Cited by 215Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness ResearchRegulation of Appetite and Obesity

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Multiple roles for orexin/hypocretin in addiction

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Mahler, Stephen V., Smith, Rachel J., Moorman, David E., Sartor, Gregory C., Aston-Jones, Gary·2012·Progress in Brain Research

DOI 10.1016/b978-0-444-59489-1.00007-0PMC PMC3643893

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Abstract

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but also play a critical role in drug addiction and reward-related behaviors. Here, we review the roles played by orexins in a variety of animal models of drug addiction, emphasizing both commonalities and differences for orexin's involvement in seeking of the major classes of abused drugs, as well as food. One common theme that emerges is an involvement of orexins in drug seeking triggered by external stimuli (e.g., cues, contexts or stressors). We also discuss the functional neuronal circuits in which orexins are embedded, and how these circuits mediate addiction-related behaviors, with particular focus on the role of orexin and glutamate interactions within the ventral tegmental area. Finally, we attempt to contextualize the role of orexins in reward by discussing ways in which these peptides, expressed in only a few thousand neurons in the brain, can have such wide-ranging effects on behavior.

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Self-citation

See all 215

Authors: Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G.
Affiliations: Medical University of South Carolina (US)
Corresponding author: Aston-Jones, Gary
ORCID: Mahler, Stephen V.
Moorman, David E.
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2012
Volume: 198
Pages: 79-121
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/b978-0-444-59489-1.00007-0
PMC: PMC3643893
OpenAlex: W4211199394
Cited by: 215
References: 320
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 15 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 19 · 2014: 26 · 2013: 17 · 2012: 3
FWCI: 23.33
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (P50AA010761)
National Institute on Drug Abuse (F32DA031519, R37DA006214, R21DA032005, F32DA026692, P50DA015369)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: orexin, drug addiction, drug-seeking behavior, reward, food reward, contextual cues, stress, neural circuits, ventral tegmental area, glutamate, arousal, wakefulness
MeSH terms: Orexins, Animals, Brain, Humans, Motivation, Neuropeptides, Substance-Related Disorders, Intracellular Signaling Peptides and Proteins

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Multiple roles for orexin/hypocretin in addiction

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