The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Lipocalin 13 Regulation of Glucose and Lipid Metabolism in Obesity
Open accessAbstract
Lipocalin (LCN) family members are small secreted proteins that bind to small hydrophobic molecules via their characteristic central β-barrels. A couple of LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, have been reported to regulate insulin sensitivity and nutrient metabolism. LCN13 is expressed by multiple tissues, including the liver, pancreas, epididymis, and skeletal muscle, and is secreted into the bloodstream in mice. Obesity is associated with a downregulation of LCN13 expression and lower levels of circulating LCN13. LCN13 therapies overcome LCN13 deficiency in mice with either genetic or dietary obesity, leading to an improvement in hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, and hepatic steatosis. In hepatocytes, LCN13 directly suppresses hepatic gluconeogenesis and lipogenesis but increases fatty acid β oxidation. LCN13 also enhances insulin sensitivity in adipocytes. The potential mechanisms of the antidiabetes and antisteatosis actions of LCN13 are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“both mRNA and plasma levels of LCN13 are low in mice with genetic or high-fat diet-induced obesity [254,257].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [254]
In the citing paper
“Expression and secretion of LCN13 in mice vary in response to changes in metabolic states, suggesting a role for this hepatokine in nutrient sensing and regulation [254].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [254]
In the citing paper
“LCN13 in particular is secreted from multiple tissues including the liver to regulate glucose homeostasis and improve insulin sensitivity [254].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [254]
In the citing paper
“Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, have been shown to regulate energy metabolism [[254], [255], [256]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [254]
In the citing paper
“it is well established that LCN13 regulates glucose metabolism in adipocytes and hepatocytes by enhancing insulin signaling, insulin-stimulated glucose uptake, and insulin suppression of glucose production [254,258].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [254]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086
The lipocalin protein family: structure and function
FLOWER, D. R. (1996) · Biochemical Journal · doi:10.1042/bj3180001 · Cited by 1,679
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,204
Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,124
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904
Self-citationThe lipocalin protein family: structural and sequence overview
Flower, D. R., North, A. C. T., & Sansom, C. E. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00148-5 · Cited by 868
Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686
The role of lipid droplets in metabolic disease in rodents and humans
Greenberg, A. S., Coleman, R., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., Yan, Q.-W., Miyoshi, H., & Mashek, D. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46069 · Cited by 620
Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
Deng, Z., Poliakov, A., Hardy, R. W., Clements, R. H., Liu, C., Liu, Y., Wang, J., Xiang, X., Zhang, S., Zhuang, X., et al. (2009) · Diabetes · doi:10.2337/db09-0216 · Cited by 596
Identification of protein pheromones that promote aggressive behaviour
Chamero, P., Marton, T. F., Logan, D. W., Flanagan, K. A., Cruz, J. R., Saghatelian, A., Cravatt, B. F., & Stowers, L. (2007) · Nature · doi:10.1038/nature05997 · Cited by 529
Recent advances in understanding leptin signaling and leptin resistance
Morris, D. L., & Rui, L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2009 · Cited by 484
Self-citationThe Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D. (2007) · Diabetes · doi:10.2337/db07-0007 · Cited by 483
The Adipocyte as an Endocrine Cell
Halberg, N., Asterholm, I. W., & Scherer, P. E. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.07.002 · Cited by 442
Ueki, K., Kondo, T., Tseng, Y., & Kahn, C. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402511101 · Cited by 389
Structure and sequence relationships in the lipocalins and related proteins
Flower, D. R., North, A. C. T., & Attwood, T. K. (1993) · Protein Science · doi:10.1002/pro.5560020507 · Cited by 342
Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome
Schreurs, M., Kuipers, F., & van der Leij, F. R. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00642.x · Cited by 304
Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity
Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 297
Norseen, J., Hosooka, T., Hammarstedt, A., Yore, M. M., Kant, S., Aryal, P., Kiernan, U. A., Phillips, D. A., Maruyama, H., Kraus, B. J., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06193-11 · Cited by 274
Infectious Disease Modeling of Social Contagion in Networks
Hill, A. L., Rand, D. G., Nowak, M. A., & Christakis, N. A. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000968 · Cited by 233
RBP4: a controversial adipokine
Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0431 · Cited by 233
Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice
Guo, H., Jin, D., Zhang, Y., Wright, W. S., Bazuine, M., Brockman, D. A., Bernlohr, D., & Chen, X. (2010) · Diabetes · doi:10.2337/db09-1735 · Cited by 214
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Schleicher, E. D., Fritsche, A., & Häring, H. (2007) · Diabetes Care · doi:10.2337/dc06-2342 · Cited by 212
Lipocalins - a family portrait
Grzyb, J., Latowski, D., & Strzałka, K. (2006) · Journal of Plant Physiology · doi:10.1016/j.jplph.2005.12.007 · Cited by 205
Berry, D. C., Jin, H., Majumdar, A., & Noy, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011115108 · Cited by 204
Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses
Lögdberg, L., & Wester, L. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00164-3 · Cited by 202
Oehninger, S., Coddington, C. C., Hodgen, G. D., & Seppälä, M. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57372-5 · Cited by 188
Non‐alcoholic fatty liver disease: Further expression of the metabolic syndrome
Tarantino, G., Saldalamacchia, G., Conca, P., & Arena, A. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04824.x · Cited by 184
Adipocytokines and Insulin Resistance
Esteve, E., Ricart, W., & Fernández‐Real, J. M. (2009) · Diabetes Care · doi:10.2337/dc09-s340 · Cited by 184
Lipocalins in drug discovery: From natural ligand-binding proteins to ‘anticalins’
Schlehuber, S., & Skerra, A. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03294-5 · Cited by 170
Multiple genes coding for the androgen-regulated major urinary proteins of the mouse
Hastie, N. D., Held, W. A., & Toole, J. (1979) · Cell · doi:10.1016/0092-8674(79)90171-5 · Cited by 162
A Phylogenetic Analysis of the Lipocalin Protein Family
Ganfornina, M. D., Gutiérrez, G., Bastiani, M. J., & Diego, S. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026224 · Cited by 159
Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice
Zhou, Y., Jiang, L., & Rui, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900754200 · Cited by 154
Self-citationAhima, R. S., & Osei, S. Y. (2008) · Frontiers of hormone research · doi:10.1159/000115365 · Cited by 136
Hui, X., Zhu, W., Wang, Y., Lam, K. S. L., Zhang, J., Wu, D., Kraegen, E. W., Li, Y., & Xu, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001107 · Cited by 130
Bratt, T. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00154-0 · Cited by 128
Öst, A., Danielsson, A., Lidén, M., Eriksson, U., Nyström, F. H., & Strålfors, P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8173com · Cited by 126
Pheromone binding by polymorphic mouse major urinary proteins
Sharrow, S. D., Vaughn, J. L., Žı́dek, L., Novotný, M. V., & Stone, M. J. (2002) · Protein Science · doi:10.1110/ps.0204202 · Cited by 120
Sheng, L., Zhou, Y., Chen, Z., Ren, D., Cho, K. W., Jiang, L., Shen, H., Sasaki, Y., & Rui, L. (2012) · Nature Medicine · doi:10.1038/nm.2756 · Cited by 109
Self-citationGetting away from glucose: fanning the flames of obesity-induced inflammation
Shoelson, S. E., & Goldfine, A. B. (2009) · Nature Medicine · doi:10.1038/nm0409-373 · Cited by 98
Major Urinary Protein Regulation of Chemical Communication and Nutrient Metabolism
Zhou, Y., & Rui, L. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)83006-7 · Cited by 97
Self-citationMolecular evolution of epididymal lipocalin genes localized on mouse chromosome 2
Suzuki, K., Lareyre, J., Sánchez, D., Gutiérrez, G., Araki, Y., Matusik, R. J., & Orgebin‐Crist, M. (2004) · Gene · doi:10.1016/j.gene.2004.06.027 · Cited by 81
A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance
Jun, L. S., Siddall, P., & Rosen, E. D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00147.2011 · Cited by 62
A Conserved Disulfide Motif in Human Tear Lipocalins Influences Ligand Binding
Glasgow, B. J., Abduragimov, A. R., Yusifov, T., Gasymov, O. K., Horwitz, J., Hubbell, W. L., & Faull, K. F. (1998) · Biochemistry · doi:10.1021/bi9720888 · Cited by 62
Mouse Major Urinary Proteins Trigger Ovulation via the Vomeronasal Organ
Morè, L. (2006) · Chemical Senses · doi:10.1093/chemse/bjj043 · Cited by 56
Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses
Chen, Z., Sheng, L., Shen, H., Zhao, Y., Wang, S., Brink, R. A., & Rui, L. (2012) · Diabetes · doi:10.2337/db11-0474 · Cited by 55
Self-citationAssociation of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women
Broch, M., Gómez, J. M., Auguet, T., Vilarrasa, N., Pastor, R., Elío, I., Olona, M., García‐España, A., & Richart, C. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0200-5 · Cited by 50
Sheng, L., Cho, K. W., Zhou, Y., Shen, H., & Rui, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256677 · Cited by 45
Self-citationCho, K. W., Zhou, Y., Sheng, L., & Rui, L. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00459-10 · Cited by 42
Self-citationRole of lipid-derived mediators in skeletal muscle insulin resistance
Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40
ISOLATION AND METABOLISM OF MALE SEX-DEPENDENT URINARY PROTEIN FROM RATS
Geertzen, H. G. M., Ouderaa, F. J. G. V. D., & Kassenaar, A. A. H. (1973) · European Journal of Endocrinology · doi:10.1530/acta.0.0720197 · Cited by 23
Multiple forms of α2u, a sex-dependent urinary protein of the adult male rat
Lane, S. E., & Neuhaus, O. W. (1972) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(72)90095-5 · Cited by 11
Cited by
Sorted by citations
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis
Osborn, L. J., Schultz, K. B., Massey, W. J., DeLucia, B., Choucair, I., Varadharajan, V., Banerjee, R., Fung, K., Horak, A. J., Orabi, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202934119 · Cited by 85
Diminished mTOR signaling: a common mode of action for endocrine longevity factors
Lamming, D. W. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-735 · Cited by 71
Lipocalin family proteins and their diverse roles in cardiovascular disease
Yang, H., Wang, X., Li, S., Liu, Y., Akbar, R., & Fan, G. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108385 · Cited by 67
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
Ekim Üstünel, B., Friedrich, K., Maida, A., Wang, X., Krones-Herzig, A., Seibert, O., Sommerfeld, A., Jones, A., Sijmonsma, T. P., Sticht, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13267 · Cited by 36
Metadata
- Authors
- Zhou, Y., & Rui, L.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Rui, Liangyou
- ORCID
- Rui, Liangyou
- Venue
- Vitamins & Hormones
- Publisher
- Elsevier
- Published
- 2013
- Volume
- 91
- Pages
- 369-383
- ISSN
- 0083-6729 (ISSN-L)
- PMC
- PMC4020521
- OpenAlex
- W2177781559
- Cited by
- 28
- References
- 63
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 5.43
- Type
- book chapter
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Vitamins and hormones (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065122)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, glucose metabolism, lipid metabolism, insulin resistance, hepatic steatosis, hepatic gluconeogenesis, lipogenesis, fatty acid beta-oxidation, adipocytes, antidiabetic therapy, retinol-binding protein 4, neutrophil gelatinase-associated lipocalin
- MeSH terms
- Animals, Blood Glucose, Gene Expression Regulation, Lipid Metabolism, Mice, Lipocalins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
