The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Engineering RNA for Targeted siRNA Delivery and Medical Application
Open accessAbstract
RNA engineering for nanotechnology and medical applications is an exciting emerging research field. RNA has intrinsically defined features on the nanometer scale and is a particularly interesting candidate for such applications due to its amazing diversity, flexibility and versatility in structure and function. Specifically, the current use of siRNA to silence target genes involved in disease has generated much excitement in the scientific community. The intrinsic ability to sequence-specifically down-regulate gene expression in a temporally- and spatially-controlled fashion has led to heightened interest and rapid development of siRNA-based therapeutics. Though methods for gene silencing with high efficacy and specificity have been achieved in vitro, the effective delivery of nucleic acids to specific cells in vivo has been a hurdle for RNA therapeutics. This review covers different RNA-based approaches for diagnosis, prevention and treatment of human disease, with a focus on the latest developments of nonviral carriers of siRNA for delivery in vivo. The applications and challenges of siRNA therapy, as well as potential solutions to these problems, the approaches for using phi29 pRNA-based vectors as polyvalent vehicles for specific delivery of siRNA, ribozymes, drugs or other therapeutic agents to specific cells for therapy will also be addressed.
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Cited by
Advancement of the emerging field of RNA nanotechnology
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Self-citationGold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
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Applications of polymer micelles for imaging and drug delivery
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Metadata
- Authors
- Guo, P., Coban, O., Snead, N. M., Trebley, J., Hoeprich, S., Guo, S., & Shu, Y.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 62
- Issue
- 6
- Pages
- 650-666
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2066319460
- Cited by
- 300
- References
- 172
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- green
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