Magnesium and the Inflammatory Response: Potential Physiopathological Implications
Abstract
The purpose of this review is to summarize experimental findings showing that magnesium modulates cellular events involved in inflammation. Experimental magnesium deficiency in the rat induces after a few days a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, release of inflammatory cytokines and acute phase proteins, excessive production of free radicals. Increase in extracellular magnesium concentration, decreases inflammatory response while reduction in the extracellular magnesium results in cell activation. Because magnesium acts as a natural calcium antagonist, the molecular basis for inflammatory response is probably the result of modulation of intracellular calcium concentration. The priming of phagocytic cells, the opening calcium channel and activation of N-methyl-d-aspartate (NMDA) receptors, the activation of nuclear factor-kappa B (NFkappaB) have been considered as potential mechanisms. Moreover, magnesium deficiency induces a systemic stress response by activation of neuro endocrinological pathways. As nervous and immune systems interact bidirectionally, the roles of neuromediators have also been considered. Magnesium deficiency contributes to an exaggerated response to immune stress and oxidative stress is the consequence of the inflammatory response. Inflammation contributes to the pro-atherogenic changes in lipoprotein metabolism, endothelial dysfunction, thrombosis, hypertension and explains the aggravating effect of magnesium deficiency on the development of metabolic syndrome. Further studies are still needed to assess more accurately the role of magnesium in immune response in humans, but these experimental findings in animal models suggest that inflammation is the missing link to explain the role of magnesium in many pathological conditions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In animals, a long-term magnesium-deficient diet disrupts redox balance and homeostasis, increases inflammation, and exacerbates development and progression of aging-related diseases such as cardiovascular diseases, hypertension, and diabetes.
“Accordingly, animal studies have confirmed that a long-term Mg-deficient diet disrupts the redox balance and homeostasis and increases inflammation, consequently exacerbating the development and progression of aging-related diseases such as cardiovascular diseases, hypertension, or diabetes [420,446].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [446]
Cites
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works
The Metabolic Syndrome: Time for a Critical Appraisal
Kahn, R., Buse, J. B., Ferrannini, E., & D, M. P. S. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,389 · see citing works
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,244 · see citing works
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works
Pathophysiology of coronary artery disease
Libby, P., & Theroux, P. (2005) · Circulation · doi:10.1161/circulationaha.105.537878 · Cited by 1,965 · see citing works
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide
Ignarro, L. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.002535 · Cited by 1,300 · see citing works
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Magnesium: Nature's physiologic calcium blocker
Iseri, L. T., & French, J. H. (1984) · American Heart Journal · doi:10.1016/0002-8703(84)90572-6 · Cited by 831 · see citing works
The oxidative modification hypothesis of atherogenesis: an overview
Chisolm, G. M., & Steinberg, D. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00344-0 · Cited by 742 · see citing works
Stress and the inflammatory response: A review of neurogenic inflammation
Black, P. H. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00021-1 · Cited by 687 · see citing works
Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X
Barbagallo, M. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00090-0 · Cited by 466 · see citing works
Ma, J., Folsom, A. R., Melnick, S. L., Eckfeldt, J. H., Sharrett, A. R., Nabulsi, A. A., Hutchinson, R. G., & Metcalf, P. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)00200-a · Cited by 441 · see citing works
Magnesium deficiency and osteoporosis: animal and human observations
Rude, R. K., & Gruber, H. E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.08.001 · Cited by 357 · see citing works
Role of the NF-kB Pathway in the Pathogenesis of Human Disease States
Yamamoto, Y., & Gaynor, R. B. (2001) · Current Molecular Medicine · doi:10.2174/1566524013363816 · Cited by 330 · see citing works
Song, Y., Ridker, P. M., Manson, J. E., Cook, N. R., Buring, J. E., & Liu, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1438 · Cited by 315 · see citing works
Dietary Magnesium and C-reactive Protein Levels
King, D. E., Mainous, A. G., Geesey, M. E., & Woolson, R. F. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719461 · Cited by 279 · see citing works
Endothelial inflammation in insulin resistance
Sjöholm, Å., & Nyström, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17912-4 · Cited by 278 · see citing works
Endothelial inflammation in insulin resistance
SJOHOLM, A., & NYSTROM, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)70804-7 · Cited by 278 · see citing works
STUDIES ON MAGNESIUM DEFICIENCY IN ANIMALS
Kruse, H. D., Orent, E. R., & McCollum, E. V. (1932) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)76290-x · Cited by 273 · see citing works
Inflammatory response following acute magnesium deficiency in the rat
Malpuech‐Brugère, C., Nowacki, W., Daveau, M., Gueux, E., Linard, C., Rock, E., Lebreton, J.-P., Mazur, A., & Rayssiguier, Y. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00018-1 · Cited by 253 · see citing works
Self-citationMaier, J. A. M., Malpuech‐Brugère, C., Zimowska, W., Rayssiguier, Y., & Mazur, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.01.002 · Cited by 252 · see citing works
Self-citationMagnesium Deficiency: Effect on Bone and Mineral Metabolism in the Mouse
Rude, R. K., Gruber, H. E., Wei, L. Y., Frausto, A., & Mills, B. G. (2003) · Calcified Tissue International · doi:10.1007/s00223-001-1091-1 · Cited by 242 · see citing works
Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin
Weglicki, W. B., Phillips, T. M., Freedman, A. M., CASSIDY, M. M., & Dickens, B. F. (1992) · Molecular and Cellular Biochemistry · doi:10.1007/bf02454195 · Cited by 239 · see citing works
Magnesium Deficiency Is Associated With Insulin Resistance in Obese Children
Huerta, M. G., Roemmich, J. N., Kington, M. L., Bovbjerg, V. E., WELTMAN, A. L., Holmes, V. F., Patrie, J. T., Rogol, A. D., & Nadler, J. L. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1175 · Cited by 233 · see citing works
High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro
Maier, J. A. M., Bernardini, D., Rayssiguier, Y., & Mazur, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.02.004 · Cited by 227 · see citing works
Self-citationRole of magnesium in the pathogenesis of hypertension
Touyz, R. M. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00094-8 · Cited by 210 · see citing works
Infection and Inflammation Induce LDL Oxidation In Vivo
Memon, R. A., Staprãns, I., Noor, M. A., Holleran, W. M., Uchida, Y., Moser, A. H., Feingold, K. R., & Grünfeld, C. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1536 · Cited by 207 · see citing works
Dickens, B. F., Weglicki, W. B., Li, Y.-S., & Mak, I. T. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81098-7 · Cited by 205 · see citing works
Magnesium dietary intake modulates blood lipid levels and atherogenesis.
Altura, B. T., Brust, M., Bloom, S. R., Barbour, R. L., Stempak, J. G., & Altura, B. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1840 · Cited by 183 · see citing works
Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis
Bernardini, D. (2005) · Frontiers in bioscience · doi:10.2741/1610 · Cited by 153 · see citing works
Ali, S., & Mann, D. A. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1082 · Cited by 141 · see citing works
Nimmo, A. J., Černak, I., Heath, D. L., Hu, X., Bennett, C. J., & Vink, R. (2004) · Neuropeptides · doi:10.1016/j.npep.2003.12.003 · Cited by 136 · see citing works
Rude, R. K., Wei, L. Y., Frausto, A., et al. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.79 · Cited by 123 · see citing works
Magnesium in clinical practice
(1989) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(89)90113-4 · Cited by 120 · see citing works
Dietary magnesium intake and the future risk of coronary heart disease (The Honolulu Heart Program)
Abbott, R. D., Ando, F., Masaki, K., et al. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00819-1 · Cited by 116 · see citing works
Effect of Magnesium Deficiency on Lipid Metabolism in Rats Fed a High Carbohydrate Diet
Rayssiguier, Y., Gueux, E., & Weiser, D. (1981) · Journal of Nutrition · doi:10.1093/jn/111.11.1876 · Cited by 106 · see citing works
Self-citationBussière, F. I., Gueux, E., Rock, E., Girardeau, J. P., Tridon, A., Mazur, A., & Rayssiguier, Y. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001498 · Cited by 103 · see citing works
Self-citationDietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats.
Rayssiguier, Y., Gueux, E., Bussière, L., et al. (1993) · Journal of the American College of Nutrition · doi:10.1080/07315724.1993.10718293 · Cited by 98 · see citing works
Self-citationMagnesium deficiency inhibits primary tumor growth but favors metastasis in mice
Nasulewicz‐Goldeman, A., Wietrzyk, J., Wolf, F. I., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.003 · Cited by 96 · see citing works
Kramer, J. H., Mišı́k, V., & Weglicki, W. B. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90186-4 · Cited by 92 · see citing works
Malpuech‐Brugère, C., Nowacki, W., Gueux, E., Kuryszko, J. J., Rock, E., Rayssiguier, Y., & Mazur, A. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599000690 · Cited by 92 · see citing works
Self-citationLow magnesium and atherosclerosis: an evidence-based link
Maier, J. A. M. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00095-x · Cited by 85 · see citing works
Self-citationBegon, S., Pickering, G. P., Eschalier, A., et al. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704354 · Cited by 85 · see citing works
Freedman, A. M., Mak, I. T., Stafford, R. E., Dickens, B. F., CASSIDY, M. M., Muesing, R. A., & Weglicki, W. B. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.6.c1371 · Cited by 85 · see citing works
Advances in magnesium research : Nutrition and health
Rayssiguier, Y., Mazur, A., & Durlach, J. (2001) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 79 · see citing works
Self-citationVitale, J. J., White, P. L., Nakamura, M., et al. (1957) · The Journal of Experimental Medicine · doi:10.1084/jem.106.5.757 · Cited by 78 · see citing works
Mak, I. T., Komarov, A. M., Wagner, T. L., Stafford, R. E., Dickens, B. F., & Weglicki, W. B. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c385 · Cited by 78 · see citing works
Perraud, A. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.04.013 · Cited by 77 · see citing works
Magnesium deficiency in rats induces a rise in plasma nitric oxide.
Rock, E., Astier, C., Lab, C., et al. (1995) · PubMed · Cited by 75 · see citing works
Self-citationMalpuech‐Brugère, C., Nowacki, W., Rock, E., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00081-7 · Cited by 75 · see citing works
Self-citationMechanism of increased erythrocyte membrane fluidity during magnesium deficiency in weanling rats
Tongyai, S., Rayssiguier, Y., Motta, C., Gueux, E., Maurois, P., & Heaton, F. W. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.257.2.c270 · Cited by 75 · see citing works
Self-citationMagnesium deficiency-induced cardiomyopathy: Protection by vitamin E
Freedman, A. M., Atrakchi, A. H., CASSIDY, M. M., et al. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90506-i · Cited by 73 · see citing works
Busserolles, J., Mazur, A., Gueux, E., Rock, E., & Rayssiguier, Y. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700918 · Cited by 71 · see citing works
Self-citationProtective effect of calcium deficiency on the inflammatory response in magnesium-deficient rats
Bussière, F. I., Gueux, E., Rock, E., et al. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-0376-0 · Cited by 70 · see citing works
Self-citationProgressive magnesium deficiency increases mortality from endotoxin challenge
Salem, M., Kasinski, N., Munoz, R., et al. (1995) · Critical Care Medicine · doi:10.1097/00003246-199501000-00019 · Cited by 67 · see citing works
Touyz, R. M., Pu, Q., He, G., Chen, X., Yao, G., Neves, M. F., & Viel, É. C. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00022 · Cited by 64 · see citing works
Shechter, M., Merz, C. N. B., Rude, R. K., et al. (2000) · American Heart Journal · doi:10.1067/mhj.2000.107553 · Cited by 61 · see citing works
Altura, B. M., Altura, B. M., Gebrewold, A., et al. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00134-4 · Cited by 60 · see citing works
Histamine-liberating Effect of Magnesium Deficiency in the Rat
Bois, P., Gascon, A. L., & Beaulnes, A. (1963) · Nature · doi:10.1038/197501a0 · Cited by 53 · see citing works
Cytokines, Neuropeptides, and Reperfusion Injury during Magnesium Deficiency a
Weglicki, W. B., Phillips, T. M., Mak, I. T., et al. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb36731.x · Cited by 52 · see citing works
Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice
Ravn, H. B., Korsholm, T. L., & Falk, E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.858 · Cited by 51 · see citing works
Luthringer, C., Rayssiguier, Y., Gueux, E., et al. (1988) · British Journal Of Nutrition · doi:10.1079/bjn19880031 · Cited by 48 · see citing works
Self-citationNeckermann, G., Bavandi, A., & Meingassner, J. G. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03411.x · Cited by 47 · see citing works
Rayssiguier, Y., Noé, L., Etienne, J. P., et al. (1991) · Lipids · doi:10.1007/bf02543968 · Cited by 47 · see citing works
Self-citationPetrault, I., Zimowska, W., Mathieu, J., et al. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00089-8 · Cited by 46 · see citing works
Malpuech‐Brugère, C., Rock, E., Astier, C., et al. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00455-x · Cited by 46 · see citing works
Self-citationEffect of acute magnesium deficiency (MgD) on aortic endothelial cell (EC) oxidant production
Wiles, M. E., Wagner, T. L., & Weglicki, W. B. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00619-4 · Cited by 45 · see citing works
Does Magnesium Have a Role in the Treatment of Patients with Coronary Artery Disease?
Shechter, M. (2003) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200303040-00001 · Cited by 42 · see citing works
Busserolles, J., Gueux, E., Rock, E., Mazur, A., & Rayssiguier, Y. (2003) · PubMed · Cited by 41 · see citing works
Self-citationMagnesium Deficiency Affects Plasma Lipoprotein Composition in Rats
Gueux, E., Mazur, A., Cardot, P., et al. (1991) · Journal of Nutrition · doi:10.1093/jn/121.8.1222 · Cited by 41 · see citing works
Self-citationBlood and Mast Cell Histamine Levels in Magnesium-Deficient Rats
Kraeuter, S. L., & Schwartz, R. (1980) · Journal of Nutrition · doi:10.1093/jn/110.5.851 · Cited by 41 · see citing works
Mak, I. T., Stafford, R., & Weglicki, W. B. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.5.c1366 · Cited by 40 · see citing works
Gueux, E., Rayssiguier, Y., Piot, M.-C., et al. (1984) · Journal of Nutrition · doi:10.1093/jn/114.8.1479 · Cited by 38 · see citing works
Self-citationTime-course of the change in blood pressure level in magnesium-deficient Wistar rats
Laurant, P., Dalle, M., BERTHELOT, A., et al. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001427 · Cited by 38 · see citing works
Bussière, F. I., Tridon, A., Zimowska, W., et al. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00291-1 · Cited by 38 · see citing works
Freedman, A. M., CASSIDY, M. M., & Weglicki, W. B. (1992) · PubMed · Cited by 37 · see citing works
High magnesium concentration in vitro decreases human leukocyte activation.
Bussière, F. I., Mazur, A., Fauquert, J., et al. (2002) · PubMed · Cited by 36 · see citing works
Self-citationHypomagnesemia, Insulin Resistance, and Non-Alcoholic Steatohepatitis in Obese Subjects
Rodríguez-Hernández, H., González, J. L., Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.008 · Cited by 36 · see citing works
Weglicki, W. B., Stafford, R. E., Freedman, A. M., et al. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.3.c723 · Cited by 36 · see citing works
Chaudhary, D. P., Boparai, R. K., Sharma, R., & Bansal, D. D. (2004) · PubMed · Cited by 35 · see citing works
Kurantsin‐Mills, J., CASSIDY, M. M., Stafford, R. E., et al. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970200 · Cited by 35 · see citing works
Zimowska, W., Girardeau, J. P., Kuryszko, J. J., et al. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002696 · Cited by 35 · see citing works
Zhou, Q., Olinescu, R. M., & Kummerow, F. A. (1999) · PubMed · Cited by 34 · see citing works
Magnesium and blood pressure. I. Animal studies.
Rayssiguier, Y., Mbega, J. D., Durlach, V., et al. (1992) · PubMed · Cited by 33 · see citing works
Self-citationMak, I. T., Dickens, B. F., Komarov, A. M., et al. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006814609769 · Cited by 33 · see citing works
Protein Oxidation in Magnesium Deficient Rat Brains and Kidneys
Stafford, R. E., Mak, I. T., Kramer, J. H., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2291 · Cited by 33 · see citing works
Magnesium in Clinical Practice
Abraham, A. S. (1989) · JAMA · doi:10.1001/jama.1989.03420120153048 · Cited by 33 · see citing works
Magnesium deficiency modulates hepatic lipogenesis and apolipoprotein gene expression in the rat
Nassir, F., Mazur, A., Giannoni, F., et al. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00065-k · Cited by 32 · see citing works
Self-citationThymic changes in the magnesium-depleted rat.
Alcock, N. W., Shils, M. E., LIEBERMAN, P. H., et al. (1973) · PubMed · Cited by 31 · see citing works
N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg2+-Deficient Rat
Tejero-Taldo, M. I., Chmielinska, J. J., Gonzalez, G., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.070003 · Cited by 31 · see citing works
Mak, I. T., Kramer, J. H., & Weglicki, W. B. (2003) · PubMed · Cited by 29 · see citing works
Leukocytosis, Bone Marrow Hyperplasia and Leukemia in Chronic Magnesium Deficiency in the Rat
MCCREARY, P. A., Battifora, H. A., Hahneman, B. M., et al. (1967) · Blood · doi:10.1182/blood.v29.4.683.683 · Cited by 28 · see citing works
Magnesium and blood pressure. II. Clinical studies.
Durlach, J., Durlach, V., Rayssiguier, Y., et al. (1992) · PubMed · Cited by 27 · see citing works
Self-citationRole of Histamine in Producing the Eosinophilia of Magnesium Deficiency.
Hungerford, G. F. (1964) · Experimental Biology and Medicine · doi:10.3181/00379727-115-28864 · Cited by 27 · see citing works
Astier, C., Rock, E., Lab, C., et al. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02180-9 · Cited by 26 · see citing works
Self-citationSherer, Y., Shaish, A., Levkovitz, H., et al. (1999) · Pathobiology · doi:10.1159/000028074 · Cited by 23 · see citing works
Bussière, F. I., Zimowska, W., Gueux, E., et al. (2002) · PubMed · Cited by 23 · see citing works
Self-citationDoes Mg2+ deficiency induce a long-term sensitization of the central nociceptive pathways?
Alloui, A., Begon, S., Chassaing, C., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01719-9 · Cited by 20 · see citing works
Malpuech‐Brugère, C., Kuryszko, J. J., Nowacki, W., et al. (1998) · PubMed · Cited by 19 · see citing works
Self-citationGueux, E., Cubizolles, C., Bussière, L., et al. (1993) · Lipids · doi:10.1007/bf02536092 · Cited by 19 · see citing works
Self-citationChanges in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process.
Nasulewicz‐Goldeman, A., Zimowska, W., Bayle, D., et al. (2004) · PubMed · Cited by 19 · see citing works
Shogi, T., Oono, H., Nakagawa, M., et al. (2002) · PubMed · Cited by 19 · see citing works
Bussière, L., Mazur, A., Gueux, E., et al. (1995) · PubMed · Cited by 18 · see citing works
Self-citationBukoski, R. D. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00009 · Cited by 16 · see citing works
Ponvert, C., Galoppin, L., & Saurat, J. ‐. (1983) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1983.tb01821.x · Cited by 12 · see citing works
Histamine metabolism and pinnal hyperaemia during magnesium deficiency in rats.
Nishio, A., Ishiguro, S., Ikegaki, I., et al. (1988) · PubMed · Cited by 9 · see citing works
Sakaguchi, H., Sakaguchi, R., Ishiguro, S., et al. (1992) · PubMed · Cited by 9 · see citing works
Cu, C., Abele, C., Hf, S., et al. (1993) · PubMed · Cited by 7 · see citing works
Claverie-Benureau, S., Lebel, B., & GAUDIN-HARDING, F. (1981) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19810411 · Cited by 6 · see citing works
In vivo and in vitro effects of magnesium deficiency on hepatic haptoglobin mRNA levels.
Nakagawa, M., Ike, T., Kawabe, K., et al. (2001) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Pascolo, L., Gianoncelli, A., Kaulich, B., Rizzardi, C., Schneider, M., Bottin, C., Polentarutti, M., Kiskinova, M., Longoni, A., & Melato, M. (2011) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-8-7 · Cited by 47 · see citing works
Mahboobi, S., Ghasvarian, M., Ghaem, H., Alipour, H., Alipour, S., & Eftekhari, M. H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1018357 · Cited by 31 · see citing works
Harahap, I. A., Salem, O., Fahmi, R. L., Ahmed, N., Leciejewska, N., & Suliburska, J. (2025) · Nutrients · doi:10.3390/nu17182917 · Cited by 2 · see citing works
- Authors
- Mazur, A., Maier, J. A. M., Rock, E., Gueux, E., Nowacki, W., & Rayssiguier, Y.
- Affiliations
- Unité de Nutrition Humaine (FR)
- University of Milan (IT)
- Corresponding author
- Mazur, Andrzej
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 458
- Issue
- 1
- Pages
- 48-56
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2093267247
- Cited by
- 474
- References
- 113
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 34 · 2023: 31 · 2022: 31 · 2021: 40 · 2020: 24 · 2019: 27 · 2018: 36 · 2017: 20 · 2016: 23 · 2015: 22 · 2014: 22 · 2013: 20 · 2012: 24
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Magnesium Oxide Properties and Applications
- Keywords
- magnesium, hypomagnesemia, inflammation, calcium channel blockade, intracellular calcium, NMDA receptor, NF-κB, macrophage activation, leukocyte activation, inflammatory cytokines, oxidative stress, neuroendocrine stress response, atherosclerosis, metabolic syndrome, endothelial dysfunction, thrombosis, hypertension
- MeSH terms
- Animals, Humans, Inflammation, Magnesium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
