The Keap1-Nrf2 system and diabetes mellitus

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

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Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

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Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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Oxidative damage to DNA in diabetes mellitus

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SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

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Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

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New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

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High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

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Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

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Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

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The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

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Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

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Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

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Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

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Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

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Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

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Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

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Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins

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Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

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Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

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Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

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Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion

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The transcription factor NRF2 protects against pulmonary fibrosis

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The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

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Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

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Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

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Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

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Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

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Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance

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Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

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Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

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Targeting the pancreatic β-cell to treat diabetes

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Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

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Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells

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Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

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NRF2 plays a protective role in diabetic retinopathy in mice

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Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2

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Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2‐deficient mice

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Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

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Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

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The Keap1–Nrf2 system as an in vivo sensor for electrophiles

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Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

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β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice

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Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

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Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

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Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome

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Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

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Superoxide dismutase is a prophylactic against alloxan diabetes

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Glucose availability is a decisive factor for Nrf2-mediated gene expression

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Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

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The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

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Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1,2‐dithiole‐3‐thione

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The GK Rat: A Prototype for the Study of Non-overweight Type 2 Diabetes

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