Cited by 238Magnesium Alloys: Properties and ApplicationsBone Tissue Engineering MaterialsMagnesium in Health and Disease

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

Hung, Chu-Chih, Chaya, Amy, Liu, Kai, Verdelis, Konstantinos, Sfeir, Charles·2019·Acta Biomaterialia

DOI 10.1016/j.actbio.2019.06.001

Open this paper in CoChat — free account

Abstract

Magnesium (Mg)-based implants have become of interest to both academia and the medical industry. The attraction largely is due to Mg's biodegradability and ability to enhance bone healing and formation. However, the underlying mechanism of how Mg regulates osteogenesis is still unclear. Based on our previous in vivo and molecular signaling work demonstrating the osteogenic effect of Mg, the current study aims to extend this work at the molecular level especially that we also observed and quantified mineral deposits in the bone marrow space in a rabbit ulna fracture model with Mg plates and screws. Histological analysis and quantitative results of micro-CT showed mineralized deposition and a significant increase in bone volume at 8 weeks and 16 weeks post-operative. These in vivo results led us to focus on studying the effect of Mg 2+ on human bone marrow stromal cells (hBMSCs). The data presented in this manuscript demonstrate the activation of the canonical Wnt signaling pathway in hBMSCs when treated with 10 mM Mg 2+. With additional Mg 2+ present, the protein expression of active β-catenin was significantly increased to a level similar to that of the positive control. Immunocytochemistry and the increased expression of LEF1 and Dkk1, downstream target genes that are controlled directly by active β-catenin, demonstrated the protein translocation and the activation of transcription. Taken together, these data suggest that Mg 2+ induces an osteogenic effect in the bone marrow space by activating the canonical Wnt signaling pathway, which in turn causes BMSCs to differentiate toward the osteoblast lineage. STATEMENT OF SIGNIFICANCE: Magnesium (Mg)-based alloys are being studied to be used in the field of implantable medical devices due to its natural biodegradability and the potential ability to promote bone regeneration. Despite many in vivo studies that demonstrated an increased new bone growth by implanting Mg-based devices, the underlying mechanism of this effect is still unclear. In order to safely use Mg-based implants on human and better control the osteogenic effect, it is necessary to understand the corresponding cellular response in the targeted area. The present study provides the rationale to study Mg ions on bone marrow stromal cells and shows the activation of canonical Wnt signaling pathway that promotes osteogenesis by in vivo and in vitro approaches.

Integrity signals

Registry

Crossref · 10.1016/j.actbio.2019.06.001

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
Magnesium and its alloys as orthopedic biomaterials: A review
Staiger, M. P., Pietak, A. M., Huadmai, J., & Dias, G. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.10.003 · Cited by 4,460
β‐catenin is a target for the ubiquitin–proteasome pathway
Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,586
Biodegradable metals
Zheng, Y., Gu, X., & Witte, F. (2014) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2014.01.001 · Cited by 2,469
In vivo corrosion of four magnesium alloys and the associated bone response
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., Meyer‐Lindenberg, A., Wirth, C. J., & Windhagen, H. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.049 · Cited by 2,403
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 1

Kubota, 2010, Wnt signaling in bone, Clinical pediatric endocrinology: case reports and clinical investigations: official journal of the Japanese Society for Pediatric, Endocrinology, 19, 49

Sorted by citations

Biodegradable magnesium-based implants in orthopedics-a general review and perspectives
Wang, J., Xu, J., Hopkins, C., Chow, D. H., & Qin, L. (2020) · Advanced Science · doi:10.1002/advs.201902443 · Cited by 574
Biodegradable materials for bone defect repair
Wei, S., Ma, J., Xu, L., Gu, X., & Ma, X. (2020) · Military Medical Research · doi:10.1186/s40779-020-00280-6 · Cited by 437
Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application
Zhou, H., Liang, B., Jiang, H., Deng, Z., & Yu, K. (2021) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2021.03.004 · Cited by 390
Bioinspired surface modification of orthopedic implants for bone tissue engineering
Hu, C. Q., Ashok, D., Nisbet, D. R., & Gautam, V. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119366 · Cited by 330
Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications
Xing, F., Li, S., Yin, D., Xie, J., Rommens, P. M., Xiang, Z., Liu, M., & Ritz, U. (2022) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2022.02.013 · Cited by 210
A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy
Jiang, S., Wang, M., & He, J. (2020) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10206 · Cited by 202
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Jing, X., Xu, C., Su, W., Ding, Q., Ye, B., Su, Y., Yu, K., Zeng, L., Yang, X., Qu, Y., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201349 · Cited by 151
Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds
Sadowska, J. M., & Ginebra, M.-P. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01379j · Cited by 144
Surface modification of titanium implants with Mg-containing coatings to promote osseointegration
Wang, S., Zhao, X. R., Hsu, Y., He, Y., Wang, F., Yang, F., Yan, F., Xia, D., & Liu, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.048 · Cited by 133
Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing
Wang, N., Yang, S., Shi, H., Song, Y., Sun, H. L., Wang, Q., Tan, L., & Guo, S. (2022) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2022.11.014 · Cited by 119
Controlled magnesium ion delivery system for in situ bone tissue engineering
Yuan, Z., Wan, Z., Gao, C., Wang, Y., Huang, J., & Cai, Q. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.036 · Cited by 119
MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration
Peng, W., Ren, S., Zhang, Y., Fan, R., Zhou, Y., Li, L., Xu, X., & Xu, Y. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.668428 · Cited by 97
Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review)
Shan, Z., Xie, X., Wu, X., Zhuang, S., & Zhang, C. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.09.013 · Cited by 99
Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction
Bosch-Rué, È., Díez-Tercero, L., Giordano-Kelhoffer, B., Delgado, L. M., Bosch, B. M., Hoyos‐Nogués, M., Mateos‐Timoneda, M. A., Tran, P. A., Gil, F. J., & Pérez, R. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.614545 · Cited by 90
Current Research Studies of Mg–Ca–Zn Biodegradable Alloys Used as Orthopedic Implants—Review
Istrate, B., Munteanu, C., Antoniac, I., & Lupescu, S. C. (2022) · Crystals · doi:10.3390/cryst12101468 · Cited by 86
Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys
Tan, C. Y., Wen, C., & Ang, H. Q. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2023.12.008 · Cited by 86
Immobilizing magnesium ions on 3D printed porous tantalum scaffolds with polydopamine for improved vascularization and osteogenesis
Ma, L., Cheng, S., Ji, X., Ye, Z., Zhang, Y., Li, Q., Tan, C., Peng, F., Zhang, Y., & Huang, W. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111303 · Cited by 84
Effects of magnesium alloy corrosion on biological response – Perspectives of metal-cell interaction
Kim, J., & Pan, H. (2022) · Progress in Materials Science · doi:10.1016/j.pmatsci.2022.101039 · Cited by 84
Dimethyloxallyl glycine/nanosilicates-loaded osteogenic/angiogenic difunctional fibrous structure for functional periodontal tissue regeneration
Shang, L., Liu, Z., Ma, B., Shao, J., Wang, B., Ma, C., & Ge, S. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.010 · Cited by 75
The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute
Coelho, C. C., Padrão, T., Costa, L., Pinto, M. T., Costa, P. C., Domingues, V. F., Quadros, P. A., Monteiro, F. J., & Sousa, S. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-76063-9 · Cited by 73
Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering
Antoniac, I., Mănescu, V., Antoniac, A., & Păltânea, G. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad095 · Cited by 69
Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair
Kazakova, G. K., Safronova, T. V., Golubchikov, D. O., Shevtsova, O., & Rau, J. V. (2021) · Materials · doi:10.3390/ma14174857 · Cited by 68
Biodegradable Mg-based alloys: biological implications and restorative opportunities
Lin, X., Saijilafu, Wu, X.-X., Wu, K., Chen, J.-Q., Tan, L., Witte, F., Yang, H.-L., Mantovani, D., Zhou, H., et al. (2022) · International Materials Reviews · doi:10.1080/09506608.2022.2079367 · Cited by 65
Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications
Luo, Y., Liu, H., Zhang, Y., Liu, Y., Liu, X., Liu, X., & Luo, E. (2023) · Biomaterials Science · doi:10.1039/d3bm01146a · Cited by 67
Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair
Dewey, M. J., & Harley, B. A. C. (2021) · RSC Advances · doi:10.1039/d1ra02557k · Cited by 66
Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction
Luo, Y., Zhang, C., Wang, J., Liu, F., Chau, K. W., Qin, L., & Wang, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.032 · Cited by 59
Sustained Release of Magnesium Ions Mediated by a Dynamic Mechanical Hydrogel to Enhance BMSC Proliferation and Differentiation
Liu, J., Zeng, H., Xiao, P., Yang, A., Situ, X., Wang, Y., Zhang, X., Li, W., Pan, W., & Wang, Y. (2020) · ACS Omega · doi:10.1021/acsomega.0c02946 · Cited by 58
Metal Ion-Containing Hydrogels: Synthesis, Properties, and Applications in Bone Tissue Engineering
Qin, S., Niu, Y., Zhang, Y., Wang, W., Zhou, J., Bai, Y., & Ma, G. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c01072 · Cited by 57
Advances in the use of calcium silicate-based materials in bone tissue engineering
Liu, Z., He, X., Chen, S., & Yu, H. (2023) · Ceramics International · doi:10.1016/j.ceramint.2023.03.063 · Cited by 55
Scaffold 3D‐Printed from Metallic Nanoparticles‐Containing Ink Simultaneously Eradicates Tumor and Repairs Tumor‐Associated Bone Defects
Lin, H., Shi, S., Lan, X., Quan, X., Xu, Q., Yao, G., Liu, J., Shuai, X., Wang, C., Li, X., et al. (2021) · Small Methods · doi:10.1002/smtd.202100536 · Cited by 52
Preclinical in vivo research of magnesium-based implants for fracture treatment: A systematic review of animal model selection and study design
Sun, Y., Helmholz, H., & Willumeit‐Römer, R. (2020) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2020.09.011 · Cited by 51
Photocrosslinkable Col/PCL/Mg composite membrane providing spatiotemporal maintenance and positive osteogenetic effects during guided bone regeneration
Wang, F., Xia, D., Wang, S., Gu, R., Yang, F., Zhao, X. R., Liu, X., Zhu, Y., Liu, H., Xu, Y., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.019 · Cited by 50
Advancements in drug-loaded hydrogel systems for bone defect repair
Shi, W., Jiang, Y., Wu, T., Zhang, Y., & Li, T. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.12.010 · Cited by 48
Supplemental mineral ions for bone regeneration and osteoporosis treatment
Su, Y., Cappock, M., Dobres, S., Kucine, A. J., Waltzer, W. C., & Zhu, D. (2023) · Engineered Regeneration · doi:10.1016/j.engreg.2023.02.003 · Cited by 54
Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities
Wang, D., Tan, J., Zhu, H., Mei, Y., & Liu, X. (2021) · Advanced Science · doi:10.1002/advs.202004393 · Cited by 49
An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion
He, X. M., Li, Y., Zou, D., Zu, H., Li, W., & Zheng, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.026 · Cited by 47
Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration
Fu, Y., Cui, S., Luo, D., & Liu, Y. (2021) · Nanomaterials · doi:10.3390/nano11030789 · Cited by 45
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation
Arya, P. N., Saranya, I., & Selvamurugan, N. (2024) · World Journal of Stem Cells · doi:10.4252/wjsc.v16.i2.102 · Cited by 42
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications
Wang, X., Wang, C., Chu, C., Xue, F., Li, J., & Bai, J. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.024 · Cited by 47
Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications
Shan, Y., Qiao, B., Ouyang, S., Du, C., Zhao, L., Wang, G., Ye, J., Xiong, Y., Wei, Y., Song, J., et al. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2024.01.034 · Cited by 39
Use of resorbable magnesium screws in children: Systematic review of the literature and short-term follow-up from our series
Baldini, M., Coppa, V., Falcioni, D., Senigagliesi, E., Marinelli, M., & Gigante, A. P. (2021) · Journal of Children s Orthopaedics · doi:10.1302/1863-2548.15.210004 · Cited by 39
Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic − angiogenic coupling effect via Wnt/ β-catenin pathway
He, X. J., Liu, W., Liu, Y., Zhang, K., Sun, Y., Lei, P., & Hu, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100348 · Cited by 38
High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling
Hamushan, M., Cai, W., Zhang, Y., Ren, Z., Du, J., Zhang, S., Zhao, C., Cheng, P., Zhang, X., Shen, H., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.008 · Cited by 37
Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges
Chen, K., Li, Z., Sun, J., Gu, X., Huang, C., Su, H., & Fan, Y. (2022) · Science China Materials · doi:10.1007/s40843-022-2118-3 · Cited by 37
Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold
Yan, Z., Sun, T., Tan, W., Wang, Z., Yan, J., Miao, J., Wu, X., Feng, P., & Deng, Y. (2023) · Small · doi:10.1002/smll.202301426 · Cited by 36
Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development
Huang, B., Yang, M., Kou, Y., & Jiang, B. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.08.015 · Cited by 37
The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery
Müller, E., Schoberwalter, T., Mader, K., Seitz, J., Kopp, A., Baranowsky, A., & Keller, J. (2024) · Biomaterials Research · doi:10.34133/bmr.0122 · Cited by 39
The fabrication of a highly efficient hydrogel based on a functionalized double network loaded with magnesium ion and BMP2 for bone defect synergistic treatment
Xiong, A., He, Y., Gao, L., Li, G., Liu, S., Weng, J., Wang, D., & Zeng, H. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112347 · Cited by 33
3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration
Zhao, X. L., Wang, S., Wang, F., Zhu, Y., Gu, R., Yang, F., Xu, Y., Xia, D., & Liu, Y. (2022) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2022.07.002 · Cited by 33
Bioabsorbable Composites Based on Polymeric Matrix (PLA and PCL) Reinforced with Magnesium (Mg) for Use in Bone Regeneration Therapy: Physicochemical Properties and Biological Evaluation
García-Sobrino, R., Muñoz, M., Rodríguez-Jara, E., Rams, J., Torres, B., & Cifuentes, S. C. (2023) · Polymers · doi:10.3390/polym15244667 · Cited by 31
Magnesium‐Based Biodegradable Alloy Materials for Bone Healing Application
Dachasa, K., Aklilu, T. C., Ewnete, B. G., Ejeta, B. M., & Bakare, F. F. (2024) · Advances in Materials Science and Engineering · doi:10.1155/2024/1325004 · Cited by 31
Customizable Silk Fibroin-Based Hydrogel Fibrous Scaffold for On-Demand Multifaceted Tissue Repair
He, X., Wang, R., Liu, X., Peng, R., Zhou, B., Wang, L., Wei, X., Wang, S., Bai, J., Feng, Q., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c03283 · Cited by 30
More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration
Ouyang, S., Wu, X. W., Li, M., Jing, X., Qiao, L., She, J., Zheng, K., Chen, X., & Pan, F. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2024.03.022 · Cited by 29
Magnesium-based nanocomposites for orthopedic applications: A review
Cheng, M., Liang, X., Cui, L., Guan, D., Qu, Y., Zhao, J., & Guan, K. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2024.11.028 · Cited by 29
Photo-click crosslinked hydrogel containing MgO2-loaded PLGA microsphere with concurrent magnesium and oxygen release for bone tissue engineering
Nasrollah, S. A. S., Karimi‐Soflou, R., & Karkhaneh, A. (2023) · Materials Today Chemistry · doi:10.1016/j.mtchem.2023.101389 · Cited by 29
Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview
Hassan, N., Krieg, T. M., Kopp, A., Bach, A. D., & Kröger, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116242 · Cited by 30
MicroRNA-16, via FGF2 Regulation of the ERK/MAPK Pathway, Is Involved in the Magnesium-Promoted Osteogenic Differentiation of Mesenchymal Stem Cells
Qi, H., Liu, Y., Wu, L. Y., Ni, S., Sun, J., Xue, J., Liu, Q., Ni, X., & Fan, W. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3894926 · Cited by 29
Marine biomaterials for sustainable bone regeneration
Wang, H., Li, X., Xuan, M., Ren, Y., Zhang, J., & Chang, J. (2024) · Giant · doi:10.1016/j.giant.2024.100298 · Cited by 29
Overview of porous magnesium-based scaffolds: development, properties and biomedical applications
Motaharinia, A., Drelich, J. W., Sharif, S., Ismail, A. F., Naeimi, F., Glover, A., Ebrahiminejad, M., & Bakhsheshi‐Rad, H. R. (2024) · Materials Futures · doi:10.1088/2752-5724/ad9493 · Cited by 27
Comprehensive review of Mg-based alloys: Mechanical, chemical and biological properties for prosthetic and orthopedic applications
Joshi, C. P., Rao, R. N., Golla, C. B., Özcan, M., & Prasad, P. S. (2025) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2025.01.215 · Cited by 26
Biocompatibility evaluation of peo-treated magnesium alloy implants placed in rabbit femur condyle notches and paravertebral muscles
Kim, S. R., Lee, K. M., Kim, J. H., Choi, Y. J., Park, H.-I., Jung, H. C., Roh, H. J., Han, J. H. L., Kim, J. R., & Lee, B. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00279-1 · Cited by 26
Microwave-Assisted Hydrothermal Treatment of Multifunctional Substituted Hydroxyapatite with Prospective Applications in Bone Regeneration
Burdușel, A.-C., Neacșu, I. A., Bîrcă, A. C., Chircov, C., Grumezescu, A. M., Holban, A. M., Curuțiu, C., Diţu, L.-M., Stan, M. S., & Andronescu, E. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14070378 · Cited by 26
Magnesium-based materials in orthopaedics: material properties and animal models.
Jing, X., Ding, Q., Wu, Q., Su, W., Yu, K., Su, Y., Ye, B., Gao, Q., Sun, T., & Guo, X. (2021) · PubMed Central · doi:10.12336/biomatertransl.2021.03.004 · Cited by 25
The Osteogenic Properties of Calcium Phosphate Cement Doped with Synthetic Materials: A Structured Narrative Review of Preclinical Evidence
Dali, S. S. M., Wong, S. K., Chin, K., & Ahmad, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087161 · Cited by 24
Determining critical Zn/Ca atomic ratio and its role in mechanical and corrosion properties of biodegradable Mg-Ca-Zn-Mn alloys
Avey, T., Cho, D., Zhang, J., Miao, J., Dean, D., & Luo, A. A. (2024) · Materialia · doi:10.1016/j.mtla.2024.102203 · Cited by 24
Enhanced mechanical and biological performances of CaO-MgO-SiO2 glass-ceramics via the modulation of glass and ceramic phases
Feng, K., Wu, Y., Wang, C., Tu, C., Lin, Y., Chen, C., Lai, P., Huang, Y.-T., & Chen, P.-Y. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112060 · Cited by 24
A soft-hard hybrid scaffold for osteochondral regeneration through integration of composite hydrogel and biodegradable magnesium
Pei, Z., Xu, H., Guo, M., Xu, W., Wen, Y., Sun, F., Zhang, T., Peng, B., Zhao, P., Huang, L., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123493 · Cited by 23
Mg.ATP-decorated ultrafine magnetic nanofibers: A bone scaffold with high osteogenic and antibacterial properties in the presence of an electromagnetic field
Meshkini, A., Sistanipour, E., & Izadi, A. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112256 · Cited by 23
Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review
Ji, Z., Wan, Y., Wang, H., Yu, M., Zhao, Z., Wang, T., Ma, G., Fan, S., & Liu, Z. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acd976 · Cited by 23
Osteogenic effects of bioabsorbable magnesium implant in rat mandibles and in vitro
He, W., Zhang, H., & Qiu, J. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0162 · Cited by 22
A review on Mg-based metallic glasses for biomedical scaffolds: experimental and computational modeling
Onyeagba, C. R., & Tesfamichael, T. (2025) · Microstructures · doi:10.20517/microstructures.2024.89 · Cited by 21
Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway
Zhu, Y., Jia, G., Yang, Y., Weng, J., Liu, S., Zhang, M., Zhang, G., Qin, H., Chen, Y., Yang, Q., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01097 · Cited by 20
Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans
Pickering, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169102 · Cited by 20
Current status and future prospects of stomatology research
Chen, Q., Wang, Y., & Shuai, J. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200702 · Cited by 20
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration
Shi, Z., Yang, F., Hu, Y., Pang, Q., Shi, L., Du, T., Cao, Y., Song, B., Yu, X., Cao, Z., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121666 · Cited by 22
Enhancement of Bone Tissue Regeneration with Multi‐Functional Nanoparticles by Coordination of Immune, Osteogenic, and Angiogenic Responses
Jeong, H., Byun, H., Lee, J., Han, Y., Huh, S. J., & Shin, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400232 · Cited by 20
Ascorbate-loaded MgFe layered double hydroxide for osteomyelitis treatment
Li, W., Huang, Y., Gu, D., Peng, S., Zhang, B., Peng, F., Zhang, D., Li, M., Jin, X., Jia, Z., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.12.072 · Cited by 19
Nanoparticle and Nanotopography-Induced Activation of the Wnt Pathway in Bone Regeneration
Jagannathan, C., Waddington, R. J., & Ayre, W. N. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0108 · Cited by 19
Divalent metal ions enhance bone regeneration through modulation of nervous systems and metabolic pathways
Luo, Y., Liu, B., Qiu, Y., Li, L., Yang, F., Zhang, C., & Wang, J. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.01.034 · Cited by 20
XPS Investigation of Sol–Gel Bioactive Glass Synthesized with Geothermal Water
Vasconcelos, H. C., Meirelles, M., & Özmenteş, R. (2025) · Surfaces · doi:10.3390/surfaces8030050 · Cited by 18
Characterization of a Magnesium Fluoride Conversion Coating on Mg-2Y-1Mn-1Zn Screws for Biomedical Applications
Gambaro, S., Nascimento, M. L., Shekargoftar, M., Ravanbakhsh, S., Sales, V., Paternoster, C., Bartosch, M., Witte, F., & Mantovani, D. (2022) · Materials · doi:10.3390/ma15228245 · Cited by 18
Raspberry-like PLA/PGS biodegradable microparticles with urethane linkages: Unlocking tailored release of magnesium ions and oxygen for bone tissue engineering
Maleki, M., Karimi‐Soflou, R., & Karkhaneh, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123760 · Cited by 19
Nanosized Silk–Magnesium Complexes for Promotion of Angiogenic and Osteogenic Activities
Cheng, W., Yang, H., Xiao, L., Yang, G., Lü, Q., & Kaplan, D. L. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c18195 · Cited by 18
Effects of Magnesium-Doped Hydroxyapatite Nanoparticles on Bioink Formulation for Bone Tissue Engineering
Montanari, M., Korkeamäki, J. T., Campodoni, E., Mohamed‐Ahmed, S., Mustafa, K., Sandri, M., & Rashad, A. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01418 · Cited by 20
High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification
He, X. M., Li, Y., Miao, H., Xu, J., Ong, M. T., Wang, C., Zheng, L., Wang, J., Huang, L., Zu, H., et al. (2022) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2022.12.006 · Cited by 17
Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model
Ma, Q., Rubenis, K., Sigurjónsson, Ó. E., Hildebrand, T., Standal, T., Zemjane, S., Ločs, J., Loča, D., & Haugen, H. J. (2023) · Smart Materials in Medicine · doi:10.1016/j.smaim.2023.04.001 · Cited by 19
Insights into the antiosteoporotic mechanism of the soy‐derived isoflavone genistein: Modulation of the Wnt/beta‐catenin signaling
Mannino, F., Imbesi, C., Irrera, N., Pallio, G., Squadrito, F., & Bitto, A. (2023) · BioFactors · doi:10.1002/biof.2008 · Cited by 19
The role and application of metal ions in maxillofacial bone defect
Hu, X., You, D., Fei, T., Wu, Y., Shao, Y., Xie, Y., Xu, M., Hu, Y., Zhang, J., & Yu, M. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152317 · Cited by 17
Strontium-Doped Whitlockite Scaffolds for Enhanced Bone Regeneration
Hennebert, P. M., Amirthalingam, S., Kang, T. H., So, K., & Hwang, N. S.-Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c13391 · Cited by 17
Versatile application of magnesium-related bone implants in the treatment of bone defects
Tao, M., Cui, Y., Sun, S., Zhang, Y., Ge, J., Yin, W., Li, P., & Wang, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101635 · Cited by 19
Magnesium alloy implant GZ31K with enhanced corrosion resistance promotes fracture healing in vitro and in vivo systems
Yusufu, Y., Zhang, Y., Liu, X., Jiang, J., Shao, Z., Sun, M., Zhang, X., & Jiang, Q. Y. (2025) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2025.03.027 · Cited by 14
Effect of biodegradable Zn screw on bone tunnel enlargement after anterior cruciate ligament reconstruction in rabbits
Mao, G., Wang, C., Feng, M., Wen, B., Yu, S., Han, X., Yu, Z., Qiu, Y., & Bian, W. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.109834 · Cited by 16
Effect of mechanical loading on osseointegration combined with degradation behavior of magnesium bone screw in vivo
Gao, Y., Huang, H., Jiang, X., Ha, T., Li, Y., Zhang, K., Wang, C., Wang, L., & Fan, Y. (2023) · Applied Materials Today · doi:10.1016/j.apmt.2023.101793 · Cited by 15
Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair
Wu, J., Shen, Y., Wang, P., Guo, Z., Bai, J., Wang, X., Chen, D., Lin, X., & Tang, C. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01565 · Cited by 15
Repair of Osteoporotic Bone Defects in Rats via the Sirtuin 1-Wnt/β-catenin Signaling Pathway by Novel Icariin/Porous Magnesium Alloy Scaffolds
Yu, F., Zhang, G., Weng, J., Jia, G., Fang, C., Xu, H., Xiong, A., Qin, H., Qi, T., Yang, Q., et al. (2024) · Biomaterials Research · doi:10.34133/bmr.0090 · Cited by 15
Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration
Gao, S., Li, H., Li, Z., Wang, H., Li, X., Yang, S., Huang, L., Zhang, B., Zhang, K., Tsoi, J. K. H., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c15922 · Cited by 17
Construction of chemokine substance P-embedded biomimetic multilayer onto bioactive magnesium silicate-titanium implant for bone regeneration
Mu, C., He, Y., Hu, Y., Li, M., Chen, M., Wang, R., Xiang, Y., Luo, Z. Y., & Cai, K. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2020.100777 · Cited by 15
Incorporation of heparin/BMP2 complex on GOCS-modified magnesium alloy to synergistically improve corrosion resistance, anticoagulation, and osteogenesis
Lin, Y., Yang, Y. F., Zhao, Y., Gao, F., Guo, X. R., Yang, M., Hong, Q., Yang, Z., Dai, J., & Pan, C. (2021) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-021-06497-8 · Cited by 15
Update on the research and development of magnesium-based biodegradable implants and their clinical translation in orthopaedics.
Luo, Y., Wang, J., Ong, M. T., Yung, P. S., Wang, J., & Qin, L. (2021) · PubMed Central · doi:10.12336/biomatertransl.2021.03.003 · Cited by 15
Novel injectable and self-setting composite materials for bone defect repair
Xu, Q., Liang, J., Xue, H., Liu, Y., Cao, L., Li, X., Tian, J., & Zhang, X. (2020) · Science China Materials · doi:10.1007/s40843-019-1233-7 · Cited by 15

Authors: Hung, C.-C., Chaya, A., Liu, K., Verdelis, K., & Sfeir, C.
Affiliations: University of Pittsburgh (US)
Corresponding author: Sfeir, Charles
ORCID: Liu, Kai
Verdelis, Konstantinos
Sfeir, Charles
Venue: Acta Biomaterialia
Publisher: Elsevier BV
Published: 2019-10
Volume: 98
Pages: 246-255
ISSN: 1742-7061 (ISSN-L)
DOI: 10.1016/j.actbio.2019.06.001
OpenAlex: W2949316410
Cited by: 237
References: 48
Citations by year: 2026: 33 · 2025: 58 · 2024: 48 · 2023: 33 · 2022: 24 · 2021: 24 · 2020: 16 · 2019: 1
FWCI: 4.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Acta Biomaterialia (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pittsburgh (NIH S10OD021533)
Topics: Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords: magnesium ions, magnesium-based implants, bone regeneration, canonical Wnt signaling pathway, mesenchymal stem cells, bone formation, β-catenin, LEF1, DKK1, biodegradable implants, ulnar fracture
MeSH terms: Alkaline Phosphatase, Animals, Bone Regeneration, Calcification, Physiologic, Ions, Magnesium, Rabbits, Transcription, Genetic, beta Catenin, X-Ray Microtomography, Mesenchymal Stem Cells, Wnt Signaling Pathway

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks