Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors

McKay, Bruce E.; Placzek, Andon N.; Dani, John A.

doi:10.1016/j.bcp.2007.07.001

Cited by 181Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors

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McKay, Bruce E., Placzek, Andon N., Dani, John A.·2007·Biochemical Pharmacology

DOI 10.1016/j.bcp.2007.07.001PMC PMC2047292

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Abstract

Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and participate in a variety of physiological functions. Recent advances have revealed roles of nAChRs in the regulation of synaptic transmission and synaptic plasticity, particularly in the hippocampus and midbrain dopamine centers. In general, activation of nAChRs causes membrane depolarization and directly and indirectly increases the intracellular calcium concentration. Thus, when nAChRs are expressed on presynaptic membranes their activation generally increases the probability of neurotransmitter release. When expressed on postsynaptic membranes, nAChR-initiated calcium signals and depolarization activate intracellular signaling mechanisms and gene transcription. Together, the presynaptic and postsynaptic effects of nAChRs generate and facilitate the induction of long-term changes in synaptic transmission. The direction of hippocampal nAChR-mediated synaptic plasticity - either potentiation or depression - depends on the timing of nAChR activation relative to coincident presynaptic and postsynaptic electrical activity, and also depends on the location of cholinergic stimulation within the local network. Therapeutic activation of nAChRs may prove efficacious in the treatment of neuropathologies where synaptic transmission is compromised, as in Alzheimer's or Parkinson's disease.

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A sign switch of synaptic plasticity, necessary in the D network when the target remains real during the REM phase, was experimentally observed by the action of acetylcholine and is also involved in the regulation of REM sleep.
“A sign switch of synaptic plasticity (necessary in the D network when the target remains real during the REM phase) was experimentally observed by the action of acetylcholine [36] and is also involved in the regulation of REM sleep [19].”
From How Adversarial REM Dreams May Facilitate Creativity, and Why We Become Aware of Them (2024) · cites this paper as [36]
An important role for both nicotinic and muscarinic acetylcholine receptors has been defined in hippocampal synaptic plasticity.
“An important role for both nAChRs and mAChRs has been defined in hippocampal synaptic plasticity (reviewed in (Giocomo and Hasselmo, 2007; McKay et al., 2007)) and these effects are mediated through intracellular signaling pathways downstream of mAChRs and nAChRs (reviewed in (Berg and Conroy, 2002; Cancela, 2001; Lanzafame et al., 2003; Rathouz et al., 1996)).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as McKay et al., 2007

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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Neuromodulation of neurons and synapses
Farzan Nadim, A., & Bucher, D. M. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.05.003 · Cited by 340 · see citing works
The Allen Brain Atlas: 5 years and beyond
Jones, A. R., Overly, C. C., & Sunkin, S. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2722 · Cited by 322 · see citing works
Tobacco and nicotine use
Le Foll, B., Piper, M. E., Fowler, C. D., Tonstad, S., Bierut, L., Lu, L., Jha, P., & Hall, W. D. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00346-w · Cited by 316 · see citing works
Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine
Dani, J. A. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.07.001 · Cited by 309 · see citing works
Self-citation
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
Shen, J., & Yakel, J. L. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.64 · Cited by 242 · see citing works
Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease
Parri, H. R., Hernandez, C. M., & Dineley, K. T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.039 · Cited by 201 · see citing works
Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?
Esposito, Z., Belli, L., Toniolo, S., Sancesario, G., Bianconi, C., & Martorana, A. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12095 · Cited by 198 · see citing works
α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson’s Disease
Quik, M., & Wonnacott, S. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003269 · Cited by 194 · see citing works
GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia
Xu, M., & Wong, A. H. C. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.172 · Cited by 159 · see citing works
Presynaptic α7- and β2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms
Dickinson, J. A., Kew, J. N. C., & Wonnacott, S. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046623 · Cited by 159 · see citing works
Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
Fabiani, C., & Antollini, S. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00309 · Cited by 152 · see citing works
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00677-x · Cited by 148 · see citing works
The cholinergic system and depression
Dagytė, G., den Boer, J. A., & Trentani, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.023 · Cited by 126 · see citing works
Nicotinic Acetylcholine Receptor Agonists for the Treatment of Alzheimer’s Dementia: An Update
Hoskin, J. L., Al-Hasan, Y. M., & Sabbagh, M. N. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty116 · Cited by 123 · see citing works
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease
Barreto, G. E., Iarkov, A., & Echeverrı́a, V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00340 · Cited by 116 · see citing works
Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders
Ruggiero, R. N., Rossignoli, M. T., Marques, D. B., de Sousa, B. M., Romcy-Pereira, R. N., Lopes-Aguiar, C., & Leite, J. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.732360 · Cited by 111 · see citing works
Molecular and Cellular Mechanisms of Action of Nicotine in the CNS
Barik, J., & Wonnacott, S. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_7 · Cited by 108 · see citing works
Nicotinergic Impact on Focal and Non-Focal Neuroplasticity Induced by Non-Invasive Brain Stimulation in Non-Smoking Humans
Thirugnanasambandam, N., Grundey, J., Adam, K., Drees, A., Skwirba, A. C., Lang, N., Paulus, W., & Nitsche, M. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.227 · Cited by 91 · see citing works
Are nicotinic acetylcholine receptors coupled to G proteins?
Kabbani, N., Nordman, J. C., Corgiat, B. A., Veltri, D., Shehu, A., Seymour, V. A. L., & Adams, D. J. (2013) · BioEssays · doi:10.1002/bies.201300082 · Cited by 87 · see citing works
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition
Richter, M., Ludewig, S., Winschel, A., Abel, T., Bold, C. S., Salzburger, L., Klein, S., Han, K., Weyer, S. W., Fritz, A., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798335 · Cited by 86 · see citing works
The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus
Cheng, Q., & Yakel, J. L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.015 · Cited by 85 · see citing works
Characterization of 2-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Dinklo, T., Shaban, H., Thuring, J. W., Lavreysen, H., Stevens, K. E., Zheng, L., Mackie, C. E., Grantham, C., Vandenberk, I., Meulders, G., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.173245 · Cited by 79 · see citing works
Nicotinic mechanisms influencing synaptic plasticity in the hippocampus
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.39 · Cited by 77 · see citing works
Self-citation
Modulation of Ion Channels in the Axon: Mechanisms and Function
Burke, K. J., & Bender, K. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00221 · Cited by 75 · see citing works
Targeting α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia
Hajós, M., & Rogers, B. N. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361434 · Cited by 73 · see citing works
Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission
Arnáiz‐Cot, J. J., Gonzalez, J., Sobrado, M., Baldelli, P., Carbone, E., Gandı́a, L., Garcı́a, A. G., & Hernández-Guijo, J. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06077.x · Cited by 69 · see citing works
Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 68 · see citing works
Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus
Parameshwaran, K., Buabeid, M. A., Karuppagounder, S. S., Uthayathas, S., Thiruchelvam, K., Shonesy, B. C., Dityatev, A. E., Escobar, M. E., Dhanasekaran, M., & Suppiramaniam, V. D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0805-4 · Cited by 67 · see citing works
Cellular and organismal function of choline metabolism
Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 66 · see citing works
The Voltage-Gated Calcium Channel Functions as the Molecular Switch of Synaptic Transmission
Atlas, D. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080411-121438 · Cited by 65 · see citing works
Peptide-mediated drug delivery across the blood-brain barrier for targeting brain tumors
Jafari, B., Pourseif, M. M., Barar, J., Rafi, M. A., & Omidi, Y. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1614911 · Cited by 65 · see citing works
Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer’s Disease Model Mouse
Shang, J., Yamashita, T., Zhai, Y., Nakano, Y., Morihara, R., Fukui, Y., Hishikawa, N., Ohta, Y., & Abe, K. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151126 · Cited by 64 · see citing works
The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system
Koukouli, F., & Maskos, U. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.018 · Cited by 61 · see citing works
Presynaptic nicotinic receptors modulating neurotransmitter release in the Central Nervous System: Functional interactions with other coexisting receptors
Marchi, M., & Grilli, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.004 · Cited by 59 · see citing works
A Novel Nicotinic Mechanism Underlies β-Amyloid-Induced Neuronal Hyperexcitation
Liu, Q., Xie, X., Lukas, R. J., John, P. A. S., & Wu, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3235-12.2013 · Cited by 60 · see citing works
Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex
Proulx, É., Piva, M., Tian, M. K., Bailey, C. D. C., & Lambe, E. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1481-3 · Cited by 57 · see citing works
Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease
Jürgensen, S., & Ferreira, S. T. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9237-0 · Cited by 57 · see citing works
Enhanced spatial memory and hippocampal long‐term potentiation in p75 neurotrophin receptor knockout mice
Barrett, G. L., Reid, C. A., Tsafoulis, C., Zhu, W.-M., Williams, D. A., Paolini, A. G., Trieu, J., & Murphy, M. (2009) · Hippocampus · doi:10.1002/hipo.20598 · Cited by 57 · see citing works
αConotoxin Arenatus IB[V11L,V16D] Is a Potent and Selective Antagonist at Rat and Human Native α7 Nicotinic Acetylcholine Receptors
Innocent, N., Livingstone, P. D., Hone, A. J., Kimura, A. K., Young, T., Whiteaker, P., McIntosh, J. M., & Wonnacott, S. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.142943 · Cited by 54 · see citing works
Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons
Cheng, Q., & Yakel, J. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.016 · Cited by 51 · see citing works
Nicotine Elicits Prolonged Calcium Signaling along Ventral Hippocampal Axons
Zhong, C., Talmage, D. A., & Role, L. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082719 · Cited by 50 · see citing works
Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis
Vieira-Alves, I., Coimbra-Campos, L. M. C., Sancho, M., da Silva, R., Côrtes, S. F., & Lemos, V. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.621769 · Cited by 48 · see citing works
Nicotine enhances context learning but not context-shock associative learning.
Kenney, J. W., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012807 · Cited by 45 · see citing works
Control of neuronal excitability by GSK-3beta: epilepsy and beyond.
Jaworski, T. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118745 · Cited by 43 · see citing works
Participation of hippocampal cholinergic system in memory persistence for inhibitory avoidance in rats
Parfitt, G. M., Campos, R. C., Barbosa, Â. K., Koth, A. P., & Barros, D. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.12.001 · Cited by 43 · see citing works
Pre‐synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms
Zappettini, S., Grilli, M., Salamone, A., Fedele, E., & Marchi, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00958.x · Cited by 42 · see citing works
Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism
Nagy, J., Kobolák, J., Berzsenyi, S., Ábrahám, Z., Avci, H. X., Bock, I., Bekes, Z., Hodoscsek, B., Chandrasekaran, A., Téglási, A., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.144 · Cited by 61 · see citing works
Nicotinic Receptors, Memory, and Hippocampus
Kutlu, M. G., & Gould, T. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13665-3_6 · Cited by 41 · see citing works
Cellular distribution of the nicotinic acetylcholine receptor α7 subunit in rat hippocampus
Mielke, J. G., & Mealing, G. A. R. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.08.003 · Cited by 36 · see citing works
Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
Echeverrı́a, V., Mendoza, C., & Iarkov, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179611 · Cited by 36 · see citing works
Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization
Wang, H., Salter, C. G., Refai, O., Hardy, H., Barwick, K. E., Akpulat, U., Kvarnung, M., Chioza, B. A., Harlalka, G. V., Taylan, F., et al. (2017) · Brain · doi:10.1093/brain/awx249 · Cited by 35 · see citing works
The development of nicotinic receptors in the human medulla oblongata: Inter-relationship with the serotonergic system
Duncan, J. R., Paterson, D. S., & Kinney, H. C. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.09.006 · Cited by 35 · see citing works
Cholinergic Modulation Differs between Basal and Apical Dendritic Excitation of Hippocampal CA1 Pyramidal Cells
Leung, L.-W. S., & Peloquin, P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp251 · Cited by 35 · see citing works
Presynaptic Nicotinic α7 and Non-α7 Receptors Stimulate Endogenous GABA Release from Rat Hippocampal Synaptosomes through Two Mechanisms of Action
Zappettini, S., Grilli, M., Lagomarsino, F., Cavallero, A., Fedele, E., & Marchi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016911 · Cited by 33 · see citing works
Cellular events in nicotine addiction
Penton, R. E., & Lester, R. A. J. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.01.001 · Cited by 32 · see citing works
Comparing the Effects of Negative and Mixed Emotional Messages on Predicted Occasional Excessive Drinking
Carrera, P., Caballero, A., & Muñoz, D. (2008) · Substance Abuse Research and Treatment · doi:10.1177/117822180800100001 · Cited by 33 · see citing works
Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome
Pardo, M., Beurel, E., & Jope, R. S. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13446 · Cited by 32 · see citing works
Prenatal nicotine exposure alters medullary nicotinic and AMPA-mediated control of respiratory frequency in vitro
Pilarski, J. Q., & Fregosi, R. F. (2009) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2009.07.022 · Cited by 29 · see citing works
A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity
Liu, Q., Xie, X., Emadi, S., Sierks, M. R., & Wu, J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.025 · Cited by 30 · see citing works
Learning cortical representations through perturbed and adversarial dreaming
Deperrois, N., Petrovici, M. A., Senn, W., & Jordan, J. (2022) · eLife · doi:10.7554/elife.76384 · Cited by 28 · see citing works
Transient Receptor Potential Vanilloid 4 Mediates Hypotonicity‐Induced Enhancement of Synaptic Transmission in Hippocampal Slices
Li, L., Yin, J., Jie, P., Lu, Z., Zhou, L., Chen, L., & Chen, L. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12143 · Cited by 26 · see citing works
Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution
Icick, R., Forget, B., Cloëz-Tayarani, I., Pons, S., Maskos, U., & Besson, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108234 · Cited by 26 · see citing works
The Impact of Electronic Nicotine Delivery System (ENDS) Flavors on Nicotinic Acetylcholine Receptors and Nicotine Addiction-Related Behaviors
Cooper, S. Y., & Henderson, B. J. (2020) · Molecules · doi:10.3390/molecules25184223 · Cited by 28 · see citing works
Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex
Tang, B., Luo, D., Yang, J., Xu, X.-Y., Zhu, B.-L., Wang, X.-F., Yan, Z., & Chen, G.-J. (2015) · Scientific Reports · doi:10.1038/srep14099 · Cited by 26 · see citing works
Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions
Wang, J., Kim, J.-M., Donovan, D. M., Becker, K. G., & Li, M. D. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.01.008 · Cited by 25 · see citing works
Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo
Bueno-Júnior, L. S., Lopes‐Aguiar, C., Ruggiero, R. N., Romcy-Pereira, R. N., & Leite, J. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047484 · Cited by 25 · see citing works
Learning cortical representations through perturbed and adversarial dreaming.
Deperrois, N., Petrovici, M. A., Senn, W., & Jordan, J. (2022) · doi:10.48350/169088 · Cited by 24 · see citing works
Recent progress in the structural study of ion channels as insecticide targets
Hadiatullah, H., Zhang, Y., Samurkas, A., Xie, Y., Sundarraj, R., Zuilhof, H. T., Qiao, J., & Yuchi, Z. (2022) · Insect Science · doi:10.1111/1744-7917.13032 · Cited by 24 · see citing works
Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats
Chen, Z., Chen, W., Li, Y., Moos, M. C., Xiao, D., & Wang, C. (2022) · iScience · doi:10.1016/j.isci.2022.104686 · Cited by 25 · see citing works
Pre‐synaptic nicotinic and D2receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens
Grilli, M., Zappettini, S., Zoli, M., & Marchi, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05933.x · Cited by 24 · see citing works
Restoring long-term potentiation impaired by amyloid-beta oligomers: Comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists
Kroker, K. S., Moreth, J., Kußmaul, L., Rast, G. F., & Rosenbrock, H. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.04.006 · Cited by 24 · see citing works
The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature
McGuigan, S., Marie, D. J., O’Bryan, L. J., Flores, F. J., Evered, L. A., SILBERT, B. S., & Scott, D. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225191 · Cited by 22 · see citing works
Choline‐mediated modulation of hippocampal sharp wave–ripple complexesin vitro
Fischer, V., Both, M., Draguhn, A., & Egorov, A. V. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12693 · Cited by 20 · see citing works
Innovative approaches in acetylcholinesterase inhibition: a pathway to effective Alzheimer’s disease treatment
Arora, P., Swati, Rani, S., Jha, S., Gupta, S., & Kumar, S. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11170-1 · Cited by 21 · see citing works
An in silico guided identification of nAChR agonists from Withania somnifera
Remya, C., Dileep, K. V., Variayr, E. J., & Sadasivan, C. (2016) · Frontiers in Life Science · doi:10.1080/21553769.2016.1207569 · Cited by 19 · see citing works
Decremental Response to High-Frequency Trains of Acetylcholine Pulses but Unaltered Fractional Ca2+ Currents in a Panel of “Slow-Channel Syndrome” Nicotinic Receptor Mutants
Elenes, S., Decker, M. M., Cymes, G. D., & Grosman, C. F. (2009) · The Journal of General Physiology · doi:10.1085/jgp.200810089 · Cited by 19 · see citing works
Neuromodulatory potential of Asparagus racemosus and its bioactive molecule Shatavarin IV by enhancing synaptic acetylcholine level and nAChR activity
Smita, S. S., Trivedi, M., Tripathi, D., Rai, S. P., & Pandey, R. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136294 · Cited by 18 · see citing works
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons
Matera, C., Bono, F., Pelucchi, S., Collo, G., Bontempi, L., Gotti, C., Zoli, M., Amici, M. D., Missale, C., Fiorentini, C., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.019 · Cited by 18 · see citing works
Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer's
Butler, T., Goldberg, J. D., Galvin, J. E., Maloney, T., Ravdin, L., Glodzik, L., de Leon, M. J., Hochman, T., Bowen, R. L., & Atwood, C. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106488 · Cited by 18 · see citing works
Kinetic properties and open probability of α7 nicotinic acetylcholine receptors
Pesti, K., Szabo, A. K., Mike, Á., & Vizi, E. S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.034 · Cited by 18 · see citing works
Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction
Jiang, J. W., Li, X., Hu, A., Zhou, G., Gao, Y.-H., Xu, C., Wu, X., & Wang, H. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1670883 · Cited by 18 · see citing works
ATP Induces Synaptic Gene Expressions in Cortical Neurons: Transduction and Transcription Control via P2Y1 Receptors
Siow, N. L., Choi, R. C. Y., Xie, H. Q., Ling Wei, K. O. N. G., Chu, G. K. Y., Chan, G. K.-L., Simon, J., Barnard, E. A., & Tsim, K. W. K. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066506 · Cited by 17 · see citing works
Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane
Westphalen, R. I., Gomez, R. S., & Hemmings, H. C. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aen387 · Cited by 17 · see citing works
High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses: the involvement of NMDA receptors, mGluR5, and (L-type) voltage-gated calcium channelsPreprint
Papatheodoropoulos, C., & Kouvaros, S. (2016) · Learning & Memory · doi:10.1101/lm.042531.116 · Cited by 17 · see citing works
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons
Corsini, S., Tortora, M., & Nistri, A. (2016) · The Journal of Physiology · doi:10.1113/jp272591 · Cited by 16 · see citing works
Quantitative changes of nicotinic receptors in the hippocampus of dystrophin-deficient mice
Ghedini, P. C., Avellar, M. C. W., de Lima, T. C. M., Lima‐Landman, M. T. R., Lapa, A. J., & Souccar, C. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.021 · Cited by 16 · see citing works
Interplay between Gating and Block of Ligand-Gated Ion Channels
Phillips, M. B., Nigam, A., & Johnson, J. W. (2020) · Brain Sciences · doi:10.3390/brainsci10120928 · Cited by 16 · see citing works
Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats
Takahashi, Y., Yamashita, R., Okano, H., Takashima, K., Ogawa, B., Ojiro, R., Tang, Q., Ozawa, S., Woo, G., Yoshida, T., et al. (2021) · Toxicology · doi:10.1016/j.tox.2021.152958 · Cited by 15 · see citing works
Correction: Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo
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Self-citation

Authors: McKay, B. E., Placzek, A. N., & Dani, J. A.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Dani, John A.
ORCID: Dani, John A.
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 2007-10
Volume: 74
Issue: 8
Pages: 1120-1133
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/j.bcp.2007.07.001
PMC: PMC2047292
OpenAlex: W1964188222
Cited by: 181
References: 181
Citations by year: 2026: 8 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 11
FWCI: 5.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Natural Sciences and Engineering Research Council of Canada
National Institute on Drug Abuse
National Institute of Neurological Disorders and Stroke (T32NS043124, R37NS021229, R01NS021229)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, synaptic transmission, synaptic plasticity, hippocampus, midbrain dopamine, presynaptic neurotransmitter release, intracellular signaling, long-term potentiation, long-term depression, cholinergic modulation, Alzheimer's disease, Parkinson's disease
MeSH terms: Animals, Hippocampus, Humans, Synaptic Transmission, Neuronal Plasticity, Receptors, Nicotinic, Signal Transduction, Ventral Tegmental Area, Long-Term Potentiation

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Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors

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