Cited by 841Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDrug Transport and Resistance Mechanisms

Enhanced Permeability and Retention (EPR) Effect for Anticancer Nanomedicine Drug Targeting

Greish, Khaled·2010·Methods in Molecular Biology

Abstract

Effective cancer therapy remains one of the most challenging tasks to the scientific community, with little advancement on overall cancer survival landscape during the last two decades. A major limitation inherent to most conventional anticancer chemotherapeutic agents is their lack of tumor selectivity. One way to achieve selective drug targeting to solid tumors is to exploit abnormalities of tumor vasculature, namely hypervascularization, aberrant vascular architecture, extensive production of vascular permeability factors stimulating extravasation within tumor tissues, and lack of lymphatic drainage. Due to their large size, nano-sized macromolecular anticancer drugs administered intravenously (i.v.) escape renal clearance. Being unable to penetrate through tight endothelial junctions of normal blood vessels, their concentration builds up in the plasma rendering them long plasma half-life. More importantly, they can selectively extravasate in tumor tissues due to its abnormal vascular nature. Overtime the tumor concentration will build up reaching several folds higher than that of the plasma due to lack of efficient lymphatic drainage in solid tumor, an ideal application for EPR-based selective anticancer nanotherapy. Indeed, this selective high local concentration of nano-sized anticancer drugs in tumor tissues has proven superior in therapeutic effect with minimal side effects in both preclinical and clinical settings.

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Crossref · 10.1007/978-1-60761-609-2_3

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  • The thermal effect, mechanical effect and the radiation force generated by ultrasound enhance the transient tissue permeability and are the reasons for stimulating the release of carrier drugs.

    “The thermal effect, mechanical effect and the radiation force generated by ultrasound enhance the transient tissue permeability and are the reasons for stimulating the release of carrier drugs.179”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [179]

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Authors
Greish, K.
Affiliations
University of Utah (US)
Corresponding author
Greish, Khaled
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2010
Volume
624
Pages
25-37
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
OpenAlex
W2273495465
Cited by
841
References
29
Citations by year
2026: 12 · 2025: 30 · 2024: 43 · 2023: 44 · 2022: 77 · 2021: 84 · 2020: 108 · 2019: 93 · 2018: 68 · 2017: 61 · 2016: 52 · 2015: 54 · 2014: 52 · 2013: 24 · 2012: 17
FWCI
25.80
Type
book chapter
Language
en
Open access
closed
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
enhanced permeability and retention effect, cancer nanomedicine, tumor targeting, extravasation, tumor selectivity, nanoparticle drug delivery, lymphatic drainage, tumor hypervascularization, nanomedicine
MeSH terms
Animals, Antineoplastic Agents, Doxorubicin, Drug Screening Assays, Antitumor, Male, Maleates, Micelles, Models, Biological, Neoplasms, Permeability, Polystyrenes, Tissue Distribution, Drug Delivery Systems, Nanomedicine, Mice

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