Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations
Abstract
The aim of this research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that possess self-antioxidative properties, having advantages in terms of minimal side effects and exhibiting the ability to simultaneously co-encapsulate and co-release two active compounds. The focus has been oriented towards developing safe cosmetic formulations with broad-spectrum photoprotection based on these new lipid nanocarriers that contain large amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane - BMDBM and octocrylene - OCT). The lipid nanocarriers have a spherical shape and show good physical stability, with a zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils play a key role in the preparation of efficient nanocarriers, leading to a less ordered arrangement of the lipid core that offers many spaces for the entrapment of large amounts of BMDBM (79%) and OCT (90%), as wells as improved antioxidant activity and UV absorption properties, particularly for the lipid nanocarriers prepared from rice bran oil. By formulating the lipid nanocarriers into creams containing only 3.5% of the UV filters and 10.5% of the vegetable oils, the resulting sunscreens exhibited improved photoprotection, reflecting up to 91% and 93% of UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV fi…
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Vegetable oils, guava-fruit extract, rice bran and raspberry seeds, and red propolis extracts can increase the SPF of sunscreens.
“It was also possible to enhance the efficiency of UV filters by increasing the SPF of the sunscreens, using vegetable oils [111,112], guava-fruit extract [113,114], rice bran and raspberry seeds [115], and red propolis extracts [116].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [115]
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- Authors
- Niculae, G., Lacatusu, I., Badea, N., Stan, R., Vasile, B. S., & Meghea, A.
- Affiliations
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
- Corresponding author
- Meghea, Aurelia
- Venue
- Photochemical & Photobiological Sciences
- Published
- 2014-04
- Volume
- 13
- Issue
- 4
- Pages
- 703-716
- ISSN
- 1474-905X (ISSN-L)
- 1474-9092
- OpenAlex
- W2035207931
- Cited by
- 60
- References
- 60
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 5
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemical & Photobiological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Keywords
- lipid-based nanocarriers, rice bran oil, raspberry seed oil, photoprotection, sunscreen formulation, co-encapsulation, controlled release, UV filters, octocrylene, Fick diffusion, zeta potential, physical stability
- MeSH terms
- Acrylates, Alkanes, Antioxidants, Chemistry, Pharmaceutical, Cosmetics, Crystallization, Diffusion, Drug Stability, Fruit, Kinetics, Lipids, Particle Size, Plant Oils, Propiophenones, Oryza, Seeds, Sunscreening Agents, Ultraviolet Rays, Chalcones, Nanocapsules, Photochemical Processes, Absorption, Radiation
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