Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas
Abstract
PURPOSE: DNA methylation is a mechanism for gene expression silencing in cancer. Limited information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 locus is common in adrenocortical carcinomas. Our aim was to characterize the methylation in adrenocortical carcinomas at a whole-genome scale and to assess its clinical significance and its impact on gene expression. EXPERIMENTAL DESIGN: Methylation patterns of CpG islands in promoter regions of 51 adrenocortical carcinomas and 84 adenomas were studied by the Infinium HumanMethylation27 Beadchip (Illumina, San Diego, CA). Methylation of 33 genes was studied by methylation-specific multiplex ligation-dependent probe amplification (MRC-Holland, Amsterdam, The Netherlands) in 15 carcinomas. Gene expression data were available for 87 tumors from a previous study (HG-U133Plus2.0 AffymetrixGeneChip; Affymetrix, Santa Clara, CA). Clinical information, including patient features and survival, were available for all tumors. RESULTS: Methylation was higher in carcinomas than in adenomas (t test P = 3.1 × 10(-9)). Unsupervised clustering of DNA methylation profiles identified two groups of carcinomas, one with an elevated methylation level, evoking a CpG island methylator phenotype (CIMP). The subgroup of hypermethylated carcinomas was further divided in two subgroups, with different levels of methylation (CIMP-high and CIMP-low). This classification could be confirmed by methylation-specific multiplex ligation-dependent probe amplification. Hypermethylation was associated with a poor survival (Cox model P = 0.02). The transcriptome/methylation correlation showed 1741 genes (of 12,250) negatively correlated; among the top genes were H19 and other tumor suppressors (PLAGL-1, G0S2, and NDRG2). CONCLUSIONS: This genome-wide methylation analysis reveals the existence of hypermethylated adrenocortical carcinomas, with a poorer prognosis. Hypermethylation in these tumors is important for silencing specific tumor suppressor genes.
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In an independent cohort, 6 loci (5q, 7p, 11p, 13q, 16q, and 22q) had diagnostic utility in differentiating ACA and ACC, with sensitivity 100% and specificity 83%.
“Moreover, in an independent cohort, the study confirmed the diagnostic utility of 6 loci (5q, 7p, 11p, 13q, 16q, and 22q) in the differentiation of ACA and ACC (sensitivity, 100%; specificity, 83%) (188).”
From Adrenocortical carcinoma (2014) · cites this paper as [188]
In ACCs, promoter hypermethylation is correlated with poor survival.
“A recent study of 51 ACCs and 84 ACAs revealed hypermethylation of promoters in ACCs with correlation to poor survival”
From Adrenocortical carcinoma (2014) · cites this paper as [188]
H19, PLAGL1, G0S2, and NDRG2 are silenced genes in ACCs.
“identified H19, PLAGL1, G0S2, and NDRG2 as silenced genes (188).”
From Adrenocortical carcinoma (2014) · cites this paper as [188]
A higher-resolution CGH array study confirmed increased chromosomal alterations in ACCs (44%) compared with ACAs (10%).
“The study confirmed increased alterations in ACCs (44%) compared with ACAs (10%).”
From Adrenocortical carcinoma (2014) · cites this paper as [188]
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- Authors
- Barreau, O., Assié, G., Wilmot-Roussel, H., Ragazzon, B., Baudry, C., Perlemoine, K., René-Corail, F., Bertagna, X., Dousset, B., Hamzaoui, N., Tissier, F., de Reynies, A., & Bertherat, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-01
- Volume
- 98
- Issue
- 1
- Pages
- E174-E184
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2042271589
- Cited by
- 132
- References
- 44
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 18 · 2019: 6 · 2018: 6 · 2017: 11 · 2016: 11 · 2015: 16 · 2014: 9 · 2013: 8
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- adrenocortical carcinoma, CpG island methylator phenotype, DNA methylation, promoter hypermethylation, adrenal adenoma, Igf2/H19 locus, tumor suppressor, gene silencing, prognosis, survival, transcriptome-methylation correlation, PLAGL1, G0S2, NDRG2
- MeSH terms
- Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Phenotype, Prognosis, Cohort Studies, Gene Expression Regulation, Neoplastic, Adrenocortical Adenoma, Adrenocortical Carcinoma, CpG Islands, DNA Methylation, Young Adult
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