The DOI matches its Crossref record; 150 of the 152 references it cites were found in a registry or an index.
Dietary Vitamin C in Human Health
Abstract
Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries. The daily intake (dose) and the corresponding systemic concentrations (response) are related in a saturable relationship, and low systemic vitamin C concentrations in observational studies are associated with negative health outcomes. However, there is no evidence that vitamin C supplementation impacts the risks for all-cause mortality, impaired cognitive performance, reduced quality of life, the development of eye diseases, infections, cardiovascular disease, and cancers. This might be related to the fact that prevention would not be realized by supplementation in populations already adequately supplied through dietary sources. Recent genetic association studies indicate that the dietary intake might not be the sole determinant of systemic concentrations, since variations in genes participating in redox homeostasis and vitamin C transport had been associated with lowered plasma concentrations. However, impact sizes are generally low and these phenomena might only affect individual of suboptimal dietary supply.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Typical symptoms of scurvy are muscle weakness, swollen and bleeding gums, loss of teeth, petechial hemorrhaging, spontaneous ecchymoses, anemia, impaired would healing, hyperkeratosis, weakness, myalgia, arthralgia, and weight loss”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“As already discussed, smokers are at much higher risk [2].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“Moreover, vitamin C deficiency is associated with higher C-reactive protein levels and with higher mortality [2,175,177].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“However, this relationship seems to be valid only for inadequate plasma levels.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“Higher levels of plasma vitamin C are correlated with a lower risk of coronary artery disease and mortality in terms of cardiovascular diseases.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“They are, therefore, fully dependent on vitamin C intake from the diet [1,2,3].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“In contrast to most of the vertebrates, guinea pigs, bats, passeriform birds, and primates, including humans, lack L-gulono-1,4-lactone oxidase, and, hence, cannot synthesize vitamin C.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“The pKa of ascorbic acid is 4.1–4.2. Hence, it is present completely as a monoanion—ascorbate at the physiological pH [1,2,4,68].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“The influence of genetic variations on vitamin C pharmacokinetics is based on single nucleotide polymorphisms (SNPs) found in SLC23A1 and SLC23A2 genes with a possible association to human diseases (reviewed in References [2,6]).”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“An effect of individual SNPs on the vitamin C system level has an additive character, which depends on genotype and an allele dosage (additive) effect that was also described.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“Biochemically, vitamin C plasma levels below 11 µM are considered to coincide with clinical symptoms of scurvy.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“Similarly, symptoms are not seen unless the total vitamin C content in the body falls below 300–400 mg [2,3,6,157,170].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“As mentioned, patients with cancer often have lower plasma levels of vitamin C than healthy adults.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“In adequate vitamin C plasma levels, supplementation with vitamin C has a little effect [2,5,189].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [2]
In the citing paper
“However, due to a genetic mutation of the L-gulonolactone oxidase gene in the last step of the synthesis pathway, humans have lost the ability to make vitamin C and thus must obtain it from the diet134.”
In the citing paper
“In advanced cases, scurvy may occur, presenting with severe fatigue, musculoskeletal pain, gingival hypertrophy, and widespread hemorrhagic manifestations [38].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [38]
Citations
Cites
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Self-citationAscorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Blot, W. J., Li, J., Taylor, P. R., Guo, W., Dawsey, S. M., Wang, G.-Q., Yang, C. S., Zheng, S., Gail, M. H., Li, G.-Y., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.18.1483 · Cited by 1,758
COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy
Prockop, D. J., & Kivirikko, K. I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002155 · Cited by 1,625
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
Vitamins C and E: Beneficial effects from a mechanistic perspective
Traber, M. G., & Stevens, J. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.017 · Cited by 1,076
Herçberg, S., Galan, P., Preziosi, P., Bertrais, S., Mennen, L. I., Malvy, D. J.-M., Roussel, A., Favier, A. E., & Briançon, S. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.21.2335 · Cited by 989
Sesso, H. D. (2008) · JAMA · doi:10.1001/jama.2008.600 · Cited by 913
Flagged first, then by citations
2 of the 152 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Bechthold, 2015, Updated ‘reference values for the nutrient supply', Ernahrungs Umschau, 62
- Delanghe, 1998, Haptoglobin polymorphism, iron metabolism and mortality in HIV infection, AIDS, 12, 1027, 10.1097/00002030-199809000-00010 · DOI · Paper page
- Lane, 2013, Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism, American Journal of Hematology, 88, E189
Cited by
Sorted by citations
Cellular Red-Ox system in health and disease: The latest update
Jena, A. B., Samal, R. R., Bhol, N. K., & Duttaroy, A. K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114606 · Cited by 587
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553
Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020) · Nutrients · doi:10.3390/nu12051501 · Cited by 455
Perut, F., Roncuzzi, L., Avnet, S., Massa, A., Zini, N., Sabbadini, S., Giampieri, F., Mezzetti, B., & Baldini, N. (2021) · Biomolecules · doi:10.3390/biom11010087 · Cited by 341
Wound Healing: A Comprehensive Review
Almadani, Y. H., Vorstenbosch, J., Davison, P. G., & Murphy, A. M. (2021) · Seminars in Plastic Surgery · doi:10.1055/s-0041-1731791 · Cited by 369
Oxidative Stress in Traumatic Brain Injury
Fesharaki‐Zadeh, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113000 · Cited by 241
The Emerging Role of Vitamin C as a Treatment for Sepsis
Kashiouris, M. G., L’Heureux, M., Cable, C. A., Fisher, B. J., Leichtle, S. W., & Fowler, A. A. (2020) · Nutrients · doi:10.3390/nu12020292 · Cited by 177
Pawłowska, E., Szczepańska, J., & Błasiak, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7286737 · Cited by 178
Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161
Antioxidant Therapies in Traumatic Brain Injury
Pietro, V. D., Yakoub, K. M., Caruso, G., Lazzarino, G., Signoretti, S., Barbey, A. K., Tavazzi, B., Lazzarino, G., Belli, A., & Amorini, A. M. (2020) · Antioxidants · doi:10.3390/antiox9030260 · Cited by 102
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92
Wearable Sensor for Continuous Sweat Biomarker Monitoring
Qiao, Y., Qiao, L., Chen, Z., Liu, B., Gao, L., & Zhang, L. (2022) · Chemosensors · doi:10.3390/chemosensors10070273 · Cited by 91
Darvin, M. E., Lademann, J. M., von Hagen, J., Lohan, S. B., Kolmar, H., Meinke, M. C., & Jung, S. (2022) · Antioxidants · doi:10.3390/antiox11081451 · Cited by 93
Das, R., Nag, S., & Banerjee, P. (2023) · Molecules · doi:10.3390/molecules28031259 · Cited by 94
Wang, L., Wei, T., Zheng, L., Jiang, F., Ma, W., Lu, M., Wu, X., & An, H. (2023) · Foods · doi:10.3390/foods12051051 · Cited by 84
Omics Technologies to Enhance Plant Based Functional Foods: An Overview
Nayak, S. N., Aravind, B., Malavalli, S. S., Sukanth, B. S., Poornima, R., Bharati, P., Hefferon, K. L., Kole, C., & Puppala, N. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.742095 · Cited by 83
Regulation of gut microbiota by vitamin C, vitamin E and β-carotene
Li, X., Meng, L., Shen, L., & Ji, H. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112749 · Cited by 85
Fruit composition profile of pepper, tomato and eggplant varieties grown under uniform conditions
Rosa-Martínez, E., García-Martínez, M. D., Adalid-Martínez, A. M., Pereira-Dias, L., Casanova, C., Soler, E., Figàs, M. R., Raigón, M. D., Plazas, M., Soler, S., et al. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110531 · Cited by 77
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Fu, Y., Xu, F., Jiang, L., Miao, Z., Liang, X., Yang, J., Larsson, S. C., & Zheng, J. (2021) · BMC Medicine · doi:10.1186/s12916-021-02041-1 · Cited by 73
Fraj, J., Petrović, L., Đekić, L., Budinčić, J. M., Bučko, S., & Katona, J. M. (2020) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2020.110353 · Cited by 68
Castiglione, D., Platania, A., Conti, A., Falla, M., D’Urso, M., & Marranzano, M. (2018) · Antioxidants · doi:10.3390/antiox7070079 · Cited by 67
Stelluti, S., Caser, M., Demasi, S., & Scariot, V. (2021) · Plants · doi:10.3390/plants10030523 · Cited by 62
Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury
Li, L., Li, Y., Fan, Z., Wang, X., Li, Z., Wen, J., Deng, J., Tan, D., Pan, M., Hu, X., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00108 · Cited by 60
Effects of vitamin C supplementation on essential hypertension
Guan, Y., Dai, P., & Wang, H. (2020) · Medicine · doi:10.1097/md.0000000000019274 · Cited by 60
Impact of Nutrition on Pulmonary Arterial Hypertension
Callejo, M., Barberà, J. A., Duarte, J., & Pérez‐Vizcaíno, F. (2020) · Nutrients · doi:10.3390/nu12010169 · Cited by 61
See, X. Z., Yeo, W. S., & Saptoro, A. (2024) · Process Safety and Environmental Protection · doi:10.1016/j.cherd.2024.04.048 · Cited by 65
Grobelna, A., Kalisz, S., & Kieliszek, M. (2019) · Agronomy · doi:10.3390/agronomy9120860 · Cited by 56
The Role of Dietary Nutrients in Peripheral Nerve Regeneration
Soury, M. E., Fornasari, B. E., Carta, G., Zen, F. D., Haastert‐Talini, K., & Ronchi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147417 · Cited by 57
Godlewska, K., Pacyga, P., Najda, A., & Michalak, I. (2023) · Molecules · doi:10.3390/molecules28145572 · Cited by 72
Quiles, J. L., Rivas‐García, L., Varela‐López, A., Llopis, J., Battino, M. A., & Sánchez‐González, C. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110053 · Cited by 53
Guevara, L., Domínguez-Anaya, M. Á., Palomo, A. O., González‐Gordo, S., Díaz, C., Vicente, F., Corpas, F. J., del Palacio, J. P., & Palma, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094476 · Cited by 60
Fan, H., Lee, H.-F., Yue, C.-T., & Chi, C. (2021) · Life · doi:10.3390/life11111111 · Cited by 51
Yusuf, E. H., Tkacz, K., Turkiewicz, I. P., Wojdyło, A., & Nowicka, P. (2021) · European Food Research and Technology · doi:10.1007/s00217-021-03857-0 · Cited by 50
Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health
Murererehe, J., Uwitonze, A. M., Nikuze, P., Patel, J. D., & Razzaque, M. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.805809 · Cited by 47
Functional food: complementary to fight against COVID-19
Farzana, M., Shahriar, S., Jeba, F. R., Tabassum, T., Araf, Y., Ullah, M. A., Tasnim, J., Chakraborty, A., Naima, T. A., Marma, K. K. S., et al. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00217-z · Cited by 45
Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy
Firczuk, M., Bajor, M., Graczyk‐Jarzynka, A., Fidyt, K., Góral, A., & Zagożdżon, R. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.037 · Cited by 45
The Potential of Cryptophyte Algae in Biomedical and Pharmaceutical Applications
Abidizadegan, M., Peltomaa, E., & Blomster, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.618836 · Cited by 47
Luo, K., Li, X., Wang, L., Rao, W., Wu, Y., Liu, Y., Pan, M., Huang, D., Zhang, W., & Mai, K. (2021) · Antioxidants · doi:10.3390/antiox10091449 · Cited by 43
Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review
Brzezińska, O. E., Styrzyński, F., Makowska, J. S., & Walczak, K. (2021) · Nutrients · doi:10.3390/nu13020701 · Cited by 46
Susa, F., & Pisano, R. (2023) · Processes · doi:10.3390/pr11113167 · Cited by 41
Metabolites, Nutritional Quality and Antioxidant Activity of Red Radish Roots Affected by Gamma Rays
EL-BELTAGI, H. S., Maraei, R. W., Shalaby, T., & Aly, A. A. (2022) · Agronomy · doi:10.3390/agronomy12081916 · Cited by 37
Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment
Das, S., Sakr, H. F., Al‐Huseini, I., Jetti, R., Al-Qasmi, S., Sugavasi, R., & Sirasanagandla, S. R. (2023) · Plants · doi:10.3390/plants12122278 · Cited by 37
Vitamin C Modes of Action in Calcium-Involved Signaling in the Brain
Żylińska, L., Lisek, M., Guo, F., & Boczek, T. (2023) · Antioxidants · doi:10.3390/antiox12020231 · Cited by 38
Trends in Vitamin C consumption in the United States: 1999-2018
Brauchla, M., Dekker, M. J., & Rehm, C. D. (2021) · Nutrients · doi:10.3390/nu13020420 · Cited by 35
Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease
Gordon, B. L., Galati, J. S., Yang, S., Longman, R., Lukin, D. J., Scherl, E., & Battat, R. J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i33.4834 · Cited by 35
Exosomes isolated from citrus lemon: a promising candidate for the treatment of Alzheimer's disease
Dolma, L., Damodaran, A., Panonnummal, R., & Nair, S. C. (2024) · Therapeutic Delivery · doi:10.1080/20415990.2024.2354119 · Cited by 38
Amorini, A. M., Listorti, I., Bilotta, G., Pallisco, R., Saab, M. W., Mangione, R., Manca, B., Lazzarino, G., Tavazzi, B., Lazzarino, G., et al. (2021) · Antioxidants · doi:10.3390/antiox10020220 · Cited by 40
Diep, T. T., Pook, C. J., Rush, E. C., & Yoo, M. J. Y. (2020) · Foods · doi:10.3390/foods9060769 · Cited by 33
Vitamin C and Its Role in Periodontal Diseases - The Past and the Present: A Narrative Review.
van der Velden, U. (2020) · PubMed Central · doi:10.3290/j.ohpd.a44306 · Cited by 33
Deng, H., Xia, H., Guo, Y., Liu, X., Lin, L., Wang, J., Xu, K., Lv, X., Hu, R., & Liang, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105808 · Cited by 31
Hung, K., Chuang, M., Chen, J., Hsu, C., Chiu, C., Chang, Y.-J., Lee, C., Chen, I., & Sun, C. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1094757 · Cited by 30
Mechanisms of Mitochondrial Oxidative Stress in Brain Injury: From Pathophysiology to Therapeutics
Nguyen, A., Patel, A. B., Kioutchoukova, I. P., Diaz, M. J., & Lucke-Wold, B. P. (2023) · Oxygen · doi:10.3390/oxygen3020012 · Cited by 30
Vitamin C fortification: need and recent trends in encapsulation technologies
Maurya, V. K., Shakya, A., McClements, D. J., Srinivasan, R., Bashir, K., Ramesh, T., Lee, J., & Sathiyamoorthi, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1229243 · Cited by 37
Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury
Guo, J., Li, L., Xu, Y., Wang, X., Liu, J., Hu, X., Tan, D., & Li, Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300459 · Cited by 29
dos Santos, D. C., Filho, J. G. D. O., de Sousa, T. L., Ribeiro, C. B., & Egea, M. B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1916430 · Cited by 32
Dietary phytochemicals targeting Nrf2 for chemoprevention in breast cancer
Wang, P., Long, F., Lin, H., & Wang, T. (2022) · Food & Function · doi:10.1039/d2fo00186a · Cited by 28
Conner, T. S., Fletcher, B. C., Haszard, J. J., Pullar, J. M., Spencer, E. S., Mainvil, L. A., & Vissers, M. C. M. (2020) · Nutrients · doi:10.3390/nu12092898 · Cited by 30
Muñoz-Sánchez, G., Godínez-Méndez, L. A., Fafutis‐Morris, M., & Delgado‐Rizo, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713162 · Cited by 28
Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment
Banella, C., Catalano, G., Travaglini, S., Pelosi, E., Ottone, T., Zaza, A., Guerrera, G., Angelini, D. F., Niscola, P., Divona, M., et al. (2022) · Cancers · doi:10.3390/cancers14102565 · Cited by 26
Purpura, M., Jäger, R., Godavarthi, A., Bhaskarachar, D., & Tinsley, G. M. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03487-8 · Cited by 24
Fiorani, M., Guidarelli, A., & Cantoni, O. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721604 · Cited by 24
Xu, Y., Guo, X., Wang, G., & Zhou, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00645 · Cited by 23
From Orchard to Wellness: Unveiling the Health Effects of Sweet Cherry Nutrients
Gonçalves, B. C., Aires, A., Oliveira, I. V., Baltazar, M., Cosme, F., Afonso, S., Pinto, T., Anjos, R., Inês, A., Morais, M. C., et al. (2024) · Nutrients · doi:10.3390/nu16213660 · Cited by 26
Haraguchi, Y., & Shimizu, T. (2021) · Biotechnology Letters · doi:10.1007/s10529-021-03106-0 · Cited by 23
Li, J., Zhang, J., Yang, X., Kong, A., Wang, N., Tang, J., & Yu, X. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142158 · Cited by 21
Scurvy: old disease, new lessons
Kinlin, L. M., & Weinstein, M. (2023) · Paediatrics and International Child Health · doi:10.1080/20469047.2023.2262787 · Cited by 21
Bermejo, N. F., & Munné‐Bosch, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134880 · Cited by 20
Elhessy, H. M., Habotta, O. A., Eldesoqui, M. B., Elsaed, W. M., Soliman, M. F. M., Sewilam, H. M., Elhassan, Y. H., & Lashine, N. H. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1090738 · Cited by 20
Borran, M., Dashti‐Khavidaki, S., Alamdari, A., & Naderi, N. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.12.017 · Cited by 20
Nutrient Composition and Physical Properties of Two Orange Seed Varieties
Adubofuor, J., Akyereko, Y. G., Batsa, V., Apeku, O.-J. D., Amoah, I., & Diako, C. (2021) · International Journal of Food Science · doi:10.1155/2021/6415620 · Cited by 19
Insect Models in Nutrition Research
Tonk, M., Vilcinskas, A., & Wagner, A. E. (2022) · Biomolecules · doi:10.3390/biom12111668 · Cited by 19
Alternative pathways leading to ascorbate biosynthesis in plants: lessons from the last 25 years
Quiñones, C. O., Gesto-Borroto, R., Wilson, R. V., Hernández-Madrigal, S. V., & Lorence, A. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae120 · Cited by 19
Review: Colostrum as an Emerging food: Nutraceutical Properties and Food Supplement
Ceniti, C., Costanzo, N., Morittu, V. M., Tilocca, B., Roncada, P., & Britti, D. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2034165 · Cited by 19
Frontiers in Topical Photoprotection
Sullivan, M., Obezo, C. G., Lipsky, Z. W., Panchal, A., & Jensen, J. (2025) · Cosmetics · doi:10.3390/cosmetics12030096 · Cited by 22
Cristofano, F., El‐Nakhel, C., Colla, G., Cardarelli, M., Pii, Y., Lucini, L., & Rouphael, Y. (2022) · Antioxidants · doi:10.3390/antiox12010107 · Cited by 19
Mitsopoulou, A.-V., Magriplis, E., Michas, G., Micha, R., Chourdakis, M., Chrousos, G. P., Roma, E. S., Panagiotakos, D. B., Zampelas, A., Karageorgou, D., et al. (2021) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12840 · Cited by 18
Overview of Phytochemical Composition of Brassica oleraceae var. capitata Cultivars
Statilko, O., Tsiaka, T., Sinanoglou, V. J., & Strati, I. F. (2024) · Foods · doi:10.3390/foods13213395 · Cited by 17
Anderson, M. J., Ibrahim, A. S., Cooper, B. R., Woolcock, A. D., Moore, G. E., & Taylor, S. D. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15896 · Cited by 16
Han, Z., Zhang, Z., Guan, Y., Chen, B., Yu, M., Zhang, L., Fang, J., Gao, Y., & Guo, Z. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.120 · Cited by 18
Behairy, A., Mohamed, W. A. M., Ebraheim, L. L. M., Soliman, M. M., Abd‐Elhakim, Y. M., El-Sharkawy, N. I., Saber, T. M., & Deib, M. M. E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.651497 · Cited by 17
Spricigo, P. C., Correia, B. S. B., Borba, K. R., Taver, I. B., Machado, G. D. O., Wilhelms, R. Z., Júnior, L. H. K. Q., Jacomino, Â. P., & Colnago, L. A. (2021) · Molecules · doi:10.3390/molecules26123613 · Cited by 17
Ren, Y., Zhang, D., Cheng, B., Bo, C., Yue, L., Cao, X., Wang, C., & Wang, Z. (2025) · ACS Agricultural Science & Technology · doi:10.1021/acsagscitech.4c00651 · Cited by 16
ACE-Vitamin Index and Risk of Glaucoma: The SUN Project
Moreno‐Montañés, J., Gándara, E., Moreno‐Galarraga, L., Hershey, M. S., López‐Gil, J. F., Kales, S. N., Bes‐Rastrollo, M., Martínez‐González, M. Á., & Fernández‐Montero, A. (2022) · Nutrients · doi:10.3390/nu14235129 · Cited by 16
Li, J., Wang, Z., Zhang, Y., Cao, X., Lian, F., & Gu, S. (2023) · Environmental Science Nano · doi:10.1039/d2en00918h · Cited by 15
Pei, X., Yao, J., Ran, S., Lu, H., Yang, S., Zhang, Y., Wang, M., Shi, H., & Tan, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1167317 · Cited by 15
Zhang, Z., Bao, C., Li, Z., He, C., Jin, W., Li, C., & Chen, Y. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12841-5 · Cited by 15
Karki, N., Achhami, H., Pachhai, B. B., Bhattarai, S., Shahi, D. K., Bhatt, L. R., & Joshi, M. K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40773 · Cited by 15
Xu, C., Yi, T., Tan, S., Xu, H., Hu, Y., Ma, J., & Xu, J. (2023) · Nutrients · doi:10.3390/nu15081848 · Cited by 13
Apoptosis induction in ascorbic acid treated human colorectal cancer cell lines (Caco-2)
Mustafa, N. N., El-Desouky, M. A., Shawush, N. A., & Hanna, D. H. (2025) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2025.2465679 · Cited by 14
Vitamin C for COVID-19 Treatment: Have We Got Enough Evidence?
Ahmad, S. R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.892561 · Cited by 13
Feng, Y., Wang, C., Chen, F., Cao, X., Wang, J., Yue, L., & Wang, Z. (2022) · Environmental Science Nano · doi:10.1039/d2en00783e · Cited by 12
Shi, S., Wang, K., Ugai, T., Giannakis, M., Cazaubiel, J., Chan, A. T., Giovannucci, E. L., Nowak, J. A., Meyerhardt, J. A., Ogino, S., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02452-2 · Cited by 12
Grădinaru, A. C., & Popa, S. (2025) · Life · doi:10.3390/life15020238 · Cited by 14
Xiao, F., Farag, M. A., Xiao, J., Yang, X., Liu, Y., Shen, J., & Lu, B. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109091 · Cited by 13
Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review
Mehta, N., Pokharna, P., & Shetty, S. R. (2022) · Nutrition and Health · doi:10.1177/02601060221139628 · Cited by 16
Silva, A. L. L. E., dos Santos, D. C., de Sousa, T. L., Silva, F. G., & Egea, M. B. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103950 · Cited by 12
Frolova, A. S., Fokina, A., Milentyeva, I., Asyakina, L. K., Proskuryakova, L. A., & Prosekov, A. Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063263 · Cited by 11
Song, Y., Cai, X., Bu, X., Liu, S., Song, M., Yang, Y., Wang, X., Shi, Q., Qin, J., & Chen, L. (2023) · Aquaculture Nutrition · doi:10.1155/2023/7228854 · Cited by 11
THE NUTRITIONAL VALUE AND HEALTH BENEFITS OF SWEET CORN KERNELS (ZEA MAYS SSP. SACCHARATA)
Baranowska, A. (2023) · Health Problems of Civilization · doi:10.5114/hpc.2023.133364 · Cited by 10
Salicornia europaea L. and Suaeda maritima (L.) Dumort: bioactive compounds and future perspectives
Dzhoglova, V., Ivanov, K., Karcheva-Bahchevanska, D. P., Koleva, N., Bozhkova, M. K., Benbassat, N., & Ivanova, S. (2024) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2024.2326291 · Cited by 10
Metadata
- Authors
- Granger, M., & Eck, P.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Eck, Peter
- Venue
- Advances in food and nutrition research
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 83
- Pages
- 281-310
- ISSN
- 1043-4526 (ISSN-L)
- OpenAlex
- W2790046020
- Cited by
- 217
- References
- 152
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 39 · 2023: 33 · 2022: 28 · 2021: 40 · 2020: 25 · 2019: 10 · 2018: 2
- FWCI
- 48.38
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in food and nutrition research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C intake, vitamin C, scurvy, vitamin C supplementation, gene-nutrient interactions, redox homeostasis, plasma vitamin C concentration, coronary artery disease, stroke, cancer prevention, all-cause mortality, cognitive performance, eye diseases, infection
- MeSH terms
- Ascorbic Acid, Diet, Haptoglobins, Homeostasis, Humans, Scurvy, Vitamins, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
