Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

The Metabolic Basis of Inherited Disease

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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,123

Receptor-Mediated Control of Cholesterol Metabolism: Study of human mutants has disclosed how cells regulate a substance that is both vital and lethal.

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Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

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Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

Brown, M. S., & Goldstein, J. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.788 · Cited by 601

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42998-0 · Cited by 545

Disturbances in Lipid and Lipoprotein Metabolism

Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

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Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

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Lipoprotein structure and metabolism.

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Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

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Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

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Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

Brown, M., Dana, S., & Goldstein, J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41498-1 · Cited by 364

Regulation of Cholesterol Metabolism

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Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.2162 · Cited by 344

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

Brown, M. S., Faust, J. R., & Goldstein, J. L. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107989 · Cited by 318

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

Goldstein, J., Brunschede, G., & Brown, M. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40894-6 · Cited by 311

Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

Goldstein, J. L., Dana, S. E., & Brown, M. S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4288 · Cited by 290

HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGIN

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Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype.

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Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

Ho, Y. K., Brown, S., Bilheimer, D. W., & Goldstein, J. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108603 · Cited by 258

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

Faust, J. R., Goldstein, J. L., & Brown, M. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40133-5 · Cited by 241

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

Basu, S., Goldstein, J. L., & Brown, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34768-3 · Cited by 210

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

Balasubramaniam, S., Goldstein, J. L., Faust, J. R., Brunschede, G. Y., & Brown, M. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40617-x · Cited by 205

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

Gospodarowicz, D., Ill, C. R., Hornsby, P. J., & Gill, G. N. (1977) · Endocrinology · doi:10.1210/endo-100-4-1080 · Cited by 201

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

Krieger, M., Brown, M. S., Faust, J. R., & Goldstein, J. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34687-2 · Cited by 193

Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants.

Andersen, J. M., & Dietschy, J. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40302-4 · Cited by 192

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote

Anderson, R. G., Goldstein, J. L., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2434 · Cited by 186

The Origin of Cholesterol in Liver, Small Intestine, Adrenal Gland, and Testis of the Rat: Dietary versus Endogenous Contributions

Morris, M. D., & Chaikoff, I. L. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98137-8 · Cited by 183

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells*

Kovanen, P. T., Faust, J. R., Brown, M. S., & Goldstein, J. L. (1979) · Endocrinology · doi:10.1210/endo-104-3-599 · Cited by 163

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO PREGNANEDIOL

Bloch, K. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51101-7 · Cited by 153

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts

Bersot, T. P., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33600-1 · Cited by 150

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.2925 · Cited by 146

Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin.

Gwynne, J. T., MAHAFFEE, D. D., Brewer, H. B., & Ney, R. L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.12.4329 · Cited by 144

Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes

Ho, Y. K., Faust, J. R., Bilheimer, D. W., Brown, M., & Goldstein, J. L. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.6.1531 · Cited by 143

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.

Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W., & Goldstein, J. L. (1978) · Journal of Clinical Investigation · doi:10.1172/jci108980 · Cited by 142

The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.

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Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*

KOVANEN, P. T., BASU, S. K., GOLDSTEIN, J. L., & BROWN, M. S. (1979) · Endocrinology · doi:10.1210/endo-104-3-610 · Cited by 131

Hormonal Control of Adrenocortical Cell Proliferation

Hornsby, P. J., & Gill, G. N. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108782 · Cited by 128

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.

Ho, Y. K., Brown, M. S., Kayden, H. J., & Goldstein, J. L. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.2.444 · Cited by 112

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

Balasubramaniam, S., Goldstein, J. L., & Brown, M. S. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1421 · Cited by 96

Characterization of Adult Bovine Adrenocortical Cells Throughout Their Life Span in Tissue Culture*

Hornsby, P. J., & GILI, G. N. (1978) · Endocrinology · doi:10.1210/endo-102-3-926 · Cited by 81

Stimulation of Adrenal Cholesterol Uptake from Plasma by Adrenocorticotrophin

DEXTER, R. N., Fishman, L. M., & Ney, R. L. (1970) · Endocrinology · doi:10.1210/endo-87-5-836 · Cited by 78

ACTH and the Metabolism of Adrenal Cell Cultures

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Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.

Balasubramaniam, S., Goldstein, J. L., Faust, J. R., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2564 · Cited by 76

Studies on fatty liver induction by 4-aminopyrazolopyrimidine

Henderson, J. (1963) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40368-2 · Cited by 60

Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins

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High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

Kovanen, P. T., Goldstein, J. L., & Brown, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34666-5 · Cited by 53

The effect of hypoxia on uptake and degradation of low density lipoproteins by cultured human arterial smooth muscle cells

Albers, J. J., & Bierman, E. L. (1976) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(76)90031-x · Cited by 53

Solubilization of apolipoprotein B and its specific binding by the cellular receptor for low density lipoprotein

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Metabolism of adrenal cholesterol in man

Borkowski, A. J., Delcroix, C., & Levin, S. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106968 · Cited by 43

The cyanogen bromide peptides of the apoprotein of low density lipoprotein (apoB): Its molecular weight from a chemical view

Bradley, W. A., Rohde, M. F., Gotto, A. M., & Jackson, R. L. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91440-7 · Cited by 39

Familial hypercholesterolemia: model for genetic receptor disease.

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Interactions of native and modified human low density lipoproteins with human skin fibroblasts

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Studies of the cyanogen bromide fragments of the apoprotein of human serum low density lipoproteins

Deutsch, D. G., Heinrikson, R. L., Foreman, J., & Scanu, A. M. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90077-2 · Cited by 29

Metabolism of adrenal cholesterol in man

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Equilibration of plasma and adrenal cholesterol in man.

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Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

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A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

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Regulation of Plasma Cholesterol by Lipoprotein Receptors

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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism

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Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

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