Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
Open accessAbstract
Background Many traditional risk factors for coronary artery disease (CAD) are associated with altered autonomic function. Inflammation may provide a link between risk factors, autonomic dysfunction, and CAD. We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measured by C-reactive protein (CRP) and interleukin-6 (IL-6).Methods We examined 264 middle-aged male twins free of symptomatic CAD. All underwent ambulatory electrocardiogram monitoring and 24-hour ultra low, very low, low, and high-frequency power were calculated using power spectral analysis. C-reactive protein and IL-6 were measured, and risk factors including age, smoking, hypertension, lipids, diabetes, body mass index (BMI), depression, and physical activity were assessed.Results Physical activity, BMI, high-density lipoprotein cholesterol, smoking, depression, and hypertension were directly associated with CRP and IL-6 and inversely associated with one or more HRV variables. There was a graded inverse relationship between all HRV parameters (except high frequency) and CRP and IL-6. After adjustment for age, BMI, activity, high-density lipoprotein, smoking, hypertension, depression, and diabetes, ultra low frequency and very low frequency remained significant predictors of CRP (P < .01).Conclusions C-reactive protein is associated with decreased HRV, even after controlling for traditional CAD risk factors. Autonomic dysregulation leading to inflammation may represent one pathway through which traditional risk factors promote development of CAD.
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Autonomic dysregulation may lead to inflammation.
“suggesting that autonomic dysregulation may lead to inflammation.28”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [28]
Decreased heart rate variability, even after controlling for traditional risk factors, is associated with increased C-reactive protein and interleukin-6.
“A decreased heart rate variability even after controlling for traditional risk factors, was associated with increased C-reactive protein and interleukin-6, suggesting that autonomic dysregulation may lead to inflammation.28”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [28]
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- Authors
- Lampert, R., Bremner, J. D., Su, S., Miller, A., Lee, F., Cheema, F., Goldberg, J., & Vaccarino, V.
- Affiliations
- Yale University (US)
- Emory University (US)
- University of Washington (US)
- Corresponding author
- Lampert, Rachel
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 156
- Issue
- 4
- Pages
- 759.e1-759.e7
- ISSN
- 0002-8703 (ISSN-L)
- PMC
- PMC2587932
- OpenAlex
- W2123814189
- Cited by
- 240
- References
- 41
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 15 · 2021: 25 · 2020: 17 · 2019: 19 · 2018: 12 · 2017: 14 · 2016: 9 · 2015: 11 · 2014: 20 · 2013: 11 · 2012: 14
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454)
- National Institute on Aging (R01AG026255)
- National Heart, Lung, and Blood Institute (R01HL068630, R01HL089314, K24HL077506, R01HL088726)
- National Institute of Mental Health (R01MH056120, K24MH076955, T32MH067547)
- National Institute on Drug Abuse (PL1DA024859)
- National Center for Research Resources (MO-1-RR-00039, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- heart rate variability, inflammation, C-reactive protein, interleukin-6, coronary artery disease, autonomic dysfunction, middle-aged men, physical activity, body mass index, hypertension, smoking, depression, cardiovascular risk factors
- MeSH terms
- Autonomic Nervous System, C-Reactive Protein, Coronary Artery Disease, Cross-Sectional Studies, Heart Rate, Humans, Inflammation, Male, Middle Aged, Risk Factors, Electrocardiography, Ambulatory, Interleukin-6
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