Cited by 4,839Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

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Liposomal drug delivery systems: From concept to clinical applications

Allen, Theresa M., Cullis, Pieter R.·2013·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2012.09.037

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Abstract

The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing combinations of drugs. These advances have led to numerous clinical trials in such diverse areas as the delivery of anti-cancer, anti-fungal and antibiotic drugs, the delivery of gene medicines, and the delivery of anesthetics and anti-inflammatory drugs. A number of liposomes (lipidic nanoparticles) are on the market, and many more are in the pipeline. Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance. We can look forward to many more clinical products in the future.

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Authors: Allen, T. M., & Cullis, P. R.
Affiliations: University of Alberta (CA)
University of British Columbia (CA)
Corresponding author: Allen, Theresa M.
ORCID: Cullis, Pieter R.
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2013-01
Volume: 65
Issue: 1
Pages: 36-48
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2012.09.037
OpenAlex: W2076226743
Cited by: 4,839
References: 294
Citations by year: 2026: 348 · 2025: 470 · 2024: 367 · 2023: 324 · 2022: 378 · 2021: 406 · 2020: 380 · 2019: 415 · 2018: 414 · 2017: 400 · 2016: 379 · 2015: 279 · 2014: 211 · 2013: 65
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
National Cancer Institute
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: liposomes, liposomal drug delivery, lipid nanoparticles, PEGylated liposomes, long-circulating liposomes, nucleic acid delivery, combination drug delivery, anticancer drug delivery, antifungal drug delivery, antibiotic delivery, gene therapy, anesthetic delivery, anti-inflammatory drug delivery, clinical translation, nanomedicine
MeSH terms: Animals, Drug Carriers, Pharmaceutical Preparations, Humans, Liposomes, Drug Delivery Systems, Nanomedicine, Nanoparticles

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Liposomal drug delivery systems: From concept to clinical applications

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