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The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway
Abstract
Magnesium (Mg)-based implants have become of interest to both academia and the medical industry. The attraction largely is due to Mg's biodegradability and ability to enhance bone healing and formation. However, the underlying mechanism of how Mg regulates osteogenesis is still unclear. Based on our previous in vivo and molecular signaling work demonstrating the osteogenic effect of Mg, the current study aims to extend this work at the molecular level especially that we also observed and quantified mineral deposits in the bone marrow space in a rabbit ulna fracture model with Mg plates and screws. Histological analysis and quantitative results of micro-CT showed mineralized deposition and a significant increase in bone volume at 8 weeks and 16 weeks post-operative. These in vivo results led us to focus on studying the effect of Mg 2+ on human bone marrow stromal cells (hBMSCs). The data presented in this manuscript demonstrate the activation of the canonical Wnt signaling pathway in hBMSCs when treated with 10 mM Mg 2+. With additional Mg 2+ present, the protein expression of active β-catenin was significantly increased to a level similar to that of the positive control. Immunocytochemistry and the increased expression of LEF1 and Dkk1, downstream target genes that are controlled directly by active β-catenin, demonstrated the protein translocation and the activation of transcription. Taken together, these data suggest that Mg 2+ induces an osteogenic effect in the bone marrow space by activating the canonical Wnt signaling pathway, which in turn causes BMSCs to differentiate toward the osteoblast lineage. STATEMENT OF SIGNIFICANCE: Magnesium (Mg)-based alloys are being studied to be used in the field of implantable medical devices due to its natural biodegradability and the potential ability to promote bone regeneration. Despite many in vivo studies that demonstrated an increased new bone growth by implanting Mg-based devices, the underlying mechanism of this effect is still unclear. In order to safely use Mg-based implants on human and better control the osteogenic effect, it is necessary to understand the corresponding cellular response in the targeted area. The present study provides the rationale to study Mg ions on bone marrow stromal cells and shows the activation of canonical Wnt signaling pathway that promotes osteogenesis by in vivo and in vitro approaches.
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“Consistent with previous reports that Mg2+ specifically activates the Wnt/β-catenin pathway by inducing LRP5 receptor phosphorylation, we propose that TNE@AHAC may promote osteoblast differentiation through this mechanism [66].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [66]
In the citing paper
“Concurrently, Mg2+-activated osteogenic pathways (e.g., Wnt signaling) act synergistically with M2 macrophage-derived reparative factors to promote collagen deposition and bone formation [36,66];”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [66]
Citations
Cites
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
Magnesium and its alloys as orthopedic biomaterials: A review
Staiger, M. P., Pietak, A. M., Huadmai, J., & Dias, G. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.10.003 · Cited by 4,460
β‐catenin is a target for the ubiquitin–proteasome pathway
Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,586
Zheng, Y., Gu, X., & Witte, F. (2014) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2014.01.001 · Cited by 2,469
In vivo corrosion of four magnesium alloys and the associated bone response
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., Meyer‐Lindenberg, A., Wirth, C. J., & Windhagen, H. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.049 · Cited by 2,403
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
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Research works printed but not linked: 1
- Kubota, 2010, Wnt signaling in bone, Clinical pediatric endocrinology: case reports and clinical investigations: official journal of the Japanese Society for Pediatric, Endocrinology, 19, 49
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Sorted by citations
Items 101–200 of 238
Recent Advances in the Development of Magnesium-Based Alloy Guided Bone Regeneration (GBR) Membrane
Chen, K., Li, Z., Huang, C., Yin, X., Zhang, X., Li, P., Gu, X., & Fan, Y. (2022) · Metals · doi:10.3390/met12122074 · Cited by 15
Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications
Weng, Y., Jian, Y., Huang, W., Xie, Z., Zhou, Y. M., & Pei, X. (2023) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35246 · Cited by 15
Osteoporotic Bone Regeneration via Plenished Biomimetic PLGA Scaffold with Sequential Release System
Lee, J., Kim, D., Park, S., Jung, J., Baek, S., Lee, S., Kim, J. H., Ahn, T., & Han, D. K. (2023) · Small · doi:10.1002/smll.202310734 · Cited by 13
Lutzweiler, G., Zhang, Y., Gens, F., Échalard, A., Ladam, G. D., Hochart, J., Janicot, T., Mofaddel, N., & Louis, B. (2022) · Materials Advances · doi:10.1039/d2ma00768a · Cited by 13
Stojkovska, J., Zvicer, J., Andrejevic, M., Janaćković, D. T., Obradović, B., & Veljovic, D. N. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34856 · Cited by 12
Lu, M., Li, L., Zheng, C., Wang, Y., Zhang, B., Wang, L., Li, Z., Zhang, Y., Zhou, Y., Zhou, C., et al. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112351 · Cited by 13
Nano-laponite encapsulated coaxial fiber scaffold promotes endochondral osteogenesis
Li, Y., Wei, J., Xiao, S., Jin, S., Xia, X., Liu, H., Liu, J., Hu, J., Zuo, Y., Li, Y., et al. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae080 · Cited by 13
Zhang, W., Sheng, X., Zhang, B., Fu, Y., Wang, Q., Yang, K., Tan, L., & Zhang, Q. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2024.08.002 · Cited by 12
Implant derived high local concentration of magnesium inhibits tumorigenicity of osteosarcoma
Gong, G., Huang, H., Tong, Z., Zheng, Y., Bian, D., & Zhang, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123263 · Cited by 11
Magnesium-incorporated sol-gel Ta2O5 coating on Ti6Al4V and in vitro biocompatibility
Chen, S., Zhang, C., Xiao, D., Shi, F., Liu, K., Wan, Y., Duan, K., Weng, J., Feng, G., & Yin, Y. (2021) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2021.127769 · Cited by 12
Baldini, M., Coppa, V., Falcioni, D., Cusano, G., Massetti, D., Marinelli, M., & Gigante, A. P. (2022) · Journal of Children s Orthopaedics · doi:10.1177/18632521221136100 · Cited by 12
Yang, X., Peng, S., Chen, X., Zhang, W., Deng, H., Zhou, L., Yan, Y., & Zhang, Q. (2024) · Applied Clay Science · doi:10.1016/j.clay.2024.107652 · Cited by 11
Tian, Y., Xu, Y., Pinc, J., Fojt, J., Hybášek, V., Kubásek, J., Msallamová, Š., Xiang, Y., Guo, M., Čapek, J., et al. (2025) · RSC Advances · doi:10.1039/d5ra02009c · Cited by 14
Qiang, L., Zhang, T., Zhang, Q., Yang, T. Q., Shan, J., Shen, G., Kong, W., Wei, J., Wang, J., Liu, Y., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501008 · Cited by 10
Magnesium-containing implants enhance bone healing: A mechanobiological perspective
Wen, Z., Lei, L., Zhang, H., Jin, Z., Shan, Z., Liu, W., Tong, W., Xu, J., & Qin, L. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100161 · Cited by 15
Mu, Y., Du, Z., Gao, W., He, Z., Xiao, L., Zhou, Y., Ahmed, I. A., Dai, H., Liu, M., Liu, J., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123928 · Cited by 10
Herzog, P., Rendenbach, C., Turostowski, M., Ellinghaus, A., Soares, A. P., Heiland, M., Duda, G. N., Schmidt‐Bleek, K., & Fischer, H. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.005 · Cited by 10
Shen, J., Pei, Y., Bai, S., Lei, S., Xia, S., Zhang, J., Li, X., Xu, H., Zheng, X., Shen, X., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123639 · Cited by 10
Xing, Y., Zhong, X., Chen, Z., & Liu, Q. (2022) · Bio-Medical Materials and Engineering · doi:10.3233/bme-221437 · Cited by 10
Ji, Z., Wan, Y., Zhao, Z., Wang, T., Yu, M., Wang, H., Fan, S., Liu, Z., & Liu, C. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202200598 · Cited by 10
Zhang, M., Jia, G., Weng, J., Zhu, Y., Lin, J., Qi, Y., Fang, C., Zeng, H., Yuan, G., Yang, J., et al. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00713 · Cited by 9
Wu, Q., Zhang, S., & Cao, R. (2024) · BMC Oral Health · doi:10.1186/s12903-024-05048-1 · Cited by 9
Innovations in 3D printing of magnesium alloys and composites for biodegradable biomedical devices
Nair, A., Gupta, S., Jangitwar, A., & Kandasubramanian, B. (2025) · Bioprinting · doi:10.1016/j.bprint.2025.e00390 · Cited by 9
Kim, J. Y., Kumar, S. B., Park, C. H., & Kim, C. S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131412 · Cited by 9
Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration
Lu, J., Sun, M., Zhang, J., Yang, X., Dong, M., He, H., Liu, A., Yu, M., Wang, B., & Wang, H. (2023) · Bio-Design and Manufacturing · doi:10.1007/s42242-023-00240-8 · Cited by 9
Copper‐doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention
El‐Sayed, S. A. M., ElShebiney, S. A., Beherei, H. H., Kumar, P., Choonara, Y. E., & Mabrouk, M. (2024) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35376 · Cited by 8
Xu, X. Q., Wang, Y., Zhu, S., Xu, Q., Liu, Z., Cheng, G., Long, D., Cheng, L., & Dai, F. (2024) · Materials Futures · doi:10.1088/2752-5724/ad9e09 · Cited by 8
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Li, P., Chen, J., Schmidt, F., Dai, J., Li, A., Yu, Z., Li, A., Yu, Z., & Witte, F. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123783 · Cited by 10
Gu, L., Huang, R., Ni, N., Zhou, R., Su, Y., Gu, P., Zhang, D., & Fan, X. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c02795 · Cited by 10
Bao, Z., Yang, J., Shen, J. F., Wang, C., Li, Y., Zhang, Y., Yang, G., Zhong, C., Xu, S., Xie, L., et al. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02702j · Cited by 8
Wu, H. W., Yu, M., Zhang, S., You, M., Xiong, A., Feng, B., Niu, J., Yuan, G., Yue, B., & Jia, P. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02744a · Cited by 8
Wu, Y., Cai, Z., Zhang, Y., Zheng, Y., Liao, L., & Jia, Z. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.018 · Cited by 7
“…(e.g., Wnt signaling) act synergistically with M2 macrophage-derived reparative factors to promote collagen deposition and bone formation [36,66]; (3) With prolonged implantation, continued degradation of the Mg alloy is accompanied by progressive bone formation, leading to successful…”
Zhang, P., Wang, T., Qian, J., Qin, H., Liu, P., Xiong, A., Udduttula, A., Wang, D., Zeng, H., & Chen, Y. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae049 · Cited by 7
Lagarrigue, P., Oh, J., Xie, J., Tenailleau, C., Duployer, B., Cazalbou, S., Poquillon, D., Drouet, C., & Soulié, J. (2024) · Next Materials · doi:10.1016/j.nxmate.2024.100147 · Cited by 7
Yuan, X., Wu, T., Lu, T., & Ye, J. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01937 · Cited by 7
Whitfield, T., Hosseini, F. S., Orlando, J. D., Deng, C., Lo, K. W. ‐., Kan, H.-M., Ghosh, D., Sydlik, S. A., & Laurencin, C. T. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf074 · Cited by 8
Sahoo, S. N., Rath, P., Mandal, S., Kamde, M. A., Saha, P., Nandi, S. K., & Roy, M. (2025) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2025.09.020 · Cited by 7
Chen, Y., Qiu, Z.-C., Hu, X., Wang, T., Li, G., Tang, Z., Fang, C., Sheng, W., Zhao, J., Yu, F., et al. (2024) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100988 · Cited by 7
Tomaszewska, E., Rudyk, H., Wojtysiak, D., Donaldson, J., Muszyński, S., Arciszewski, M. B., Lisova, N., Brezvyn, O. M., Puzio, I., Abramowicz, B., et al. (2022) · Animals · doi:10.3390/ani12182353 · Cited by 7
Witte, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816137-1.00021-0 · Cited by 7
Bhattarai, G., Shrestha, S. K., Rijal, S., Kook, S., & Lee, J. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37812 · Cited by 7
Chen, K., Chen, C., Wang, W.-R., Lee, Y. B., Chen, C., & Wong, P. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213963 · Cited by 7
Xiong, W., Zhou, Y., Li, Y., Yuan, Y., Liu, K., Huang, X., Li, J., Zhang, Z., Shi, X., & Li, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-13056-6 · Cited by 6
Antoniac, I., Mănescu, V., Păltânea, G., Antoniac, A., Fosca, M., Lăptoiu, D., & Rau, J. V. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.07.035 · Cited by 6
Jalilinejad, N., Baheiraei, N., Azami, M., Ramezani, M., Haramshahi, S. M. A., & Shahrezaee, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-13449-7 · Cited by 6
Chen, C., Tang, R., Guo, Y., Lei, X., Min, Q., Lu, Y., & Dai, Y. (2026) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2026.01.005 · Cited by 6
Wang, L., Li, Y., Jiang, S., Zhang, Z., Zhao, S., Song, Y., Liu, J., & Tan, F. (2023) · Biomedical Materials · doi:10.1088/1748-605x/ace9a5 · Cited by 6
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Ren, Y., Jung, O., Batinic, M., Burckhardt, K., Görke, O., Alkildani, S., Köwitsch, A., Najman, S. J., Stojanović, S., Liu, L., et al. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1408702 · Cited by 6
Blašković, M., Prpić, I. B., Aslan, S., Gabrić, D., Blašković, D., Cvijanović, O., Čandrlić, M., & Kačarević, Ž. P. (2024) · Biomedicines · doi:10.3390/biomedicines12112537 · Cited by 6
Costa, V., Raimondi, L., Scilabra, S. D., Pinto, M. L., Bellavia, D., Luca, A. D., Guglielmi, P., Cusanno, A., Cattini, L., Pulsatelli, L., et al. (2025) · Materials · doi:10.3390/ma18061254 · Cited by 6
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Miyake, R., Shimabukuro, M., Terauchi, M., Marukawa, E., & Kawashita, M. (2025) · Advanced Biology · doi:10.1002/adbi.202500401 · Cited by 5
Chathoth, B. M., Helmholz, H., Angrisani, N., Wiese, B., Reifenrath, J., & Willumeit‐Römer, R. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37862 · Cited by 5
Dukle, A., Dua, R., Deepati, A. K., & Sankar, M. R. (2025) · Hybrid Advances · doi:10.1016/j.hybadv.2025.100425 · Cited by 5
He, J., Qiao, L., Lan, Y., Peng, C., Fu, Q., Dai, X., Fan, Z., Lan, H., Li, S., Zhang, X., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.11.022 · Cited by 5
Magnesium metabolism: A potential breakthrough in osteoporosis intervention
Xiong, W., Zhou, Y., Yan, Y., Li, Y., Li, J., Yuan, Y., Shi, X., & Liu, K. (2025) · iScience · doi:10.1016/j.isci.2025.114437 · Cited by 7
Luo, X., Li, M., Cai, H., Yang, S., Hao, L., Ebel, T., Helmholz, H., Huang, B., & Wang, X. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00710 · Cited by 5
Zhang, Z., Cao, J., Xing, H., Liu, J., Li, L., & Zhang, Y. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05834-9 · Cited by 5
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Janani, S. P. (2023) · International Journal of Clinicopathological Correlation · doi:10.56501/intjclinicopatholcorrel.v7i2.926 · Cited by 5
Shen, S., Fan, Z., Guo, X., Zhao, W., Zhang, J., Wang, L., Tan, L., Wang, X., & Ren, W. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501796 · Cited by 4
Namnabat, M., Tamjid, E., Najafi, P., & Bazazzadeh, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-28284-z · Cited by 4
Baicalein-manganese nanoparticles for antioxidant and osteogenic therapy of bone injury
Wang, R., Jin, Q., Meng, Z., Cao, X., Wu, Y., Yang, C., & Yuan, J. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115400 · Cited by 6
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
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Sahoo, S. N., Rath, P., Nandi, S. K., & Roy, M. (2026) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2026.102052 · Cited by 4
Liu, S., Zhou, S., Zou, T., Hou, G., Xiao, Q., Li, L., Yang, J., Chen, W., Zhang, Y., & Lv, H. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501938 · Cited by 4
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Yang, Z., Lu, J., Yan, T., Ibrahim, M., Wang, Q., Tan, L., Wang, Q., Mu, Y., & Gao, Y. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00949 · Cited by 4
Ansari, K. R., Singh, A., Singh, S., Singh, A., Ali, I. H., Younas, M., & Lin, Y. (2025) · Corrosion Reviews · doi:10.1515/corrrev-2024-0083 · Cited by 4
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He, X. M., Li, Y., Miao, H., Sun, J., Ong, M. T., Zu, H., & Li, W. (2022) · Crystals · doi:10.3390/cryst12091287 · Cited by 4
Slavin, B. V., Mirsky, N. A., Stauber, Z. M., Nayak, V. V., Smay, J. E., Rivera, C. F., Mijares, D. Q., Coelho, P. G., Cronstein, B. N., Tovar, N., et al. (2024) · Bio-Medical Materials and Engineering · doi:10.3233/bme-230214 · Cited by 3
Wang, Y., Liu, Z., Wu, X., Zhang, L., Wang, J., Zhao, Y., Fan, L., Sun, Y., Lv, L., Yang, Z., et al. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214740 · Cited by 3
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Jo, H. J., Kang, M. S., Kim, J., Raja, I. S., Jang, H. J., Park, K. M., & Han, D. (2024) · Biomedical Materials & Devices · doi:10.1007/s44174-023-00151-3 · Cited by 3
AITKEN, K. J., Schröder, A., Haddad, A., Sidler, M., Penna, F. J., Fernández, N., Ahmed, T., Marino, V. J., Bechbache, M., Jiang, J., et al. (2024) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2024.06.008 · Cited by 3
Harris, J., & Kaarthikeyan, G. (2024) · Journal of Indian Society of Periodontology · doi:10.4103/jisp.jisp_554_23 · Cited by 3
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Song, D., Fu, Y., Zhou, Q., Fu, M., Wu, X., Sun, Y., Bi, W., Sun, J., Yang, F., Guo, H., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501452 · Cited by 3
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Tang, W., Liu, Q., Tan, W., Sun, T., & Deng, Y. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01140-w · Cited by 3
Niknafs, B., Ahangar, P., Meskaraf-asadabadi, M., & Ghanbari, E. (2026) · Scientific Reports · doi:10.1038/s41598-026-50227-5 · Cited by 3
Kotelyukh, B. A., Movchan, O., Teslia, S., & Shtonda, D. V. (2025) · Wiadomości Lekarskie · doi:10.36740/wlek/197141 · Cited by 2
Kamel, R., El‐Sayed, S. A. M., Mabrouk, M., Behere, H. H., El‐Wakil, N. A., Abdel-Rahman, R. F., Amer, M., & ElKasabgy, N. A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107083 · Cited by 2
Kim, J.-H., Jung, Y., Lee, Y.-S., Choi, S.-W., Hwang, G., & Yun, K. (2025) · Biomimetics · doi:10.3390/biomimetics10090583 · Cited by 2
Gmitro, S., Larraza, A., Sotoudehbagha, P., Mata, A. A., Romero, A., Lovejoy, J., & Razavi, M. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1685918 · Cited by 3
Wang, T., Bian, Y., Hu, T., Li, M., Tan, Y., Yang, Y., Jian, X., Weng, X., Tan, C., & Liang, R. (2026) · Advanced Science · doi:10.1002/advs.202524296 · Cited by 2
Wang, L., Wang, M., Zhang, R., Wang, W., Wu, J., & Tang, C. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag098 · Cited by 2
Biochemical aspects of magnesium-enhanced bone regeneration
Baraeva, L. M., Baida, A. S., Быков, И. М., Курзанов, А. Н., Владимирович, Ц. О., Pavlyuchenko, I. I., & Сторожук, А. П. (2023) · Innovative medicine of Kuban · doi:10.35401/2541-9897-2023-26-2-103-108 · Cited by 2
Design and Culture of Biomaterial Scaffolds for Orthopedic Applications
Gibson, J., Chen, W., Graham, A., McLay, S. J., Guo-Yue, A., & Priddy, L. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-81743-4_6 · Cited by 2
Liang, W., Wang, W.-S., Gao, P., Lin, Z., Chen, L., Yu, Y., Zhang, B., Subin, B., Wu, X., & Zhang, T. (2025) · Rare Metals · doi:10.1007/s12598-025-03322-x · Cited by 2
Xu, C., Luo, Y., Cai, Z., Ji, J., Guo, Z., Cai, Z., You, C., Zhou, Y., Chen, Z., Zhang, W., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.019 · Cited by 2
In Vivo Study of Biodegradable Pure Magnesium Membrane-Guided Bone Regeneration
Zhao, Y., Yang, M., Shang, Y., Hong, W., Zhang, X., Yang, J., & Wang, C. (2023) · Journal of Orthopedic Research and Therapy · doi:10.29011/2575-8241.001304 · Cited by 2
Jaramillo, N., Moreno, A. I., Arenas, R. L. S., Ospina, V., Peláez-Vargas, A., García-Negrete, C. A., & Paucar, C. G. (2021) · MRS Advances · doi:10.1557/s43580-021-00036-x · Cited by 2
Chen, L., Wu, G., Liu, S., Yan, Z., Yue, H., Zhu, J., Ge, N., Wang, Y., Li, Q., Liu, G., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.013 · Cited by 1
A Systematic Review of Metal Composite Bone Grafts in Preclinical Spinal Fusion Models
Rajkovic, C. J., Shafi, M., Sarkar, N., Hernandez, V. N., Yang, L., & Witham, T. F. (2025) · Biomimetics · doi:10.3390/biomimetics10090594 · Cited by 1
Matić, T., Daou, F., Petrović, J., Ristic, B. Z., Cochis, A., Rimondini, L., & Veljovic, D. N. (2026) · Journal of the European Ceramic Society · doi:10.1016/j.jeurceramsoc.2026.118129 · Cited by 1
Wang, J., Yan, Y., Sheng, L., Zheng, Y., Liu, Y., & Jung, I. (2026) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2026.101991 · Cited by 2
Ma, J.-Y., Zhou, X., Yao, Z.-H., Lu, X.-R., Zhu, X., Li, S.-D., & Qiu, J. D. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115555 · Cited by 1
Kim, J. H., Kang, T. H., Jeon, S., & Hwang, N. S.-Y. (2026) · Science Advances · doi:10.1126/sciadv.aeb2091 · Cited by 2
Bucher, C. H., Fischer, H., Ellinghaus, A., Schmidt-Bleek, O., Jahn, D., Soares, A. P., Tsitsilonis, S., Duda, G. N., Heiland, M., Schmidt‐Bleek, K., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.09.023 · Cited by 1
Sun, S., Gao, L., Huang, Z., Guo, C., Chu, C., & Dong, Y. (2023) · Materials Today Communications · doi:10.1016/j.mtcomm.2023.106643 · Cited by 1
Effect of magnesium deficiency on bone health
Dedukh, N. V., Grygorieva, N. V., & Musiіenko, А. S. (2024) · ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS · doi:10.15674/0030-598720234121-127 · Cited by 2
Metadata
- Authors
- Hung, C.-C., Chaya, A., Liu, K., Verdelis, K., & Sfeir, C.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Sfeir, Charles
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 98
- Pages
- 246-255
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2949316410
- Cited by
- 237
- References
- 48
- Citations by year
- 2026: 33 · 2025: 58 · 2024: 48 · 2023: 33 · 2022: 24 · 2021: 24 · 2020: 16 · 2019: 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh (NIH S10OD021533)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- magnesium ions, magnesium-based implants, bone regeneration, canonical Wnt signaling pathway, mesenchymal stem cells, bone formation, β-catenin, LEF1, DKK1, biodegradable implants, ulnar fracture
- MeSH terms
- Alkaline Phosphatase, Animals, Bone Regeneration, Calcification, Physiologic, Ions, Magnesium, Rabbits, Transcription, Genetic, beta Catenin, X-Ray Microtomography, Mesenchymal Stem Cells, Wnt Signaling Pathway
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