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Cited by 301

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells

Open access
Gittens, Rolando A., Olivares-Navarrete, Rene, Cheng, Alice, Anderson, David M., McLachlan, Taylor, Stephan, Ingrid, Geis-Gerstorfer, Jürgen, Sandhage, Kenneth H., Fedorov, Andrei G., Rupp, Frank, Boyan, Barbara D., Tannenbaum, Rina, Schwartz, Zvi·2013·Acta Biomaterialia
DOI 10.1016/j.actbio.2012.12.002
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Abstract

Surface micro and nanostructural modifications of dental and orthopaedic implants have shown promising in vitro, in vivo, and clinical results. Surface wettability has also been suggested to play an important role in osteoblast differentiation and osseointegration. However, the available techniques to measure surface wettability are not reliable on clinically-relevant, rough surfaces. Furthermore, how the differentiation state of osteoblast lineage cells impacts their response to micro/nanostructured surfaces, and the role of wettability on this response, remains unclear. In the current study, surface wettability analyses (optical sessile drop analysis, ESEM analysis, and the Wilhelmy technique) indicated hydrophobic static responses for deposited water droplets on microrough and micro/nanostructured specimens, while hydrophilic responses were observed with dynamic analyses of micro/nanostructured specimens. The maturation and local factor production of human immature osteoblast-like MG63 cells was synergistically influenced by nanostructures superimposed onto microrough titanium (Ti) surfaces. In contrast, human mesenchymal stem cells (MSCs) cultured on micro/nanostructured surfaces in the absence of exogenous soluble factors, exhibited less robust osteoblastic differentiation and local factor production compared to cultures on unmodified microroughened Ti. Our results support previous observations using Ti6Al4V surfaces showing that recognition of surface nanostructures and subsequent cell response is dependent on the differentiation state of osteoblast lineage cells. The results also indicate that this effect may be partly modulated by surface wettability. These findings support the conclusion that the successful osseointegration of an implant depends on contributions from osteoblast lineage cells at different stages of osteoblast commitment.

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Metadata

Authors
Gittens, R. A., Olivares-Navarrete, R., Cheng, A., Anderson, D. M., McLachlan, T., Stephan, I., Geis-Gerstorfer, J., Sandhage, K. H., Fedorov, A. G., Rupp, F., Boyan, B. D., Tannenbaum, R., & Schwartz, Z.
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2013-04
Volume
9
Issue
4
Pages
6268-6277
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2012.12.002
OpenAlex
W2088467308
Cited by
301
References
32
FWCI
8.89
Type
journal article
Language
en
Open access
green

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Gittens, R. A., Olivares-Navarrete, R., Cheng, A., Anderson, D. M., McLachlan, T., Stephan, I., Geis-Gerstorfer, J., Sandhage, K. H., Fedorov, A. G., Rupp, F., Boyan, B. D., Tannenbaum, R., & Schwartz, Z. (2013). The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2012.12.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.