Nanotechnology-based strategies for siRNA brain delivery for disease therapy

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476 · see citing works

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699 · see citing works

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926 · see citing works

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800 · see citing works

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., et al. (2015) · Nature · doi:10.1038/nature15373 · Cited by 1,795 · see citing works

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609 · see citing works

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Schöttler, S., Becker, G., Winzen, S., Steinbach, T., Mohr, K., Landfester, K., Mailänder, V., & Wurm, F. R. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.330 · Cited by 1,272 · see citing works

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246 · see citing works

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

Banks, W. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.21 · Cited by 1,204 · see citing works

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,180 · see citing works

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., Brown, B. S., Khaled, S. Z., Yazdi, I. K., Enzo, M. V., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.212 · Cited by 1,174 · see citing works

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

Lee, H., Lytton‐Jean, A. K. R., Chen, Y., Love, K. T., Park, A. I., Karagiannis, E. D., Sehgal, A., Querbes, W., Zurenko, C., Jayaraman, M., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.73 · Cited by 1,168 · see citing works

Overcoming cellular barriers for RNA therapeutics

Dowdy, S. F. (2017) · Nature Biotechnology · doi:10.1038/nbt.3802 · Cited by 1,139 · see citing works

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,005 · see citing works

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

Xue, J., Zhao, Z., Zhang, L., Xue, L., Shen, S., Wen, Y., Wei, Z., Wang, L., Kong, L., Sun, H., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.54 · Cited by 955 · see citing works

RNA-Based Therapeutics: Current Progress and Future Prospects

Burnett, J., & Rossi, J. J. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.12.008 · Cited by 910 · see citing works

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Kinoshita, M., McDannold, N. J., Jolesz, F. A., & Hynynen, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604318103 · Cited by 645 · see citing works

Breaking down the barriers: siRNA delivery and endosome escape

Domińska, M., & Dykxhoorn, D. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.066399 · Cited by 632 · see citing works

Tau protein kinases: Involvement in Alzheimer's disease

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., Yardin, C., & Terro, F. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.003 · Cited by 631 · see citing works

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. J., Patel, P. C., Cutler, J. I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006839 · Cited by 592 · see citing works

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Wiley, D. T., Webster, P. C., Gale, A., & Davis, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307152110 · Cited by 521 · see citing works

Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

Cooper, J. A. D., Wiklander, O. P. B., Nordin, J. Z., Al‐Shawi, R., Wood, M. J. A., Vithlani, M., Schapira, A. H. V., Simons, J. P., Andaloussi, S. E., & Alvarez‐Erviti, L. (2014) · Movement Disorders · doi:10.1002/mds.25978 · Cited by 509 · see citing works

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. T., Weksler, B., Romero, I., Couraud, P., Vermes, I., van der Meer, A. D., & van den Berg, A. (2012) · Biomedical microdevices · doi:10.1007/s10544-012-9699-7 · Cited by 503 · see citing works

Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

Miura, Y., Takenaka, T., Toh, K., Wu, S., Nishihara, H., Kano, M. R., Ino, Y., Nomoto, T., Matsumoto, Y., Koyama, H., et al. (2013) · ACS Nano · doi:10.1021/nn402662d · Cited by 455 · see citing works

Recent progress in development of siRNA delivery vehicles for cancer therapy

Kim, H. J., Kim, A., Miyata, K., & Kataoka, K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.011 · Cited by 424 · see citing works

Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications

Liu, W., Choi, H. S., Zimmer, J. P., Tanaka, E., Frangioni, J. V., & Bawendi, M. G. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073790m · Cited by 415 · see citing works

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

Lajoie, J. M., & Shusta, E. V. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124852 · Cited by 399 · see citing works

SyM-BBB: a microfluidic blood brain barrier model

Prabhakarpandian, B., Shen, M.-C., Nichols, J. B., Mills, I. R., Sidoryk‐Wȩgrzynowicz, M., Aschner, M., & Pant, K. (2012) · Lab on a Chip · doi:10.1039/c2lc41208j · Cited by 341 · see citing works

β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease

Gouras, G. K., Olsson, T. T., & Hansson, O. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0313-y · Cited by 331 · see citing works

Development and Brain Delivery of Chitosan−PEG Nanoparticles Functionalized with the Monoclonal Antibody OX26

Aktaş, Y., Yemişçi, M., Andrieux, K., Gürsoy, R. N., Alonso, M. J., Fernández-Megía, E., Novoa-Carballal, R., Quiñoá, E., Riguera, R., Sargon, M. F., et al. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050217o · Cited by 318 · see citing works

Engineering RNA for Targeted siRNA Delivery and Medical Application

Guo, P., Coban, O., Snead, N. M., Trebley, J., Hoeprich, S., Guo, S., & Shu, Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.008 · Cited by 301 · see citing works

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Anraku, Y., Kuwahara, H., Fukusato, Y., Mizoguchi, A., Ishii, T., Nitta, K., Matsumoto, Y., Toh, K., Miyata, K., Uchida, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00952-3 · Cited by 295 · see citing works

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

Clark, A. J., & Davis, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517048112 · Cited by 279 · see citing works

Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas

Yang, Z., Li, J., Wang, Z.-Z., Dong, D., & Qi, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.017 · Cited by 267 · see citing works

Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood–tumor and blood–brain barriers improve outcomes in a rat glioma model

Aryal, M., Vykhodtseva, N. I., Zhang, Y., Park, J., & McDannold, N. J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.007 · Cited by 261 · see citing works

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

Rassu, G., Soddu, E., Posadino, A. M., Pintus, G., Sarmento, B., Giunchedi, P., & Gavini, E. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.01.031 · Cited by 239 · see citing works

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

Song, Q., Huang, M., Yao, L., Wang, X., Gu, X., Chen, J., Chen, J., Huang, J., Hu, Q., Kang, T., et al. (2014) · ACS Nano · doi:10.1021/nn4058215 · Cited by 219 · see citing works

INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES

van de Water, F. M., Boerman, O. C., Wouterse, A. C., Peters, J. G. P., Rüssel, F. G. M., & Masereeuw, R. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.009555 · Cited by 217 · see citing works

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Huang, J., Jiang, G., Song, Q., Gu, X. Q., Meng, H., Wang, X.-L., Song, H., Chen, L., Lin, Y., Jiang, D. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15144 · Cited by 211 · see citing works

A review of the current status of siRNA nanomedicines in the treatment of cancer

Resnier, P., Montier, T., Mathieu, V., Benoît, J., & Passirani, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.060 · Cited by 209 · see citing works

A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries

Mann, A. P., Scodeller, P., Hussain, S., Joo, J., Kwon, E. J., Braun, G. B., Mölder, T., She, Z. G., Kotamraju, V. R., Ranscht, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms11980 · Cited by 181 · see citing works

A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery

Liu, Y., Li, J., Shao, K., Huang, R., Ye, L., Lou, J., & Jiang, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.011 · Cited by 172 · see citing works

RNAi-based nanomedicines for targeted personalized therapy

Daka, A., & Peer, D. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.014 · Cited by 168 · see citing works

Overcoming the Blood–Brain Barrier for Delivering Drugs into the Brain by Using Adenosine Receptor Nanoagonist

Gao, X., Qian, J., Zheng, S., Changyi, Y., Zhang, J., Ju, S., Zhu, J., & Li, C. (2014) · ACS Nano · doi:10.1021/nn5003375 · Cited by 165 · see citing works

Recent Developments in Nucleic Acid Delivery with Polyethylenimines

Neuberg, P., & Kichler, A. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800148-6.00009-2 · Cited by 163 · see citing works

Virus‐Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo

Zou, Y., Zheng, M., Yang, W., Meng, F., Miyata, K., Kim, H. J., Kataoka, K., & Zhong, Z. (2017) · Advanced Materials · doi:10.1002/adma.201703285 · Cited by 160 · see citing works

Self‐Sealing Porous Silicon‐Calcium Silicate Core–Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain

Kang, J., Joo, J., Kwon, E. J., Skalak, M., Hussain, S., She, Z., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2016) · Advanced Materials · doi:10.1002/adma.201600634 · Cited by 148 · see citing works

Chemical and structural modifications of RNAi therapeutics

Ku, S. H., Jo, S. D., Lee, Y. K., Kim, K., & Kim, S. H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.015 · Cited by 146 · see citing works

Why is the global CNS pharmaceutical market so under-penetrated?

Pardridge, W. M. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02082-7 · Cited by 144 · see citing works

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries

Kwon, E. J., Skalak, M., Bu, R. L., & Bhatia, S. N. (2016) · ACS Nano · doi:10.1021/acsnano.6b03858 · Cited by 134 · see citing works

Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease

Park, T., Singh, B., Li, H.-S., Lee, J.-Y., Kang, S., Choi, Y., & Cho, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.068 · Cited by 133 · see citing works

Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles

Kanazawa, T., Morisaki, K., Suzuki, S., & Takashima, Y. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400644e · Cited by 133 · see citing works

Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles

Wei, L., Guo, X., Yang, T., Yu, M., Chen, D., & Wang, J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.127 · Cited by 133 · see citing works

Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging

Han, L., Kong, D. K., Zheng, M.-Q., Murikinati, S., Ma, C., Yuan, P., Li, L., Tian, D., Cai, Q., Ye, C., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07573 · Cited by 122 · see citing works

Core-Shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery

Gao, L.-Y., Liu, X.-Y., Chen, C.-J., Wang, J.-C., Feng, Q., Yu, M.-Z., Ma, X.-F., Pei, X.-W., Niu, Y.-J., Qiu, C., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.046 · Cited by 114 · see citing works

Effect of PLGA NP size on efficiency to target traumatic brain injury

Cruz, L. J., Stammes, M. A., Que, I., van Beek, E. R., Blankevoort, V., Snoeks, T. J. A., Chan, A. B., Kaijzel, E. L., & Löwik, C. W. G. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.029 · Cited by 112 · see citing works

Brain Facts: A Primer on the Brain and Nervous System

Carey, J. (2002) · Cited by 111 · see citing works

Orphan drugs, orphan diseases. The first decade of orphan drug legislation in the EU

Joppi, R., Bertelè, V., & Garattini, S. K. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1423-2 · Cited by 111 · see citing works

The blood-brain barrier and neurotherapeutics

Pardridge, W. M. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.1 · Cited by 108 · see citing works

Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches

Kogan, M. J., Aguirre, M. V., Morales-Zavala, F., Toledo, E. G., Guerrero, S., Giralt, E., & Araya, E. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s82310 · Cited by 105 · see citing works

In vivo delivery of siRNA to the brain by carbosilane dendrimer

Serramía, M. J., Álvarez, S., Fuentes‐Paniagua, E., Clemente, M. I., Sánchez‐Nieves, J., Gómez, R., de la Mata, J., & Muñoz‐Fernández, M. Á. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.042 · Cited by 105 · see citing works

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

Han, L., Cai, Q., Tian, D., Kong, D. K., Gou, X., Chen, Z., Strittmatter, S. M., Wang, Z., Sheth, K. N., & Zhou, J. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.03.005 · Cited by 101 · see citing works

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

Mäger, I., Meyer, A. H., Li, J., Lenter, M., Hildebrandt, T., Leparc, G., & Wood, M. J. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.025 · Cited by 100 · see citing works

Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption

Foley, C. P., Rubin, D. G., Santillán, A., Sondhi, D., Dyke, J. P., Gobin, Y. P., Crystal, R. G., & Ballon, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.09.018 · Cited by 96 · see citing works

Penetrating the Blood–Brain Barrier: Promise of Novel Nanoplatforms and Delivery Vehicles

Ali, I., & Chen, X. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b05341 · Cited by 93 · see citing works

Generation of a Library of Non‐Toxic Quantum Dots for Cellular Imaging and siRNA Delivery

Subramaniam, P., Lee, S. J., Shah, S., Patel, S., Starovoytov, V., & Lee, K. (2012) · Advanced Materials · doi:10.1002/adma.201201019 · Cited by 91 · see citing works

Drugging RNAi

Haussecker, D., & Kay, M. A. (2015) · Science · doi:10.1126/science.1252967 · Cited by 80 · see citing works

A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment

Gao, S., Tian, H., Xing, Z., Zhang, D., Guo, Y., Guo, Z., Zhu, X., & Chen, X. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.027 · Cited by 79 · see citing works

siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core

Kim, H. J., Miyata, K., Nomoto, T., Zheng, M., Kim, A., Liu, X., Cabral, H., Christie, R. J., Nishiyama, N., & Kataoka, K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.016 · Cited by 77 · see citing works

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

Peluffo, H., Unzueta, U., Negro‐Demontel, M. L., Xu, Z., Váquez, E., Ferrer‐Miralles, N., & Villaverde, A. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.02.004 · Cited by 76 · see citing works

A hybrid siRNA delivery complex for enhanced brain penetration and precise amyloid plaque targeting in Alzheimer’s disease mice

Zheng, X., Pang, X., Yang, P., Xu, W., Wei, Y., Guo, Q., Zhang, Q., & Jiang, X. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.029 · Cited by 68 · see citing works

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Backer, L. D., Naessens, T., Koker, S. D., Zagato, E., Demeester, J., Grooten, J., Smedt, S. C. D., & Raemdonck, K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.030 · Cited by 67 · see citing works

Antibody Approaches To Treat Brain Diseases

Neves, V., Aires‐da‐Silva, F., Côrte‐Real, S., & Castanho, M. A. R. B. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.10.005 · Cited by 61 · see citing works

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

Gomes, M. J., Martins, S., & Sarmento, B. F. C. C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.001 · Cited by 59 · see citing works

Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer

Kim, H. J., Ishii, T., Zheng, M., Watanabe, S. T., Toh, K., Matsumoto, Y., Nishiyama, N., Miyata, K., & Kataoka, K. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0175-6 · Cited by 47 · see citing works

Mononuclear phagocytes as a target, not a barrier, for drug delivery

Yong, S., Song, Y., Kim, H. J., Ain, Q. U., & Kim, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.024 · Cited by 47 · see citing works

New 2016 Data and Statistics for Global Pharmaceutical Products and Projections through 2017

Lindsley, C. W. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00253 · Cited by 47 · see citing works

Monoclonal Antibody-Glial-Derived Neurotrophic Factor Fusion Protein Penetrates the Blood-Brain Barrier in the Mouse

Zhou, Q.-H., Boado, R. J., Lu, J. Z., Hui, E. K., & Pardridge, W. M. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.031534 · Cited by 45 · see citing works

A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain

Haroon, M. M., Dar, G. H., Jeyalakshmi, D., Venkatraman, U., Saba, K., Rangaraj, N., Patel, A. B., & Gopal, V. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.007 · Cited by 30 · see citing works

Cell-mediated drug delivery to the brain

Batrakova, E. V., & Kabanov, A. V. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50061-x · Cited by 29 · see citing works

The Yin and Yang of nucleic acid-based therapy in the brain

Gustincich, S., Zucchelli, S., & Mallamaci, A. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.11.001 · Cited by 27 · see citing works

Worth the RISC?

Garber, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3810 · Cited by 27 · see citing works

Bioinformatic Approaches to siRNA Selection and Optimization

Muhonen, P., & Holthöfer, H. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-588-0_6 · Cited by 11 · see citing works

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Ouyang, J., Xie, A., Zhou, J. M., Liu, R., Wang, L., Liu, H., Kong, N., & Tao, W. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01148k · Cited by 388 · see citing works

Advanced drug delivery applications of layered double hydroxide

Shirin, V. K. A., Sankar, R., Johnson, A. P., Gangadharappa, H. V., & Pramod, K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.041 · Cited by 308 · see citing works

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Zhou, Y., Zhu, F., Liu, Y., Zheng, M., Wang, Y., Zhang, D., Anraku, Y., Zou, Y., Li, J., Wu, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc7031 · Cited by 304 · see citing works

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

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A Robust Intrinsically Green Fluorescent Poly(Amidoamine) Dendrimer for Imaging and Traceable Central Nervous System Delivery in Zebrafish

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