Effects of probiotic and magnesium co-supplementation on mood, cognition, intestinal barrier function and inflammation in individuals with obesity and depressed mood: a randomized, double-blind placebo-controlled clinical trial
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Background The co-occurrence of obesity and mood impairments named as “metabolic mood syndrome” (MMS) is often neglected in the obesity management. This study aimed to evaluate effects of Probio-Tec ®BG-VCap-6.5 and magnesium co-supplementation on mood, cognition, intestinal barrier function and serum C reactive protein (CRP) levels in participants with obesity and depressed mood. Design Seventy-four eligible participants were randomly allocated to either Probio-Tec®BG-VCap-6.5 [containing Lactobacillus rhamnosus (LGG®) and Bifidobacterium animalis subsp. Lactis (BB-12®)] + Magnesium chloride or placebo for 9 weeks. Sociodemographic data were collected in the beginning. Anthropometric, dietary and physical activity (PA) assessments were carried out. Beck Depression Inventory-II (BDI-II) and Montreal Cognitive Assessment (MoCA) scores were assessed through validated questionnaires. Fasting plasma zonulin, lipopolysaccharide (LPS) and (CRP) were measured by ELIZA kits. Results Of seventy-four participants (mean age 37.51 ± 8.10), 52 completed the study. Changes in serum LPS and zonulin were not different significantly between groups (−3.04 ± 44.75 ng/dl, 0.11 ± 5.13, ng/dl, p > 0.05 for LPS and 1.40 ± 48.78 ng/dl, −0.17 ± 6.60, p > 0.05 for zonulin, respectively). CRP levels reduced significantly in intervention group compared to placebo [−474.75 (−1,300.00, −125.00) mg/l vs. 175.20 (−957.75, 1,683.25) mg/l, p = 0.016]. Changes in BDI-II and MoCA scores were not significantly different between intervention (−7.13 ± 5.67, 1.20 ± 2.16, respectively) and placebo (−5.42 ± 6.71, 1.94 ± 1.86, respectively) groups (p > 0.05). Conclusion Nine weeks of probiotic and magnesium co-supplementation resulted in decreased CRP levels as an indicator of inflammatory state with no significant effects on mood, cognition and intestinal integrity in individuals with obesity and depressed mood.
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Co-administration of a probiotic containing L. rhamnosus, B. animalis, and magnesium chloride for nine weeks to obese male and female participants with depression did not rescue their altered cognition, mood, and intestinal integrity, but did decrease CRP levels.
“Co-administration of a probiotic containing L. rhamnosus, B. animalis, and magnesium chloride for nine weeks to obese male and female participants with depression did not rescue their altered cognition, mood, and intestinal integrity, but did decrease CRP levels (482).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [482]
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Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
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Magnesium and LongevityPreprint
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System Overview from Physiological and Pathological Standpoints
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- Authors
- Mahboobi, S., Ghasvarian, M., Ghaem, H., Alipour, H., Alipour, S., & Eftekhari, M. H.
- Affiliations
- Shiraz University of Medical Sciences (IR)
- Shiraz University (IR)
- Corresponding author
- Eftekhari, Mohammad Hassan
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2022-09-28
- Volume
- 9
- Pages
- 1018357-1018357
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC9555745
- OpenAlex
- W4297543277
- Cited by
- 31
- References
- 87
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 11 · 2023: 4
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shiraz University of Medical Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, magnesium supplementation, obesity, depressive mood, Lactobacillus rhamnosus, Bifidobacterium animalis subsp. lactis, intestinal barrier function, zonulin, lipopolysaccharide, C-reactive protein, inflammation, cognition, mood, dietary supplementation, physical activity, sleep duration, sleep quality, gut microbiota
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