Cited by 191Hematopoietic Stem Cell TransplantationGenomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

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PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

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Olson, Marilyn C., Scott, Edward W., Hack, Andrew A., Su, Gloria H., Tenen, Daniel G., Singh, Harinder, Simon, M.Celeste·1995·Immunity

DOI 10.1016/1074-7613(95)90060-8

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Abstract

We have previously shown using gene targeting that PU.1 is essential for the development of lymphoid and myeloid lineages during fetal liver hematopoiesis. We now show that PU.1 is required for the maturation of yolk sac-derived myeloid progenitors and for the differentiation of ES cells into macrophages. The role of PU.1 in regulating target genes, thought to be critical in the development of monocytes and granulocytes, has been analyzed. Early genes such as GM-CSFR, G-CSFR, and myeloperoxidase are expressed in PU.1-/- embryos and differentiated PU.1-/- ES cells. However, the expression of genes associated with terminal myeloid differentiation (CD11b, CD64, and M-CSFR) is eliminated in differentiated PU.1-/- ES cells. Development of macrophages is restored with the introduction of a PU.1 cDNA regulated by its own promoter. The PU.1-/- ES cells represent an important model for analyzing myeloid cell development.

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Authors: Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C.
Affiliations: Howard Hughes Medical Institute (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Olson, Marilyn C.
Scott, Edward W.
Su, Gloria H.
Tenen, Daniel G.
Singh, Harinder
Simon, M.Celeste
Venue: Immunity
Publisher: Elsevier BV
Published: 1995-12
Volume: 3
Issue: 6
Pages: 703-714
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/1074-7613(95)90060-8
OpenAlex: W2050347737
Cited by: 191
References: 58
Citations by year: 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 4
FWCI: 9.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6438 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (2r01hl052094-05a1, 5f32ai008933-02)
National Heart, Lung, and Blood Institute (HL5-2094)
National Institute of Allergy and Infectious Diseases (F32 AI08933)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: PU.1, myeloid differentiation, embryonic stem cells, macrophage differentiation, GM-CSF receptor, G-CSF receptor, myeloperoxidase, CD11b, CD64, M-CSF receptor, hematopoiesis, monocytes, granulocytes, transcription factors
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Female, Granulocytes, Hematopoietic Stem Cells, Male, Mice, Mutant Strains, Molecular Sequence Data, Monocytes, Proto-Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Mice

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PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

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