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DNA Methylation and Cancer
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Human DNA methylomes at base resolution show widespread epigenomic differences
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Self-citationThe Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700
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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor
Prokhortchouk, A., Hendrich, B., Jørgensen, H., Ruzov, A., Wilm, M., Georgiev, G., Bird, A., & Prokhortchouk, E. (2001) · Genes & Development · doi:10.1101/gad.198501 · Cited by 533
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
Baker, E. K., Johnstone, R. W., Zalcberg, J. R., & El-Osta, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208955 · Cited by 196
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The exposome: from concept to utility
Wild, C. P. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr236 · Cited by 1,416
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097
“On the other hand, methylation of DNA can also be a barrier for certain transcription factors to bind to promoter sites such as AP-2, c-Myc, CREB/ATF, E2F, and NF-kB.(13) As for methyl-group binding proteins, many studies have investigated their roles in various cancers, but the mechanism underlying these alterations…”
BackgroundDynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092
Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Kenny, R. G., & Marmion, C. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00271 · Cited by 636
Mechanisms and Implications of Metabolic Heterogeneity in Cancer
Kim, J., & DeBerardinis, R. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.013 · Cited by 606
The emerging role of epigenetic therapeutics in immuno-oncology
Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433
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Metabolic signatures of cancer cells and stem cells
Intlekofer, A. M., & Finley, L. W. S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0032-0 · Cited by 322
Reconfiguration of DNA methylation in aging
Zampieri, M., Ciccarone, F., Calabrese, R., Franceschi, C., Bürkle, A., & Caiafa, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.002 · Cited by 254
“The loss of the bulk of enome methylation and/or the introduction of anomalous methyl roups onto generally unmethylated regions occur physiologically n aging but also in several pathological states (Bacalini et al., 2014; alabrese et al., 2012; Kulis and Esteller, 2010; Lu et al., 2013).”
Kinde, B., Gabel, H. W., Gilbert, C. S., Griffith, E. C., & Greenberg, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411269112 · Cited by 236
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
Sadida, H. Q., Abdulla, A., Marzooqi, S. A., Hashem, S., Macha, M. A., Akil, A. S. A.-S., & Bhat, A. A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101821 · Cited by 151
Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas
Barreau, O., Assié, G., Wilmot-Roussel, H., Ragazzon, B., Baudry, C., Perlemoine, K., René-Corail, F., Bertagna, X., Dousset, B., Hamzaoui, N., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2993 · Cited by 132
Beyond the Warburg effect: How do cancer cells regulate one-carbon metabolism?
Rosenzweig, A., Blenis, J., & Gomes, A. P. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00090 · Cited by 107
Genetics of tumors of the adrenal cortex
Bonnet-Serrano, F., & Bertherat, J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0361 · Cited by 80
Altered placental DNA methylation patterns associated with maternal smoking: current perspectives
Maccani, J. Z. J., & Maccani, M. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s61518 · Cited by 62
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Tommasi, S., Zheng, A., Weninger, A., Bates, S. E., Li, X. A., Wu, X., Hollstein, M., & Besaratinia, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1051 · Cited by 45
Rlip depletion prevents spontaneous neoplasia in TP53 null mice
Awasthi, S., Tompkins, J., Singhal, J., Riggs, A. D., Yadav, S., Wu, X., Singh, S., Warden, C., Liu, Z., Wang, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719586115 · Cited by 33
Blum, K., Bowirrat, A., Baron, D., Elman, I., Makale, M. T., Cadet, J. L., Thanos, P. K., Hanna, C., Ahmed, R., Gondre-Lewis, M. C., et al. (2024) · Gene & Protein in Disease · doi:10.36922/gpd.1966 · Cited by 14
(2024) · Journal of Addiction Psychiatry · doi:10.17756/jap.2024-045 · Cited by 3
Fariha, F. T. J., Fuad, M., Saha, C. S., Hossen, S., & Hossain, M. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-13315-6 · Cited by 1
Metadata
- Authors
- Kulis, M., & Esteller, M.
- Venue
- Advances in Genetics
- Publisher
- Elsevier
- Published
- 2010
- Volume
- 70
- Pages
- 27-56
- ISSN
- 0065-2660 (ISSN-L)
- OpenAlex
- W1831033366
- Cited by
- 1,566
- References
- 9
- FWCI
- 57.45
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
