito, F., Shinohara, M., Maruyama, M., Inamura, K., Nishikawa, M., & Sakai, Y. (2020) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2020.12.009 · Cited by 8 · see citing works
Chen, X., Wang, K., Han, Y., Pan, Q., Jiang, X., Yu, Z., Zhang, W., Wang, Z., Yan, H., Sun, P., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132376 · Cited by 10 · see citing works
Self-citationIshak, N., Chan, M., Ang, S. C., Cheung, C., & Swee‐Hin, T. (2020) · Engineering Reports · doi:10.1002/eng2.12092 · Cited by 9 · see citing works
Jiang, Z., Jiang, K., Si, H., McBride, R., Kisiday, J. D., & Oakey, J. S. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01057 · Cited by 9 · see citing works
The future of islet transplantation beyond the BLA approval: challenges and opportunities
Wang, Y., McGarrigle, J. J., Cook, J., Rios, P., Monica, G. L., Chen, Y., Wei, W., & Oberholzer, J. (2025) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1522409 · Cited by 9 · see citing works
Orimi, H. E., Champion, K. S., Gauvin, L., Brassard, J. A., Strand, B. L., Leask, R. L., & Hoesli, C. A. (2025) · Biotechnology and Bioengineering · doi:10.1002/bit.70095 · Cited by 8 · see citing works
Canavesi, I., Viswakarma, N., Epel, B., & Kotecha, M. (2024) · Molecular Imaging and Biology · doi:10.1007/s11307-024-01963-5 · Cited by 8 · see citing works
Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes
Kieffer, T. J., Hoesli, C. A., & Shapiro, A. M. J. (2025) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041624 · Cited by 7 · see citing works
Sánchez-Cardona, Y., Cuartas-Gómez, E., Echeverri-Cuartas, C. E., Arévalo-Enríquez, K., López, M. E. L., & Moreno-Castellanos, N. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140800 · Cited by 6 · see citing works
Abbasi, P., Alemzadeh, I., & Vossoughi, M. (2024) · Canadian Journal of Chemical Engineering · doi:10.1002/cjce.25288 · Cited by 6 · see citing works
Zhang, Y., Chen, X., Yao, Y., Huang, Z., Yang, Y., Yang, C., Zhu, Y., Qiu, Y., Wang, Q., Huang, D., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115184 · Cited by 5 · see citing works
Azad, A., Altunbaş, H., & Manguoğlu, A. E. (2024) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2024.2347263 · Cited by 5 · see citing works
Dani, S., Duin, S., Akkineni, A. R., Lehmann, S., Ludwig, B., Kühl, M., Gelinsky, M., & Lode, A. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505927 · Cited by 3 · see citing works
Tissue Engineering and Nanoparticle-Based Approaches for Hair Follicle Regeneration
Çelik, H., & Bal‐Öztürk, A. (2025) · BioNanoScience · doi:10.1007/s12668-025-01897-4 · Cited by 2 · see citing works
Oxygenation and vascularization of pancreatic islet graft: An overview
Cristante, J., Tubbs, E., Benhamou, P., & Lablanche, S. (2021) · Trends in Transplantation · doi:10.15761/tit.1000307 · Cited by 2 · see citing works
Kattner, N., Carlsson, P., & Scott, W. (2021) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2021.100046 · Cited by 1 · see citing works
Deshmukh, K., & Bit, A. (2024) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ad30cc · Cited by 1 · see citing works
Jiang, K., Zhou, S., Li, Z., Guo, Y., Lei, S., Wang, X., Sun, M., Ramsey, E., Chen, H., Oakey, J. S., et al. (2025) · Applied Materials Today · doi:10.1016/j.apmt.2025.103035 · Cited by 1 · see citing works
Cuartas-Gómez, E., Vargas-Ceballos, O., & Moreno-Castellanos, N. (2026) · Macromolecular Bioscience · doi:10.1002/mabi.70227 · Cited by 1 · see citing works
Islet Macroencapsulation: Strategies to Boost Islet Graft Oxygenation
Ludwig, B., Heller, C., Sarangova, V., & Welzel, P. B. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_12 · Cited by 1 · see citing works
Bioactive Materials for Use in Stem Cell Therapies for the Treatment of Type 1 Diabetes
Hinchliffe, J., & Roy, I. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_11 · Cited by 1 · see citing works
Scaffolds for Encapsulation of Stem Cell-Derived β Cells
de Vries, R. H. W., & van Apeldoorn, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_7 · Cited by 1 · see citing works
Further perspectives and challenges
Rydosz, A. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99887-1.00005-4
Wang, D., Guo, Y., Huang, Y. H., Zhu, B., Pan, H., & Wang, Z. (2022) · PubMed Central · doi:10.7507/1002-1892.202201063
Reversing Type 1 Diabetes: The Magnifying Potential of Stem Cell Encapsulation
Bagherian, A., Jain, A., Prathap, D., & Nguyen, V.-L. (2022) · Berkeley Pharma Tech Journal of Medicine · doi:10.52243/bptjm.v1i2.27
Thomson, E. A., Lee, S., Xu, H., Moeller, H. P., Sands, J., Lal, R., Annes, J. P., & Poon, A. S. Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.11.570688
Considerations Pertaining to Implant Sites for Cell-Based Insulin Replacement Therapies
Marfil‐Garza, B. A., Cuesta‐Gomez, N., & Shapiro, A. M. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_16 · Cited by 1 · see citing works
Huang, D., Zhang, Y., Huang, Z., Chen, X., Yang, Y. K., Cheng, Y., Qiu, Y., Zhu, Y., Dong, J., Guan, H., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114646
Stratégies pour remédier à l'hypoxie dans le pancréas bio-artificiel
Moure, A. G. (2019) · theses.fr (ABES) · doi:10.70675/d4a88d98z2b02z4759zb6eazcb4ecf630341
Microscale strategies in engineering the pancreas: Toward clinical translation.
Billaud, M., Campbell, B. E., Zhu, X., Ling, S.-D., Movasat, H., Li, C., Prezelj, D., Vdovenko, D., Shakiba, N., Hoesli, C. A., et al. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115919
Chen, D., Wang, H., Tang, Y., Li, J., Tian, X., Pang, Y., Bao, S., Lang, L., Wang, Z., Wang, H., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.07.057
Self-citationNavigating Hypoxia in Tissue Engineering: From Biological Mechanisms to Therapeutic Strategies.
Vieira, B., Cerqueira, A., Nunes, P., & Mano, J. F. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.10.041
- Authors
- Coronel, M. M., Liang, J.-P., Li, Y., & Stabler, C. L.
- Affiliations
- University of Florida (US)
- University of Florida Health (US)
- Corresponding author
- Stabler, C.L.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 210
- Pages
- 1-11
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC6527135
- OpenAlex
- W2938362547
- Cited by
- 85
- References
- 61
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 8 · 2019: 6
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Juvenile Diabetes Research Foundation United States of America (3-SRA-2015-38-Q-R, 1F31DK097956)
- National Institutes of Health (1F31DK097956)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- calcium peroxide, polydimethylsiloxane encapsulation, beta-cell function, islet transplantation, type 1 diabetes, hypoxia, islet viability, insulin production, cell therapy, tissue engineering
- MeSH terms
- Animals, Biocompatible Materials, Cell Line, Diabetes Mellitus, Experimental, Disease Models, Animal, Graft Survival, Humans, Male, Mice, Inbred C57BL, Oxygen, Cells, Immobilized, Insulin-Secreting Cells
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