MAPKs: new JNK expands the group

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886

Nuclear protein CBP is a coactivator for the transcription factor CREB

Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

Zhang, F., Strand, A., Robbins, D., Cobb, M. H., & Goldsmith, E. J. (1994) · Nature · doi:10.1038/367704a0 · Cited by 592

Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

Choi, K.-W., & Benzer, S. (1994) · Cell · doi:10.1016/0092-8674(94)90579-7 · Cited by 339

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

Hill, C. S., & Treisman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90403-4 · Cited by 1,012

A conserved docking motif in MAP kinases common to substrates, activators and regulators

Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

Chung, J., Uchida, E., Grammer, T. C., & Blenis, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6508 · Cited by 620

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1

Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J., & Bokoch, G. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23934 · Cited by 614

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y.-N., Campbell, A., Sudha, T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.322 · Cited by 429

The innate immune response of the respiratory epithelium: Innate immunity in the airway

Diamond, G., Legarda, D., & Ryan, L. K. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917304.x · Cited by 422

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

Ishida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., & Takeya, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205063200 · Cited by 377

Mitogenic signaling via G protein-coupled receptors

van BIESEN, T., LUTTRELL, L. M., HAWES, B. E., & LEFKOWITZ, R. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-698 · Cited by 361

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

Smith, J. A., Poteet-Smith, C. E., Malarkey, K., & Sturgill, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2893 · Cited by 283

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7539 · Cited by 279

Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

Bardwell, L., Cook, J. G., Chang, E. C., Cairns, B. R., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3637 · Cited by 161

IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway

Hashimoto, S., Gon, Y., Takeshita, I., Maruoka, S., & Horie, T. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.114702 · Cited by 151

Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus

Brott, B. K., Pinsky, B. A., & Erikson, R. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.963 · Cited by 130

Phosphorylation of activation functions AF‐1 and AF‐2 of RARα and RARγ is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment

Taneja, R., Rochette‐Egly, C., Plassat, J., Penna, L., Gaub, M., & Chambon, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6452 · Cited by 113

MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells

Roduit, R., & Schorderet, D. F. (2008) · Apoptosis · doi:10.1007/s10495-008-0179-8 · Cited by 110

Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli?

Hellingwerf, K. J., Postma, P. W., Tommassen, J., & Westerhoff, H. V. (1995) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1995.tb00178.x · Cited by 86

Gonadotropin-releasing hormone activates mitogen-activated protein kinase in human ovarian and placental cells

Keun Kang, S., Tai, C.-J., Wa Cheng, K., & Leung, P. C. K. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00320-8 · Cited by 62

Effect of human papillomavirus type 16 oncogenes on MAP kinase activity

Gu, Z., & Matlashewski, G. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.8051-8056.1995 · Cited by 62

The importance of mitochondrial DNA in aging and cancer

Desler, C., Marcker, M. L., Singh, K. K., & Rasmussen, L. J. (2011) · Journal of Aging Research · doi:10.4061/2011/407536 · Cited by 49

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli

Zhuang, Z.-H., Zhou, Y., Yu, M.-C., Silverman, N., & Ge, B.-X. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.013 · Cited by 45

TREM2 in neurodegeneration and diseases

Abdulkhaliq, A. A., Alasiri, G., Kim, B., Khan, J., Ajoolabady, A., Yousof, S. M., Ren, J., Tuomilehto, J., Borai, A., Alrfaei, B. M., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03505-7 · Cited by 16

Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis.2

Balmer, D., Bapst-Wicht, L., Pyakurel, A., Emery, M., Nanchen, N., Bochet, C. G., & Roduit, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00043 · Cited by 6

ERK1/2 pathway is activated in degenerated Rpe65-deficient mice

Métrailler, S., Emery, M., Schorderet, D. F., Cottet, S., & Roduit, R. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.015 · Cited by 5