Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery
Abstract
Apical membrane-located receptors on intestinal Peyer's patch M cells have been identified as pathogen binding sites which have potential as targets for the delivery of formulated subunit and recombinant vaccine antigens. Gene expression studies have correlated outputs from a series of models including human intestinal M-like cell cultures and human Peyer's patch tissue. Outputs comprise novel receptors with unknown function and also conserved binding sites for an ever-increasing list of pathogens. Screening for ligands to mimic pathways used by selected pathogens for invading the human intestine has the potential for increasing the efficiency of delivery of oral vaccine antigens to M cells and consequently to sub-epithelial sites for antigen processing. Synthesis of efficient and specific targeting ligands to human M cells may eventually lead to formulations based on the formats of targeted antigen-loaded nanoparticles or ligand-conjugated stable antigens.
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α-l-fucose is part of sparsely mucus-coated glycocalyx of M cells, so lectin-coated formulations can mediate binding of active substances.
“Since α-l-fucose is part of the sparsely mucus-coated glycocalyx of M cells, binding of active substances can be mediated by lectin-coated formulations.”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [130]
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- Authors
- Brayden, D.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Brayden, D
- ORCID
- Brayden, D
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2004-04-19
- Volume
- 56
- Issue
- 6
- Pages
- 721-726
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1986718084
- Cited by
- 43
- References
- 40
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- M cells, Peyer's patches, oral vaccine delivery, targeted antigen delivery, ligand screening, nanoparticle vaccine
- MeSH terms
- Administration, Oral, Cell Membrane, Humans, Intestinal Mucosa, Peyer's Patches, Vaccines, Drug Delivery Systems
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