S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

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Conjugated Equine Estrogens and Incidence of Probable Dementia and Mild Cognitive Impairment in Postmenopausal Women Women's Health Initiative Memory Study

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Estrogen Signaling and Cardiovascular Disease

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S-Equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora1–4,

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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

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Hormone therapy and Alzheimer disease dementia

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Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

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Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist

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Testosterone levels and cognition in elderly men: A review

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Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

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The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function

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Estrogen therapy: is time of initiation critical for neuroprotection?

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Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production

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The Isoflavone Equol Mediates Rapid Vascular Relaxation

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Postmenopausal hormone therapy and cognitive outcomes: The Women's Health Initiative Memory Study (WHIMS)

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New equol supplement for relieving menopausal symptoms

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Low Affinity GPCRs for Metabolic Intermediates: Challenges for Pharmacologists

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The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification

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Cardiovascular targets for estrogens and phytoestrogens: Transcriptional regulation of nitric oxide synthase and antioxidant defense genes

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Fetal exposure to phytoestrogens—The difference in phytoestrogen status between mother and fetus

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Hip fracture in postmenopausal women after cessation of hormone therapy

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Dietary isoflavones and vascular protection: Activation of cellular antioxidant defenses by SERMs or hormesis?

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Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging

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Pasta Naturally Enriched with Isoflavone Aglycons from Soy Germ Reduces Serum Lipids and Improves Markers of Cardiovascular Risk

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Isoflavone Soy Protein Supplementation and Atherosclerosis Progression in Healthy Postmenopausal Women

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Photoaging and chronological aging profile: Understanding oxidation of the skin

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SOY in Health and Disease Prevention

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Isoflavones, Equol and Cardiovascular Disease: Pharmacological and Therapeutic Insights

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Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1

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A “window of opportunity:” the reduction of coronary heart disease and total mortality with menopausal therapies is age- and time-dependent

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Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells

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Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke

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Postmenopausal skin and estrogen

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Topical isoflavones provide effective photoprotection to skin

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Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection

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Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

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Urinary isoflavonoids and risk of coronary heart disease

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Reduced Expression of Heme Oxygenase-1 in Patients with Coronary Atherosclerosis

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The effects of natural S-equol supplementation on skin aging in postmenopausal women

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The effect of the chemical composition of maize plant lignin on the digestibility of maize stalk in the rumen of cattle

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A Role for Estrogen Receptor-α and Estrogen Receptor-β in Collagen Biosynthesis in Mouse Skin

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Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptoms

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Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods

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17β‐Estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation

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Estrogen Receptor β Is a Novel Therapeutic Target for Photoaging

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Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

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Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome

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Elucidation of the metabolic pathway of S-equol in rat, monkey and man

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Protection Against Photoaging in the Hairless Mouse by the Isoflavone Equol

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Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant response element

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Antioxidant effects of equol on bovine aortic endothelial cells

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Evaluation of Equol Function on Anti‐ or Prooxidant Status in vivo

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Soya isoflavone consumption in relation to carotid intima–media thickness in Chinese equol excretors aged 40–65 years

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Relationship Between Serum Isoflavone Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: Nested Case-Control Study of the Tsurugaya Project

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Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies

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R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia

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Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism

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Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works

Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal

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Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging

Zhang, B., Zhang, X., Ma, L., Li, D., Li, Y., Lin, S., Peng, L., & He, L. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113168 · Cited by 1 · see citing works

Assessment of Antioxidant, Antimicrobial and Anticancer Activities and Chemical Composition of Bark of Mahonia napaulensis DC. of NepalPreprint

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Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist

Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00400.x · Cited by 195 · see citing works

S-equol, a Natural Metabolite of Soy Daidzein, for the Treatment of Menopausal Symptoms and Osteoporosis in Postmenopausal Women

Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-373-2_10 · Cited by 1 · see citing works

Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome

Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01362.x · Cited by 41 · see citing works

Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms

Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works

Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans

Zhang, X., Veliky, C. V., Birru, R. L., Barinas‐Mitchell, E., Magnani, J. W., & Sekikawa, A. M. (2021) · Nutrients · doi:10.3390/nu13113739 · Cited by 54 · see citing works