The DOI matches its Crossref record; 320 of the 320 references it cites were found in a registry or an index.
Multiple roles for orexin/hypocretin in addiction
Open accessAbstract
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but also play a critical role in drug addiction and reward-related behaviors. Here, we review the roles played by orexins in a variety of animal models of drug addiction, emphasizing both commonalities and differences for orexin's involvement in seeking of the major classes of abused drugs, as well as food. One common theme that emerges is an involvement of orexins in drug seeking triggered by external stimuli (e.g., cues, contexts or stressors). We also discuss the functional neuronal circuits in which orexins are embedded, and how these circuits mediate addiction-related behaviors, with particular focus on the role of orexin and glutamate interactions within the ventral tegmental area. Finally, we attempt to contextualize the role of orexins in reward by discussing ways in which these peptides, expressed in only a few thousand neurons in the brain, can have such wide-ranging effects on behavior.
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Research works printed but not linked: 3
- Downs, 1932, The effect of repeated doses of cocaine on the rat, The Journal of Pharmacology and Experimental Therapeutics, 46, 199
- McDonald, 2011, Summary of the probe development effort to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [Summary], Ed. S. R. I. M. S. Center. PubChem.
- NIDA, 2009, (2009). Principals of Drug Addiction Treatment: A Research-Based Guide, Ed. D. o. H. a. H. S. National Institutes of Health. NIH.
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Sorted by citations
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
The contribution of brain reward circuits to the obesity epidemic
Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.001 · Cited by 274
Brown, R. M., Khoo, S. Y.-S., & Lawrence, A. J. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000333 · Cited by 101
Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.293 · Cited by 79
Lopez, M. F., Moorman, D. E., Aston-Jones, G., & Becker, H. C. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.049 · Cited by 62
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Metadata
- Authors
- Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Aston-Jones, Gary
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2012
- Volume
- 198
- Pages
- 79-121
- ISSN
- 0079-6123 (ISSN-L)
- PMC
- PMC3643893
- OpenAlex
- W4211199394
- Cited by
- 215
- References
- 320
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 15 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 19 · 2014: 26 · 2013: 17 · 2012: 3
- FWCI
- 23.33
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA010761)
- National Institute on Drug Abuse (F32DA031519, R37DA006214, R21DA032005, F32DA026692, P50DA015369)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- orexin, drug addiction, drug-seeking behavior, reward, food reward, contextual cues, stress, neural circuits, ventral tegmental area, glutamate, arousal, wakefulness
- MeSH terms
- Orexins, Animals, Brain, Humans, Motivation, Neuropeptides, Substance-Related Disorders, Intracellular Signaling Peptides and Proteins
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