Photoaging and chronological aging profile: Understanding oxidation of the skin
Abstract
The impact of chronological aging and photoaging on the skin is particularly concerning, especially when oxidative stress is involved. This article provides evidence of quantitative and qualitative differences in the oxidative stress generated by chronological aging and photoaging of the skin in HRS/J hairless mice. Analysis of the results revealed an increase in lipid peroxides as the skin gets older and in photoaged skin (10.086 ± 0.70 η MDA/mg and 14.303 ± 1.81 η MDA/mg protein, respectively), although protein oxidation was only verified in chronological aged skin (15.449 ± 0.99 η protein/mg protein). The difference between both skin types is the decay in the capacity of lipid membrane turnover revealed by the dislocation of older skin to the left in the chemiluminescence curve. Imbalance between antioxidant and oxidation processes was verified by the decrease in total antioxidant capacity of chronological and photoaged skins. Although superoxide dismutase remained unchanged, catalase increased in the 18 and 48-week-old skin groups and decreased in irradiated mice, demonstrating that neither enzyme is a good parameter to determine oxidative stress. The differences observed between chronological and photoaging skin represent a potential new approach to understanding the phenomenon of skin aging and a new target for therapeutic intervention.
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Skin wrinkle formation is a hallmark of both intrinsic aging and photoaging and is closely associated with collagen degradation and alterations in skin surface topography.
“Skin wrinkle formation is a hallmark of both intrinsic aging and photoaging and is closely associated with collagen degradation and alterations in skin surface topography [4,41,42].”
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- Authors
- Peres, P. S., Terra, V. A., Guarnier, F. A., Cecchini, R., & Cecchini, A. L.
- Affiliations
- Universidade Estadual de Londrina (BR)
- Corresponding author
- Cecchini, A.L.
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 103
- Issue
- 2
- Pages
- 93-97
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W1993624173
- Cited by
- 112
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 10 · 2013: 10 · 2012: 12
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- photoaging, chronological aging, skin aging, oxidative stress, lipid peroxidation, malondialdehyde, protein oxidation, antioxidant capacity, superoxide dismutase, catalase, chemiluminescence, UV irradiation
- MeSH terms
- Aging, Animals, Antioxidants, Catalase, Female, Lipid Peroxides, Male, Mice, Hairless, Oxidation-Reduction, Skin, Superoxide Dismutase, Ultraviolet Rays, Skin Aging, Oxidative Stress, Mice
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