Cited by 126Bone Metabolism and DiseasesT-cell and B-cell ImmunologyBone health and osteoporosis research

Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

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Sato, Mari, Asada, Noboru, Kawano, Yuko, Wakahashi, Kanako, Minagawa, Kentaro, Kawano, Hiroki, Sada, Akiko, Ikeda, Kyoji +2 more·2013·Cell Metabolism

Abstract

Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs.

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Authors
Sato, M., Asada, N., Kawano, Y., Wakahashi, K., Minagawa, K., Kawano, H., Sada, A., Ikeda, K., Matsui, T., & Katayama, Y.
Affiliations
  • Hokkaido University (JP)
  • Kobe University (JP)
  • National Center for Geriatrics and Gerontology (JP)
  • Japan Science and Technology Agency (JP)
Corresponding author
Katayama, Yoshio
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2013-11
Volume
18
Issue
5
Pages
749-758
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2062462056
Cited by
126
References
33
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 10 · 2015: 12 · 2014: 10
FWCI
4.77
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology (23118517)
  • Takeda Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
osteocytes, lymphopenia, lymphoid stroma, bone marrow, thymus, thymic atrophy, fat metabolism, parabiosis, hypothalamus, hepatic steatosis, lymphocyte development, mechanosensing
MeSH terms
Animals, Atrophy, Bone Marrow, Lymphoid Tissue, Lymphopenia, Mice, Inbred C57BL, Osteocytes, Stromal Cells, Lymphopoiesis, Lipid Metabolism, Mice, Thymocytes, Cellular Microenvironment

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