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The skin thickness, from the epidermis to subcutaneous tissue, changes with the hair cycle, being the thickest in anagen and thinnest in telogen.
“The skin thickness, from the epidermis to subcutaneous tissue, also changes with the hair cycle, being the thickest in anagen and thinnest in telogen (Fig. 6)9, 31.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
The density of hair follicles varies with species, with higher follicle densities in rodents and lower densities in humans, monkeys, and minipigs.
“The density of hair follicles varies with species, with higher follicle densities in rodents and lower densities in humans, monkeys, and minipigs7, 9.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
Species differences in epidermal thickness have been reported.
“Similar to the present results, species differences in the epidermal thickness have also been reported9, 22, 23.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
The hair cycle consists of three stages: anagen, catagen, and telogen.
“The hair cycle consists of three stages: an actively growing phase (anagen), transition phase (catagen), and quiescent phase (telogen) (Fig. 6)1, 9, 12.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
Melanin consists of black or brown eumelanins and red or yellow pheomelanins, which cover the skin and protect the nuclear DNA from UV radiation.
“Melanin consists of black or brown eumelanins and red or yellow pheomelanins, which cover the skin and protect the nuclear DNA from UV radiation2, 9.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
Merkel cells are located in the outer root sheath of hair follicles and are receptive to tactile sensation.
“Merkel cells have been identified in many experimental animals and are located in the outer root sheath of the hair follicles. They are also receptive to tactile sensation9, 20.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [9]
Citations
Cites
Melanocyte biology and skin pigmentation
Lin, J. Y., & Fisher, D. E. (2007) · Nature · doi:10.1038/nature05660 · Cited by 1,379
Review of hair follicle dermal cells
Yang, C.-C., & Cotsarelis, G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.11.005 · Cited by 418
Regulation of human skin pigmentation and responses to ultraviolet radiation
Miyamura, Y., Coelho, S. G., Wolber, R., Miller, S. A., Wakamatsu, K., Zmudzka, B. Z., Ito, S., Smuda, C., Passeron, T., Choi, W., et al. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00358.x · Cited by 250
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Cited by
Sorted by citations
Morphological characteristics and notes of the skin in preclinical toxicity assessment
Moroki, T. (2023) · Journal of Toxicologic Pathology · doi:10.1293/tox.2022-0103 · Cited by 26
Metadata
- Authors
- Diegel, K. L., Danilenko, D. M., & Wojcinski, Z. W.
- Affiliations
- Genentech (US)
- Venue
- Haschek and Rousseaux's Handbook of Toxicologic Pathology
- Publisher
- Elsevier
- Published
- 2013
- Pages
- 2219-2275
- OpenAlex
- W3021314379
- Cited by
- 6
- References
- 3
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2019: 1 · 2016: 1
- FWCI
- 0.63
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Elsevier eBooks (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Medicine and Dermatology Studies History
- Keywords
- skin, integument, toxicologic pathology, jaundice, ultraviolet radiation, chemical exposure
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