Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy
Open accessAbstract
Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (Φ Δ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). STATEMENT OF SIGNIFICANCE: The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show high singlet oxygen QY (Φ Δ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics and a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the PDT/PTT combination therapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BODIPY derivatives are an emerging class of small-molecule fluorophores that are key components in NIR dyes due to their strongly electron-withdrawing BF2 group and exceptional stability.
“BODIPY derivatives are an emerging class of small-molecule fluorophores that are key components in NIR dyes due to their strongly electron-withdrawing BF2 group and exceptional stability (Fig. 7 and Table 3)153–168.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [155]
Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,171 · see citing works
Zhu, X., Feng, W., Chang, J., Tan, Y.-W., Li, J., Chen, M., Sun, Y., & Li, F. (2016) · Nature Communications · doi:10.1038/ncomms10437 · Cited by 1,014 · see citing works
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958 · see citing works
Jiang, Y., Li, J., Xu, Z. J., Xie, C., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201705980 · Cited by 601 · see citing works
Porphyrin photosensitizers in photodynamic therapy and its applications
Kou, J., Dou, D., & Yang, L. M. (2017) · Oncotarget · doi:10.18632/oncotarget.20189 · Cited by 588 · see citing works
Targeted zwitterionic near-infrared fluorophores for improved optical imaging
Choi, H. S., Gibbs, S. L., Lee, J. H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park, G., Xie, Y., Bae, S., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2468 · Cited by 560 · see citing works
Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H., Zhu, T., Jiang, Z., Liu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10334 · Cited by 554 · see citing works
Whole Genome Phylogeny of Bacillus by Feature Frequency Profiles (FFP)
Wang, A., & Ash, G. J. (2015) · Scientific Reports · doi:10.1038/srep13644 · Cited by 519 · see citing works
A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues
Wan, H., Yue, J., Zhu, S., Uno, T., Zhang, X., Yang, Q., Yu, K., Hong, G., Wang, J., Li, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03505-4 · Cited by 450 · see citing works
Self-citationBright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging
Zhang, M., Yue, J., Cui, R., Ma, Z., Wan, H., Wang, F., Zhu, S., Zhou, Y., Kuang, Y., Zhong, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806153115 · Cited by 432 · see citing works
Self-citationTian, J., Ding, L., Xu, H., Shen, Z., Ju, H., Li, J., Bao, L., & Yu, J. (2013) · Journal of the American Chemical Society · doi:10.1021/ja408286k · Cited by 416 · see citing works
Self-citationLi, J., Xu, Z. J., Lyu, Y., Jiang, Y., Huang, J., & Pu, K. (2018) · ACS Nano · doi:10.1021/acsnano.8b04066 · Cited by 377 · see citing works
Zhang, D., Wu, M., Zeng, Y., Wu, L., Wang, Q., Han, X., Liu, X., & Liu, J. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01027 · Cited by 357 · see citing works
Wang, Q., Dai, Y.-N., Xu, J.-Z., Cai, J., Niu, X., Zhang, L., Chen, R.-F., Shen, Q.-M., Huang, W., & Fan, Q.-L. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901480 · Cited by 313 · see citing works
Organic Dye Based Nanoparticles for Cancer Phototheranostics
Cai, Y., Si, W., Huang, W., Chen, P., Shao, J., & Dong, X. (2018) · Small · doi:10.1002/smll.201704247 · Cited by 309 · see citing works
Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy
Huang, L. F., Li, Z., Zhao, Y., Zhang, Y., Wu, S., Zhao, J., & Han, G. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05390 · Cited by 301 · see citing works
Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses
Chen, Q., Chen, M., & Liu, Z. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00271e · Cited by 289 · see citing works
ROS-responsive drug delivery systems for biomedical applications
Tao, W., & He, Z. (2017) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.11.002 · Cited by 255 · see citing works
Qi, J., Fang, Y., Kwok, R. T. K., Zhang, X., Hu, X., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b03062 · Cited by 246 · see citing works
Mou, J., Lin, T., Huang, F., Chen, H., & Shi, J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.009 · Cited by 211 · see citing works
Electrospun sulfated silk fibroin nanofibrous scaffolds for vascular tissue engineering
Liu, H., Li, X., Zhou, G., Fan, H., & Fan, Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.002 · Cited by 207 · see citing works
A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors
Chatterjee, S., Lesniak, W. G., Gabrielson, M., Lisok, A., Wharram, B. L., Sysa‐Shah, P., Azad, B. B., Pomper, M. G., & Nimmagadda, S. (2016) · Oncotarget · doi:10.18632/oncotarget.7143 · Cited by 194 · see citing works
Molecular Imaging in the Second Near‐Infrared Window
Wan, H., Du, H., Wang, F., & Dai, H. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900566 · Cited by 180 · see citing works
Self-citationLiu, Z., Song, F., Shi, W., Gurzadyan, G. G., Yin, H., Song, B., Liang, R., & Peng, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04488 · Cited by 156 · see citing works
Taratula, O. R., Schumann, C., Duong, T., Taylor, K. L., & Taratula, O. (2014) · Nanoscale · doi:10.1039/c4nr06050d · Cited by 129 · see citing works
NIR-II light activated photodynamic therapy with protein-capped gold nanoclusters
Chen, Q., Chen, J., Yang, Z., Zhang, L., Dong, Z., & Liu, Z. (2017) · Nano Research · doi:10.1007/s12274-017-1917-4 · Cited by 113 · see citing works
A theranostic agent for cancer therapy and imaging in the second near-infrared window
Ma, Z., Wan, H., Wang, W., Zhang, X., Uno, T., Yang, Q., Yue, J., Gao, H., Zhong, Y., Tian, Y., et al. (2018) · Nano Research · doi:10.1007/s12274-018-2210-x · Cited by 92 · see citing works
Self-citationWang, Q., Tian, L., Xu, J., Xia, B., Li, J., Lu, F., Lü, X., Wang, W., Huang, W., & Fan, Q. (2018) · Chemical Communications · doi:10.1039/c8cc05560b · Cited by 87 · see citing works
NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods
Li, M., Yan, H., Teh, C., Korzh, V. P., & Zhao, Y. (2014) · Chemical Communications · doi:10.1039/c4cc02966f · Cited by 80 · see citing works
Multifunctional Theranostic Nanoplatform for Cancer Combined Therapy Based on Gold Nanorods
Chen, W., Yang, C., Qiu, W., Luo, G., Jia, H., Lei, Q., Wang, X., Liu, G., Zhuo, R., & Zhang, X. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500453 · Cited by 78 · see citing works
Tao, J., Sun, D., Sun, L., Li, Z., Fu, B., Liu, J., Zhang, L., Wang, S., Fang, Y., & Xu, H. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.04.054 · Cited by 78 · see citing works
Self-citationSun, T., Chen, X., Wang, X., Liu, S., Liu, J., & Xie, Z. (2018) · Materials Chemistry Frontiers · doi:10.1039/c8qm00459e · Cited by 75 · see citing works
Functionalized Flexible Soft Polymer Optical Fibers for Laser Photomedicine
Jiang, N., Ahmed, R., Aoni, R. A., Guo, J., Yin, Y., Montelongo, Y., Butt, H., & Yetisen, A. K. (2017) · Advanced Optical Materials · doi:10.1002/adom.201701118 · Cited by 73 · see citing works
Self-citationBODIPY-doped silica nanoparticles with reduced dye leakage and enhanced singlet oxygen generation
Wang, Z., Hong, X., Zong, S., Tang, C., Cui, Y., & Zheng, Q. (2015) · Scientific Reports · doi:10.1038/srep12602 · Cited by 68 · see citing works
Chatterjee, S., Lesniak, W. G., & Nimmagadda, S. (2017) · Molecular Imaging · doi:10.1177/1536012117718459 · Cited by 61 · see citing works
ROS-triggered degradation of selenide-containing polymers based on selenoxide elimination
Wang, L., Zhu, K., Cao, W., Sun, C., Lu, C., & Xu, H. (2019) · Polymer Chemistry · doi:10.1039/c9py00171a · Cited by 57 · see citing works
Self-citationSelf-destructive PEG–BODIPY nanomaterials for photodynamic and photothermal therapy
Li, C., Lin, W., Liu, S., Zhang, W., & Xie, Z. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00752k · Cited by 55 · see citing works
Jin, R., Yang, J., Ding, P., Li, C., Zhang, B., Chen, W., Zhao, Y., Cao, Y., & Liu, B. (2020) · Nanotechnology · doi:10.1088/1361-6528/ab72b9 · Cited by 53 · see citing works
Chlorin e6 conjugated copper sulfide nanoparticles for photodynamic combined photothermal therapy
Bharathiraja, S., Manivasagan, P., Santhamoorthy, M., Bui, N. Q., Lee, K. D., & Oh, J. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.04.005 · Cited by 52 · see citing works
Leng, X., Wang, J., Carson, A. R., Chen, X., Fu, H., Ottoboni, S., Wagner, W. R., & Villanueva, F. S. (2014) · Molecular Imaging · doi:10.2310/7290.2014.00006 · Cited by 52 · see citing works
Self-citationLi, S.-H., Yang, W., Liu, Y., Song, X., Liu, R., Chen, G., Lü, C., & Yang, H. (2018) · Nano Research · doi:10.1007/s12274-018-2075-z · Cited by 50 · see citing works
NIR Light-Activated Drug Release for Synergetic Chemo–Photothermal Therapy
Yuan, A., Wei, H. J., Liu, X., Zhang, Z., Zhang, Y., Wu, J., & Hu, Y. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00820 · Cited by 45 · see citing works
Tian, Y., Guo, R., Wang, Y., & Yang, W. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600877 · Cited by 42 · see citing works
Self-citationIn Vitro Photodynamic Studies of a BODIPY‐Based Photosensitizer
Kim, B., Sui, B., Yue, X., Tang, S. Y., Tichy, M. G., & Belfield, K. D. (2016) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201601054 · Cited by 39 · see citing works
Near infrared light-controlled therapeutic molecules release of nanocarriers in cancer therapy
Guo, X., & You, J. (2017) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-017-0321-0 · Cited by 32 · see citing works
In vivo singlet molecular oxygen measurements: Sensitive to changes in oxygen saturation during PDT
Looft, A., Pfitzner, M., Preuß, A., & Röder, B. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.07.006 · Cited by 21 · see citing works
Chemical amplification accelerates reactive oxygen species triggered polymeric degradation
Lee, S., Stubelius, A., Olejniczak, J., Jang, H., Huu, V. A. N., & Almutairi, A. (2017) · Biomaterials Science · doi:10.1039/c7bm00758b · Cited by 20 · see citing works
Huang, Z. Q., Liu, X., Deng, G., Yuan, H., Wang, Q., Zhang, L., & Lü, J. (2018) · Dalton Transactions · doi:10.1039/c7dt04901c · Cited by 16 · see citing works
A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer
Wang, X.-S., Kong, D.-J., Lin, T., Li, X.-C., Izumiya, Y., Ding, X.-Z., Zhang, L., Hu, X.-C., Yang, J.-Q., Gao, S.-G., et al. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.43 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics
Roy, S., Bag, N., Bardhan, S., Hasan, I., & Guo, B. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114821 · Cited by 183 · see citing works
Liu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151 · see citing works
Design strategies and applications of cyanine dyes in phototherapy
Yuan, J., Yang, H., Huang, W., Liu, S., Zhang, H., Zhang, X., & Peng, X. (2025) · Chemical Society Reviews · doi:10.1039/d3cs00585b · Cited by 143 · see citing works
Meng, X., Pang, X., Zhang, K., Gong, C., Yang, J., Dong, H., & Zhang, X. (2022) · Small · doi:10.1002/smll.202202035 · Cited by 135 · see citing works
Luo, H., & Gao, S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.056 · Cited by 118 · see citing works
Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential
Li, J., Wang, S., Fontana, F., Tapeinos, C., Shahbazi, M., Han, H., & Santos, H. A. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.013 · Cited by 112 · see citing works
Near-infrared boron–dipyrrin (BODIPY) nanomaterials: Molecular design and anti-tumor therapeutics
Li, Y., Jiang, M., Yan, M., Ye, J., Li, Y., Dehaen, W., & Yin, S. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215718 · Cited by 81 · see citing works
Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy
He, L., Li, Y., Zhang, C., Zhang, X., Wang, B., Ren, T., & Yuan, L. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216549 · Cited by 57 · see citing works
Construction and optimization of organic fluorophores in NIR-II fluorescence imaging
Li, X., Yang, Y., Zhang, R., & Huang, W. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00063g · Cited by 52 · see citing works
Synergistic chemotherapy and phototherapy based on red blood cell biomimetic nanomaterials
Meng, D., Yang, S., Yang, Y., Zhang, L., & Cui, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.019 · Cited by 38 · see citing works
Yan, T., Alimu, G., Zhu, L., Fan, H., Zhang, L., Du, Z., Ma, R., Chen, S., Alifu, N., & Zhang, X. (2022) · ACS Omega · doi:10.1021/acsomega.2c02977 · Cited by 31 · see citing works
Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy
Chen, S., Zhao, L., Chen, Z., Huang, C., Kong, R., Wang, Y., Zhang, D., Li, S., Ti, H., & Cheng, H. B. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.059 · Cited by 31 · see citing works
Zhang, W., Cai, F., Xu, H., Wu, Y. L., Yu, X., Sun, L., Zhang, T., Yu, B., Zheng, X., & Tian, J. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01106 · Cited by 28 · see citing works
Self-citationZhu, J., Zhang, Y., Li, Z., Bao, X., Zhou, Y., Ma, B., Xie, Y., Yan, P., Wu, Z., Zhang, Q., et al. (2023) · Materials Horizons · doi:10.1039/d3mh00242j · Cited by 26 · see citing works
Ma, Z., Han, Z., Wan, M., Wang, Z., Gao, M., Zhao, Y., & Sun, L. (2025) · Surfaces and Interfaces · doi:10.1016/j.surfin.2025.106153 · Cited by 21 · see citing works
Ye, J., Wang, D., Yao, H., Cong, H., Shen, Y., & Yu, B. (2025) · Small · doi:10.1002/smll.202409722 · Cited by 22 · see citing works
Li, P., Zhang, W., Wang, Y., Tian, J., Shi, D., & Xu, H. (2023) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2023.114735 · Cited by 20 · see citing works
Self-citationReaching new lights: a review on photo-controlled nanomedicines and their in vivo evaluation
Remmers, R. C. P. A., & Neumann, K. (2023) · Biomaterials Science · doi:10.1039/d2bm01621d · Cited by 20 · see citing works
Jiang, Q., Li, J., Du, Z., Li, M., Chen, L., Zhang, X., Tang, X., Shen, Y., Ma, D., Wen, L., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400962 · Cited by 19 · see citing works
Organic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
Huang, B., Tang, T., Liu, F., Chen, S., Zhang, Z., Zhang, M., & Cui, R. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109694 · Cited by 15 · see citing works
Liu, X., Meng, L., Wang, Z., Yu, Z., Zhang, C., Liu, L., Coen, Z., Yang, Z., & Wu, G. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115207 · Cited by 14 · see citing works
Li, M., Li, T., Wu, F., Ren, F. Z., Xue, S., & Li, C. (2024) · Chemosensors · doi:10.3390/chemosensors12060113 · Cited by 13 · see citing works
Гусева, Г. Б., Lapshina, E. N., Antina, E. V., Eremeeva, Y. V., Lisovskaya, S. А., Izmailov, A., & Nikitina, L. E. (2024) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2024.115700 · Cited by 12 · see citing works
Mo, Q., Zhong, T., Cao, B., Han, Z., Hu, X., Zhao, S., Wei, X., Yang, Z., & Qin, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116474 · Cited by 11 · see citing works
Bovine serum albumin-bound homologous targeted nanoparticles for breast cancer combinatorial therapy
Chen, C., Xie, B., Sun, S., Guo, S., Yang, Z., Yang, L., Zhang, Y., Li, S., Sun, W., Wang, Z., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136090 · Cited by 11 · see citing works
Functional nanostructured biomaterials in cancer phototherapy and biomedicine
Nguyen, T. X., Duong, T. K. N., Truong, T. T., Phan, T. N. L., Doan, V. H. M., Dinh, T. N., Choi, J., Pal, U., Ahn, J. S., Oh, J., et al. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217077 · Cited by 11 · see citing works
A novel activated NIR-II phototheranostic nanoagent and its application to photothermal therapy
Xu, L., Tan, D., Huang, L., Wang, X., & Lin, W. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.135089 · Cited by 10 · see citing works
Tian, J. H., Huang, B., Weng, S., Zheng, W., & Zhang, W. (2022) · Materials Today Advances · doi:10.1016/j.mtadv.2022.100229 · Cited by 9 · see citing works
Self-citationpH indicator and rotary fluorescent properties of the Sn(IV)-octaetylporphyrin-(BODIPY)2 triad
Likhonina, A. E., Lebedev, I. S., Mamardashvili, G. M., & Mamardashvili, N. Z. (2022) · Inorganica Chimica Acta · doi:10.1016/j.ica.2022.121150 · Cited by 8 · see citing works
Li, Z., Dang, Z., Dang, Z., Li, X., Zhu, S., & Li, X. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135931 · Cited by 7 · see citing works
Huang, Y., Tang, K., Zeng, G., Yuan, H., Xin, Q., Zhao, Y., Qu, T., Yang, J., Zeng, C. C., Wu, X., et al. (2025) · RSC Advances · doi:10.1039/d5ra03041b · Cited by 6 · see citing works
Thiophene Stability in Photodynamic Therapy: A Mathematical Model Approach
Alcázar, J. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052528 · Cited by 7 · see citing works
“They have gained significant attention as potential building blocks in the design of photosensitizers, primarily due to their electron-donating ability [20], their enhanced π -conjugation [21–29], and their unique photophysical and photochemical properties [30–33].”
BackgroundInfluentialVenkatesan, A., Cherian, A. R., & Nizam, A. (2025) · The Analyst · doi:10.1039/d5an01012h · Cited by 5 · see citing works
Jena, S., & Douhal, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104819 · Cited by 3 · see citing works
Ni-doped carbon dots unlock dual NIR-II photothermal and photodynamic cancer therapy
Song, J., Kang, M., Li, Y., Guo, J., Wang, H., Liu, L., Qu, J., & Ye, S. (2025) · Materials Chemistry Frontiers · doi:10.1039/d5qm00680e · Cited by 3 · see citing works
Liu, J., Ma, D., Li, W., Zhang, X., Cui, J., Zhang, M., Wang, L., Qin, Y., & Chen, H. (2026) · Small · doi:10.1002/smll.202514912 · Cited by 3 · see citing works
Photophysics of α-azinyl-substituted 4,4-difluoro-8-(4-R-phenyl)-4-bora-3a,4a-diaza-s-indacenes
Pevtsov, D. N., Nikolenko, L. M., Nevidimov, A. V., Tovstun, S. A., Gadomska, A. V., Kuzmin, V. A., Разумов, В. Ф., Trestsova, M. A., Utepova, I. A., Чупахин, О. Н., et al. (2022) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2022.114109 · Cited by 3 · see citing works
Qin, P., Pang, Y., Kong, L., Lv, Y., Du, H., Zhou, Y., & Wang, J. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c00125 · Cited by 2 · see citing works
Self-citationRational design of thiophene-based HBI near-infrared photosensitizers for photodynamic therapy
Liu, Y., Wang, Y., Zhang, S., Yang, S., Wang, C., & Yang, H. (2026) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2026.117216
Research Progress of Near‐Infrared Donor‐Acceptor Molecular Probes in Disease Theranostics
Long, Y., Li, L., Zhang, X. Q., Ren, Y., & Tang, Y. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71275 · Cited by 1 · see citing works
Jiang, Y., Guo, C., Sun, Z., Du, K., Liang, Y., Zhuang, J., Sarfraz, A., Sun, Y., Liu, J., & Liu, Q. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6c00801
Self-citation
- Authors
- Liu, Q., Tian, J., Tian, Y., Sun, Q., Sun, D., Liu, D., Wang, F., Xu, H., Ying, G., Wang, J., Yetisen, A. K., & Jiang, N.
- Affiliations
- China Academy of Chinese Medical Sciences (CN)
- China Pharmaceutical University (CN)
- Southern Medical University (CN)
- Chinese Academy of Sciences (CN)
- Nanjing Forestry University (CN)
- Stanford University (US)
- Brigham and Women's Hospital (US)
- Southern University of Science and Technology (CN)
- Imperial College London (GB)
- Harvard University (US)
- Corresponding author
- Xu, Haijun
- Ying, Guoliang
- Wang, Jigang
- Jiang, Nan
- ORCID
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 127
- Pages
- 287-297
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W3149750019
- Cited by
- 43
- References
- 50
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Update notices
- erratum (2022-04-01)
- Open access
- green
- doi.org
- Locations
- Acta Biomaterialia (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China (21775166)
- Natural Science Foundation of Jiangsu Province (BK20151513, BK20180026)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- NIR-II fluorescence imaging, boron dipyrromethene, thiophene donor, photothermal therapy, photodynamic therapy, docetaxel, combination therapy, folic acid targeting, polymeric nanoparticles, tumor targeting, 4T1 breast cancer, near-infrared photosensitizer
- MeSH terms
- Animals, Photochemotherapy, Thiophenes, Photosensitizing Agents, Cell Line, Tumor, Mice, Nanoparticles, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
