Desensitization of neuronal nicotinic receptors

Quick, Michael W.; Lester, Robin A.J.

doi:10.1002/neu.10109

Cited by 456Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Desensitization of neuronal nicotinic receptors

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Quick, Michael W., Lester, Robin A.J.·2002·Journal of Neurobiology

DOI 10.1002/neu.10109

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Abstract

The loss of functional response upon continuous or repeated exposure to agonist, desensitization , is an intriguing phenomenon if not as yet a well‐defined physiological mechanism. However, detailed evaluation of the properties of desensitization, especially for the superfamily of ligand‐gated ion channels, reveals how the nervous system could make important use of this process that goes far beyond simply curtailing excessive receptor stimulation and the prevention of excitotoxicity. Here we will review the mechanistic basis of desensitization and discuss how the subunit‐dependent properties and regulation of nicotinic acetylcholine receptor (nAChR) desensitization contribute to the functional diversity of these channels. These studies provide the essential framework for understanding how the physiological regulation of desensitization could be a major determinant of synaptic efficacy by controlling, in both the short and long term, the number of functional receptors. This type of mechanism can be extended to explain how the continuous occupation of desensitized receptors during chronic nicotine exposure contributes to drug addiction, and highlights the potential significance of prolonged nAChR desensitization that would also occur as a result of extended acetylcholine lifetime during treatment of Alzheimer's disease with cholinesterase inhibitors. Thus, a clearer picture of the importance of nAChR desensitization in both normal information processing and in various diseased states is beginning to emerge. © 2002 Wiley Periodicals, Inc. J Neurobiol 53: 457–478, 2002

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Desensitized nAChRs have a higher affinity for ACh and other ligands than those in the activatable state.
“Despite the decreased response of AChRs to agonists in the desensitized state, desensitized nAChRs have a higher affinity for ACh and other ligands than those in the “activatable” state (Heidmann et al., 1983; Quick and Lester, 2002);”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Quick and Lester, 2002
Chronic administration of nicotinic agonists can desensitize rather than activate nAChRs, leading to functional antagonism.
“A number of studies have shown that chronic administration of nicotinic agonists (including nicotine through regular smoking or as delivered through the nicotine patch) can desensitize rather than activate nAChRs (Reitstetter et al., 1999), leading to functional antagonism (Gentry and Lukas, 2002; Quick and Lester, 2002).”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Quick and Lester, 2002
Because desensitized nAChR conformations have higher agonist affinity, chronic nicotine exposure causes nAChRs to increasingly adopt desensitized conformations.
“Because desensitized nAChR conformations have a higher affinity for agonist, nAChRs will increasingly adopt desensitized conformations in response to chronic nicotine exposure (Quick and Lester 2002; Picciotto et al. 2008).”
From Nicotine Withdrawal (2015) · cites this paper as Quick and Lester 2002
The dose-response relations of nAChR-lynx complexes agree better with in vivo agonist responses than with nAChRs expressed alone in vitro.
“The dose–response relations of nAChR-lynx complexes agree better with in vivo agonist responses than with nAChRs expressed alone in vitro (115).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [115]

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A quantitative description of membrane current and its application to conduction and excitation in nerve
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191 · see citing works
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate
Katz, B., & Thesleff, S. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005838 · Cited by 1,463 · see citing works
A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy
Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., & Berkovic, S. F. (1995) · Nature Genetics · doi:10.1038/ng1095-201 · Cited by 1,134 · see citing works
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
Sargent, P. B. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002155 · Cited by 1,052 · see citing works
Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
Acetylcholine receptor channel imaged in the open state
Unwin, N. C. (1995) · Nature · doi:10.1038/373037a0 · Cited by 1,011 · see citing works
A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX
Couturier, S., Bertrand, D., Matter, J., Hernandez, M., Bertrand, S., Millar, N. S., Valera, S., BARKAS, T., & Ballivet, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90344-f · Cited by 941 · see citing works
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880 · see citing works
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
Elgoyhen, A. B., Vetter, D. E., Katz, E., Rothlin, C. V., Heinemann, S. F., & Boulter, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051622798 · Cited by 673 · see citing works
Acetylcholine Receptor: An Allosteric Protein
Changeux, J.-P., Devillers-Thiéry, A., & Chemouilli, P. (1984) · Science · doi:10.1126/science.6382611 · Cited by 623 · see citing works
Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist
Sakmann, B. J., Patlak, J. B., & Neher, E. (1980) · Nature · doi:10.1038/286071a0 · Cited by 609 · see citing works
Molecular and cellular aspects of nicotine abuse
Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605 · see citing works
Transmitter timecourse in the synaptic cleft: its role in central synaptic function
Clements, J. D. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10024-2 · Cited by 598 · see citing works
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
Zhou, F.-M., Liang, Y., & Dani, J. A. (2001) · Nature Neuroscience · doi:10.1038/nn769 · Cited by 585 · see citing works
Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
Luetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558 · see citing works
International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits
Lukas, R. J., Changeux, J., Novère, N. G. L., Albuquerque, E. X., Balfour, D. J. K., Berg, D. K., Bertrand, D., Chiappinelli, V. A., Clarke, P. B. S., Collins, A. C., et al. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01406-6 · Cited by 536 · see citing works
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
Revah, F., Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M., & Changeux, J. (1991) · Nature · doi:10.1038/353846a0 · Cited by 524 · see citing works
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Orr-Urtreger, A., Göldner, F., Saeki, M., Lorenzo, I., Goldberg, L., Biasi, M. D., Dani, J. A., Patrick, J., & Beaudet, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 493 · see citing works
The impact of receptor desensitization on fast synaptic transmission
Jones, M. V., & Westbrook, G. L. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80037-3 · Cited by 472 · see citing works
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
Vernino, S. A., Amador, M., Luetje, C. W., Patrick, J., & Dani, J. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90114-s · Cited by 468 · see citing works
Effects of chronic nicotine infusion on tolerance development and nicotinic receptors
Marks, M. J., Burch, J. B., & Collins, A. C. (1983) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21831-6 · Cited by 464 · see citing works
Nicotinic receptors in the brain: correlating physiology with function
Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 447 · see citing works
Regulation of neurotransmitter receptor desensitization by protein phosphorylation
Huganir, R. L., & Greengardt, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90211-w · Cited by 443 · see citing works
Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons
Alkondon, M., Pereira, E. F. R., Cartes, W. S., Maelicke, A., & Albuquerque, E. X. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01702.x · Cited by 441 · see citing works
Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization
Huganir, R. L., Delcour, A. H., Greengard, P., & Hess, G. P. (1986) · Nature · doi:10.1038/321774a0 · Cited by 419 · see citing works
Functional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover
Peng, X., Gerzanich, V, Anand, R., Whiting, P. J., & Lindstrom, J. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09730-5 · Cited by 391 · see citing works
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387 · see citing works
Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation
Mulle, C., Choquet, D., Korn, H., & Changeux, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90115-t · Cited by 351 · see citing works
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 343 · see citing works
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332 · see citing works
Self-citation
Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329 · see citing works
Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions
Conroy, W. G., & Berg, D. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4424 · Cited by 297 · see citing works
Nicotinic receptor function: new perspectives from knockout mice
Cordero‐Erausquin, M., Marubio, L. M., Klink, R., & Changeux, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01489-9 · Cited by 295 · see citing works
In Vivo Regulation of [3H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs
Schwartz, R. D., & Kellar, K. J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb04005.x · Cited by 282 · see citing works
Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies
Whiting, P. J., & Lindström, J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03395.1988 · Cited by 262 · see citing works
Neuronal nicotinic receptors: Molecular organization and regulations
Galzi, J., & Changeux, J. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00034-4 · Cited by 256 · see citing works
Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels
Zhang, Z., Vijayaraghavan, S., & Berg, D. K. (1994) · Neuron · doi:10.1016/0896-6273(94)90161-9 · Cited by 254 · see citing works
Nicotine addiction: the possible role of functional upregulation
Buisson, B., & Bertrand, D. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01979-9 · Cited by 254 · see citing works
Rat α3/β4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function
Xiao, Y., Meyer, E. L., Thompson, J. M., Surin, A. M., Wroblewski, J. T., & Kellar, K. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.2.322 · Cited by 247 · see citing works
alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.
Gerzanich, V., Wang, F., Kuryatov, A., & Lindstrom, J. M. (1998) · PubMed · Cited by 242 · see citing works
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.
Bertrand, D., Devillers‐Thiéry, A., Revah, F., Galzi, J., Hussy, N., Mulle, C., Bertrand, S., Ballivet, M., & Changeux, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1261 · Cited by 241 · see citing works
Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat Hippocampus
McQuiston, A. R., & Madison, D. V. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02887.1999 · Cited by 239 · see citing works
Phosphorylation of ligand‐gated ion channels: a possible mode of synaptic plasticity
Swope, S. L., Moss, S. J., Blackstone, C. D., & Huganir, R. L. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1375568 · Cited by 232 · see citing works
Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.
Palma, E., Bertrand, S., Binzoni, T., & Bertrand, D. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021203 · Cited by 218 · see citing works
Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.
Gerzanich, V., Anand, R., & Lindstrom, J. M. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09916-x · Cited by 218 · see citing works
Activation of ion channels in the frog end‐plate by high concentrations of acetylcholine.
Colquhoun, D. M., & Ogden, D. C. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp016912 · Cited by 216 · see citing works
Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels
Khiroug, S. S., Harkness, P. C., Lamb, P. W., Sudweeks, S. N., Khiroug, L. S., Millar, N. S., & Yakel, J. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013847 · Cited by 215 · see citing works
A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit
Sgard, F., Charpantier, E., Bertrand, S., Walker, N., Caput, D., Graham, D., Bertrand, D., & Besnard, F. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.150 · Cited by 212 · see citing works
Desensitization at the frog neuromuscular junction: a biphasic process
Feltz, A., & Trautmann, A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014036 · Cited by 208 · see citing works
Desensitization of the nicotinic acetylcholine receptor: Molecular mechanisms and effect of modulators
Ochoa, E. L. M., Chattopadhyay, A., & McNamee, M. G. (1989) · Cellular and Molecular Neurobiology · doi:10.1007/bf00713026 · Cited by 206 · see citing works
Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine
Fenster, C. P., Whitworth, T. L., Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04804.1999 · Cited by 204 · see citing works
Self-citation
Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels
Role, L. W. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90112-x · Cited by 196 · see citing works
Downregulation of nicotinic receptor function after chronic nicotine infusion.
Marks, M. J., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39368-7 · Cited by 190 · see citing works
Chronic Nicotine Treatment Up-regulates Human α3β2 but Not α3β4 Acetylcholine Receptors Stably Transfected in Human Embryonic Kidney Cells
Wang, F., Nelson, M. E., Kuryatov, A., Olale, F., Cooper, J., Keyser, K., & Lindstrom, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28721 · Cited by 187 · see citing works
Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorata
Heidmann, T., & Changeux, J. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12893.x · Cited by 185 · see citing works
Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.
Gopalakrishnan, M., Monteggia, L. M., Anderson, D. J., Molinari, E. J., Piattoni-Kaplan, M., Donnelly-Roberts, D., Arneric, S. P., & Sullivan, J. P. (1996) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12264-7 · Cited by 178 · see citing works
Pharmacology of Neuronal Nicotinic Acetylcholine Receptor Subtypes
Colquhoun, L. M., & Patrick, J. W. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60072-1 · Cited by 177 · see citing works
Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · PubMed · Cited by 172 · see citing works
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.
Parker, M. J., Beck, A., & Luetje, C. W. (1998) · PubMed · Cited by 165 · see citing works
[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study.
Perry, D. C., & Kellar, K. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12091-0 · Cited by 163 · see citing works
Neuronal Nicotinic Receptor β2 and β4 Subunits Confer Large Differences in Agonist Binding Affinity
Parker, M. J., Beck, A., & Luetje, C. W. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.1132 · Cited by 161 · see citing works
Agonist-Induced Up-Regulation of α4β2 Nicotinic Acetylcholine Receptors in M10 Cells: Pharmacological and Spatial Definition
Whiteaker, P., Sharples, C. G. V., & Wonnacott, S. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13263-4 · Cited by 152 · see citing works
An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics
Weiland, S., Witzemann, V., Villarroel, A., Propping, P., & Steinlein, O. K. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01215-x · Cited by 151 · see citing works
α3β4 subunit-containing nicotinic receptors dominate function in rat medial habenula neurons
Quick, M. W., Ceballos, R. M., Kasten, M. R., McIntosh, J. M., & Lester, R. A. J. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00024-6 · Cited by 150 · see citing works
Self-citation
Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.
Whiteaker, P., Sharples, C. G., & Wonnacott, S. (1998) · PubMed · doi:10.7270/q2b856pt · Cited by 147 · see citing works
Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C.
Fenster, C. P., Beckman, M. L., Parker, J. C., Sheffield, E. B., Whitworth, T. L., Quick, M. W., & Lester, R. A. J. (1999) · PubMed · Cited by 143 · see citing works
Self-citation
Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method
Wilson, G. G., & Karlin, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1241 · Cited by 138 · see citing works
Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization
Neubig, R. R., Boyd, N. D., & Cohen, J. B. (1982) · Biochemistry · doi:10.1021/bi00257a032 · Cited by 136 · see citing works
Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose‐ and time‐dependent effects of nicotine treatment
Ke, L., Eisenhour, C. M., Bencherif, M., & Lukas, R. J. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37658-x · Cited by 136 · see citing works
Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways
Gopalakrishnan, M., Molinari, E. J., & Sullivan, J. P. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.3.524 · Cited by 132 · see citing works
Choline and acetylcholine have similar kinetic properties of activation and desensitization on the α7 nicotinic receptors in rat hippocampal neurons
Mike, Á., Castro, N. G., & Albuquerque, E. X. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02863-8 · Cited by 131 · see citing works
Neural mechanisms underlying nicotine dependence
Balfour, D. J. K. (1994) · Addiction · doi:10.1111/j.1360-0443.1994.tb03738.x · Cited by 130 · see citing works
Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.
Margiotta, J. F., Berg, D. K., & Dionne, V. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8155 · Cited by 130 · see citing works
Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus
Alkondon, M., Pereira, E. F. R., Almeida, L. E. F., Randall, W. R., & Albuquerque, E. X. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00156-8 · Cited by 129 · see citing works
α5 Subunit Alters Desensitization, Pharmacology, Ca++ Permeability and Ca++ Modulation of Human Neuronal α3 Nicotinic Receptors
Gerzanich, V., Wang, F., Kuryatov, A., & Lindstrom, J. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37589-5 · Cited by 129 · see citing works
Desensitization of Nicotine‐Stimulated [3H]Dopamine Release from Mouse Striatal Synaptosomes
Grady, S. R., Marks, M. J., & Collins, A. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62041390.x · Cited by 126 · see citing works
Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single‐channel behaviour.
Sivilotti, L. G., Mcneil, D. K., Lewis, T., Nassar, M. A., Schoepfer, R., & Colquhoun, D. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022004 · Cited by 126 · see citing works
Substance P enhances cholinergic receptor desensitization in a clonal nerve cell line.
Stallcup, W. B., & Patrick, J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.634 · Cited by 120 · see citing works
Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones.
Mathie, A. A., Colquhoun, D. M., & Cull-Candy, S. G. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018191 · Cited by 119 · see citing works
Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons.
Downing, J. R., & Role, L. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7739 · Cited by 115 · see citing works
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization.
Alkondon, M., Reinhardt, S., Lobron, C., Hermsen, B., Maelicke, A., & Albuquerque, E. X. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22712-4 · Cited by 113 · see citing works
α7 Receptor-selective agonists and modes of α7 receptor activation
Papke, R. L., Meyer, E. M., Nutter, T., & Uteshev, V. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00009-1 · Cited by 110 · see citing works
Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors
Corringer, P., Bertrand, S., Bohler, S., Edelstein, S. J., Changeux, J., & Bertrand, D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00648.1998 · Cited by 108 · see citing works
Activation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists
Briggs, C. A., & McKenna, D. G. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00110-5 · Cited by 108 · see citing works
Intracellular calcium and desensitization of acetylcholine receptors
Miledi, R. (1980) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1980.0106 · Cited by 108 · see citing works
Mammalian Nicotinic Receptors with α7 Subunits That Slowly Desensitize and Rapidly Recover from α-Bungarotoxin Blockade
Cuevas, J., & Berg, D. K. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10335.1998 · Cited by 108 · see citing works
Inactivation of α7 ACh receptors and activation of non-α7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region
Fujii, S., Ji, Z., & Sumikawa, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01076-4 · Cited by 106 · see citing works
Identification of a novel nicotinic binding site in mouse brain using [125I]‐epibatidine
Whiteaker, P., Jimenez, M., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703616 · Cited by 105 · see citing works
Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
Dani, J. A., Radcliffe, K. A., & Pidoplichko, V. I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00003-0 · Cited by 103 · see citing works
Nicotinic acetylcholine receptors containing α7 subunits on rat cortical neurons do not undergo long‐lasting inactivation even when up‐regulated by chronic nicotine exposure
Kawai, H. D., & Berg, D. K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00526.x · Cited by 102 · see citing works
The multiple phenotypes of allosteric receptor mutants.
Galzi, J. L., Edelstein, S. J., & Changeux, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1853 · Cited by 99 · see citing works
Substance P modulation of acetylcholine-induced currents in embryonic chicken sympathetic and ciliary ganglion neurons.
Role, L. W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2924 · Cited by 96 · see citing works
Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.
Cachelin, A. B., & Colquhoun, D. M. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017717 · Cited by 96 · see citing works
Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells.
Boyd, N. D. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016646 · Cited by 95 · see citing works
A molecular scheme for the reaction between acetylcholine and nicotinic channels
Franke, C., Parnas, H., Hovav, G., et al. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81374-2 · Cited by 94 · see citing works
Brain Nicotine Binding Sites
Wonnacott, S. (1987) · Human Toxicology · doi:10.1177/096032718700600502 · Cited by 93 · see citing works
Chronic Nicotine Exposure Differentially Affects the Function of Human α3, α4, and α7 Neuronal Nicotinic Receptor Subtypes
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37064-8 · Cited by 90 · see citing works
Dependence of Nicotinic Acetylcholine Receptor Recovery from Desensitization on the Duration of Agonist Exposure
Reitstetter, R., Lukas, R. J., & Gruener, R. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38184-4 · Cited by 87 · see citing works
Two distinct classes of functional α7‐containing nicotinic receptor on rat superior cervical ganglion neurons
Cuevas, J., Roth, A. L., & Berg, D. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00735.x · Cited by 87 · see citing works
Nicotinic acetylcholine receptor subunit mRNA expression and channel function in medial habenula neurons
Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00138-6 · Cited by 87 · see citing works
Self-citation
Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes
Hsu, Y., Αmin, J., Weiss, D. S., & Wecker, L. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66020667.x · Cited by 87 · see citing works
Nicotinic acetylcholine currents in cultured postnatal rat hippocampal neurons.
Zorumski, C. F., Thio, L. L., Isenberg, K. E., & Clifford, D. B. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09166-7 · Cited by 84 · see citing works
Initial Characterization of the Nicotinic Acetylcholine Receptors in Rat Hippocampal Neurons
Alkondon, M., & Albuquerque, E. X. (1991) · Journal of Receptor Research · doi:10.3109/10799899109064693 · Cited by 83 · see citing works
Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion.
Collins, A. C., Luo, Y., Selvaag, S., & Marks, M. J. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22727-6 · Cited by 81 · see citing works
Regulation of α4β2 Nicotinic Receptor Desensitization by Calcium and Protein Kinase C
Fenster, C. P., Beckman, M. L., Parker, J. C., Sheffield, E. B., Whitworth, T. L., Quick, M. W., & Lester, R. A. J. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12167-0 · Cited by 81 · see citing works
Self-citation
Effects of Chronic Nicotinic Ligand Exposure on Functional Activity of Nicotinic Acetylcholine Receptors Expressed by Cells of the PC12 Rat Pheochromocytoma or the TE671/RD Human Clonal Line
Lukas, R. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11403.x · Cited by 79 · see citing works
Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons
Lester, R. A. J., & Dani, J. A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.1.195 · Cited by 77 · see citing works
Self-citation
Functional Properties of Human Nicotinic Achrs Expressed by Imr-32 Neuroblastoma Cells Resemble Those of α3β4 Achrs Expressed in Permanently Transfected Hek Cells
Nelson, M. E., Wang, F., Kuryatov, A., Choi, C. H., Gerzanich, V., & Lindstrom, J. M. (2001) · The Journal of General Physiology · doi:10.1085/jgp.118.5.563 · Cited by 77 · see citing works
Recovery from Desensitization of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells Is Modulated by Intracellular Calcium through Distinct Second Messengers
Khiroug, L. S., Sokolova, E., Giniatullin, R. A., Afzalov, R. A., & Nistri, A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02458.1998 · Cited by 75 · see citing works
Up-regulation of human α7 nicotinic receptors by chronic treatment with activator and antagonist ligands
Molinari, E. J., Delbono, O., Messi, M. L., Renganathan, M., Arnerić, S. P., Sullivan, J. P., & Gopalakrishnan, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00084-3 · Cited by 75 · see citing works
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells
Chavez-Noriega, L. E., Gillespie, A. J., Stauderman, K. A., Crona, J. H., Claeps, B. O., Elliott, K. J., Reid, R. T., Rao, T. S., Veliçelebi, G., Harpold, M. M., et al. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00134-9 · Cited by 73 · see citing works
Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism
Eilers, H., Schaeffer, E., Bickler, P. E., & Forsayeth, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1105 · Cited by 71 · see citing works
Long-Term Desensitization of Nicotinic Acetylcholine Receptors Is Regulated via Protein Kinase A-Mediated Phosphorylation
Paradiso, K. G., & Brehm, P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09227.1998 · Cited by 70 · see citing works
Characterization of Nicotine‐Induced Desensitization of Evoked Dopamine Release from Rat Striatal Synaptosomes
Rowell, P. P., & Hillebrand, J. A. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63020561.x · Cited by 70 · see citing works
From Muscle Endplate to Brain Synapses: A Short History of Synapses and Agonist-Activated Ion Channels
Colquhoun, D. M., & Sakmann, B. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80982-4 · Cited by 66 · see citing works
Ligand Binding and Activation of Rat Nicotinic α4β2 Receptors Stably Expressed in HEK293 Cells
Sabey, K., Paradiso, K. G., Zhang, J., & Steinbach, J. H. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.1.58 · Cited by 66 · see citing works
Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes.
Marks, M. J., Robinson, S. F., & Collins, A. C. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13086-3 · Cited by 65 · see citing works
Kinetics and mechanism of L-[3H]nicotine binding to putative high affinity receptor sites in rat brain.
Lippiello, P. M., Sears, S. B., & Fernandes, K. G. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10448-3 · Cited by 65 · see citing works
Nanomolar concentrations of nicotine increase the release of [3H]dopamine from rat striatal synaptosomes
Rowell, P. P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11471-8 · Cited by 64 · see citing works
Agonist and antagonist effects of nicotine on chick neuronal nicotinic receptors are defined by alpha and beta subunits
Hussy, N., Ballivet, M., & Bertrand, D. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.3.1317 · Cited by 63 · see citing works
Long-Lasting Enhancement of Glutamatergic Synaptic Transmission by Acetylcholine Contrasts with Response Adaptation after Exposure to Low-Level Nicotine
Girod, R., & Role, L. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05182.2001 · Cited by 62 · see citing works
? subunits determine the time course of desensitization in rat ?3 neuronal nicotinic acetylcholine receptors
Cachelin, A. B., & Jaggi, R. B. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00370298 · Cited by 62 · see citing works
Nicotinic acetylcholine sensitivity of rat petrosal sensory neurons in dissociated cell culture
Zhong, H., & Nurse, C. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00526-x · Cited by 62 · see citing works
Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: role of the ? subunit in agonist sensitivity and desensitization
Gross, A., Ballivet, M., Rungger, D., et al. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00370805 · Cited by 62 · see citing works
Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor alpha-type subunit
Vijayaraghavan, S., Schmid, H., Halvorsen, S. W., & Berg, D. K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-10-03255.1990 · Cited by 61 · see citing works
Actin Filaments and the Opposing Actions of CaM Kinase II and Calcineurin in Regulating α7-Containing Nicotinic Receptors on Chick Ciliary Ganglion Neurons
Liu, Q., & Berg, D. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10280.1999 · Cited by 61 · see citing works
Desensitization of Nicotine‐Stimulated 86Rb+ Efflux from Mouse Brain Synaptosomes
Marks, M. J., Grady, S. R., Yang, J., Lippiello, P. M., & Collins, A. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062125.x · Cited by 61 · see citing works
Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells.
Meyer, E. L., Xiao, Y., & Kellar, K. J. (2001) · PubMed · Cited by 58 · see citing works
Agonist Regulation of Rat α3β4 Nicotinic Acetylcholine Receptors Stably Expressed in Human Embryonic Kidney 293 Cells
Meyer, E. L., Xiao, Y., & Kellar, K. J. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12620-x · Cited by 58 · see citing works
A study of the bovine adrenal chromaffin nicotinic receptor using patch clamp and concentration‐jump techniques.
Maconochie, D. J., & KNIGHT, D. E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019257 · Cited by 55 · see citing works
A desensitized form of neuronal acetylcholine receptor detected by 3H- nicotine binding on bovine adrenal chromaffin cells [published erratum appears in J Neurosci 1988 Dec;8(12):preceding 4415]
Higgins, L., & Berg, D. K. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01436.1988 · Cited by 54 · see citing works
Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine
Rowell, P. P., & Duggan, D. S. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(97)00193-7 · Cited by 52 · see citing works
Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed inXenopus laevis oocytes
Vibat, C. R. T., Lasalde, J. A., McNamee, M. G., & Ochoa, E. L. M. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02071877 · Cited by 51 · see citing works
Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors.
Cohen, B. N., Figl, A., Quick, M. W., Labarca, C. G., Davidson, N., & Lester, H. A. (1995) · The Journal of General Physiology · doi:10.1085/jgp.105.6.745 · Cited by 50 · see citing works
Self-citation
Nicotine Enhances the Cyclic AMP‐Dependent Protein Kinase‐Mediated Phosphorylation of α4 Subunits of Neuronal Nicotinic Receptors
Hsu, Y., Edwards, S. C., & Wecker, L. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062427.x · Cited by 47 · see citing works
Time-dependent changes in central nicotinic acetylcholine channel kinetics in excised patches
Lester, R. A. J., & Dani, J. A. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90093-0 · Cited by 47 · see citing works
Self-citation
Imaging of intracellular calcium during desensitization of nicotinic acetylcholine receptors of rat chromaffin cells
Khiroug, L. S., Giniatullin, R. A., Sokolova, E., Talantova, M. V., & Nistri, A. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701518 · Cited by 47 · see citing works
Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 Subunit by cAMP-dependent protein kinase
Moss, S. J., McDonald, B. J., Rudhard, Y., et al. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00083-4 · Cited by 43 · see citing works
Desensitization of Neuronal Nicotinic Acetylcholine Receptors Conferred by N-Terminal Segments of the β2 Subunit
Bohler, S., Gay, S., Bertrand, S., Corringer, P. J., Edelstein, S. J., Changeux, J., & Bertrand, D. (2001) · Biochemistry · doi:10.1021/bi0020022 · Cited by 41 · see citing works
Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation
Kuryatov, A., Olale, F., Choi, C. H., & Lindstrom, J. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00027-3 · Cited by 41 · see citing works
A nicotinic acetylcholine receptor subunit from insect brain forms a non-desensitising homo-oligomeric nicotinic acetylcholine receptor when expressed in Xenopus oocytes
Amar, M., Thomas, P., Wonnacott, S., et al. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12033-z · Cited by 40 · see citing works
Desensitization of nicotinic agonist-induced [3H]gamma-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists.
Lu, Y., Marks, M. J., & Collins, A. C. (1999) · PubMed · Cited by 39 · see citing works
Activation and Ca2+Permeation of Stably Transfected α3/β4 Neuronal Nicotinic Acetylcholine Receptor
Zhang, J., Xiao, Y., Abdrakhmanova, G., et al. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.6.970 · Cited by 37 · see citing works
Two components of carbamylcholine-induced loss of nicotinic acetylcholine receptor function in the neuronal cell line PC12.
Simasko, S. M., Soares, J. R., & Weiland, G. A. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10307-6 · Cited by 37 · see citing works
Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro
Nakayama, H., Okuda, H., & Nakashima, T. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90123-7 · Cited by 36 · see citing works
Subtype-Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Cocaine Is Determined by the α4 and β4 Subunits
Francis, M. M., Vazquez, R. W., Papke, R. L., & Oswald, R. E. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.109 · Cited by 35 · see citing works
α-bungarotoxin-sensitive nicotinic responses in rat tuberomammillary neurons
Uteshev, V. V., Stevens, D. R., & Haas, H. L. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050176 · Cited by 34 · see citing works
Cyclic AMP‐dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of α4 neuronal nicotinic receptor subunits
Wecker, L., Guo, X., Rycerz, A. M., & Edwards, S. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00041.x · Cited by 33 · see citing works
Allosteric modulation of neuronal nicotinic acetylcholine receptors
Buisson, B., & Bertrand, D. (1998) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(98)80144-7 · Cited by 31 · see citing works
Properties of neuronal type acetylcholine receptors in voltage clamped mouse neuroblastoma cells
Oortgiesen, M., & Vijverberg, H. P. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90038-9 · Cited by 31 · see citing works
Human nicotinic acetylcholine receptor: the influence of second messengers on activation and desensitization
Siara, J., Ruppersberg, J. P., & Rüdel, R. (1990) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf02584008 · Cited by 26 · see citing works
Experssion of α-Bungarotoxin Receptro Subtypes in Chick Central Nervous System During Development
Gotti, C., Moretti, M., Loughi, R., et al. (1994) · Journal of Receptor Research · doi:10.3109/10799899409101508 · Cited by 24 · see citing works
Modulation of acetylcholine‐elicited currents in clonal rat phaeochromocytoma (PC12) cells by internal polyphosphates.
Ifune, C. K., & Steinbach, J. H. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019603 · Cited by 21 · see citing works
The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo
Viseshakul, N., Figl, A., Lytle, C. Y., & Cohen, B. N. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00128-4 · Cited by 20 · see citing works
Distribution of Cholinergic Neurons in the Mammalian Brain with Special Reference to their Relationship with Neuronal Nicotinic Acetylcholine Receptors
Zoli, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_2 · Cited by 20 · see citing works
Prolonged stimulation of presynaptic nicotinic acetylcholine receptors in the rat interpeduncular nucleus has differential effects on transmitter release
Covernton, P. J. O., & Lester, R. A. J. (2002) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(02)00036-9 · Cited by 18 · see citing works
Self-citation
Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization
Hardwick, J. C., & Parsons, R. L. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.6.3609 · Cited by 18 · see citing works
Desensitization of Nicotinic Agonist-Induced [3H]γ-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists
Lü, Y., Marks, M. J., & Collins, A. C. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35218-8 · Cited by 16 · see citing works
Calcium Modulation of Activation and Desensitization of Nicotinic Receptors from Mouse Brain
Booker, T. K., Smith, K. W., Dodrill, C., & Collins, A. C. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041490.x · Cited by 14 · see citing works

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Cragg, S. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.003 · Cited by 245 · see citing works
Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction
Pidoplichko, V. I., Noguchi, J., Areola, O. O., Liang, Y., Peterson, J., Zhang, T., & Dani, J. A. (2004) · Learning & Memory · doi:10.1101/lm.70004 · Cited by 196 · see citing works
Nicotine Withdrawal
McLaughlin, I., Dani, J. A., & De Biasi, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-319-13482-6_4 · Cited by 173 · see citing works
“Because desensitized nAChR conformations have a higher affinity for agonist, nAChRs will increasingly adopt desensitized conformations in response to chronic nicotine exposure (Quick and Lester 2002; Picciotto et al. 2008).”
Background
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo
Miwa, J. M., Stevens, T. R., King, S. L., Caldarone, B. J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R. M., Pavlides, C., Lester, H. A., Picciotto, M. R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.025 · Cited by 154 · see citing works
Nicotine and Parkinson's disease: implications for therapy
Quik, M., O'Leary, K., & Tanner, C. M. (2008) · Movement Disorders · doi:10.1002/mds.21900 · Cited by 154 · see citing works
Short-Term Adolescent Nicotine Exposure has Immediate and Persistent Effects on Cholinergic Systems: Critical Periods, Patterns of Exposure, Dose Thresholds
Abreu-Villaça, Y., Seidler, F. J., Qiao, D., Tate, C. A., Cousins, M. M., Thillai, I., & Slotkin, T. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300221 · Cited by 151 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma
Song, P., Sekhon, H. S., Fu, X. W., Maier, M., Jia, Y., Duan, J., Proskosil, B. J., Gravett, C., Lindstrom, J., Mark, G. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0183 · Cited by 141 · see citing works
Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them
Xiao, Y., Fan, H., Musachio, J. L., Wei, Z.-L., Chellappan, S. K., Kozikowski, A. P., & Kellar, K. J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027318 · Cited by 141 · see citing works
Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
Berrendero, F., Robledo, P., Trigo, J. M., Martín-García, E., & Maldonado, R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.006 · Cited by 140 · see citing works
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Mineur, Y. S., Somenzi, O., & Picciotto, M. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.006 · Cited by 137 · see citing works
Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors
Kassam, S. M., Herman, P. M., Goodfellow, N. M., Alves, N. C., & Lambe, E. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2645-08.2008 · Cited by 100 · see citing works
Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal
De Biasi, M., & Salas, R. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-mr-355 · Cited by 95 · see citing works
Cytisine-based nicotinic partial agonists as novel antidepressant compounds
Mineur, Y. S., Eibl, C., Young, G., Kochevar, C., Papke, R. L., Gündisch, D., & Picciotto, M. R. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149609 · Cited by 75 · see citing works
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
Huang, H., Xu, Y., & van den Pol, A. N. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00740.2010 · Cited by 70 · see citing works
Sazetidine-A, a Selective α4β2 Nicotinic Receptor Desensitizing Agent and Partial Agonist, Reduces Nicotine Self-Administration in Rats
Levin, E. D., Rezvani, A. H., Xiao, Y., Slade, S., Cauley, M., Wells, C., Hampton, D., Petro, A., Rose, J. E., Brown, M. L., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162073 · Cited by 65 · see citing works
Age dependent nicotinic influences over dopamine neuron synaptic plasticity
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.014 · Cited by 61 · see citing works
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties
Mineur, Y. S., Einstein, E. B., Seymour, P. A., Coe, J. W., O'Neill, B. T., Rollema, H., & Picciotto, M. R. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328347546d · Cited by 49 · see citing works
Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats
Johnson, J. E., Slade, S., Wells, C., Petro, A., Sexton, H., Rezvani, A. H., Brown, M. L., Paige, M. A., McDowell, B. E., Xiao, Y., et al. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2642-z · Cited by 35 · see citing works
Selectivity of ABT-089 for α4β2* and α6β2* nicotinic acetylcholine receptors in brain
Marks, M. J., Wageman, C. R., Grady, S. R., Gopalakrishnan, M., & Briggs, C. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.022 · Cited by 30 · see citing works
Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats
Robinson, S. E., Vann, R. E., Britton, A. F., O’Connell, M. M., James, J. R., & Rosecrans, J. A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0687-6 · Cited by 22 · see citing works
Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats
Suyama, H., Egger, V., & Lukas, M. (2021) · Communications Biology · doi:10.1038/s42003-021-02129-7 · Cited by 21 · see citing works
Short- and Long-Lasting Consequences ofIn VivoNicotine Treatment on Hippocampal Excitability
Penton, R. E., Quick, M. W., & Lester, R. A. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4362-10.2011 · Cited by 19 · see citing works
Self-citation
Electrophysiological changes in laterodorsal tegmental neurons associated with prenatal nicotine exposure: Implications for heightened susceptibility to addict to drugs of abuse
Christensen, M. H., Nielsen, M. L., & Kohlmeier, K. A. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017441400049x · Cited by 17 · see citing works

Mechanisms of rapid desensitization to arginine vasopressin in vascular smooth muscle cells
Caramelo, C. A., Tsai, P., Okada, K., et al. (1991) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1991.260.1.f46 · Cited by 24 · see citing works
Desensitization of the human V2 vasopressin receptor. Homologous effects in the absence of heterologous desensitization.
Birnbaumer, M. E., Antaramián, A., Themmen, A. P. N., & Gilbert, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49766-4 · Cited by 43 · see citing works
Homologous β-adrenergic desensitization in isolated rat hepatocytes
García-Sáinz, J. A., & Michel, B. (1987) · Biochemical Journal · doi:10.1042/bj2460331 · Cited by 12 · see citing works
Desensitization of human basophils with suboptimal concentrations of agonist. Evidence for reversible and irreversible desensitization.
Pruzansky, J. J., & Patterson, R. (1988) · PubMed · Cited by 26 · see citing works
Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing
Lin, F., & Butcher, E. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8335 · Cited by 41 · see citing works

Authors: Quick, M. W., & Lester, R. A. J.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Lester, Robin A.J.
Venue: Journal of Neurobiology
Publisher: Wiley
Published: 2002-11-15
Volume: 53
Issue: 4
Pages: 457-478
ISSN: 0022-3034 (ISSN-L)
1097-4695
DOI: 10.1002/neu.10109
OpenAlex: W2061475648
Cited by: 456
References: 163
Citations by year: 2026: 8 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 15 · 2019: 24 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 22 · 2014: 23 · 2013: 21 · 2012: 21
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA-11940, R01DA011940)
National Institute of Neurological Disorders and Stroke (NS13669)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: receptor desensitization, nicotinic acetylcholine receptors, ligand-gated ion channels, receptor subunit composition, synaptic efficacy, chronic nicotine exposure, nicotine dependence, cholinesterase inhibitors, Alzheimer's disease, acetylcholine, excitotoxicity
MeSH terms: Acetylcholine, Animals, Drug Tolerance, Humans, Ion Channels, Membrane Potentials, Nicotine, Receptors, Nicotinic

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Desensitization of neuronal nicotinic receptors

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