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The Role of Orexins/Hypocretins in Alcohol Use and Abuse

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Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

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Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

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Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence

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Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value

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Identification of discrete, intermingled hypocretin neuronal populations

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Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats

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Suvorexant to treat alcohol use disorder and comorbid insomnia: Plan for a phase II trial

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Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal

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Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

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Introduction to the Special Issue: “Making orexin-based therapies for addiction a reality: What are the steps from here?”

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Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence

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Alternative use of suvorexant (Belsomra®) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence

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Orexin in Patients with Alcohol Dependence Treated for Relapse Prevention: A Pilot Study

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Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats

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Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future

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The effect of orexin 1 and orexin 2 receptors antagonisms in the basolateral amygdala on memory processing in a passive avoidance task

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Different Molecular/Behavioral Endophenotypes in C57BL/6J Mice Predict the Impact of OX1 Receptor Blockade on Binge-Like Ethanol Intake

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Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?

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Faculty Opinions recommendation of Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.

de Lecea, L. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726068380.793550010

Chronic but not acute morphine exposure reversibly impairs spike generation and repetitive firing in a functionally distinct subpopulation of orexin neuronsPreprint

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Investigating the effects of orexin receptor 1 antagonism on decision making under uncertainty

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Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

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