Liposomal drug delivery systems: From concept to clinical applications

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,781

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954

Doxil® — The first FDA-approved nano-drug: Lessons learned

Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792

Diffusion of univalent ions across the lamellae of swollen phospholipids

Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664

Drug Delivery Systems: Entering the Mainstream

Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552

Delivering nanomedicine to solid tumors

Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,265

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

Szoka, F. C., & Papahadjopoulos, D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4194 · Cited by 2,350

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

Hope, M. J., Bally, M. B., Webb, G., & Cullis, P. R. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90521-8 · Cited by 2,078

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822

Vesicles of variable sizes produced by a rapid extrusion procedure

Mayer, L. D., Hope, M. J., & Cullis, P. R. (1986) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(86)90302-0 · Cited by 1,693

Ligand-targeted therapeutics in anticancer therapy

Allen, T. M. (2002) · Nature reviews. Cancer · doi:10.1038/nrc903 · Cited by 1,648

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621

Phosphatidylcholine vesicles. Formation and physical characteristics

Huang, C.-H. (1969) · Biochemistry · doi:10.1021/bi00829a048 · Cited by 1,528

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

Allen, T. M., Hansen, C., Martin, F., Redemann, C. T., & Yau‐Young, A. O. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90246-5 · Cited by 1,392

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.

Gabizón, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., & Barenholz, Y. (1994) · PubMed · Cited by 1,382

Single bilayer liposomes prepared without sonication

Batzri, S., & Korn, E. D. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90408-2 · Cited by 1,360

RNAi-mediated gene silencing in non-human primates

Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.063 · Cited by 1,324

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y.-L., Border, R., Ramsey, P., Martin, M. U., & Felgner, P. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41980-6 · Cited by 1,313

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Abuchowski, A., McCoy, J. R., Palczuk, N. C., Es, T. V., & Davis, F. F. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40292-4 · Cited by 1,276

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203263 · Cited by 1,267

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., & Park, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4199 · Cited by 1,129

Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes

Olson, F. C., Hunt, C. A., Szoka, F. C., Vail, W. J., & Papahadjopoulos, D. (1979) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(79)90085-3 · Cited by 1,126

Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers

Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj070 · Cited by 911

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

Torchilin, V. P., Rammohan, R., Weissig, V., & Levchenko, T. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151247498 · Cited by 777

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

Needham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746

Large unilamellar liposomes with low uptake into the reticuloendothelial system

Allen, T. M., & Chonn, A. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80506-9 · Cited by 729

Liposomes for the sustained drug release in vivo

Blume, G., & Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90440-y · Cited by 707

Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

Lee, R., & Low, P. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41848-5 · Cited by 694

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., et al. (2012) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2012.28 · Cited by 685

Liposomes as immunological adjuvants

Allison, A. C., & Gregoriadis, G. C. (1974) · Nature · doi:10.1038/252252a0 · Cited by 676

Reduced Cardiotoxicity and Preserved Antitumor Efficacy of Liposome-Encapsulated Doxorubicin and Cyclophosphamide Compared With Conventional Doxorubicin and Cyclophosphamide in a Randomized, Multicenter Trial of Metastatic Breast Cancer

Batist, G., Ramakrishnan, G., Rao, C. S., Chandrasekharan, A., Gutheil, J. C., Guthrie, T. H., Shah, P. M., Khojasteh, A., Nair, M. K., Hoelzer, K. L., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.5.1444 · Cited by 669

Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization—verteporfin in photodynamic therapy report 2

Bressler, N. M. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01237-5 · Cited by 666

Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.

Park, J. W., Hong, K., Kirpotin, D. B., Colbern, G. T., Shalaby, R., Baselga, J. M., Shao, Y. Y., Nielsen, U. B., Marks, J. D., Moore, D. H., et al. (2002) · PubMed · Cited by 652

Amphotericin B Lipid Complex for Invasive Fungal Infections: Analysis of Safety and Efficacy in 556 Cases

Walsh, T. J., Hiemenz, J. W., Seibel, N. L., Perfect, J. R., Horwith, G., Lee, L., Silber, J. L., DiNubile, M. J., Reboli, A. C., Bow, E. J., et al. (1998) · Clinical Infectious Diseases · doi:10.1086/516353 · Cited by 623

Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2

Safra, T., Muggia, F. M., Jeffers, S., Tsao-Wei, D. D., Groshen, S. G., Lyass, O., Henderson, R., Berry, G. J., & Gabizón, A. (2000) · Annals of Oncology · doi:10.1023/a:1008365716693 · Cited by 618

The Carrier Potential of Liposomes in Biology and Medicine

Gregoriadis, G. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609232951305 · Cited by 596

Pharmacokinetics of stealth versus conventional liposomes: effect of dose

Allen, T. M., & Hansen, C. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90201-i · Cited by 589

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

Li, W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.041 · Cited by 588

Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

Harrington, K. J., Mohammadtaghi, S., Uster, P. S., Glass, D. M., Peters, A. M., Vile, R. G., & Stewart, J. S. W. (2001) · PubMed · Cited by 575

Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo

Judge, A. D., Bola, G., Lee, A. C. H., & MacLachlan, I. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.11.002 · Cited by 571

Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.

Leamon, C. P., & Low, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5572 · Cited by 558

RECENT APPROACHES TO INTRACELLULAR DELIVERY OF DRUGS AND DNA AND ORGANELLE TARGETING

Torchilin, V. P. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095735 · Cited by 548

A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.

Glantz, M., Jaeckle, K. A., Chamberlain, M. C., Phuphanich, S., Recht, L. D., Swinnen, L. J., Maria, B., LaFollette, S., Schumann, G. B., Cole, B. F., et al. (1999) · PubMed · Cited by 529

Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles

Senior, J. H., Delgado, C., Fisher, D., Tilcock, C., & Gregoriadis, G. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90337-8 · Cited by 521

The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs

Juliano, R. L., & Stamp, D. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80433-5 · Cited by 521

On the formulation of pH-sensitive liposomes with long circulation times

Simões, S. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.038 · Cited by 485

Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target

Klibanov, A. L., Maruyama, K., Beckerleg, A. M., Torchilin, V. P., & Huang, L. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90385-l · Cited by 480

Serum-induced leakage of liposome contents

Allen, T. M., & Cleland, L. G. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90118-2 · Cited by 472

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

Chonn, A., Semple, S. C., & Cullis, P. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37026-7 · Cited by 461

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., et al. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00343-6 · Cited by 454

Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors

Laginha, K. M., Verwoert, S., Charrois, G. J. R., & Allen, T. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0343 · Cited by 441

Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells

Filion, M. C., & Phillips, N. C. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00126-0 · Cited by 428

Targeted Liposomal Drug Delivery to Monocytes and Macrophages

Kelly, C., Jefferies, C. A., & Cryan, S. (2010) · Journal of Drug Delivery · doi:10.1155/2011/727241 · Cited by 426

Drug entrapment in liposomes

Gregoriadis, G. (1973) · FEBS Letters · doi:10.1016/0014-5793(73)80394-1 · Cited by 424

Introduction of liposome-encapsulated SV40 DNA into cells.

Fraley, R. T., Subramani, S. E., Berg, P. R., & Papahadjopoulos, D. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70482-7 · Cited by 416

p H-Sensitive Liposomes: Possible Clinical Implications

Yatvin, M. B., Kreutz, W., Horwitz, B. A., & Shinitzky, M. (1980) · Science · doi:10.1126/science.7434025 · Cited by 415

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

Juweid, M. E., Neumann, R. D., Paik, C. H., Pérez-Bacete, M., Sato, J., van Osdol, W. W., & Weinstein, J. N. (1992) · PubMed · Cited by 406

Liposomal Amphotericin B for the Treatment of Systemic Fungal Infections in Patients with Cancer: A Preliminary Study

Lopez‐Berestein, G., Fainstein, V., Hopfer, R. L., Mehta, K. M., Sullivan, M. P., Keating, M., Rosenblum, M. G., Mehta, R. S., Luna, M. A., Hersh, E. M., et al. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/151.4.704 · Cited by 405

Randomized Trial of a Slow-Release Versus a Standard Formulation of Cytarabine for the Intrathecal Treatment of Lymphomatous Meningitis

Glantz, M., LaFollette, S., Jaeckle, K. A., Shapiro, W., Swinnen, L. J., Rozental, J. R., Phuphanich, S., Rogers, L. R., Gutheil, J. C., Batchelor, T. T., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3110 · Cited by 402

The effect of cholesterol on the structure of phosphatidylcholine bilayers

McIntosh, T. J. (1978) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(78)90110-4 · Cited by 394

Challenges in Development of Targeted Liposomal Therapeutics

Sawant, R. R., & Torchilin, V. P. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9330-0 · Cited by 393

Endocytosis of liposomes and intracellular fate of encapsulated molecules: Encounter with a low pH compartment after internalization in coated vesicles

Straubinger, R. M., Hong, K., Friend, D. S., & Papahadjopoulos, D. (1983) · Cell · doi:10.1016/0092-8674(83)90291-x · Cited by 393

Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A

Leserman, L., Barbet, J., Kourilsky, F. M., & Weinstein, J. N. (1980) · Nature · doi:10.1038/288602a0 · Cited by 391

Development of a Highly Active Nanoliposomal Irinotecan Using a Novel Intraliposomal Stabilization Strategy

Drummond, D. C., Noble, C. O., Guo, Z., Hong, K., Park, J. W., & Kirpotin, D. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4007 · Cited by 381

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

Mayer, L. D., Bally, M. B., & Cullis, P. R. (1986) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(86)90105-7 · Cited by 378

Co-Delivery of siRNA and An Anticancer Drug for Treatment of Multidrug-Resistant Cancer

Saad, M., Garbuzenko, O. B., & Minko, T. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.761 · Cited by 370

Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo

Mori, A., Klibanov, A. L., Torchilin, V. P., & Huang, L. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80699-4 · Cited by 369

Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

Weinstein, J. N., Magin, R. L., Yatvin, M. B., & Zaharko, D. S. (1979) · Science · doi:10.1126/science.432641 · Cited by 363

Phospholipid model membranes. II. Permeability properties of hydrated liquid crystals

Papahadjopoulos, D., & Watkins, J. C. (1967) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(67)90095-8 · Cited by 358

Nucleic Acid Delivery: The Missing Pieces of the Puzzle?

Nguyen, J., & Szoka, F. C. (2012) · Accounts of Chemical Research · doi:10.1021/ar3000162 · Cited by 356

Tumor targeting using anti-her2 immunoliposomes

Park, J. W., Kirpotin, D. B., Hong, K., Shalaby, R., Shao, Y., Nielsen, U. B., Marks, J. D., Papahadjopoulos, D., & Benz, C. C. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00315-7 · Cited by 341

Design considerations for liposomal vaccines: Influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

Watson, D. S., Endsley, A. N., & Huang, L. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.070 · Cited by 339

A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Popović, Z., Liu, W., Chauhan, V. P., Lee, J., Wong, C., Greytak, A. B., Insin, N., Nocera, D. G., Fukumura, D., Jain, R. K., et al. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201003142 · Cited by 337

A Double‐Blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients

Bowden, R. A., Chandrasekar, P. H., White, M. H., Li, X., Pietrelli, L. A., Gurwith, M., van Burik, J., Laverdière, M., Safrin, S., & Wingard, J. R. (2002) · Clinical Infectious Diseases · doi:10.1086/341401 · Cited by 334

Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice

Mayer, L. D., Harasym, T. O., Tardi, P. G., Harasym, N. L., Shew, C. R., Johnstone, S. A., Ramsay, E. C., Bally, M. B., & Janoff, A. S. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0118 · Cited by 332

Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing.

Zhigaltsev, I. V., Belliveau, N. M., Hafez, I. M., Leung, A. K. K., Huft, J., Hansen, C., & Cullis, P. (2012) · Langmuir · doi:10.1021/la204833h · Cited by 330

Accelerated clearance of PEGylated liposomes in rats after repeated injections

Ishida, T., Maeda, R., Ichihara, M., Irimura, K., & Kiwada, H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00462-5 · Cited by 327

The Carrier Potential of Liposomes in Biology and Medicine

Gregoriadis, G. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609302951406 · Cited by 325

First-In-Man Study of CPX-351: A Liposomal Carrier Containing Cytarabine and Daunorubicin in a Fixed 5:1 Molar Ratio for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia

Feldman, E. J., Lancet, J. E., Kolitz, J. E., Ritchie, E. K., Roboz, G. J., List, A. F., Allen, S. L., Asatiani, E., Mayer, L. D., Swenson, C. E., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.5961 · Cited by 310

Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures

Hansen, C. B., Kao, G. Y., Moase, E. H., Zalipsky, S., & Allen, T. M. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00138-s · Cited by 309

Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer

Charrois, G. J. R., & Allen, T. M. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.03.006 · Cited by 304

The Design of Cationic Lipids for Gene Delivery

Martin, B., Sainlos, M., Aissaoui, A., Oudrhiri, N., Hauchecorne, M., VIGNERON, J. ‐., Lehn, J., & Lehn, P. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382133 · Cited by 304

Stabilized plasmid-lipid particles: construction and characterization

Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300821 · Cited by 301

Skin structure and mode of action of vesicles

Bouwstra, J. A., & Honeywell‐Nguyen, P. L. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00114-x · Cited by 296

Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy.

Pastorino, F., Brignole, C., Marimpietri, D., Cilli, M., Gambini, C., Ribatti, D., Longhi, R., Allen, T. M., Corti, A., & Ponzoni, M. (2003) · PubMed · Cited by 296

A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells

Allen, T. M., Brandeis, E., Hansen, C. B., Kao, G. Y., & Zalipsky, S. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00085-h · Cited by 288

Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases

Gregoriadis, G. C., & Ryman, B. E. (1971) · Biochemical Journal · doi:10.1042/bj1240058p · Cited by 286

Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated drugs

Alving, C. R., Steck, E. A., Chapman, W. L., Waits, V. B., Hendricks, L. D., Swartz, G. M., & Hanson, W. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2959 · Cited by 284

Targeted Delivery of Antisense Oligodeoxynucleotide and Small Interference RNA into Lung Cancer Cells

Li, S., & Huang, L. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060039w · Cited by 282

Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times

Blume, G., Cevc, G., Crommelin, M. D. J. A., Bakker‐Woudenberg, I. A. J. M., Kluft, C., & Storm, G. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90039-3 · Cited by 282

Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3

McDonagh, C. F., Huhalov, A., Harms, B. D., Adams, S., Paragas, V. B., Oyama, S., Zhang, B., Luus, L., Overland, R. P., Nguyen, S., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0820 · Cited by 278

Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor-bearing mice

Newman, M. S., Colbern, G. T., Working, P. K., Engbers, C. M., & Amantea, M. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050855 · Cited by 275

Acoustically active liposomes for drug encapsulation and ultrasound-triggered release

Huang, S.-L., & MacDonald, R. C. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.07.003 · Cited by 268

The response of fluorescent amines to pH gradients across liposome membranes

Deamer, D. W., Prince, R. C., & Crofts, A. R. (1972) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(72)90180-0 · Cited by 266

Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol) s conjugated at their distal terminals to monoclonal antibodies

Maruyama, K., 知子, 滝., Yuda, T., Kennel, S. J., Huang, L., & Iwatsuru, M. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)00263-o · Cited by 265

Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.

Gabizón, A., Dagan, A., Goren, D., Barenholz, Y., & FUKS, Z. Y. (1982) · PubMed · Cited by 263

In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma.

de Menezes, D. E. L., Pilarski, L. M., & Allen, T. M. (1998) · PubMed · Cited by 260

Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.

Wang, S., Lee, R. J., Cauchon, G., Gorenstein, D. G., & Low, P. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3318 · Cited by 257

The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey

Madden, T. D., Harrigan, P. R., Tai, L. C. L., Bally, M. B., Mayer, L. D., Redelmeier, T. E., Loughrey, H. C., Tilcock, C., Reinish, L. W., & Cullis, P. R. (1990) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(90)90131-a · Cited by 255

Effective anti-tumor activity of oxaliplatin encapsulated in transferrin–PEG-liposome

Suzuki, R., 知子, 滝., Kuwata, Y., Mutoh, M., Ishiguro, N., Utoguchi, N., Shinohara, A., Eriguchi, M., Yanagië, H., & Maruyama, K. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.010 · Cited by 252

Ligand-Targeted Liposomes for Cancer Treatment

Sapra, P., Tyagi, P., & Allen, T. M. (2005) · Current Drug Delivery · doi:10.2174/156720105774370159 · Cited by 250

A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs

Ishida, T., Iden, D. L., & Allen, T. M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01320-4 · Cited by 247

Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins

Scherphof, G. L., Roerdink, F. H., Waite, M. B., & Parks, J. S. (1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90025-9 · Cited by 246

Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients

Mayer, L. D., Tai, L. C. L., Bally, M. B., Mitilenes, G. N., Ginsberg, R. S., & Cullis, P. R. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90091-2 · Cited by 245

Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs.

Sapra, P., & Allen, T. M. (2002) · PubMed · Cited by 242

The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi’s sarcoma patients treated with pegylated liposomal doxorubicin

Berry, G. J., Billingham, M. E., Alderman, E. L., Richardson, P., Torti, F. M., Lum, B. L., Patek, A., & Martin, F. J. (1998) · Annals of Oncology · doi:10.1023/a:1008216430806 · Cited by 240

Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes

Lappalainen, K., Jääskeläinen, I., Syrjänen, K. J., Urtti, A. O., & Syrjänen, S. (1994) · Pharmaceutical Research · doi:10.1023/a:1018932714745 · Cited by 238

Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy

Ryu, J. H., Koo, H., Sun, I., Yuk, S. H., Choi, K., Kim, K., & Kwon, I. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.012 · Cited by 237

Antibody Targeting of Liposomes: Cell Specificity Obtained by Conjugation of F(ab′) 2 to Vesicle Surface

Heath, T. D., Fraley, R. T., & Papahdjopoulos, D. (1980) · Science · doi:10.1126/science.7423203 · Cited by 237

Liposomes for intravitreal drug delivery: A state of the art

Bochot, A., & Fattal, E. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.019 · Cited by 235

Targeting Liposomal Chemotherapy via Both Tumor Cell–Specific and Tumor Vasculature–Specific Ligands Potentiates Therapeutic Efficacy

Pastorino, F., Brignole, C., Paolo, D. D., Nico, B., Pezzolo, A., Marimpietri, D., Pagnan, G., Piccardi, F., Cilli, M., Longhi, R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2117 · Cited by 233

Steric Stabilization of Fusogenic Liposomes by a Low-pH Sensitive PEG−Diortho Ester−Lipid Conjugate

Guo, X. D., & Szoka, F. C. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000110v · Cited by 233

Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes

Maurer, N., Wong, K. F., Stark, H., Louie, L. J., McIntosh, D. P., Wong, T., Scherrer, P., Semple, S. C., & Cullis, P. R. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76202-9 · Cited by 232

Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.

Ahmad, I. N., Longenecker, M., Samuel, J., & Allen, T. M. (1993) · PubMed · Cited by 230

Chemotherapy-Associated Palmar-Plantar Erythrodysesthesia Syndrome

Lokich, J. J., & MOORE, C. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-6-798 · Cited by 225

Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells

Ishida, T., Kirchmeier, M. J., Moase, E. H., Zalipsky, S., & Allen, T. M. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00409-6 · Cited by 222

In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach

Iden, D. L., & Allen, T. M. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00357-1 · Cited by 220

Immunospecific targeting of liposomes to cells: a novel and efficient method for covalent attachment of Fab' fragments via disulfide bonds

Martin, F. J., Hubbell, W. L., & Papahadjopoulos, D. (1981) · Biochemistry · doi:10.1021/bi00517a043 · Cited by 217

Targeted accumulation of polyethylene glycol‐coated immunoliposomes in infarcted rabbit myocardium

Torchilin, V. P., Klibanov, A. L., Huang, L., O'Donnell, S. M., Nossiff, N. D., & Khaw, B. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.9.1612296 · Cited by 216

Interactions of liposomes with the reticuloendothelial system

Hsu, M. J., & Juliano, R. L. (1982) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(82)90120-3 · Cited by 216

Ammonium Sulfate Gradients for Efficient and Stable Remote Loading of Amphipathic Weak Bases into Liposomes and Ligandoliposomes.

Bolotin, E. M., Cohen, R., Bar, L. K., Emanuel, N., Ninio, S., Barenholz, Y., & Lasiç, D. D. (1994) · Journal of Liposome Research · doi:10.3109/08982109409037057 · Cited by 207

Control of the Rate of Hepatic Uptake and Catabolism of Liposome‐Entrapped Proteins Injected into Rats. Possible Therapeutic Applications

Gregoriadis, G. C., & Neerunjun, D. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03681.x · Cited by 207

Liposomal doxorubicin (Doxil): An effective new treatment for Kaposi's sarcoma in AIDS

James, N. D., Coker, R. J., Tomlinson, D., Harris, J. R. W., Gompels, M. M., Pinching, A. J., & Stewart, J. S. W. (1994) · Clinical Oncology · doi:10.1016/s0936-6555(05)80269-9 · Cited by 205

Fate of cationic liposomes and their complex with oligonucleotive in vivo

Litzinger, D. C., Brown, J. M., Wala, I., Kaufman, S. A., han, G. Y., Farrell, C. L., & Collins, D. W. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00268-5 · Cited by 201

Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial

Davidson, R. N., di Martino, L., Gradoni, L., Giacchino, R., RUSSO, R., Gaeta, G. B., Pempinello, R., Scott, S., Raimondi, F., Cascio, A., et al. (1994) · QJM · doi:10.1093/oxfordjournals.qjmed.a068903 · Cited by 196

Magnetically Responsive Microspheres and Other Carriers for the Biophysical Targeting of Antitumor Agents

Widder, K. J., Senyei, A. E., & Ranney, D. F. (1979) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60246-x · Cited by 195

Lipid vesicles as carriers for introducing materials into cultured cells: influence of vesicle lipid composition on mechanism(s) of vesicle incorporation into cells.

Poste, G. H., & Papahadjopoulos, D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.5.1603 · Cited by 195

Liposomal amphotericin B is toxic to fungal cells but not to mammalian cells

Mehta, R. T., Lopez‐Berestein, G., Hopfer, R. L., Mills, K., & Juliano, R. L. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90135-4 · Cited by 192

Liposomal Blockade of the Reticuloendothelial System: Improved Tumor Imaging with Small Unilamellar Vesicles

Proffitt, R. T., Williams, L. E., Presant, C. A., Tin, G. W., Uliana, J. A., Gamble, R. C., & Baldeschwieler, J. D. (1983) · Science · doi:10.1126/science.6836294 · Cited by 190

Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy

Chen, Y., Wu, J. J., & Huang, L. (2010) · Molecular Therapy · doi:10.1038/mt.2009.291 · Cited by 185

Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.

Huang, S. K., Stauffer, P. R., Hong, K., Guo, J., Phillips, T. L., Huang, A., & Papahadjopoulos, D. (1994) · PubMed · Cited by 183

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Basha, G., Novobrantseva, T. I., Rosin, N. L., Tam, Y. Y. C., Hafez, I. M., Wong, M., Sugo, T., Ruda, V. M., Qin, J., Klebanov, B., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.190 · Cited by 182

Liposome-mediated delivery of deoxyribonucleic acid to cells: enhanced efficiency of delivery by changes in lipid composition and incubation conditions

Fraley, R. T., Straubinger, R. M., Rule, G. S., Springer, E. L., & Papahadjopoulos, D. (1981) · Biochemistry · doi:10.1021/bi00527a031 · Cited by 180

Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies

Goren, D., Horowitz, A. T., Zalipsky, S., Woodle, M. C., Yarden, Y., & Gabizón, A. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.625 · Cited by 179

Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates

Senter, P. D., & Springer, C. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00206-x · Cited by 178

pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide.

Parente, R. A., Nir, S., & Szoka, F. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68843-x · Cited by 175

Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes

Patel, N. R., Rathi, A., Mongayt, D., & Torchilin, V. P. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.082 · Cited by 174

Relationship between labeling indices of KI-67 and brdurd in human malignant tumors

Sasaki, K., Matsumura, K., Tsuji, T., Shinozaki, F., & Takahashi, M. (1988) · Cancer · doi:10.1002/1097-0142(19880901)62:5 · Cited by 172

Liposomes in cosmeceutics

Rahimpour, Y., & Hamishehkar, H. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.666968 · Cited by 170

Rate of biodistribution of STEALTH® liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity

Charrois, G. J. R., & Allen, T. M. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00661-2 · Cited by 170

Pharmacokinetics of liposome-encapsulated anti-tumor drugs

Juliano, R. L., & Stamp, D. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90252-6 · Cited by 166

A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

Francis, R. J., Sharma, S. K., Springer, C. J., Green, A. J., Hope‐Stone, L., Sena, L. A., Martin, J. E., Adamson, K., Robbins, A., Gumbrell, L. A., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600517 · Cited by 163

Stealth liposomes: an improved sustained release system for 1-beta-D-arabinofuranosylcytosine.

Allen, T. M., Mehra, T., Hansen, C., & Chin, Y. C. (1992) · PubMed · Cited by 159

Localised drug release using MRI-controlled focused ultrasound hyperthermia

Staruch, R., Chopra, R., & Hynynen, K. (2010) · International Journal of Hyperthermia · doi:10.3109/02656736.2010.518198 · Cited by 159

Pegylated Liposomal Doxorubicin: Optimizing the Dosing Schedule in Ovarian Cancer

Rose, P. G. (2005) · The Oncologist · doi:10.1634/theoncologist.10-3-205 · Cited by 155

Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations

Johnston, M., Semple, S. C., Klimuk, S. K., Edwards, K., Eisenhardt, M. L., Leng, E. C., Karlsson, G., Yanko, D., & Cullis, P. R. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.01.009 · Cited by 152

Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes

Vaage, J., Mayhew, E. G., Lasic, D. D., & Martin, F. J. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910510618 · Cited by 150

Systemic p53 Gene Therapy of Cancer with Immunolipoplexes Targeted by Anti-Transferrin Receptor scFv

Xu, L., Tang, W., Huang, C., Alexander, W., Xiang, L., Pirollo, K. F., Rait, A. S., & Chang, E. H. (2001) · Molecular Medicine · doi:10.1007/bf03401962 · Cited by 148

Is half‐life of circulating liposomes determined by changes in their permeability?

Senior, J., & Gregoriadis, G. C. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81216-7 · Cited by 148

A Comparison of Depodur???, a Novel, Single-Dose Extended-Release Epidural Morphine, with Standard Epidural Morphine for Pain Relief After Lower Abdominal Surgery

Gambling, D. R., Hughes, T., Martin, G., Horton, W., & Manvelian, G. Z. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000145009.03574.78 · Cited by 148

Cationic Lipid Vectors for Plasmid DNA Delivery

Hirko, A. C., Tang, F., & Hughes, J. A. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457412 · Cited by 148

Trigger release liposome systems: local and remote controlled delivery?

Bibi, S., Lattmann, E., Mohammed, A. R., & Perrie, Y. (2011) · Journal of Microencapsulation · doi:10.3109/02652048.2011.646330 · Cited by 147

Interactions of liposomes with the reticuloendothelial system effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles

Kao, Y. J., & Juliano, R. L. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90259-2 · Cited by 146

Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA

Mok, K. W. C., & Cullis, P. R. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78282-1 · Cited by 146

Vincristine sulfate liposomes injection (Marqibo) in heavily pretreated patients with refractory aggressive non‐Hodgkin lymphoma

Rodriguez, M. A., Pytlík, R., Kozák, T., Chhanabhai, M., Gascoyne, R. D., Lu, B., Deitcher, S. R., & Winter, J. N. (2009) · Cancer · doi:10.1002/cncr.24359 · Cited by 145

Liposomal vincristine in relapsed non-Hodgkin's lymphomas: Early results of an ongoing phase II trial

Sarris, A. H., Hagemeister, F. B., Romaguera, J. E., Rodríguez, M., McLaughlin, P. J., Tsimberidou, A. M., Medeiros, L. J., Samuels, B. I., Pate, O., Oholendt, M. S., et al. (2000) · Annals of Oncology · doi:10.1023/a:1008348010437 · Cited by 143

Pharmacokinetics and antitumor activity of epirubicin encapsulated in long‐circulating liposomes incorporating a polyethylene glycol‐derivatized phospholipid

Mayhew, E. G., Lasiç, D. D., Babbar, S., & Martin, F. J. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910510221 · Cited by 142

Lateral diffusion rates of phosphatidylcholine in vesicle membranes: Eeffects of cholesterol and hydrocarbon phase transitions

Cullis, P. R. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80762-4 · Cited by 139

Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue

Davidsen, J. R., Jørgensen, K., Andresen, T. L., & Mouritsen, O. G. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00659-4 · Cited by 138

Lipid-based amphotericin B: a review of the last 10 years of use

Hann, I. M., & Prentice, H. G. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00341-1 · Cited by 137

A study of phospholipid interactions between high-density lipoproteins and small unilamellar vesicles

Allen, T. M. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90464-8 · Cited by 134

Liposomal daunorubicin as treatment for Kaposi’s sarcoma

Dittmer, D. P., & Petre, C. E. (2020) · PubMed · doi:10.17615/wyf0-9n94 · Cited by 132

Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study

Gabizón, A., Peretz, T., Sulkes, A., Amselem, S., Ben‐Yosef, R., Ben-Baruch, N. E., Catane, R., Biran, S., & Barenholz, Y. (1989) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(89)90350-7 · Cited by 130

A novel class of photo-triggerable liposomes containing DPPC:DC8,9PC as vehicles for delivery of doxorubcin to cells

Yavlovich, A., Singh, A., Blumenthal, R. P., & Puri, A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.07.030 · Cited by 127

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN

de Jong, S. D., Chikh, G., Sekirov, L., Raney, S. G., Semple, S. C., Klimuk, S. K., Yuan, N., Hope, M., Cullis, P. R., & Tam, Y. K. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0276-x · Cited by 127

Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors.

Boman, N. L., Masin, D., Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994) · PubMed · Cited by 126

From “Banghasomes” to liposomes: A memoir of Alec Bangham, 1921–2010

Deamer, D. W. (2010) · The FASEB Journal · doi:10.1096/fj.10-0503 · Cited by 125

Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts

Krauze, M. T., Noble, C. O., Kawaguchi, T., Drummond, D. C., Kirpotin, D. B., Yamashita, Y., Kullberg, E. B., Forsayeth, J., Park, J. W., & Bankiewicz, K. S. (2007) · Neuro-Oncology · doi:10.1215/15228517-2007-019 · Cited by 124

Endothelial Endocytic Pathways: Gates for Vascular Drug Delivery

Muro, S., Koval, M. H., & Muzykantov, V. R. (2004) · Current Vascular Pharmacology · doi:10.2174/1570161043385736 · Cited by 122

Liposomes targeted via two different antibodies: Assay, B-cell binding and cytotoxicity

Laginha, K. M., Mumbengegwi, D. R., & Allen, T. M. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.02.007 · Cited by 120

The swollen leg: ultrasonographic demonstration of non-thrombotic causes

Bell, J. M., Ross, F. G. M., Mackenzie, S., & Goddard, P. R. (1985) · Postgraduate Medical Journal · doi:10.1136/pgmj.61.711.23 · Cited by 119

Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study

Maurer, N., Wong, K. F., Hope, M. J., & Cullis, P. R. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00125-4 · Cited by 118

A comparison of the haemodynamic effects of propofol ('Diprivan') and thiopentone in patients with coronary artery disease.

Patrick, M. R., Blair, I., Feneck, R. O., & Sebel, P. S. (1985) · PubMed · Cited by 116

Effect of molecular weight in amphipathic polyethyleneglycol on prolonging the circulation time of large unilamellar liposomes.

Maruyama, K., Tsutomu, Y. U. D. A., Okamoto, A., Ishikura, C., Kojima, S., & Iwatsuru, M. (1991) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.39.1620 · Cited by 114

Influence of lipid composition on the antitumor activity exerted by doxorubicin-containing liposomes in a rat solid tumor model.

Storm, G., Roerdink, F. H., Steerenberg, P. A., de Jong, W. H., & Crommelin, D. J. A. (1987) · PubMed · Cited by 112

The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs

Richard, B. M., Newton, P. E., Ott, L. R., Haan, D., Brubaker, A. N., Cole, P. I., ROSS, P. E., Rebelatto, M. C., & Nelson, K. (2012) · Journal of Drug Delivery · doi:10.1155/2012/962101 · Cited by 111

Characterization of In Vivo Immunoliposome Targeting to Pulmonary Endothelium

Maruyama, K., Holmberg, E. G., Kennel, S. J., Klibanov, A. L., Torchilin, V. P., & Huang, L. (1990) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600791107 · Cited by 110

Antibody-targeted liposomes: increase in specific toxicity of methotrexate-gamma-aspartate.

Heath, T. D., Montgomery, J. A., Piper, J. R., & Papahadjopoulos, D. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.5.1377 · Cited by 108

Phase II study of liposomal cisplatin (SPI-77) in platinum-sensitive recurrences of ovarian cancer.

Seetharamu, N., Kim, E., Höchster, H. S., Martin, F., & Muggia, F. M. (2010) · PubMed · Cited by 107

Delivery of c-myb Antisense Oligodeoxynucleotides to Human Neuroblastoma Cells Via Disialoganglioside GD2-Targeted Immunoliposomes: Antitumor Effects

Pagnan, G., Stuart, D. D., Pastorino, F., Raffaghello, L., Montaldo, P. G., Allen, T. M., Calabretta, B., & Ponzoni, M. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.253 · Cited by 106

Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier".

Weinstein, J. N., & van Osdol, W. (1992) · PubMed · Cited by 104

Comparative in vivo studies with paclitaxel and liposome-encapsulated paclitaxel.

Cabanes, A., Briggs, K., Gokhale, P. C., Treat, J., & Rahman, A. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.5.1035 · Cited by 103

Comparison of liposomal cisplatin versus cisplatin in non-squamous cell non-small-cell lung cancer

Stathopoulos, G. P., Antoniou, D., Dimitroulis, J., Stathopoulos, J., Marosis, K., & Michalopoulou, P. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1572-5 · Cited by 102

Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles

Zhigaltsev, I. V., Winters, G. C., Srinivasulu, M., Crawford, J. B., Wong, M., Amankwa, L. N., Waterhouse, D., Masin, D., Webb, M. S., & Harasym, N. L. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.029 · Cited by 101

Vascular and pharmacokinetic effects of EndoTAG-1 in patients with advanced cancer and liver metastasis

Fasol, U., Frost, A., Büchert, M., Arends, J., Fiedler, U., Scharr, D., Scheuenpflug, J., & Mross, K. B. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr300 · Cited by 101

Lyso-Thermosensitive Liposomal Doxorubicin: An Adjuvant to Increase The Cure Rate of Radiofrequency Ablation in Liver Cancer

Poon, R. T. P., & Borys, N. (2011) · Future Oncology · doi:10.2217/fon.11.73 · Cited by 100

The effect of entrapment in liposomes on the in vivo distribution of [3H]methotrexate in a primate.

Kimelberg, H. K., Tracy, T. F., Biddlecome, S. M., & BOURKE, R. S. (1976) · PubMed · Cited by 99

A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability

Stuart, D. D., & Allen, T. M. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00209-6 · Cited by 99

Chronic liposome administration in mice: effects on reticuloendothelial function and tissue distribution.

Allen, T. M., Murray, L., MacKeigan, S., & Shah, M. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21855-9 · Cited by 97

The bilayer stabilizing role of sphingomyelin in the presence of cholesterol. A 31P NMR study

Cullis, P. R., & Hope, M. J. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90225-4 · Cited by 97

Pharmaco attributes of dioleoylphosphatidylethanolamine/cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers

Zhang, J. X. (2003) · Pharmacological Research · doi:10.1016/j.phrs.2003.09.003 · Cited by 95

Influence of Drug-to-Lipid Ratio on Drug Release Properties and Liposome Integrity in Liposomal Doxorubicin Formulations

Johnston, M., Edwards, K., Karlsson, G., & Cullis, P. R. (2008) · Journal of Liposome Research · doi:10.1080/08982100802129372 · Cited by 94

A novel, long-circulating, and functional liposomal formulation of antisense oligodeoxynucleotides targeted against MDR1

Stuart, D. D., Kao, G. Y., & Allen, T. M. (2000) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700145 · Cited by 94

Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors

Rudin, C. M., Marshall, J. L., Huang, C. H., Kindler, H. L., Zhang, C., Kumar, D., Gokhale, P. C., Steinberg, J., Wanaski, S., Kasid, U. N., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0642 · Cited by 92

Lipid-based systems for the intracellular delivery of genetic drugs

Maurer, N., Mori, A., Palmer, L., Monck, M. A., Mok, K. W. C., Mui, B. L., Akhong, Q.-F., & Cullis, P. R. (1999) · Molecular Membrane Biology · doi:10.1080/096876899294869 · Cited by 91

Treatment of Acute Lymphoblastic Leukaemia

Apostolidou, E., Swords, R. T., Alvarado, Y., & Giles, F. J. (2007) · Drugs · doi:10.2165/00003495-200767150-00004 · Cited by 90

Immune Stimulation by a CpG-Containing Oligodeoxynucleotide Is Enhanced When Encapsulated and Delivered in Lipid Particles

Mui, B. L., Raney, S. G., Semple, S. C., & Hope, M. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29491-x · Cited by 90

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218

Advances and Challenges of Liposome Assisted Drug Delivery

Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586

Lipid NanoparticlesFrom Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164

NANOPARTICLES DRUG DELIVERY SYSTEM USING LIPOSOMES FOR CANCER TREATMENT

Juthi, A. Z., Bithi, T. Z., Babu, M. S. I., Talukder, M. E., & Hossen, M. S. (2005) · World Journal of Pharmaceutical and life sciences

Liposomal Medicine Drug Delivery Systems from Concept to Clinical Operation

Dhotre, S., Baokar, S., & Patil, R. (2025) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2025.v85i7.009

Progress with liposomal drug delivery systems: Formulation to therapy

Mahapatra, A. K., Murthy, P. N., Sravanthi, C. H., Ana, A., Swain, R. P., & Polei, N. (2014) · Der pharmacia lettre · Cited by 2

Lipopharmaceuticals- A Critical Review Focused on Recent Advances in Liposomal Drug Delivery

Rastogi, H., Shree, M., Srivastava, S., & Kaur, D. (2020) · INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) · doi:10.37021/ijper.v2i1.2 · Cited by 2

LIPOSOMES AS DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW WITH RECENT ADVANCES

Pal, A., Maurya, V. K., & Kumar, K. (2026) · GLOBAL JOURNAL OF PHARMACEUTICAL AND SCIENTIFIC RESEARCH · doi:10.66204/gjpsr-1124-2026-2-7-6