The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
Open accessAbstract
We have previously shown using gene targeting that PU.1 is essential for the development of lymphoid and myeloid lineages during fetal liver hematopoiesis. We now show that PU.1 is required for the maturation of yolk sac-derived myeloid progenitors and for the differentiation of ES cells into macrophages. The role of PU.1 in regulating target genes, thought to be critical in the development of monocytes and granulocytes, has been analyzed. Early genes such as GM-CSFR, G-CSFR, and myeloperoxidase are expressed in PU.1-/- embryos and differentiated PU.1-/- ES cells. However, the expression of genes associated with terminal myeloid differentiation (CD11b, CD64, and M-CSFR) is eliminated in differentiated PU.1-/- ES cells. Development of macrophages is restored with the introduction of a PU.1 cDNA regulated by its own promoter. The PU.1-/- ES cells represent an important model for analyzing myeloid cell development.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“All activated macrophages, regardless of polarization state, express high levels of the transcription factors runt-related transcription factor 1 (RUNX1) and PU.1, which are thought to represent global regulators of macrophage phenotypic expression [20–22].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [21]
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Self-citationGranulocyte colony-stimulating factor and its receptor
Demetri, G. D., & Griffin, J. D. (1991) · Blood · doi:10.1182/blood.v78.11.2791.2791 · Cited by 1,066
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
Mucenski, M. L., McLain, K., Kier, A. B., Swerdlow, S. H., Schreiner, C. M., Miller, T. A., Pietryga, D. W., Scott, W. J., & Potter, S. S. (1991) · Cell · doi:10.1016/0092-8674(91)90099-k · Cited by 1,028
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954
Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation
Freeman, G. J., Gribben, J. G., Boussiotis, V. A., Ng, J. W., Restivo, V. A., Lombard, L. A., Gray, G. S., & Nadler, L. M. (1993) · Science · doi:10.1126/science.7694363 · Cited by 903
Hematopoietic Commitment During Embryonic Stem Cell Differentiation in Culture
Keller, G. M., Kennedy, M. A., Papayannopoulou, T., & Wiles, M. V. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.473 · Cited by 874
Alonso, S., Minty, A. J., Bourlet, Y., & BUCKINGHAM, M. E. (1986) · Journal of Molecular Evolution · doi:10.1007/bf02100994 · Cited by 643
Pandolfi, P. P., Roth, M. E., Karis, A., Leonard, M. W., Dzierzak, E. A., Grosveld, F. G., Engel, J. D., & Lindenbaum, M. (1995) · Nature Genetics · doi:10.1038/ng0995-40 · Cited by 625
Research works printed but not linked: 1
- Wilks, 1988, Mouse c-fes proto-oncogene mRNA for c-fes protein, Oncogene, 3, 289
Cited by
Sorted by citations
Items 101–190 of 190
Hemogenic endothelium: Origins, regulation, and implications for vascular biology
Zape, J. P., & Zovein, A. C. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.10.003 · Cited by 50
Developmental changes in the differentiation capacity of haematopoietic stem cells
Bonifer, C., Faust, N., Geiger, H., & Müller, A. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01259-6 · Cited by 47
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)
Sierra, A., Miron, V. E., Paolicelli, R. C., & Ransohoff, R. M. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041366 · Cited by 47
Differential Regulation of Primitive Myelopoiesis in the Zebrafish by Spi-1/Pu.1 and C/ebp1
Su, F., Juarez, M. A., Cooke, C. L., LaPointe, L. D., Shavit, J. A., Yamaoka, J. S., & Lyons, S. E. (2007) · Zebrafish · doi:10.1089/zeb.2007.0505 · Cited by 48
Kim, J., & Feldman, R. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1903-1918.2002 · Cited by 46
Neutrophils at the crossroads of acute viral infections and severity
Rawat, S., Vrati, S., & Banerjee, A. K. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100996 · Cited by 49
Yoshida, H., Ichikawa, H., Tagata, Y., Katsumoto, T., Ohnishi, K., Akao, Y., Naoe, T., Pandolfi, P. P., & Kitabayashi, I. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02422-06 · Cited by 45
DNA Methylation and Chromatin Structure Regulate PU.1 Expression
Amaravadi, L., & Klemsz, M. J. (1999) · DNA and Cell Biology · doi:10.1089/104454999314737 · Cited by 44
van Dijk, T. B., Caldenhoven, E., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., & de Groot, R. P. (1998) · Blood · doi:10.1182/blood.v91.6.2126 · Cited by 43
Analysis of the Modulation of Transcriptional Activity in Myelopoiesis and Leukemogenesis
Behre, G., Zhang, P., Zhang, D., & Tenen, D. G. (1999) · Methods · doi:10.1006/meth.1998.0733 · Cited by 41
Self-citationProtein Acetylation Regulates Both PU.1 Transactivation and Igκ 3′ Enhancer Activity
Bai, Y., Srinivasan, L., Perkins, L., & Atchison, M. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5160 · Cited by 39
Transcriptional Regulation of ILT Family Receptors
Nakajima, H., Asai, A., Okada, A., Ping, L., Hamajima, F., Sata, T., & Isobe, K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6611 · Cited by 37
Neo, W. H., Lie‐A‐Ling, M., Fadlullah, M. Z. H., & Lacaud, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631699 · Cited by 37
In Vitro Differentiation of Mouse ES Cells: Hematopoietic and Vascular Development
Kearney, J. B., & Bautch, V. L. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)65006-8 · Cited by 36
Duplexes of 21‐nucleotide RNAs mediate RNA interference in differentiated mouse ES cells
Zou, G.-M., Wu, W., Chen, J., & Rowley, J. D. (2003) · Biology of the Cell · doi:10.1016/s0248-4900(03)00079-0 · Cited by 35
Diverse mechanisms of IRF5 action in inflammatory responses
Khoyratty, T. E., & Udalova, I. A. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.03.012 · Cited by 34
Ma, Y., Su, Q., & Tempst, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8727 · Cited by 34
Miller, J., Stacy, T., Liu, P. P., & Speck, N. A. (2001) · Blood · doi:10.1182/blood.v97.8.2248 · Cited by 33
Kårehed, K., Dimberg, A., Dahl, S., Nilsson, K., & Oberg, F. G. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.01.013 · Cited by 32
Wang, H., Diamond, R. A., & Rothenberg, E. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6831 · Cited by 32
The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects
McKercher, S. R., Henkel, G. W., & Maki, R. A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.727 · Cited by 28
Tosun, B., Wolff, L. I., Houben, A., Nutt, S. L., & Hartmann, C. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4629 · Cited by 27
Zou, G.-M., Chan, R. J., Shelley, W. C., & Yöder, M. C. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0272 · Cited by 27
Transcriptional Control of Hematopoiesis
Robb, L. G., Elefanty, A. G., & Begley, C. G. (1999) · Elsevier eBooks · doi:10.1016/b978-012624960-6/50003-0 · Cited by 27
PU.1 supports proliferation of immature erythroid progenitors
Fisher, R. C., Slayton, W. B., Chien, C. D., Guthrie, S. M., Bray, C. L., & Scott, E. W. (2003) · Leukemia Research · doi:10.1016/s0145-2126(03)00178-4 · Cited by 29
Self-citationHIF-1 is Essential for Multilineage Hematopoiesis in the Embryo
Adelman, D. M., Maltepe, E., & Simon, M. C. (2002) · Advances in Experimental Medicine and Biology · doi:10.1007/0-306-46825-5_26 · Cited by 25
Self-citationLasitschka, F., Giese, T., Paparella, M., Kurzhals, S. R., Wabnitz, G. H., Jacob, K., Gras, J., Bode, K. A., Heninger, A., Sziskzai, T., et al. (2017) · Immunity Inflammation and Disease · doi:10.1002/iid3.184 · Cited by 24
Zhang, C., WANG, S., Liao, C.-P., Shao, S., Lasbury, M. E., Durant, P. J., & Lee, C. (2010) · Infection and Immunity · doi:10.1128/iai.01141-09 · Cited by 23
Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Yi, C., He, J., Huang, D. F., Zhao, Y., Zhang, C., Ye, X., Huang, Y., Nussinov, R., Zheng, J., Liu, M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05434-z · Cited by 22
Chen, F., Rao, J., & Studzinski, G. P. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.559 · Cited by 22
MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes
Hu, J., Zheng, L., Shen, X., Zhang, Y., Cheng, L., & Xi, T. (2017) · Gene · doi:10.1016/j.gene.2017.04.002 · Cited by 21
Zayas, J., Spassov, D. S., Nachtman, R. G., & Jurecic, R. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0101 · Cited by 20
Faust, N., Bonifer, C., & Sippel, A. E. (1999) · DNA and Cell Biology · doi:10.1089/104454999315042 · Cited by 20
Functional diversity of macrophages in vascular biology and disease
Park, I., Kassiteridi, C., & Monaco, C. G. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.10.005 · Cited by 19
Transcriptional Regulation of c-fms Gene Expression
Xie, Y., Chen, C., & Hume, D. A. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:1:001 · Cited by 19
Anatomy and physiology of hematopoiesis
Eaves, C. J., & Eaves, A. C. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511471001.005 · Cited by 19
Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fc receptor I promoter activation
Aittomäki, S. (2004) · International Immunology · doi:10.1093/intimm/dxh037 · Cited by 18
PU.1 regulates the expression of the human neutrophil elastase gene
Srikanth, S., & Rado, T. A. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00039-6 · Cited by 18
Zou, D., Yang, X., Tan, Y., Wang, P., Zhu, X., Yang, W., Jia, X., Zhang, J., & Wang, K. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.09.012 · Cited by 17
Towards the better understanding of myelopoiesis using single-cell technologies
Dress, R. J., Liu, Z., & Ginhoux, F. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.04.020 · Cited by 16
Identification of the microRNA networks contributing to macrophage differentiation and function
Zhou, H., Zhang, J., Eyers, F., Xiang, Y., Herbert, C. A., Tay, H. L., Foster, P. S., & Yang, M. (2016) · Oncotarget · doi:10.18632/oncotarget.8933 · Cited by 16
Blood cell progenitors: Insights into the properties of stem cells
Yöder, M. C. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10133 · Cited by 16
Rogers, P. B., Driessnack, M. G., & Schwartz, E. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181985 · Cited by 15
Chiang, M. Y., & Monroe, J. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.10.6091 · Cited by 16
Yanai, N., Matsui, N., Matsuda, K.-I., Furusawa, T., Okubo, T., Nakazawa, T., Ishibashi, K., Nawa, K., & Obinata, M. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00027-2 · Cited by 15
MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression
Nemoto, T., Shibata, Y., Inoue, S., Igarashi, A., Tokairin, Y., Yamauchi, K., Kimura, T., Sato, M., Sato, K., Nakano, H., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.070 · Cited by 14
Hackenmiller, R., & Simon, M. C. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0643 · Cited by 14
Self-citationHume, D. A. (2023) · European Journal of Immunology · doi:10.1002/eji.202250242 · Cited by 14
Var, S. R., Strell, P., Johnson, S. T., Roman, A., Vasilakos, Z., & Low, W. C. (2023) · Cell Transplantation · doi:10.1177/09636897231171001 · Cited by 15
Intestinal Mononuclear Phagocytes in Health and Disease
Sanders, T. J., Yrlid, U., & Maloy, K. J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0047-2016 · Cited by 13
Scotti, E., & Tontonoz, P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00171-10 · Cited by 13
Differential expression of five laminin α (1-5) chains in developing and adult mouse kidney
Sorokin, L. M., Pausch, F., Durbeej, M., & Ekblom, P. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199712)210:4 · Cited by 152
Ramírez, C., & Mendoza, L. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx736 · Cited by 12
Hodawadekar, S., Park, K., Farrar, M. A., & Atchison, M. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102239 · Cited by 10
Transcriptional Activation of the Pirb Gene in B Cells by PU.1 and Runx3
Arita, K., Endo, S., Kaifu, T., Kitaguchi, K., Nakamura, A., Ohmori, H., Kohu, K., Satake, M., & Takai, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001302 · Cited by 9
Kwok, J. C., Perdomo, J., & Chong, B. H. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21264 · Cited by 9
Expression of Scl in mesoderm rescues hematopoiesis in the absence of Oct-4
Kong, K. Y., Williamson, E. A., Rogers, J. H., Tran, T., Hromas, R., & Dahl, R. E. (2009) · Blood · doi:10.1182/blood-2008-08-174755 · Cited by 8
Loureiro, R. M. B., Monaco, K., Kearney, J. B., Blickarz, C. E., Kirby, S. L., Inamdar, M. S., & Bautch, V. L. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07105.x · Cited by 7
Borowska, D., Sives, S., Vervelde, L., & Sutton, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1064084 · Cited by 6
Monocyte Subsets and Their Role in Tumor Progression
Doseff, A. I., & Parihar, A. (2012) · InTech eBooks · doi:10.5772/32615 · Cited by 6
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy
Qu, Y., Liang, W., Yu, M., Wang, C., Luo, M., Zhong, L., Li, Z., & Wang, F. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241957 · Cited by 5
Regulatory Co-options in the Evolution of Deuterostome Immune Systems
Rothenberg, E. V., & Davidson, E. H. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-320-0_4 · Cited by 5
Sturrock, A., Franklin, K. F., Norman, K. G., & Hoidal, J. R. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2003.10.005 · Cited by 5
3 Use of embryonal stem cells in studies of molecular haemopoiesis
Hole, N., & Graham, G. J. (1997) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(97)80021-2 · Cited by 5
Transcriptional Regulation of Early B Cell Development
Hagman, J. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397933-9.00003-5 · Cited by 4
Origin and Development of Microglia
Patro, N., & Patro, I. K. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_7 · Cited by 3
Transcriptional frequency and cell determination
Flickinger, R. A. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.05.020 · Cited by 3
From totipotency to T in a dish
Rothenberg, E. V. (2004) · Nature Immunology · doi:10.1038/ni0404-359 · Cited by 3
PU.1, a Versatile Transcription Factor and a Suppressor of Myeloid Leukemia
Takahashi, S. (2011) · InTech eBooks · doi:10.5772/25853 · Cited by 3
Granulocyte colony-stimulating factor
WHITE, S., & Tweardy, D. J. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50026-0 · Cited by 2
Fallatah, W., Mary, J., Dhinoja, S., Vallabhaneni, S., & Jagadeeswaran, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-88866-9 · Cited by 1
The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors
Scott, E. W. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4_7 · Cited by 1
Self-citationThe interaction of Staphylococcus aureus with macrophages
Jubrail, J. (2014) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1
Mutations in human cancer: how close should we look?
Cammenga, J., & Nimer, S. D. (2002) · Leukemia Research · doi:10.1016/s0145-2126(01)00174-6 · Cited by 1
Sierra, A., Pereira‐Iglesias, M., Martinson, W. D., Falcó, C., Maldonado-Teixidó, J., González-Domínguez, M., Senovilla-Ganzo, R., Benito, E., Beccari, S., Valero, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.03.685577 · Cited by 1
Interleukin-4 induced leukocyte differentiation
Ahlfors, H. (2010) · UTUPub (University of Turku) · Cited by 1
Regulation of human FcαR gene expression
Shimokawa, T., Tsuge, T., & Ra, C. (2001) · Springer eBooks · doi:10.1007/978-4-431-53940-7_5
The Macrophage Epigenome and the Control of Inflammatory Gene Expression
Polletti, S., Curina, A., Natoli, G., & Ghisletti, S. (2014) · Epigenetics and human health · doi:10.1007/978-3-642-45198-0_15
The gene encoding the transcription factor Spi-B maps to mouse Chromosome 7
Peters, L. L., Ciciotte, S. L., Su, G. H., & Simon, M. C. (1997) · Mammalian Genome · doi:10.1007/s003359900469
Self-citationETS transcription factor knockouts: A review
Bassuk, A. G. (1999) · Clinical Immunology Newsletter · doi:10.1016/s0197-1859(00)89197-9
Zierden, M. (2001) · Kölner Universitäts PublikationsServer (Universität zu Köln)
Yücel, R. (2004) · DuEPublico (University of Duisburg-Essen)
Palmer, S. (2000) · Enlighten: Theses (The University of Glasgow)
Functional analysis of epithelium-specific Ets transcription factor-1 in inflammation
Lee, C. M. (2016) · TSpace (University of Toronto)
Defining Novel Mechanisms in Cardiovascular Development
Plein, A. (2015) · UCL Discovery (University College London)
Generation and analysis of granulocyte elastase-deficient cre-transgenic mice
Phylactides, M. (1998) · UCL Discovery (University College London)
Intestinal Mononuclear Phagocytes in Health and Disease
Sanders, T. J., Yrlid, U., & Maloy, K. J. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch39
Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50493-2
Sharrocks, A. D. (2002) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1007998.101056
Mastering self-renewal for lineage reprogramming : Application to macrophage to beta cell conversion
Imperatore, F. (2013) · theses.fr (ABES) · doi:10.70675/c50451dcz5c35z4befzba7dze6365925fc5f
Metadata
- Authors
- Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 3
- Issue
- 6
- Pages
- 703-714
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2050347737
- Cited by
- 191
- References
- 58
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (2r01hl052094-05a1, 5f32ai008933-02)
- National Heart, Lung, and Blood Institute (HL5-2094)
- National Institute of Allergy and Infectious Diseases (F32 AI08933)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- PU.1, myeloid differentiation, embryonic stem cells, macrophage differentiation, GM-CSF receptor, G-CSF receptor, myeloperoxidase, CD11b, CD64, M-CSF receptor, hematopoiesis, monocytes, granulocytes, transcription factors
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Female, Granulocytes, Hematopoietic Stem Cells, Male, Mice, Mutant Strains, Molecular Sequence Data, Monocytes, Proto-Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review