Cited by 432Quantum Dots Synthesis And PropertiesOptical Imaging and Spectroscopy TechniquesNanoplatforms for cancer theranostics

Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging

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Zhang, Mingxi, Yue, Jingying, Cui, Ran, Ma, Zhuoran, Wan, Hao, Wang, Feifei, Zhu, Shoujun, Zhou, Ying +4 more·2018·Proceedings of the National Academy of Sciences

Abstract

Significance: In vivo fluorescence imaging in near IR-IIb window (1,500–1,700 nm) can provide high spatial and temporal resolution and deep tissue penetration for fundamental research and potential translations. Herein, a bright fluorescent probe emitting at ∼1,600 nm based on lead sulfide (PbS)/CdS quantum dots was developed. The CdS shell helped to chemically passivate and retain the high fluorescence of the PbS core after phase transfer to aqueous solutions for biocompatibility. The 1,600-nm emitting probe allowed noninvasive, millimeter-deep fluorescence imaging at high speeds up to 60 frames per second with micrometer-scale spatial resolution in 2D wide-field and 3D confocal modes. The probes were nontoxic and largely excreted over 1 month, providing a tool for in vivo research of preclinical animal models.

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Authors
Zhang, M., Yue, J., Cui, R., Ma, Z., Wan, H., Wang, F., Zhu, S., Zhou, Y., Kuang, Y., Zhong, Y., Pang, D.-W., & Dai, H.
Affiliations
  • Wuhan University of Technology (CN)
  • Stanford University (US)
  • Wuhan University (CN)
Venue
Proceedings of the National Academy of Sciences
Published
2018-06-11
Volume
115
Issue
26
Pages
6590-6595
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2808317537
Cited by
432
References
61
Citations by year
2026: 34 · 2025: 55 · 2024: 48 · 2023: 55 · 2022: 63 · 2021: 70 · 2020: 66 · 2019: 32 · 2018: 9
FWCI
16.52
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • DH | National Institute for Health Research (DP1-NS-105737)
  • Natural Science Foundation of Hubei Province (2015CFB401)
  • China Scholarship Council (201606955059)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
PbS quantum dots, core-shell quantum dots, fluorescent probes, aqueous stability, amphiphilic polymer coating, blood circulation half-life, tumor vasculature imaging, enhanced permeability and retention effect, tumor accumulation, biliary excretion, deep tissue imaging, autofluorescence suppression
MeSH terms
Intravital Microscopy, Adenocarcinoma, Animals, Colonic Neoplasms, Drug Stability, Femoral Artery, Femoral Vein, Fluorescent Dyes, Half-Life, Hindlimb, Lead, Mice, Inbred C57BL, Microscopy, Electron, Microscopy, Fluorescence, Sulfides, Video Recording, Microscopy, Confocal, Imaging, Three-Dimensional, Quantum Dots, Mice, Optical Imaging

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